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Figen Zihnioglu - One of the best experts on this subject based on the ideXlab platform.

  • extraction and characterization of novel Multifunctional Peptides from trachinus draco greater weever myofibrillar proteins with ace dpp4 inhibitory antioxidant and metal chelating activities
    Journal of Food Biochemistry, 2020
    Co-Authors: Elif Kula, Ebru Kocadag Kocazorbaz, Hichem Moulahoum, Senol Alpat, Figen Zihnioglu
    Abstract:

    Marine organisms represent a great source of natural bioactive molecules, from which bioactive Peptides are of great importance in biomedicine application in many diseases such as diabetes and its related complications. In this study, greater weever (Trachinus Draco) myofibrillar proteins were sequentially hydrolyzed and the different RP-HPLC purified fractions were tested for potential inhibitory activities of ACE and DPP4, in addition to metal chelation and antioxidant activities. Four fractions were found to have high levels of activity (with two Peptides being Multifunctional) and were subsequently sequenced using the de novo sequencing method. The results indicate that the Peptides are novel and highly effective for each related activity compared to reference molecules. The current findings suggest these Multifunctional Peptides as promising therapeutics against oxidative stress, hypertension, and diabetes. PRACTICAL APPLICATIONS: We have described the finding of two Multifunctional bioactive Peptides from Trachinus Draco (greater weever) myofibrillar proteins having two or more activities. They have ACE inhibitory, DPP4 inhibitory, antioxidant, and metal chelation activities. These new Peptides could be used for future biomedicine applications as a stand-alone treatment, in combination with other molecules, or as a supplement. Furthermore, after identification of their sequence in our work, it would have a great potential to be artificially synthesized. The field of food supplements could be explored further.

  • Extraction and characterization of novel Multifunctional Peptides from Trachinus Draco (greater weever) myofibrillar proteins with ACE/DPP4 inhibitory, antioxidant, and metal chelating activities
    Journal of Food Biochemistry, 2020
    Co-Authors: Elif Kula, Ebru Kocadag Kocazorbaz, Hichem Moulahoum, Senol Alpat, Figen Zihnioglu
    Abstract:

    Marine organisms represent a great source of natural bioactive molecules, from which bioactive Peptides are of great importance in biomedicine application in many diseases such as diabetes and its related complications. In this study, greater weever (Trachinus Draco) myofibrillar proteins were sequentially hydrolyzed and the different RP-HPLC purified fractions were tested for potential inhibitory activities of ACE and DPP4, in addition to metal chelation and antioxidant activities. Four fractions were found to have high levels of activity (with two Peptides being Multifunctional) and were subsequently sequenced using the de novo sequencing method. The results indicate that the Peptides are novel and highly effective for each related activity compared to reference molecules. The current findings suggest these Multifunctional Peptides as promising therapeutics against oxidative stress, hypertension, and diabetes. PRACTICAL APPLICATIONS: We have described the finding of two Multifunctional bioactive Peptides from Trachinus Draco (greater weever) myofibrillar proteins having two or more activities. They have ACE inhibitory, DPP4 inhibitory, antioxidant, and metal chelation activities. These new Peptides could be used for future biomedicine applications as a stand-alone treatment, in combination with other molecules, or as a supplement. Furthermore, after identification of their sequence in our work, it would have a great potential to be artificially synthesized. The field of food supplements could be explored further.

Elif Kula - One of the best experts on this subject based on the ideXlab platform.

  • extraction and characterization of novel Multifunctional Peptides from trachinus draco greater weever myofibrillar proteins with ace dpp4 inhibitory antioxidant and metal chelating activities
    Journal of Food Biochemistry, 2020
    Co-Authors: Elif Kula, Ebru Kocadag Kocazorbaz, Hichem Moulahoum, Senol Alpat, Figen Zihnioglu
    Abstract:

    Marine organisms represent a great source of natural bioactive molecules, from which bioactive Peptides are of great importance in biomedicine application in many diseases such as diabetes and its related complications. In this study, greater weever (Trachinus Draco) myofibrillar proteins were sequentially hydrolyzed and the different RP-HPLC purified fractions were tested for potential inhibitory activities of ACE and DPP4, in addition to metal chelation and antioxidant activities. Four fractions were found to have high levels of activity (with two Peptides being Multifunctional) and were subsequently sequenced using the de novo sequencing method. The results indicate that the Peptides are novel and highly effective for each related activity compared to reference molecules. The current findings suggest these Multifunctional Peptides as promising therapeutics against oxidative stress, hypertension, and diabetes. PRACTICAL APPLICATIONS: We have described the finding of two Multifunctional bioactive Peptides from Trachinus Draco (greater weever) myofibrillar proteins having two or more activities. They have ACE inhibitory, DPP4 inhibitory, antioxidant, and metal chelation activities. These new Peptides could be used for future biomedicine applications as a stand-alone treatment, in combination with other molecules, or as a supplement. Furthermore, after identification of their sequence in our work, it would have a great potential to be artificially synthesized. The field of food supplements could be explored further.

