The Experts below are selected from a list of 36 Experts worldwide ranked by ideXlab platform

R. A. Voyer - One of the best experts on this subject based on the ideXlab platform.

  • Interactive cytotoxicities of selected organic and inorganic substances to brown cells ofMercenaria mercenaria
    Cell Biology and Toxicology, 1995
    Co-Authors: G. Zaroogian, R. A. Voyer
    Abstract:

    Toxicities of binary Mixtures of Cu^2+, Cd^2+, benzo(a)pyrene [B(a)P] and N -ethylmaleimide (NEM) were screened using the in vitro neutral red (NR) assay to test the hypothesis that combined toxicity is more than or less than additive relative to the influence of each Mixture Constituent on toxicant uptake and brown cell lysosomal membrane stability. Significant cytotoxicity was observed at 25 μmol/L Cu^2+, 500 μmol/L Cd^2+ and 25 μmol/L NEM. B(a)P at 12 μmol/L exerted no toxicity under the conditions of the assay. Interactions between Cu^2+ and NEM, between Cd^2+ and NEM, and between Cd^2+ and B(a)P significantly influenced brown cell survival. Comparison of observed joint toxicity with estimates made using a model of independent joint action indicates that interactive effects are less than additive in character. The 3-way interaction involving Cu^2+, B(a)P, and NEM also affected brown cell survival to a statistically significant degree. However, the interactive cytotoxicity of this Mixture is attributable mainly to the combined effect of Cu^2+ and NEM. Results also indicate that new. hypotheses and additional experimentation are needed to understand the interactive toxicity of Mixture Constituents.

  • Interactive cytotoxicities of selected organic and inorganic substances to brown cells of Mercenaria mercenaria.
    Cell biology and toxicology, 1995
    Co-Authors: G. Zaroogian, R. A. Voyer
    Abstract:

    Toxicities of binary Mixtures of Cu2+, Cd2+, benzo(a)pyrene [B(a)P] andN-ethylmaleimide (NEM) were screened using thein vitro neutral red (NR) assay to test the hypothesis that combined toxicity is more than or less than additive relative to the influence of each Mixture Constituent on toxicant uptake and brown cell lysosomal membrane stability. Significant cytotoxicity was observed at 25 μmol/L Cu2+, 500 μmol/L Cd2+ and 25 μmol/L NEM. B(a)P at 12 μmol/L exerted no toxicity under the conditions of the assay. Interactions between Cu2+ and NEM, between Cd2+ and NEM, and between Cd2+ and B(a)P significantly influenced brown cell survival. Comparison of observed joint toxicity with estimates made using a model of independent joint action indicates that interactive effects are less than additive in character. The 3-way interaction involving Cu2+, B(a)P, and NEM also affected brown cell survival to a statistically significant degree. However, the interactive cytotoxicity of this Mixture is attributable mainly to the combined effect of Cu2+ and NEM. Results also indicate that new. hypotheses and additional experimentation are needed to understand the interactive toxicity of Mixture Constituents.

G. Zaroogian - One of the best experts on this subject based on the ideXlab platform.

  • Interactive cytotoxicities of selected organic and inorganic substances to brown cells ofMercenaria mercenaria
    Cell Biology and Toxicology, 1995
    Co-Authors: G. Zaroogian, R. A. Voyer
    Abstract:

    Toxicities of binary Mixtures of Cu^2+, Cd^2+, benzo(a)pyrene [B(a)P] and N -ethylmaleimide (NEM) were screened using the in vitro neutral red (NR) assay to test the hypothesis that combined toxicity is more than or less than additive relative to the influence of each Mixture Constituent on toxicant uptake and brown cell lysosomal membrane stability. Significant cytotoxicity was observed at 25 μmol/L Cu^2+, 500 μmol/L Cd^2+ and 25 μmol/L NEM. B(a)P at 12 μmol/L exerted no toxicity under the conditions of the assay. Interactions between Cu^2+ and NEM, between Cd^2+ and NEM, and between Cd^2+ and B(a)P significantly influenced brown cell survival. Comparison of observed joint toxicity with estimates made using a model of independent joint action indicates that interactive effects are less than additive in character. The 3-way interaction involving Cu^2+, B(a)P, and NEM also affected brown cell survival to a statistically significant degree. However, the interactive cytotoxicity of this Mixture is attributable mainly to the combined effect of Cu^2+ and NEM. Results also indicate that new. hypotheses and additional experimentation are needed to understand the interactive toxicity of Mixture Constituents.

