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J W Spears - One of the best experts on this subject based on the ideXlab platform.
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effect of dietary copper amount and source on copper metabolism and oxidative stress of weanling pigs in short term feeding
Journal of Animal Science, 2015Co-Authors: Yanling Huang, M S Ashwell, K E Lloyd, W L Flowers, J W SpearsAbstract:: Forty-eight weanling barrows were used to determine the effects of amount and source of dietary Cu on Cu metabolism, oxidative stress in the duodenum, and VFA ratios in the cecum of weanling pigs in short-term feeding. At 21 d of age, newly weaned pigs were stratified by BW (7.03 ± 1.20 kg) and equally assigned to 1 of the following dietary treatments: 1) control (5 mg supplemental Cu/kg diet from CuSO4), 2) 225 mg supplemental Cu/kg diet from CuSO4, or 3) 225 mg supplemental Cu/kg diet from tribasic Cu chloride (TBCC). Pigs were housed 2 pigs per pen and were fed a complex diet until harvest on d 11 and 12. During harvest, bile and liver were obtained for Mineral Analysis, and liver samples were obtained for Analysis of mRNA expression of Cu regulatory proteins. Digesta of duodenum, proximal jejunum, and ileum were collected for soluble Cu Analysis. Mucosal scrapings of duodenum, proximal jejunum, and ileum were obtained for Analysis of mucosal Cu concentration and mRNA expression of Cu regulatory proteins. Duodenal mucosal scrapings were also collected for Analysis of malondialdehyde (MDA). Pigs fed high Cu had markedly greater (P < 0.0001) Cu concentrations in the duodenal, proximal jejunal, and ileal mucosa than controls. Copper in the duodenal mucosa was greater (P = 0.003) in CuSO4 than TBCC pigs. Duodenal MDA concentrations were greater (P = 0.003) in CuSO4 vs. control pigs and tended (P = 0.06) to be greater than in TBCC pigs. Duodenal antioxidant 1 (Atox1) mRNA was downregulated (P < 0.01) in pigs fed high Cu compared to controls and was not affected by Cu source. Compared with control pigs, those fed CuSO4 and TBCC had greater (P < 0.001) liver and bile Cu concentrations. Liver Cu was also greater (P = 0.0007) in TBCC than CuSO4-fed pigs. Hepatic Cu transporting β-polypeptide ATPase (Atp7b) was upregulated (P = 0.02) in the Cu-supplemented pigs compared with controls and did not differ among Cu sources. The acetate:propionate ratio in cecal contents was much greater in pigs supplemented with 225 mg Cu/kg diet than in controls. When fed at 225 mg Cu/kg diet, TBCC may cause less oxidative stress in the duodenum than CuSO4. Feeding weanling pigs increased Cu resulted in modulation of duodenal and liver at the transcription level.
