The Experts below are selected from a list of 171 Experts worldwide ranked by ideXlab platform

Katsuyuki Aozasa - One of the best experts on this subject based on the ideXlab platform.

  • Epstein-Barr virus in patients with polymorphic reticulosis (lethal Midline Granuloma) from China and Japan.
    Cancer, 1994
    Co-Authors: Kenji Mishima, Shizuo Kojya, Masahiko Ohsawa, Horiuchi K, Hiroomi Takahashi, Katsuyuki Aozasa
    Abstract:

    Background. Polymorphic reticulosis is one of several diseases constituting lethal Midline Granuloma (LMG). Previous immunohistochemical studies suggested a T-cell nature of proliferating cells; the term nasal T-cell lymphoma (NTL-LMG) has since been used widely. The authors' previous study in Asian countries showed the clustering of Mongolian patients with NTL-LMG, but the frequency varied with geographic area; it was much higher in Korea and southwest Japan (Okinawa) than in Shanghai and Honshu, Japan. Recently an etiologic role of Epstein-Barr virus (EBV) for the development of NTL-LMG has been postulated. Methods. In this study, the presence of EBV and human T-cell lymphocytic leukemia virus type 1 (HTLV-1) genomes were examined in NTL-LMG patients from Southwest Japan (Okinawa, 10 patients), another Japanese district (Honshu, 21 patients), and Shanghai, China (5 patients). All of the tissues from different geographic sites were analyzed at one central location. Results. Immunohistochemistry showed that proliferating large cells were positive for CD43 and/or CD45RO, identical with reported NTL-LMG cases. Polymerase chain reaction (PCR) revealed the presence of EBV genome in the NTL-LMG lesions, but the frequency varied according to the geographic area: 67% in Okinawa, 33% in Honshu, and 100% in Shanghai. In situ hybridization provided positive signals in the nuclei of proliferating cells. Expression of latent membrane protein in the proliferating cells of cases positive for EBV by PCR and in situ hybridization was confirmed. Conclusions. The results suggest that the EBV may play a role in the development of NTL-LMG. However, the variation of frequency of EBV genome in different geographic locations suggests that EBV infection may not be an indispensable condition for the disease. Cancer 1994; 73:3041–6.

  • Lethal Midline Granuloma in Okinawa with Special Emphasis on Polymorphic Reticulosis
    Japanese journal of cancer research : Gann, 1994
    Co-Authors: Shizuo Kojya, Tetsuo Itokazu, Norihide Maeshiro, Hiroaki Esu, Yutaka Noda, Kenji Mishima, Masahiko Ohsawa, Katsuyuki Aozasa
    Abstract:

    Lethal Midline Granuloma (LMG) is a clinical term used to describe a condition which may be manifested histologically as Wegener's Granulomatosis (WG), polymorphic reticulosis (PR), and malignant lymphoma (ML). WG is an inflammatory disease, and PR and ML are considered to represent a neoplastic proliferation of lymphoreticular cells. In this report, twenty-two cases of LMG in Okinawa were examined. The frequency of LMG per 100,000 outpatients of the ear, nose and throat clinic in Okinawa was 67, and the higher frequency of PR (27) and ML (34) in Okinawa than in other districts of Japan was characteristic. Polymerase chain reaction, in situ hybridization, and immunohistochemical studies showed that the proliferating cells in PR were CD43+ and simultaneously contained Epstein-Barr viral genome in their nuclei. The higher frequency of PR and ML in Okinawa is discussed in conjunction with a review of pertinent literature: multiple factors including genetic, viral environmental, and socioeconomic factors seem to affect the frequencies of these diseases.

M Chowdhury - One of the best experts on this subject based on the ideXlab platform.

  • Non Wegener's Midline Granuloma with bilateral thalamic involvement.
    Neurology India, 1996
    Co-Authors: B Maiti, S Mukherjee, S Das, M Chowdhury
    Abstract:

    A rare case of non Wegener's Midline Granuloma with bilateral thalamic involvement is presented. A 53 year old male presented with a nonhealing Midline Granuloma of nose for one year and right hemiparesis for five months with bilateral pyramidal signs. Biopsy from the nasal lesion revealed picture of malignant Midline reticulosis with angiocentric cellular infiltrate. Cranial CT scan revealed bilateral thalamic involvement.

