The Experts below are selected from a list of 237 Experts worldwide ranked by ideXlab platform

John H Stone - One of the best experts on this subject based on the ideXlab platform.

  • riedel s thyroiditis and Multifocal Fibrosclerosis are part of the igg4 related systemic disease spectrum
    Arthritis Care and Research, 2010
    Co-Authors: Mollie Dahlgren, Arezou Khosroshahi, Petur G Nielsen, Vikram Deshpande, John H Stone
    Abstract:

    Objective Riedel's thyroiditis is a chronic fibrosing disorder of unknown etiology often associated with “Multifocal Fibrosclerosis.” IgG4-related systemic disease is characterized by IgG4+ plasma cell infiltration and fibrosis throughout many organs. We hypothesized that Riedel's thyroiditis is part of the IgG4-related systemic disease spectrum. Methods We searched our institution's pathology database using the terms “Riedel's,” “struma,” “thyroid,” and “fibrosis,” and identified 3 cases of Riedel's thyroiditis. Riedel's thyroiditis was diagnosed if there was a fibroinflammatory process involving all or a portion of the thyroid gland, with evidence of extension of the process into surrounding tissues. Immunohistochemical stains for IgG4 and IgG were performed. The histopathologic and immunohistochemical features of each involved organ were evaluated. The clinical features of one patient with multiple organ system disease were described. Results All 3 thyroidectomy samples stained positively for IgG4-bearing plasma cells. One patient had extensive extrathyroidal involvement diagnostic of IgG4-related systemic disease, including cholangitis, pseudotumors of both the lung and lacrimal gland, and a lymph node contiguous to the thyroid that stained intensely for IgG4+ plasma cells. The histologic features of all organs involved were consistent with IgG4-related systemic disease. Patient 3 had 10 IgG4+ plasma cells per high-power field initially, but rebiopsy 2 years later demonstrated no IgG4+ plasma cells. That patient's second biopsy, characterized by fibrosis and minimal residual inflammation, further solidifies the link between IgG4-bearing plasma cells in tissue and the histologic evolution to Riedel's thyroiditis. Conclusion Riedel's thyroiditis is part of the IgG4-related systemic disease spectrum. In many cases, Multifocal Fibrosclerosis and IgG4-related systemic disease are probably the same entity.

Luc Mortelmans - One of the best experts on this subject based on the ideXlab platform.

  • riedel s thyroiditis and retroperitoneal fibrosis in Multifocal Fibrosclerosis positron emission tomographic findings
    Clinical Nuclear Medicine, 2002
    Co-Authors: O Drieskens, Daniel Engelbert Blockmans, Annick Van Den Bruel, Luc Mortelmans
    Abstract:

    PURPOSE: The authors describe F-18 fluorodeoxyglucose positron emission tomographic (FDG PET) imaging features of Riedel's thyroiditis and retroperitoneal fibrosis in a patient with Multifocal Fibrosclerosis. MATERIALS AND METHODS: A 41-year-old woman in whom Riedel's thyroiditis had been diagnosed 7 months earlier was examined for fatigue, anorexia, and lower back pain, irradiating to the abdomen. Abdominal sonography and computed tomography showed a retroperitoneal mass. A biopsy of this mass showed histopathologic findings of retroperitoneal fibrosis. FDG PET was performed to evaluate the activity of the retroperitoneal fibrosis and to screen for other areas of Fibrosclerosis. RESULTS: The FDG-PET images showed an intense hypermetabolic abdominal mass surrounding the aorta and increased glucose metabolism in the thyroid. No other sites of abnormal FDG metabolism were noted. These abnormalities disappeared after 4 months of steroid therapy. CONCLUSIONS: Sites of Multifocal Fibrosclerosis can be demonstrated by FDG PET, probably as a result of active inflammation involving lymphocytes, plasma cells, and fibroblast proliferation. FDG PET can help to establish the diagnosis of Multifocal Fibrosclerosis and evaluate the activity and patient response to corticosteroid therapy.

Aysenur Cila - One of the best experts on this subject based on the ideXlab platform.