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amount and source of dietary copper affects small intestine morphology duodenal lipid peroxidation hepatic oxidative stress and mrna expression of hepatic copper regulatory proteins in weanling pigs
Journal of Animal Science, 2012Co-Authors: M S Ashwell, K E Lloyd, W L Flowers, A T Onan, K R Stewart, J W SpearsAbstract:Thirty weanling, crossbred barrows (SUS SCROFA) were used to determine the effects of amount and source of dietary Cu on small intestinal morphology and lipid peroxidation, Cu metabolism, and mRNA expression of proteins involved in hepatic Cu homeostasis. At 21 d of age, pigs were stratifi ed by BW (6.33 ± 0.23 kg) and allocated to 1 of the following dietary treatments: i) control (no supplemental Cu; 6.7 mg Cu/kg), ii) 225 mg supplemental Cu/kg diet from Cu sulfate (CuSO 4 ), or iii) 225 mg supplemental Cu/ kg diet from tribasic Cu chloride (TBCC). Pigs were housed 2 pigs per pen and were fed a 3-phase diet regi- men until d 35 or 36 of the study. During harvest, bile and liver were obtained for Mineral Analysis, and liver samples were also obtained for Analysis of liver gluta- thione (GSH) and mRNA expression of Cu regulatory proteins. Segments of duodenum, proximal jejunum, and ileum were obtained for mucosal morphology, and duodenal mucosal scrapings were collected from all pigs for Analysis of malondialdehyde (MDA). Duodenal villus height was reduced in CuSO 4 pigs compared with control (P = 0.001) and TBCC (P = 0.03) pigs. Villus height in the proximal jejunum of CuSO 4 pigs was reduced (P = 0.03) compared with control pigs, but ileal villus height was not affected (P = 0.82) by treat- ment. Duodenal MDA concentrations were greater (P = 0.03) in CuSO 4 pigs and tended to be greater (P = 0.10) in pigs supplemented with TBCC compared with control pigs. Liver Cu was greater (P = 0.01) in CuSO 4 vs. control pigs, and tended (P = 0.07) to be greater in TBCC pigs than control pigs. Bile Cu concentrations were greater (P < 0.001) in CuSO 4 and TBCC pigs vs. controls and were also greater (P = 0.04) in TBCC vs. CuSO 4 pigs. Total liver GSH concentrations were less (P = 0.02) in pigs fed diets supplemented with CuSO 4 vs. pigs fed control diets but total liver GSH did not dif- fer (P = 0.11) between control and TBCC pigs. Hepatic mRNA of cytochrome c oxidase assembly protein 17 was less (P = 0.01) in CuSO 4 and tended to be less (P = 0.08) in TBCC pigs vs. control pigs. Expression of anti- oxidant 1 mRNA was greater (P = 0.04) in TBCC pigs and tended to be greater (P = 0.06) in CuSO 4 pigs com- pared with control pigs. Results of this study indicated that, when fed at 225 mg Cu/kg diet, TBCC may cause less oxidative stress in the duodenum than CuSO 4 . Feeding weanling pigs increased Cu resulted in modu- lation of certain Cu transporters and chaperones at the transcription level.
M S Ashwell - One of the best experts on this subject based on the ideXlab platform.
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effect of dietary copper amount and source on copper metabolism and oxidative stress of weanling pigs in short term feeding
Journal of Animal Science, 2015Co-Authors: Yanling Huang, M S Ashwell, K E Lloyd, W L Flowers, J W SpearsAbstract:: Forty-eight weanling barrows were used to determine the effects of amount and source of dietary Cu on Cu metabolism, oxidative stress in the duodenum, and VFA ratios in the cecum of weanling pigs in short-term feeding. At 21 d of age, newly weaned pigs were stratified by BW (7.03 ± 1.20 kg) and equally assigned to 1 of the following dietary treatments: 1) control (5 mg supplemental Cu/kg diet from CuSO4), 2) 225 mg supplemental Cu/kg diet from CuSO4, or 3) 225 mg supplemental Cu/kg diet from tribasic Cu chloride (TBCC). Pigs were housed 2 pigs per pen and were fed a complex diet until harvest on d 11 and 12. During harvest, bile and liver were obtained for Mineral Analysis, and liver samples were obtained for Analysis of mRNA expression of Cu regulatory proteins. Digesta of duodenum, proximal jejunum, and ileum were collected for soluble Cu Analysis. Mucosal scrapings of duodenum, proximal jejunum, and ileum were obtained for Analysis of mucosal Cu concentration and mRNA expression of Cu regulatory proteins. Duodenal mucosal scrapings were also collected for Analysis of malondialdehyde (MDA). Pigs fed high Cu had markedly greater (P < 0.0001) Cu concentrations in the duodenal, proximal jejunal, and ileal mucosa than controls. Copper in the duodenal mucosa was greater (P = 0.003) in CuSO4 than TBCC pigs. Duodenal MDA concentrations were greater (P = 0.003) in CuSO4 vs. control pigs and tended (P = 0.06) to be greater than in TBCC pigs. Duodenal antioxidant 1 (Atox1) mRNA was downregulated (P < 0.01) in pigs fed high Cu compared to controls and was not affected by Cu source. Compared with control pigs, those fed CuSO4 and TBCC had greater (P < 0.001) liver and bile Cu concentrations. Liver Cu was also greater (P = 0.0007) in TBCC than CuSO4-fed pigs. Hepatic Cu transporting β-polypeptide ATPase (Atp7b) was upregulated (P = 0.02) in the Cu-supplemented pigs compared with controls and did not differ among Cu sources. The acetate:propionate ratio in cecal contents was much greater in pigs supplemented with 225 mg Cu/kg diet than in controls. When fed at 225 mg Cu/kg diet, TBCC may cause less oxidative stress in the duodenum than CuSO4. Feeding weanling pigs increased Cu resulted in modulation of duodenal and liver at the transcription level.