  • Non Wegener's Midline Granuloma with bilateral thalamic involvement.
    Neurology India, 1995
    Co-Authors: B Maiti, S Mukherjee, S Das, M Chowdhury
    Abstract:

    A rare case of non Wegener's Midline Granuloma with bilateral thalamic involvement is presented. A 53 year old male presented with a nonhealing Midline Granuloma of nose for one year and right hemiparesis for five months with bilateral pyramidal signs. Biopsy from the nasal lesion picture of malignant Midline reticulosis with angiocentric cellular infiltrate. Cranial CT scan reveled bilateral thalamic involvement.

Kenji Mishima - One of the best experts on this subject based on the ideXlab platform.

  • Epstein-Barr virus in patients with polymorphic reticulosis (lethal Midline Granuloma) from China and Japan.
    Cancer, 1994
    Co-Authors: Kenji Mishima, Shizuo Kojya, Masahiko Ohsawa, Horiuchi K, Hiroomi Takahashi, Katsuyuki Aozasa
    Abstract:

    Background. Polymorphic reticulosis is one of several diseases constituting lethal Midline Granuloma (LMG). Previous immunohistochemical studies suggested a T-cell nature of proliferating cells; the term nasal T-cell lymphoma (NTL-LMG) has since been used widely. The authors' previous study in Asian countries showed the clustering of Mongolian patients with NTL-LMG, but the frequency varied with geographic area; it was much higher in Korea and southwest Japan (Okinawa) than in Shanghai and Honshu, Japan. Recently an etiologic role of Epstein-Barr virus (EBV) for the development of NTL-LMG has been postulated. Methods. In this study, the presence of EBV and human T-cell lymphocytic leukemia virus type 1 (HTLV-1) genomes were examined in NTL-LMG patients from Southwest Japan (Okinawa, 10 patients), another Japanese district (Honshu, 21 patients), and Shanghai, China (5 patients). All of the tissues from different geographic sites were analyzed at one central location. Results. Immunohistochemistry showed that proliferating large cells were positive for CD43 and/or CD45RO, identical with reported NTL-LMG cases. Polymerase chain reaction (PCR) revealed the presence of EBV genome in the NTL-LMG lesions, but the frequency varied according to the geographic area: 67% in Okinawa, 33% in Honshu, and 100% in Shanghai. In situ hybridization provided positive signals in the nuclei of proliferating cells. Expression of latent membrane protein in the proliferating cells of cases positive for EBV by PCR and in situ hybridization was confirmed. Conclusions. The results suggest that the EBV may play a role in the development of NTL-LMG. However, the variation of frequency of EBV genome in different geographic locations suggests that EBV infection may not be an indispensable condition for the disease. Cancer 1994; 73:3041–6.

  • Lethal Midline Granuloma in Okinawa with Special Emphasis on Polymorphic Reticulosis
    Japanese journal of cancer research : Gann, 1994
    Co-Authors: Shizuo Kojya, Tetsuo Itokazu, Norihide Maeshiro, Hiroaki Esu, Yutaka Noda, Kenji Mishima, Masahiko Ohsawa, Katsuyuki Aozasa
    Abstract:

    Lethal Midline Granuloma (LMG) is a clinical term used to describe a condition which may be manifested histologically as Wegener's Granulomatosis (WG), polymorphic reticulosis (PR), and malignant lymphoma (ML). WG is an inflammatory disease, and PR and ML are considered to represent a neoplastic proliferation of lymphoreticular cells. In this report, twenty-two cases of LMG in Okinawa were examined. The frequency of LMG per 100,000 outpatients of the ear, nose and throat clinic in Okinawa was 67, and the higher frequency of PR (27) and ML (34) in Okinawa than in other districts of Japan was characteristic. Polymerase chain reaction, in situ hybridization, and immunohistochemical studies showed that the proliferating cells in PR were CD43+ and simultaneously contained Epstein-Barr viral genome in their nuclei. The higher frequency of PR and ML in Okinawa is discussed in conjunction with a review of pertinent literature: multiple factors including genetic, viral environmental, and socioeconomic factors seem to affect the frequencies of these diseases.

Shizuo Kojya - One of the best experts on this subject based on the ideXlab platform.