  • Extraction and characterization of novel Multifunctional Peptides from Trachinus Draco (greater weever) myofibrillar proteins with ACE/DPP4 inhibitory, antioxidant, and metal chelating activities
    Journal of Food Biochemistry, 2020
    Co-Authors: Elif Kula, Ebru Kocadag Kocazorbaz, Hichem Moulahoum, Senol Alpat, Figen Zihnioglu
    Abstract:

    Marine organisms represent a great source of natural bioactive molecules, from which bioactive Peptides are of great importance in biomedicine application in many diseases such as diabetes and its related complications. In this study, greater weever (Trachinus Draco) myofibrillar proteins were sequentially hydrolyzed and the different RP-HPLC purified fractions were tested for potential inhibitory activities of ACE and DPP4, in addition to metal chelation and antioxidant activities. Four fractions were found to have high levels of activity (with two Peptides being Multifunctional) and were subsequently sequenced using the de novo sequencing method. The results indicate that the Peptides are novel and highly effective for each related activity compared to reference molecules. The current findings suggest these Multifunctional Peptides as promising therapeutics against oxidative stress, hypertension, and diabetes. PRACTICAL APPLICATIONS: We have described the finding of two Multifunctional bioactive Peptides from Trachinus Draco (greater weever) myofibrillar proteins having two or more activities. They have ACE inhibitory, DPP4 inhibitory, antioxidant, and metal chelation activities. These new Peptides could be used for future biomedicine applications as a stand-alone treatment, in combination with other molecules, or as a supplement. Furthermore, after identification of their sequence in our work, it would have a great potential to be artificially synthesized. The field of food supplements could be explored further.

H. Meisel - One of the best experts on this subject based on the ideXlab platform.

  • Multifunctional Peptides encrypted in milk proteins
    BioFactors, 2004
    Co-Authors: H. Meisel
    Abstract:

    Many bioactivities of milk are latent in that they are inactive within the protein sequence, requiring enzymatic proteolysis for release of bioactive Peptides from milk proteins precursors. Bioactivities of Peptides encrypted in major milk proteins are latent until released and activated, e.g. during gastrointestinal digestion or food processing. Bioactive Peptides can be produced in vivo following intake of milk proteins, and the proteolytic system of bacterial species used in the production of fermented milk products and cheese can contribute to the liberation of bioactive Peptides or precursors thereof. Activated Peptides are potential modulators of various regulatory processes in the living system: immunomodulatory Peptides stimulate the activities of cells of the immune system and several cytomodulatory Peptides inhibit cancer cell growth, antimicrobial Peptides kill sensitive microorganisms, angiotensin-I-converting enzyme (ACE)-inhibitory Peptides exert an hypotensive effect, opioid Peptides are opioid receptor ligands which can modulate absorption processes in the intestinal tract, mineral binding Peptides may function as carriers for different minerals, especially calcium. Many milk-derived Peptides reveal Multifunctional properties, i.e. specific peptide sequences having two or more different biological activities have been reported. Milk protein-derived bioactive Peptides are claimed to be health enhancing components that can be used to reduce the risk of disease or to enhance a certain physiological function.

Hichem Moulahoum - One of the best experts on this subject based on the ideXlab platform.

  • extraction and characterization of novel Multifunctional Peptides from trachinus draco greater weever myofibrillar proteins with ace dpp4 inhibitory antioxidant and metal chelating activities
    Journal of Food Biochemistry, 2020
    Co-Authors: Elif Kula, Ebru Kocadag Kocazorbaz, Hichem Moulahoum, Senol Alpat, Figen Zihnioglu
    Abstract:

    Marine organisms represent a great source of natural bioactive molecules, from which bioactive Peptides are of great importance in biomedicine application in many diseases such as diabetes and its related complications. In this study, greater weever (Trachinus Draco) myofibrillar proteins were sequentially hydrolyzed and the different RP-HPLC purified fractions were tested for potential inhibitory activities of ACE and DPP4, in addition to metal chelation and antioxidant activities. Four fractions were found to have high levels of activity (with two Peptides being Multifunctional) and were subsequently sequenced using the de novo sequencing method. The results indicate that the Peptides are novel and highly effective for each related activity compared to reference molecules. The current findings suggest these Multifunctional Peptides as promising therapeutics against oxidative stress, hypertension, and diabetes. PRACTICAL APPLICATIONS: We have described the finding of two Multifunctional bioactive Peptides from Trachinus Draco (greater weever) myofibrillar proteins having two or more activities. They have ACE inhibitory, DPP4 inhibitory, antioxidant, and metal chelation activities. These new Peptides could be used for future biomedicine applications as a stand-alone treatment, in combination with other molecules, or as a supplement. Furthermore, after identification of their sequence in our work, it would have a great potential to be artificially synthesized. The field of food supplements could be explored further.