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amount and source of dietary copper affects small intestine morphology duodenal lipid peroxidation hepatic oxidative stress and mrna expression of hepatic copper regulatory proteins in weanling pigs
Journal of Animal Science, 2012Co-Authors: M S Ashwell, K E Lloyd, W L Flowers, A T Onan, K R Stewart, J W SpearsAbstract:Thirty weanling, crossbred barrows (SUS SCROFA) were used to determine the effects of amount and source of dietary Cu on small intestinal morphology and lipid peroxidation, Cu metabolism, and mRNA expression of proteins involved in hepatic Cu homeostasis. At 21 d of age, pigs were stratifi ed by BW (6.33 ± 0.23 kg) and allocated to 1 of the following dietary treatments: i) control (no supplemental Cu; 6.7 mg Cu/kg), ii) 225 mg supplemental Cu/kg diet from Cu sulfate (CuSO 4 ), or iii) 225 mg supplemental Cu/ kg diet from tribasic Cu chloride (TBCC). Pigs were housed 2 pigs per pen and were fed a 3-phase diet regi- men until d 35 or 36 of the study. During harvest, bile and liver were obtained for Mineral Analysis, and liver samples were also obtained for Analysis of liver gluta- thione (GSH) and mRNA expression of Cu regulatory proteins. Segments of duodenum, proximal jejunum, and ileum were obtained for mucosal morphology, and duodenal mucosal scrapings were collected from all pigs for Analysis of malondialdehyde (MDA). Duodenal villus height was reduced in CuSO 4 pigs compared with control (P = 0.001) and TBCC (P = 0.03) pigs. Villus height in the proximal jejunum of CuSO 4 pigs was reduced (P = 0.03) compared with control pigs, but ileal villus height was not affected (P = 0.82) by treat- ment. Duodenal MDA concentrations were greater (P = 0.03) in CuSO 4 pigs and tended to be greater (P = 0.10) in pigs supplemented with TBCC compared with control pigs. Liver Cu was greater (P = 0.01) in CuSO 4 vs. control pigs, and tended (P = 0.07) to be greater in TBCC pigs than control pigs. Bile Cu concentrations were greater (P < 0.001) in CuSO 4 and TBCC pigs vs. controls and were also greater (P = 0.04) in TBCC vs. CuSO 4 pigs. Total liver GSH concentrations were less (P = 0.02) in pigs fed diets supplemented with CuSO 4 vs. pigs fed control diets but total liver GSH did not dif- fer (P = 0.11) between control and TBCC pigs. Hepatic mRNA of cytochrome c oxidase assembly protein 17 was less (P = 0.01) in CuSO 4 and tended to be less (P = 0.08) in TBCC pigs vs. control pigs. Expression of anti- oxidant 1 mRNA was greater (P = 0.04) in TBCC pigs and tended to be greater (P = 0.06) in CuSO 4 pigs com- pared with control pigs. Results of this study indicated that, when fed at 225 mg Cu/kg diet, TBCC may cause less oxidative stress in the duodenum than CuSO 4 . Feeding weanling pigs increased Cu resulted in modu- lation of certain Cu transporters and chaperones at the transcription level.