  • Interactive cytotoxicities of selected organic and inorganic substances to brown cells of Mercenaria mercenaria.
    Cell biology and toxicology, 1995
    Co-Authors: G. Zaroogian, R. A. Voyer
    Abstract:

    Toxicities of binary Mixtures of Cu2+, Cd2+, benzo(a)pyrene [B(a)P] andN-ethylmaleimide (NEM) were screened using thein vitro neutral red (NR) assay to test the hypothesis that combined toxicity is more than or less than additive relative to the influence of each Mixture Constituent on toxicant uptake and brown cell lysosomal membrane stability. Significant cytotoxicity was observed at 25 μmol/L Cu2+, 500 μmol/L Cd2+ and 25 μmol/L NEM. B(a)P at 12 μmol/L exerted no toxicity under the conditions of the assay. Interactions between Cu2+ and NEM, between Cd2+ and NEM, and between Cd2+ and B(a)P significantly influenced brown cell survival. Comparison of observed joint toxicity with estimates made using a model of independent joint action indicates that interactive effects are less than additive in character. The 3-way interaction involving Cu2+, B(a)P, and NEM also affected brown cell survival to a statistically significant degree. However, the interactive cytotoxicity of this Mixture is attributable mainly to the combined effect of Cu2+ and NEM. Results also indicate that new. hypotheses and additional experimentation are needed to understand the interactive toxicity of Mixture Constituents.

Zhu Hongzhou - One of the best experts on this subject based on the ideXlab platform.

  • asphalt Mixture Constituent structure optimization based on rut resistance property
    Journal of Huazhong University of Science and Technology, 2006
    Co-Authors: Zhu Hongzhou
    Abstract:

    The effect of Constituent structure on rutting performance of asphalt Mixtures is analyzed.For the optimizing target of rutting performance,the asphalt Mixtures are optimized by combining BP neural net with Genetic Algorithms.The relations between different passing percent,filling-bitumen ratio,voids percent and dynamic stability of asphalt Mixture specimen are obtained,which can be consulted in asphalt Mixture design based on performances.

Seong-wan Park - One of the best experts on this subject based on the ideXlab platform.

  • Experimental Evaluation of Anti-stripping Additives in Bituminous Mixtures through Multiple Scale Laboratory Test Results
    Construction and Building Materials, 2012
    Co-Authors: Yong-rak Kim, Ingryd Pinto, Seong-wan Park
    Abstract:

    Abstract This paper presents performance changes and material characteristics associated with moisture damage due to anti-stripping additives in asphalt Mixtures through various laboratory tests. Two additives (hydrated lime and fly ash) are investigated by adding them into two types of mixes where different asphalt binders and aggregates are used. Two widely-used asphalt concrete Mixture performance tests (the AASHTO T-283 and the asphalt pavement analyzer under water) and two Mixture Constituent tests (the boiling water test and the pull-off tensile strength test) are conducted to characterize the effects of anti-stripping additives on the binder–aggregate bonding potential in Mixtures. Results from laboratory tests indicate that the mixes, where high-quality aggregates and polymer-modified binder are used, are fairly self-resistant to moisture damage without treating any anti-stripping additive and do not show any visible sensitivity between additives, whereas the effects of additives and their sensitivity are significant in the mixes that use the unmodified binder and low-quality aggregates. With the limited amount of test data, both hydrated lime and fly ash contribute to reducing moisture damage, which implies potential significant cost savings by the use of fly ash as an alternative additive.

Zhu Hong-zhou - One of the best experts on this subject based on the ideXlab platform.

  • Asphalt Mixture Constituent structure optimization based on fatigue performance
    Journal of Chongqing Jiaotong University, 2006
    Co-Authors: Zhu Hong-zhou
    Abstract:

    To prolong the fatigue life of asphalt pavement, the fatigue performance of asphalt Mixtures must be improved by changing the Constituent structure of Mixture primarily.In this paper,the effect of Constituent structure on fatigue performance of asphalt Mixtures was analyzed.In succession,for the optimizing target as fatigue performance,the asphalt Mixture were optimized combining BP nerve net with Genetic Algorithms.As a result,the relation between 4.75mm passing percent,0.075 mm passing percent,filling-bitumen ratio and voids percent and fatigue performance of asphalt Mixture,which can be considered in asphalt Mixture design based on performances.