  • Epstein-Barr virus in patients with polymorphic reticulosis (lethal Midline Granuloma) from China and Japan.
    Cancer, 1994
    Co-Authors: Kenji Mishima, Shizuo Kojya, Masahiko Ohsawa, Horiuchi K, Hiroomi Takahashi, Katsuyuki Aozasa
    Abstract:

    Background. Polymorphic reticulosis is one of several diseases constituting lethal Midline Granuloma (LMG). Previous immunohistochemical studies suggested a T-cell nature of proliferating cells; the term nasal T-cell lymphoma (NTL-LMG) has since been used widely. The authors' previous study in Asian countries showed the clustering of Mongolian patients with NTL-LMG, but the frequency varied with geographic area; it was much higher in Korea and southwest Japan (Okinawa) than in Shanghai and Honshu, Japan. Recently an etiologic role of Epstein-Barr virus (EBV) for the development of NTL-LMG has been postulated. Methods. In this study, the presence of EBV and human T-cell lymphocytic leukemia virus type 1 (HTLV-1) genomes were examined in NTL-LMG patients from Southwest Japan (Okinawa, 10 patients), another Japanese district (Honshu, 21 patients), and Shanghai, China (5 patients). All of the tissues from different geographic sites were analyzed at one central location. Results. Immunohistochemistry showed that proliferating large cells were positive for CD43 and/or CD45RO, identical with reported NTL-LMG cases. Polymerase chain reaction (PCR) revealed the presence of EBV genome in the NTL-LMG lesions, but the frequency varied according to the geographic area: 67% in Okinawa, 33% in Honshu, and 100% in Shanghai. In situ hybridization provided positive signals in the nuclei of proliferating cells. Expression of latent membrane protein in the proliferating cells of cases positive for EBV by PCR and in situ hybridization was confirmed. Conclusions. The results suggest that the EBV may play a role in the development of NTL-LMG. However, the variation of frequency of EBV genome in different geographic locations suggests that EBV infection may not be an indispensable condition for the disease. Cancer 1994; 73:3041–6.

  • Lethal Midline Granuloma in Okinawa with Special Emphasis on Polymorphic Reticulosis
    Japanese journal of cancer research : Gann, 1994
    Co-Authors: Shizuo Kojya, Tetsuo Itokazu, Norihide Maeshiro, Hiroaki Esu, Yutaka Noda, Kenji Mishima, Masahiko Ohsawa, Katsuyuki Aozasa
    Abstract:

    Lethal Midline Granuloma (LMG) is a clinical term used to describe a condition which may be manifested histologically as Wegener's Granulomatosis (WG), polymorphic reticulosis (PR), and malignant lymphoma (ML). WG is an inflammatory disease, and PR and ML are considered to represent a neoplastic proliferation of lymphoreticular cells. In this report, twenty-two cases of LMG in Okinawa were examined. The frequency of LMG per 100,000 outpatients of the ear, nose and throat clinic in Okinawa was 67, and the higher frequency of PR (27) and ML (34) in Okinawa than in other districts of Japan was characteristic. Polymerase chain reaction, in situ hybridization, and immunohistochemical studies showed that the proliferating cells in PR were CD43+ and simultaneously contained Epstein-Barr viral genome in their nuclei. The higher frequency of PR and ML in Okinawa is discussed in conjunction with a review of pertinent literature: multiple factors including genetic, viral environmental, and socioeconomic factors seem to affect the frequencies of these diseases.

B Maiti - One of the best experts on this subject based on the ideXlab platform.

  • Non Wegener's Midline Granuloma with bilateral thalamic involvement.
    Neurology India, 1996
    Co-Authors: B Maiti, S Mukherjee, S Das, M Chowdhury
    Abstract:

    A rare case of non Wegener's Midline Granuloma with bilateral thalamic involvement is presented. A 53 year old male presented with a nonhealing Midline Granuloma of nose for one year and right hemiparesis for five months with bilateral pyramidal signs. Biopsy from the nasal lesion revealed picture of malignant Midline reticulosis with angiocentric cellular infiltrate. Cranial CT scan revealed bilateral thalamic involvement.

  • Non Wegener's Midline Granuloma with bilateral thalamic involvement.
    Neurology India, 1995
    Co-Authors: B Maiti, S Mukherjee, S Das, M Chowdhury
    Abstract:

    A rare case of non Wegener's Midline Granuloma with bilateral thalamic involvement is presented. A 53 year old male presented with a nonhealing Midline Granuloma of nose for one year and right hemiparesis for five months with bilateral pyramidal signs. Biopsy from the nasal lesion picture of malignant Midline reticulosis with angiocentric cellular infiltrate. Cranial CT scan reveled bilateral thalamic involvement.