K E Lloyd - One of the best experts on this subject based on the ideXlab platform.
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effect of dietary copper amount and source on copper metabolism and oxidative stress of weanling pigs in short term feeding
Journal of Animal Science, 2015Co-Authors: Yanling Huang, M S Ashwell, K E Lloyd, W L Flowers, J W SpearsAbstract:: Forty-eight weanling barrows were used to determine the effects of amount and source of dietary Cu on Cu metabolism, oxidative stress in the duodenum, and VFA ratios in the cecum of weanling pigs in short-term feeding. At 21 d of age, newly weaned pigs were stratified by BW (7.03 ± 1.20 kg) and equally assigned to 1 of the following dietary treatments: 1) control (5 mg supplemental Cu/kg diet from CuSO4), 2) 225 mg supplemental Cu/kg diet from CuSO4, or 3) 225 mg supplemental Cu/kg diet from tribasic Cu chloride (TBCC). Pigs were housed 2 pigs per pen and were fed a complex diet until harvest on d 11 and 12. During harvest, bile and liver were obtained for Mineral Analysis, and liver samples were obtained for Analysis of mRNA expression of Cu regulatory proteins. Digesta of duodenum, proximal jejunum, and ileum were collected for soluble Cu Analysis. Mucosal scrapings of duodenum, proximal jejunum, and ileum were obtained for Analysis of mucosal Cu concentration and mRNA expression of Cu regulatory proteins. Duodenal mucosal scrapings were also collected for Analysis of malondialdehyde (MDA). Pigs fed high Cu had markedly greater (P < 0.0001) Cu concentrations in the duodenal, proximal jejunal, and ileal mucosa than controls. Copper in the duodenal mucosa was greater (P = 0.003) in CuSO4 than TBCC pigs. Duodenal MDA concentrations were greater (P = 0.003) in CuSO4 vs. control pigs and tended (P = 0.06) to be greater than in TBCC pigs. Duodenal antioxidant 1 (Atox1) mRNA was downregulated (P < 0.01) in pigs fed high Cu compared to controls and was not affected by Cu source. Compared with control pigs, those fed CuSO4 and TBCC had greater (P < 0.001) liver and bile Cu concentrations. Liver Cu was also greater (P = 0.0007) in TBCC than CuSO4-fed pigs. Hepatic Cu transporting β-polypeptide ATPase (Atp7b) was upregulated (P = 0.02) in the Cu-supplemented pigs compared with controls and did not differ among Cu sources. The acetate:propionate ratio in cecal contents was much greater in pigs supplemented with 225 mg Cu/kg diet than in controls. When fed at 225 mg Cu/kg diet, TBCC may cause less oxidative stress in the duodenum than CuSO4. Feeding weanling pigs increased Cu resulted in modulation of duodenal and liver at the transcription level.
