The Experts below are selected from a list of 384 Experts worldwide ranked by ideXlab platform
Augusto Vaglio - One of the best experts on this subject based on the ideXlab platform.
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response to eosinophilic granulomatosis with polyangiitis can manifest lacrimal and salivary glands swelling by granulomatous inflammation a potential mimicker of igg4 related Disease by akiyama et al
Annals of the Rheumatic Diseases, 2020Co-Authors: Augusto Vaglio, Federica Maritati, Jochen ZwerinaAbstract:In their insightful correspondence, Akiyama et al 1 focus on a peculiar feature of eosinophilic granulomatosis with polyangiitis (EGPA), that is, the involvement of salivary and lacrimal glands, which mimics the Mikulicz Disease, a common manifestation of IgG4-related Disease (IgG4-RD). Given that EGPA shows high serum IgG4 levels (particularly in its active phases),2 and that IgG4-RD often features allergy, eosinophilia and respiratory tract involvement, the differential diagnosis between these two disorders may be challenging. The observation that patients with EGPA can present with Mikulicz-like salivary and lacrimal gland involvement enhances the difficulty in the differential diagnosis with …
Tsutomu Takeuchi - One of the best experts on this subject based on the ideXlab platform.
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eosinophilic granulomatosis with polyangiitis can manifest lacrimal and salivary glands swelling by granulomatous inflammation a potential mimicker of igg4 related Disease
Annals of the Rheumatic Diseases, 2020Co-Authors: Mitsuhiro Akiyama, Yuko Kaneko, Tsutomu TakeuchiAbstract:We read the paper by Vaglio et al in your journal with great interest.1 They reported that patients with eosinophilic granulomatosis with polyangiitis (EGPA), previously known as Churg-Strauss syndrome, showed high serum IgG4 levels, correlating with Disease activity and the extent of organ involvement.1 Since then, the association between EGPA and IgG4-related Disease has been discussed by researchers.2–4 EGPA is one of the systemic vasculitis and is typically preceded by bronchial asthma, allergic rhinitis and/or sinusitis and followed by peripheral blood eosinophilia and eosinophil infiltration into organs. IgG4-related Disease is an emerging Disease entity characterised by high serum IgG4 levels and marked IgG4-positive plasma cell infiltration at lesions. Mikulicz Disease, a prototype of IgG4-related Disease, presents with enlarged lacrimal and salivary glands and often has allergic features such as asthma and chronic sinusitis. Pathogenically, T helper …
Jochen Zwerina - One of the best experts on this subject based on the ideXlab platform.
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response to eosinophilic granulomatosis with polyangiitis can manifest lacrimal and salivary glands swelling by granulomatous inflammation a potential mimicker of igg4 related Disease by akiyama et al
Annals of the Rheumatic Diseases, 2020Co-Authors: Augusto Vaglio, Federica Maritati, Jochen ZwerinaAbstract:In their insightful correspondence, Akiyama et al 1 focus on a peculiar feature of eosinophilic granulomatosis with polyangiitis (EGPA), that is, the involvement of salivary and lacrimal glands, which mimics the Mikulicz Disease, a common manifestation of IgG4-related Disease (IgG4-RD). Given that EGPA shows high serum IgG4 levels (particularly in its active phases),2 and that IgG4-RD often features allergy, eosinophilia and respiratory tract involvement, the differential diagnosis between these two disorders may be challenging. The observation that patients with EGPA can present with Mikulicz-like salivary and lacrimal gland involvement enhances the difficulty in the differential diagnosis with …
Mitsuhiro Akiyama - One of the best experts on this subject based on the ideXlab platform.
