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Julie Banerji - One of the best experts on this subject based on the ideXlab platform.
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review on chemistry and pharmacology of Murraya koenigii spreng rutaceae
Journal of chemical and pharmaceutical research, 2010Co-Authors: Anupam Nayak, Suvra Mandal, Avijit Banerji, Julie BanerjiAbstract:Murraya koenigii Spreng (Rutaceae), a medicinally important herb of Indian origin, has been used for centuries in the Ayurvedic System of Medicine. The leaves, bark and the roots of the plant are used in indigenous medicine as tonic, stomachic, stimulant and carminative. An infusion of the roasted leaves is used to prevent vomiting. The green tender leaves are eaten raw for the cure of dysentery. The juice of the root is taken to relieve pain associated with kidney ailments. The aim of the present review is to summarize the research related to the chemistry and pharmacology of this popular Indian Species.
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antidiarrhoeal activity of carbazole alkaloids from Murraya koenigii spreng rutaceae seeds
Fitoterapia, 2010Co-Authors: Suvra Mandal, Anupam Nayak, Samir K. Banerjee, Avijit Banerji, Manoj Kar, Ashes Das, S N Upadhyay, Rakesh Singh, Julie BanerjiAbstract:Abstract The bioassay guided fractionation of the n-hexane extract of the seeds of Murraya koenigii Spreng (Rutaceae) resulted in the isolation of three bioactive carbazole alkaloids, kurryam (I), koenimbine (II) and koenine (III). The structures of the compounds were confirmed from their 1H-, 13C-, and 2D-NMR spectral data. Of the three compounds (I) and (II) exhibited significant inhibitory activity against castor oil-induced diarrhoea and PGE2-induced enteropooling in rats. The compounds also produced a significant reduction in gastrointestinal motility in the charcoal meal test in Wister rats.
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A New Carbazole Alkaloid from Murraya koenigii Spreng (Rutaceae)
Natural Product Communications, 2008Co-Authors: Suvra Mandal, Anupam Nayak, Samir K. Banerjee, Julie Banerji, Avijit BanerjiAbstract:A new carbazole alkaloid (kurryam) oxygenated at the 4-position, hitherto unknown among carbazole alkaloids, has been isolated from the seeds of an Indian medicinal plant, Murraya koenigii (Rutacea...
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studies on a carbazole alkaloid from Murraya koenigii spreng and flavonoids from pongamia glabra vent
Journal of the Indian Chemical Society, 2005Co-Authors: Naznin Ara Begum, Julie Banerji, D N Choudhury, B P DasAbstract:Phytochemical investigations on the root bark of Murraya koenigii Spreng. (Fam. Rutactae) afforded a new carbazole alkaloid (1a), churactcrized as 3,6-dimethyl-1-isopentenylcarbazole, on the basis of spectral data, and its N-methyl derivative (1b) was also synthesized. In addition, two known flavonoids, pongamol (2), and karanjin (3) were isolated from the seeds of Pangamia glabra Vent. (Fam. Leguminosae) and these two compounds were independently characterized by us with some new structural probability of pongamol (2) on the basis of spectral evidences. All these compounds were subjected to the comparative larvicidal studies on the third instar larvae of Culex quinquefasciatus at 100 ppm concentration at an interval of 24 h; some activity was observed which was related to their structural features.
Leela Srinivas - One of the best experts on this subject based on the ideXlab platform.
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potent antibacterial property of apc protein from curry leaves Murraya koenigii l
Food Chemistry, 2010Co-Authors: Mylarappa Ningappa, B L Dhananjaya, R Dinesha, R Harsha, Leela SrinivasAbstract:A monomeric protein with molecular mass of 35 kDa, isolated from Murraya koenigii L. (curry leaves) shows potent antibacterial activity. The protein designated as APC (antioxidant protein from curry leaves) demonstrated potent antibacterial activity against all the human pathogenic strains tested. APC effectively inhibited Escherichia coli, Staphylococcus aureus, Vibrio cholerae, Klebsiella pneumoniae, Salmonella typhi and Bacillus subtilis. The inhibition is comparable to that of commercial antibiotics chloramphenicol, streptomycin and gentamycin. APC inhibited bacterial growth, with MIC values ranging from 13 to 24 lg/ ml, which are comparable to MIC values of standard antibiotics. APC is devoid of ribonuclease/deoxyribonuclease and protease activity. APC is non-toxic at tested doses. These results encourage further studies of APC as a potent therapeutic agent.