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amount and source of dietary copper affects small intestine morphology duodenal lipid peroxidation hepatic oxidative stress and mrna expression of hepatic copper regulatory proteins in weanling pigs
Journal of Animal Science, 2012Co-Authors: M S Ashwell, K E Lloyd, W L Flowers, A T Onan, K R Stewart, J W SpearsAbstract:Thirty weanling, crossbred barrows (SUS SCROFA) were used to determine the effects of amount and source of dietary Cu on small intestinal morphology and lipid peroxidation, Cu metabolism, and mRNA expression of proteins involved in hepatic Cu homeostasis. At 21 d of age, pigs were stratifi ed by BW (6.33 ± 0.23 kg) and allocated to 1 of the following dietary treatments: i) control (no supplemental Cu; 6.7 mg Cu/kg), ii) 225 mg supplemental Cu/kg diet from Cu sulfate (CuSO 4 ), or iii) 225 mg supplemental Cu/ kg diet from tribasic Cu chloride (TBCC). Pigs were housed 2 pigs per pen and were fed a 3-phase diet regi- men until d 35 or 36 of the study. During harvest, bile and liver were obtained for Mineral Analysis, and liver samples were also obtained for Analysis of liver gluta- thione (GSH) and mRNA expression of Cu regulatory proteins. Segments of duodenum, proximal jejunum, and ileum were obtained for mucosal morphology, and duodenal mucosal scrapings were collected from all pigs for Analysis of malondialdehyde (MDA). Duodenal villus height was reduced in CuSO 4 pigs compared with control (P = 0.001) and TBCC (P = 0.03) pigs. Villus height in the proximal jejunum of CuSO 4 pigs was reduced (P = 0.03) compared with control pigs, but ileal villus height was not affected (P = 0.82) by treat- ment. Duodenal MDA concentrations were greater (P = 0.03) in CuSO 4 pigs and tended to be greater (P = 0.10) in pigs supplemented with TBCC compared with control pigs. Liver Cu was greater (P = 0.01) in CuSO 4 vs. control pigs, and tended (P = 0.07) to be greater in TBCC pigs than control pigs. Bile Cu concentrations were greater (P < 0.001) in CuSO 4 and TBCC pigs vs. controls and were also greater (P = 0.04) in TBCC vs. CuSO 4 pigs. Total liver GSH concentrations were less (P = 0.02) in pigs fed diets supplemented with CuSO 4 vs. pigs fed control diets but total liver GSH did not dif- fer (P = 0.11) between control and TBCC pigs. Hepatic mRNA of cytochrome c oxidase assembly protein 17 was less (P = 0.01) in CuSO 4 and tended to be less (P = 0.08) in TBCC pigs vs. control pigs. Expression of anti- oxidant 1 mRNA was greater (P = 0.04) in TBCC pigs and tended to be greater (P = 0.06) in CuSO 4 pigs com- pared with control pigs. Results of this study indicated that, when fed at 225 mg Cu/kg diet, TBCC may cause less oxidative stress in the duodenum than CuSO 4 . Feeding weanling pigs increased Cu resulted in modu- lation of certain Cu transporters and chaperones at the transcription level.
W L Flowers - One of the best experts on this subject based on the ideXlab platform.
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effect of dietary copper amount and source on copper metabolism and oxidative stress of weanling pigs in short term feeding
Journal of Animal Science, 2015Co-Authors: Yanling Huang, M S Ashwell, K E Lloyd, W L Flowers, J W SpearsAbstract:: Forty-eight weanling barrows were used to determine the effects of amount and source of dietary Cu on Cu metabolism, oxidative stress in the duodenum, and VFA ratios in the cecum of weanling pigs in short-term feeding. At 21 d of age, newly weaned pigs were stratified by BW (7.03 ± 1.20 kg) and equally assigned to 1 of the following dietary treatments: 1) control (5 mg supplemental Cu/kg diet from CuSO4), 2) 225 mg supplemental Cu/kg diet from CuSO4, or 3) 225 mg supplemental Cu/kg diet from tribasic Cu chloride (TBCC). Pigs were housed 2 pigs per pen and were fed a complex diet until harvest on d 11 and 12. During harvest, bile and liver were obtained for Mineral Analysis, and liver samples were obtained for Analysis of mRNA expression of Cu regulatory proteins. Digesta of duodenum, proximal jejunum, and ileum were collected for soluble Cu Analysis. Mucosal scrapings of duodenum, proximal jejunum, and ileum were obtained for Analysis of mucosal Cu concentration and mRNA expression of Cu regulatory proteins. Duodenal mucosal scrapings were also collected for Analysis of malondialdehyde (MDA). Pigs fed high Cu had markedly greater (P < 0.0001) Cu concentrations in the duodenal, proximal jejunal, and ileal mucosa than controls. Copper in the duodenal mucosa was greater (P = 0.003) in CuSO4 than TBCC pigs. Duodenal MDA concentrations were greater (P = 0.003) in CuSO4 vs. control pigs and tended (P = 0.06) to be greater than in TBCC pigs. Duodenal antioxidant 1 (Atox1) mRNA was downregulated (P < 0.01) in pigs fed high Cu compared to controls and was not affected by Cu source. Compared with control pigs, those fed CuSO4 and TBCC had greater (P < 0.001) liver and bile Cu concentrations. Liver Cu was also greater (P = 0.0007) in TBCC than CuSO4-fed pigs. Hepatic Cu transporting β-polypeptide ATPase (Atp7b) was upregulated (P = 0.02) in the Cu-supplemented pigs compared with controls and did not differ among Cu sources. The acetate:propionate ratio in cecal contents was much greater in pigs supplemented with 225 mg Cu/kg diet than in controls. When fed at 225 mg Cu/kg diet, TBCC may cause less oxidative stress in the duodenum than CuSO4. Feeding weanling pigs increased Cu resulted in modulation of duodenal and liver at the transcription level.