  • Extraction and characterization of novel Multifunctional Peptides from Trachinus Draco (greater weever) myofibrillar proteins with ACE/DPP4 inhibitory, antioxidant, and metal chelating activities
    Journal of Food Biochemistry, 2020
    Co-Authors: Elif Kula, Ebru Kocadag Kocazorbaz, Hichem Moulahoum, Senol Alpat, Figen Zihnioglu
    Abstract:

    Marine organisms represent a great source of natural bioactive molecules, from which bioactive Peptides are of great importance in biomedicine application in many diseases such as diabetes and its related complications. In this study, greater weever (Trachinus Draco) myofibrillar proteins were sequentially hydrolyzed and the different RP-HPLC purified fractions were tested for potential inhibitory activities of ACE and DPP4, in addition to metal chelation and antioxidant activities. Four fractions were found to have high levels of activity (with two Peptides being Multifunctional) and were subsequently sequenced using the de novo sequencing method. The results indicate that the Peptides are novel and highly effective for each related activity compared to reference molecules. The current findings suggest these Multifunctional Peptides as promising therapeutics against oxidative stress, hypertension, and diabetes. PRACTICAL APPLICATIONS: We have described the finding of two Multifunctional bioactive Peptides from Trachinus Draco (greater weever) myofibrillar proteins having two or more activities. They have ACE inhibitory, DPP4 inhibitory, antioxidant, and metal chelation activities. These new Peptides could be used for future biomedicine applications as a stand-alone treatment, in combination with other molecules, or as a supplement. Furthermore, after identification of their sequence in our work, it would have a great potential to be artificially synthesized. The field of food supplements could be explored further.

Ebru Kocadag Kocazorbaz - One of the best experts on this subject based on the ideXlab platform.

  • extraction and characterization of novel Multifunctional Peptides from trachinus draco greater weever myofibrillar proteins with ace dpp4 inhibitory antioxidant and metal chelating activities
    Journal of Food Biochemistry, 2020
    Co-Authors: Elif Kula, Ebru Kocadag Kocazorbaz, Hichem Moulahoum, Senol Alpat, Figen Zihnioglu
    Abstract:

    Marine organisms represent a great source of natural bioactive molecules, from which bioactive Peptides are of great importance in biomedicine application in many diseases such as diabetes and its related complications. In this study, greater weever (Trachinus Draco) myofibrillar proteins were sequentially hydrolyzed and the different RP-HPLC purified fractions were tested for potential inhibitory activities of ACE and DPP4, in addition to metal chelation and antioxidant activities. Four fractions were found to have high levels of activity (with two Peptides being Multifunctional) and were subsequently sequenced using the de novo sequencing method. The results indicate that the Peptides are novel and highly effective for each related activity compared to reference molecules. The current findings suggest these Multifunctional Peptides as promising therapeutics against oxidative stress, hypertension, and diabetes. PRACTICAL APPLICATIONS: We have described the finding of two Multifunctional bioactive Peptides from Trachinus Draco (greater weever) myofibrillar proteins having two or more activities. They have ACE inhibitory, DPP4 inhibitory, antioxidant, and metal chelation activities. These new Peptides could be used for future biomedicine applications as a stand-alone treatment, in combination with other molecules, or as a supplement. Furthermore, after identification of their sequence in our work, it would have a great potential to be artificially synthesized. The field of food supplements could be explored further.

  • Extraction and characterization of novel Multifunctional Peptides from Trachinus Draco (greater weever) myofibrillar proteins with ACE/DPP4 inhibitory, antioxidant, and metal chelating activities
    Journal of Food Biochemistry, 2020
    Co-Authors: Elif Kula, Ebru Kocadag Kocazorbaz, Hichem Moulahoum, Senol Alpat, Figen Zihnioglu
    Abstract:

    Marine organisms represent a great source of natural bioactive molecules, from which bioactive Peptides are of great importance in biomedicine application in many diseases such as diabetes and its related complications. In this study, greater weever (Trachinus Draco) myofibrillar proteins were sequentially hydrolyzed and the different RP-HPLC purified fractions were tested for potential inhibitory activities of ACE and DPP4, in addition to metal chelation and antioxidant activities. Four fractions were found to have high levels of activity (with two Peptides being Multifunctional) and were subsequently sequenced using the de novo sequencing method. The results indicate that the Peptides are novel and highly effective for each related activity compared to reference molecules. The current findings suggest these Multifunctional Peptides as promising therapeutics against oxidative stress, hypertension, and diabetes. PRACTICAL APPLICATIONS: We have described the finding of two Multifunctional bioactive Peptides from Trachinus Draco (greater weever) myofibrillar proteins having two or more activities. They have ACE inhibitory, DPP4 inhibitory, antioxidant, and metal chelation activities. These new Peptides could be used for future biomedicine applications as a stand-alone treatment, in combination with other molecules, or as a supplement. Furthermore, after identification of their sequence in our work, it would have a great potential to be artificially synthesized. The field of food supplements could be explored further.