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antioxidant and free radical scavenging activities of polyphenol enriched curry leaf Murraya koenigii l extracts
Food Chemistry, 2008Co-Authors: Mylarappa Ningappa, R Dinesha, Leela SrinivasAbstract:Abstract The in vitro antioxidant properties of different extracts (water, alcohol, alcohol:water, hexane or chloroform extract) of curry leaves (Murraya koenigii L.) were evaluated using various assays. The alcohol:water (1:1) extract of curry leaves (AWEC) showed the highest antioxidant and free radical scavenging activity. It inhibited membrane lipid peroxidation by 76%, at 50 μg/ml, scavenged 93% of superoxides at 200 μg/3 ml and scavenged approximately 90% of hydroxyl and 1,1-diphenyl-2-picrylhydrazayl radicals at 4–5-fold lower concentrations compared to the other tested extracts. In addition, the alcohol:water extract reduced cytochrome c and ferric ion levels, chelated ferrous ions and inhibited ferrous sulfate:ascorbate-induced fragmentation and sugar oxidation of DNA. These results establish the antioxidant potential of AWEC, which could be used as natural antioxidant source.
Norlelawati A Talib - One of the best experts on this subject based on the ideXlab platform.
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beneficial effect of the leaves of Murraya koenigii linn spreng rutaceae on diabetes induced renal damage in vivo
Journal of Ethnopharmacology, 2011Co-Authors: Hassan Yankuzo, Qamar Uddin Ahmed, Rahajoe Imam Santosa, Seikh Farid Uddin Akter, Norlelawati A TalibAbstract:Ethnopharmacological relevance Murraya koenigii (Linn.) Spreng (curry leaf) is widely used as a nephroprotective agent in kidney's infirmities among diabetics by the traditional practitioners in Malaysia. However, the latter role of curry leaf has been grossly under reported and is yet to receive proper scientific evaluation. Aim of the study The present study was designed to investigate the beneficial effect of the leaves of Murraya koenigii (Linn.) on diabetes-induced renal damage in vivo with regard to prove its efficacy by local traditional practitioners in the treatment of kidney frailties in diabetics. Materials and methods Aqueous (AQ) extract of the leaves of Murraya koenigii (Linn.) was administered to both normal and streptozotocin (STZ) induced diabetic male rats (Sprague–Dawley strain). Animals were divided into six groups (n = 6) and treated with variable dose levels of AQ extract (200 and 400 mg/kg body weight/day) for 30 days. At the end of 30 days, animals were sacrificed, blood was collected, processed and stored at −70 °C for the zestimation of serum urea and creatinine, changes in plasma antioxidant capacity by FRAP assay, and glutathione peroxidase levels, in the normal and STZ-induced diabetic rats. Histological changes of the kidneys of these animals were also evaluated by light microscopy to determine the beneficial effect of the leaves. Results Daily oral administration of variable dose levels of the AQ extract for 30 days, produced significant dose dependant decrease in serum urea and creatinine levels (p < 0.001), and marked increase in the levels of plasma antioxidant capacity (p < 0.01) in diabetic treated rats, compared to the control (non-diabetic) subjects. However, the normal treated rats showed minimal variation in these parameters in comparison to normal controls. Histological studies of the kidneys of these animals showed comparable tissue regeneration by the AQ extract. Conclusion The results of our study scientifically support the traditional belief for using the leaves of Murraya koenigii (Linn.) as adjuvant, in the treatment of pain disorders related to renal impairments among diabetics.
Suvra Mandal - One of the best experts on this subject based on the ideXlab platform.
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antidiarrhoeal activity of carbazole alkaloids from Murraya koenigii spreng rutaceae seeds
Fitoterapia, 2010Co-Authors: Suvra Mandal, Anupam Nayak, Samir K. Banerjee, Avijit Banerji, Manoj Kar, Ashes Das, S N Upadhyay, Rakesh Singh, Julie BanerjiAbstract:Abstract The bioassay guided fractionation of the n-hexane extract of the seeds of Murraya koenigii Spreng (Rutaceae) resulted in the isolation of three bioactive carbazole alkaloids, kurryam (I), koenimbine (II) and koenine (III). The structures of the compounds were confirmed from their 1H-, 13C-, and 2D-NMR spectral data. Of the three compounds (I) and (II) exhibited significant inhibitory activity against castor oil-induced diarrhoea and PGE2-induced enteropooling in rats. The compounds also produced a significant reduction in gastrointestinal motility in the charcoal meal test in Wister rats.
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review on chemistry and pharmacology of Murraya koenigii spreng rutaceae
Journal of chemical and pharmaceutical research, 2010Co-Authors: Anupam Nayak, Suvra Mandal, Avijit Banerji, Julie BanerjiAbstract:Murraya koenigii Spreng (Rutaceae), a medicinally important herb of Indian origin, has been used for centuries in the Ayurvedic System of Medicine. The leaves, bark and the roots of the plant are used in indigenous medicine as tonic, stomachic, stimulant and carminative. An infusion of the roasted leaves is used to prevent vomiting. The green tender leaves are eaten raw for the cure of dysentery. The juice of the root is taken to relieve pain associated with kidney ailments. The aim of the present review is to summarize the research related to the chemistry and pharmacology of this popular Indian Species.