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amount and source of dietary copper affects small intestine morphology duodenal lipid peroxidation hepatic oxidative stress and mrna expression of hepatic copper regulatory proteins in weanling pigs
Journal of Animal Science, 2012Co-Authors: M S Ashwell, K E Lloyd, W L Flowers, A T Onan, K R Stewart, J W SpearsAbstract:Thirty weanling, crossbred barrows (SUS SCROFA) were used to determine the effects of amount and source of dietary Cu on small intestinal morphology and lipid peroxidation, Cu metabolism, and mRNA expression of proteins involved in hepatic Cu homeostasis. At 21 d of age, pigs were stratifi ed by BW (6.33 ± 0.23 kg) and allocated to 1 of the following dietary treatments: i) control (no supplemental Cu; 6.7 mg Cu/kg), ii) 225 mg supplemental Cu/kg diet from Cu sulfate (CuSO 4 ), or iii) 225 mg supplemental Cu/ kg diet from tribasic Cu chloride (TBCC). Pigs were housed 2 pigs per pen and were fed a 3-phase diet regi- men until d 35 or 36 of the study. During harvest, bile and liver were obtained for Mineral Analysis, and liver samples were also obtained for Analysis of liver gluta- thione (GSH) and mRNA expression of Cu regulatory proteins. Segments of duodenum, proximal jejunum, and ileum were obtained for mucosal morphology, and duodenal mucosal scrapings were collected from all pigs for Analysis of malondialdehyde (MDA). Duodenal villus height was reduced in CuSO 4 pigs compared with control (P = 0.001) and TBCC (P = 0.03) pigs. Villus height in the proximal jejunum of CuSO 4 pigs was reduced (P = 0.03) compared with control pigs, but ileal villus height was not affected (P = 0.82) by treat- ment. Duodenal MDA concentrations were greater (P = 0.03) in CuSO 4 pigs and tended to be greater (P = 0.10) in pigs supplemented with TBCC compared with control pigs. Liver Cu was greater (P = 0.01) in CuSO 4 vs. control pigs, and tended (P = 0.07) to be greater in TBCC pigs than control pigs. Bile Cu concentrations were greater (P < 0.001) in CuSO 4 and TBCC pigs vs. controls and were also greater (P = 0.04) in TBCC vs. CuSO 4 pigs. Total liver GSH concentrations were less (P = 0.02) in pigs fed diets supplemented with CuSO 4 vs. pigs fed control diets but total liver GSH did not dif- fer (P = 0.11) between control and TBCC pigs. Hepatic mRNA of cytochrome c oxidase assembly protein 17 was less (P = 0.01) in CuSO 4 and tended to be less (P = 0.08) in TBCC pigs vs. control pigs. Expression of anti- oxidant 1 mRNA was greater (P = 0.04) in TBCC pigs and tended to be greater (P = 0.06) in CuSO 4 pigs com- pared with control pigs. Results of this study indicated that, when fed at 225 mg Cu/kg diet, TBCC may cause less oxidative stress in the duodenum than CuSO 4 . Feeding weanling pigs increased Cu resulted in modu- lation of certain Cu transporters and chaperones at the transcription level.