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eosinophilic granulomatosis with polyangiitis can manifest lacrimal and salivary glands swelling by granulomatous inflammation a potential mimicker of igg4 related Disease
Annals of the Rheumatic Diseases, 2020Co-Authors: Mitsuhiro Akiyama, Yuko Kaneko, Tsutomu TakeuchiAbstract:We read the paper by Vaglio et al in your journal with great interest.1 They reported that patients with eosinophilic granulomatosis with polyangiitis (EGPA), previously known as Churg-Strauss syndrome, showed high serum IgG4 levels, correlating with Disease activity and the extent of organ involvement.1 Since then, the association between EGPA and IgG4-related Disease has been discussed by researchers.2–4 EGPA is one of the systemic vasculitis and is typically preceded by bronchial asthma, allergic rhinitis and/or sinusitis and followed by peripheral blood eosinophilia and eosinophil infiltration into organs. IgG4-related Disease is an emerging Disease entity characterised by high serum IgG4 levels and marked IgG4-positive plasma cell infiltration at lesions. Mikulicz Disease, a prototype of IgG4-related Disease, presents with enlarged lacrimal and salivary glands and often has allergic features such as asthma and chronic sinusitis. Pathogenically, T helper …
Kaori Togashi - One of the best experts on this subject based on the ideXlab platform.
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utility of fdg pet ct in igg4 related systemic Disease
Clinical Radiology, 2012Co-Authors: Koya Nakatani, Yuji Nakamoto, Kaori TogashiAbstract:IgG4-related systemic Disease (IgG4-RSD) is an emerging clinical entity about which much remains to be elucidated, in terms of its aetiology, pathogenesis, diagnosis, treatment and outcome. Autoimmune pancreatitis (AIP) and Mikulicz Disease (MD) are the two major, well-studied constituents of IgG4-RSD. AIP and MD have common characteristics of forming tumour-mimicking lesions that consist of lymphoplasmacytic infiltrates and fibrosclerosis with numerous immunoglobulin G4 (IgG4)-positive plasma cells, as well as various multi-organ manifestations of IgG4-RSD. 2-[ 18 F]-fluoro-2-deoxy- d- glucose positron-emission tomography/ computed tomography (FDG PET/CT) enables the acquisition of whole-body images and provides functional information about Disease activity; as such it has a valuable role in staging extent of Disease, guiding biopsy, and monitoring response to treatment. However, FDG PET/CT is likely to be only one component of the management strategy, and clinical, laboratory, imaging and histological findings are crucial in the overall diagnosis of the condition. At present FDG PET/CT does not have a well-established role in the assessment of patients with IgG4-RSD and future prospective studies are required to define the cost-effectiveness and clinical impact in this patient group more accurately.
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Utility of FDG PET/CT in IgG4-related systemic Disease
Clinical Radiology, 2011Co-Authors: Koya Nakatani, Yuji Nakamoto, Kaori TogashiAbstract:IgG4-related systemic Disease (IgG4-RSD) is an emerging clinical entity about which much remains to be elucidated, in terms of its aetiology, pathogenesis, diagnosis, treatment and outcome. Autoimmune pancreatitis (AIP) and Mikulicz Disease (MD) are the two major, well-studied constituents of IgG4-RSD. AIP and MD have common characteristics of forming tumour-mimicking lesions that consist of lymphoplasmacytic infiltrates and fibrosclerosis with numerous immunoglobulin G4 (IgG4)-positive plasma cells, as well as various multi-organ manifestations of IgG4-RSD. 2-[ 18 F]-fluoro-2-deoxy- d- glucose positron-emission tomography/ computed tomography (FDG PET/CT) enables the acquisition of whole-body images and provides functional information about Disease activity; as such it has a valuable role in staging extent of Disease, guiding biopsy, and monitoring response to treatment. However, FDG PET/CT is likely to be only one component of the management strategy, and clinical, laboratory, imaging and histological findings are crucial in the overall diagnosis of the condition. At present FDG PET/CT does not have a well-established role in the assessment of patients with IgG4-RSD and future prospective studies are required to define the cost-effectiveness and clinical impact in this patient group more accurately.