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A New Carbazole Alkaloid from Murraya koenigii Spreng (Rutaceae)
Natural Product Communications, 2008Co-Authors: Suvra Mandal, Anupam Nayak, Samir K. Banerjee, Julie Banerji, Avijit BanerjiAbstract:A new carbazole alkaloid (kurryam) oxygenated at the 4-position, hitherto unknown among carbazole alkaloids, has been isolated from the seeds of an Indian medicinal plant, Murraya koenigii (Rutacea...
Nobuji Nakatani - One of the best experts on this subject based on the ideXlab platform.
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Comparison of antioxidative properties of carbazole alkaloids from Murraya koenigii leaves.
Journal of agricultural and food chemistry, 2003Co-Authors: Yukari Tachibana, Hiroe Kikuzaki, Nordin H. Lajis, Nobuji NakataniAbstract:A new dimeric carbazole alkaloid, 8,10‘-[3,3‘,11,11‘-tetrahydro-9,9‘-dihydroxy-3,3‘,5,8‘-tetramethyl-3,3‘-bis(4-methyl-3-pentenyl)]bipyrano[3,2-a]carbazole (12), was isolated from the CH2Cl2 extract of Murraya koenigii together with six known carbazole alkaloids, koenimbine (6), O-methylMurrayamine A (7), O-methylmahanine (8), isomahanine (9), bismahanine (10), and bispyrayafoline (11). Their structures were determined on the basis of 1H and 13C NMR spectroscopic and mass spectrometric (MS) data. The antioxidative properties of 12 carbazole alkaloids isolated from leaves of M. koenigii were evaluated on the basis of the oil stability index together with their radical scavenging ability against 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical. On the basis of the lag time to reach a steady state, the 12 carbazoles were classified into three groups. It is suggested that an aryl hydroxyl substituent on the carbazole rings plays a role in stabilizing the thermal oxidation and rate of reaction against DPPH radical...
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antioxidative activity of carbazoles from Murraya koenigii leaves
Journal of Agricultural and Food Chemistry, 2001Co-Authors: Yukari Tachibana, Hiroe Kikuzaki, Nordin H. Lajis, Nobuji NakataniAbstract:The antioxidative properties of the leaves extracts of Murraya koenigii using different solvents were evaluated based on the oil stability index (OSI) together with their radical scavenging ability against 1-1-diphenyl-2-picrylhydrazyl (DPPH). The methylene chloride (CH2Cl2) extract and the ethyl acetate (EtOAc) soluble fraction of the 70% acetone extract significantly prolonged the OSI values comparable to those of α-tocopherol and BHT. Five carbazole alkaloids were isolated from the CH2Cl2 extract and their structures were identified to be euchrestine B (1), bisMurrayafoline E (2), mahanine (3), mahanimbicine (4), and mahanimbine (5) based on 1H and 13C NMR and mass (MS) spectral data. The OSI value of carbazoles at 110 °C decreased in the order 1 and 3 > α-tocopherol > BHT > 2 > 4, 5 and control. It is assumed that compounds 1 and 3 contributed to the high OSI value of the CH2Cl2 extract of M. koenigii. The DPPH radical scavenging activity for these carbazoles was in the order ascorbic acid > 2 > 1, 3 ...
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antioxidative activity of carbazoles from Murraya koenigii leaves
Journal of Agricultural and Food Chemistry, 2001Co-Authors: Yukari Tachibana, Hiroe Kikuzaki, Nordin H. Lajis, Nobuji NakataniAbstract:The antioxidative properties of the leaves extracts of Murraya koenigii using different solvents were evaluated based on the oil stability index (OSI) together with their radical scavenging ability against 1-1-diphenyl-2-picrylhydrazyl (DPPH). The methylene chloride (CH(2)Cl(2)) extract and the ethyl acetate (EtOAc) soluble fraction of the 70% acetone extract significantly prolonged the OSI values comparable to those of alpha-tocopherol and BHT. Five carbazole alkaloids were isolated from the CH(2)Cl(2) extract and their structures were identified to be euchrestine B (1), bisMurrayafoline E (2), mahanine (3), mahanimbicine (4), and mahanimbine (5) based on (1)H and (13)C NMR and mass (MS) spectral data. The OSI value of carbazoles at 110 degrees C decreased in the order 1 and 3 > alpha-tocopherol > BHT > 2 > 4, 5 and control. It is assumed that compounds 1 and 3 contributed to the high OSI value of the CH(2)Cl(2) extract of M. koenigii. The DPPH radical scavenging activity for these carbazoles was in the order ascorbic acid > 2 > 1, 3 and alpha-tocopherol > BHT > 4 and 5.