Andrew G Whitham - One of the best experts on this subject based on the ideXlab platform.
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u pb shrimp ages of detrital granulite facies rutiles further constraints on provenance of jurassic sandstones on the norwegian margin
Geological Magazine, 2011Co-Authors: Guido Meinhold, Andrew C Morton, Mark C Fanning, Andrew G WhithamAbstract:Electron microprobe analyses of 128 detrital rutile grains from two Jurassic sandstone samples (Hettangian and Bajocian–Bathonian in age) from hydrocarbon exploration wells on the Norwegian margin confirm that more than 85 % of the rutiles were derived from metapelitic rocks. Zr-in-rutile geothermometry confirms that about 83 % of the rutile was formed under high-grade metamorphism (>750 °C). Sixty-two rutile grains, including 60 of the identified high-temperature rutile population, were also analysed for U–Pb geochronology using SHRIMP. The 206 Pb– 238 U rutile ages range from approximately 485–292 Ma, with a major cluster between 450 and 380 Ma. These data suggest that the detrital rutile was predominantly derived from a felsic source that experienced granulite-facies metamorphism about 450–380 Ma ago. This conclusion is consistent with derivation from high-grade Caledonian metasedimentary rocks, probably the Krummedal sequence in central East Greenland, as previously suggested by an earlier provenance study using conventional heavy Mineral Analysis, garnet geochemistry and detrital zircon age dating. The present study underscores the importance of rutile geochemistry and geochronology in quantitative single-Mineral provenance Analysis of clastic sedimentary rocks.
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provenance of late cretaceous to paleocene submarine fan sandstones in the norwegian sea integration of heavy Mineral Mineral chemical and zircon age data
Sedimentary Geology, 2005Co-Authors: Andrew C Morton, Andrew G Whitham, Christopher FanningAbstract:Abstract This paper describes a strategy for effective discrimination and provenance evaluation of sandstones transported by different sediment dispersal systems using an integrated programme of heavy Mineral Analysis, Mineral chemistry and zircon age dating. Sandstones derived from different source regions are initially discriminated using provenance–sensitive heavy Mineral parameters (ratios of abundances of stable, hydraulically equivalent Minerals). Differences between the heavy Mineral populations are reinforced by single-grain Mineral chemical Analysis, which also provides further information on the nature of the source terrains. Zircon age dating of representative samples places further constraints on the location of the source areas, by identifying the main crust-forming events. In addition, the validity of the Mineralogical discrimination can be tested by the zircon age data. The value of this integrated approach is illustrated by a case study of deep marine Late Cretaceous–Paleocene sandstones in the Norwegian Sea. Potential sources of coarse clastic sediment lie both to the east, in mid-Norway, and the west, in East Greenland. Three main sand types (MN1, MN2 and MN3) have been identified, each of which has a unique combination of heavy Mineral ratios (rutile/zircon, monazite/zircon, chrome spinel/zircon and apatite/tourmaline) and Mineral chemistry (garnet and tourmaline). Sand type MN1 has a simple zircon age spectrum, with a large Early–Middle Proterozoic group and a small Early Paleozoic group, indicating derivation from northern mid-Norway. Sand type MN2 has a complex age structure including Archaean and early Proterozoic zircons. It can be divided into two subtypes, MN2a and MN2b, and can be ascribed to a source in East Greenland. Sand type MN3 has a simple age structure dominated by Middle Proterozoic zircons, and it was sourced from southern mid-Norway. Since reservoir presence is a major area of uncertainty in the deep water Norwegian Sea, the use of heavy Mineral, Mineral chemical and zircon age data to discriminate sandstones of eastern and western origin is crucial to hydrocarbon exploration of the area.