  • Multifocal Fibrosclerosis a new case report and review of the literature
    European Radiology, 2002
    Co-Authors: Kader Karli Oguz, Aysenur Cila, Hayyam Kiratli, Oguzhan Oguz, Aytac Gokoz
    Abstract:

    A case of Multifocal Fibrosclerosis is presented with MR images. Bilateral sclerosing orbital pseudotumor invading cavernous sinuses were the presenting disorder. Magnetic resonance imaging showed involvement of paranasal sinuses bilaterally and multiple supratentorial dural masses. Retroperitoneal fibrosis was associated with the condition. Multifocal involvement should be considered in patients with sclerosing orbital pseudotumor and an imaging approach should be performed on the appropriate clinical condition to document possible coexistence of other disorders including retroperitoneal fibrosis, mediastinal fibrosis, sclerosing cholangitis, and Riedel's thyroiditis

  • riedel s thyroiditis in Multifocal Fibrosclerosis ct and mr imaging findings
    American Journal of Neuroradiology, 2000
    Co-Authors: Ali Ozgen, Aysenur Cila
    Abstract:

    Summary: Riedel’s thyroiditis is a rare disorder of unknown etiology and may be seen isolated or as a part of Multifocal Fibrosclerosis. It is important to distinguish Riedel’s thyroiditis from thyroid carcinoma. Reports about imaging features of Riedel’s thyroiditis are limited in the radiologic literature. We describe herein CT and MR imaging features of Riedel’s thyroiditis in a case of Multifocal Fibrosclerosis with previously unreported radiologic observations.

Mollie Dahlgren - One of the best experts on this subject based on the ideXlab platform.

  • riedel s thyroiditis and Multifocal Fibrosclerosis are part of the igg4 related systemic disease spectrum
    Arthritis Care and Research, 2010
    Co-Authors: Mollie Dahlgren, Arezou Khosroshahi, Petur G Nielsen, Vikram Deshpande, John H Stone
    Abstract:

    Objective Riedel's thyroiditis is a chronic fibrosing disorder of unknown etiology often associated with “Multifocal Fibrosclerosis.” IgG4-related systemic disease is characterized by IgG4+ plasma cell infiltration and fibrosis throughout many organs. We hypothesized that Riedel's thyroiditis is part of the IgG4-related systemic disease spectrum. Methods We searched our institution's pathology database using the terms “Riedel's,” “struma,” “thyroid,” and “fibrosis,” and identified 3 cases of Riedel's thyroiditis. Riedel's thyroiditis was diagnosed if there was a fibroinflammatory process involving all or a portion of the thyroid gland, with evidence of extension of the process into surrounding tissues. Immunohistochemical stains for IgG4 and IgG were performed. The histopathologic and immunohistochemical features of each involved organ were evaluated. The clinical features of one patient with multiple organ system disease were described. Results All 3 thyroidectomy samples stained positively for IgG4-bearing plasma cells. One patient had extensive extrathyroidal involvement diagnostic of IgG4-related systemic disease, including cholangitis, pseudotumors of both the lung and lacrimal gland, and a lymph node contiguous to the thyroid that stained intensely for IgG4+ plasma cells. The histologic features of all organs involved were consistent with IgG4-related systemic disease. Patient 3 had 10 IgG4+ plasma cells per high-power field initially, but rebiopsy 2 years later demonstrated no IgG4+ plasma cells. That patient's second biopsy, characterized by fibrosis and minimal residual inflammation, further solidifies the link between IgG4-bearing plasma cells in tissue and the histologic evolution to Riedel's thyroiditis. Conclusion Riedel's thyroiditis is part of the IgG4-related systemic disease spectrum. In many cases, Multifocal Fibrosclerosis and IgG4-related systemic disease are probably the same entity.

Rolf Janka - One of the best experts on this subject based on the ideXlab platform.

  • multiple bone lesions of systemic Multifocal Fibrosclerosis
    American Journal of Roentgenology, 2005
    Co-Authors: Norbert Blank, Roland Repp, Wolfgang Romer, Joachim R Kalden, Gisela Helm, Thomas Harrer, Hannsmartin Lorenz, Rolf Janka
    Abstract:

    4Department of Radiology, University of Erlangen, Erlangen, Germany. ystemic Multifocal Fibrosclerosis is a rare disorder of unknown cause and is characterized by multiple fibrous lesions occurring with a variety of combined manifestations. Clinical variants include retroperitoneal fibrosis, Riedel’s thyroiditis, sclerosing cholangitis, mediastinal fibrosis, and orbital pseudotumor [1, 2]. An accurate diagnosis is based on tissue biopsy and pathologic examination. We describe a case of systemic Multifocal Fibrosclerosis with extensive bone involvement that was detected on MRI, gallium-67 scanning, and bone scintigraphy, with only subtle changes on conventional radiography.