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Minoru Okita - One of the best experts on this subject based on the ideXlab platform.
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mechanisms of macrophages accumulation in the process of immobilized induced Muscle Contracture in rats
Annals of Physical and Rehabilitation Medicine, 2018Co-Authors: Natsumi Tanaka, Jiro Nakano, Junya Sakamoto, Yuichiro Honda, Hideki Kataoka, Minoru OkitaAbstract:Introduction/Background Skeletal Muscle fibrosis is the main pathology of immobilized-induced Muscle Contracture. Our previous studies revealed that upregulation of interleukin-1β/transforming growth factor-β1 associated with macrophages accumulation was related to the development of skeletal Muscle fibrosis. However, the mechanisms underlying the increase in the number of macrophages in the immobilized soleus Muscle are unclear. In this study, we investigated the mechanisms of macrophages accumulation in the immobilized soleus Muscle of rat ankle- joint Contracture models. Material and method Rats were divided into immobilization and control groups. In the immobilization group, both ankle joints of each rats were immobilized in full plantar flexion with plaster casts for 1 and 2 weeks. To assess alterations of macrophages, the number of CD11b-positive cells and the monocyte chemotactic protein (MCP)-1 mRNA expression were measured. Additionally, to assess alterations of the myocyte, the number of myonuclei and TUNEL-positive cells, cross-sectional area (CSA) of myofibers, and the myonuclear domain size were measured. Results Immobilization resulted in a significant increase in the number of CD11b-positive cells and the MCP-1 mRNA expression at 1 and 2 weeks. The number of myonuclei and the CSA of myofibers were significantly decreased in the immobilization group compared to the control group at 1 and 2 weeks. Only the CSA of myofibers significantly decreased, depending on the immobilization period. The myonuclear domain size was significantly lower in the immobilization group at 2 weeks compared to the control group. TUNEL-positive cells were significantly increased in the immobilization group compared to the control group at 1 and 2 weeks. Conclusion These results indicated that joint immobilization after 1 week induced macrophages accumulation and reduced the number of myonuclei associated with myocyte apoptosis, which caused a decrease in the CSA of myofibers. These changes suggest that immobilized-induced Muscle fiber atrophy following myocyte apoptosis induce macrophage accumulation.
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effect of hif 1α inhibitors for preventing the progress of Muscle Contracture in rat soleus Muscles
Annals of Physical and Rehabilitation Medicine, 2018Co-Authors: Yasuhiro Kajiwara, Jiro Nakano, Junya Sakamoto, Yuichiro Honda, Hideki Kataoka, Natsumi Tanaka, Minoru OkitaAbstract:Introduction/Background Immobilization-induced Muscle fibrosis is important regarding the pathogenesis of Muscle Contracture, and the therapeutic target for this fibrotic lesion is unknown. On the other hand, hypoxia-inducible factor (HIF)-1α is expected to be a new therapeutic target for fibrotic disease in the viscera. Accordingly, preventing the negative alteration of HIF-1α may suppress the progress of immobilization-induced Muscle fibrosis. Therefore, this study investigated the effect of the HIF-1α inhibitor for immobilization-induced Muscle fibrosis in rat soleus Muscles. Material and method Wistar rats were randomly divided into control and experimental groups. In the experimental group, both ankle joints were fixed in full plantar flexion with plaster casts for 4 weeks. Some rats in the experimental group were immobilized throughout the 4-week period (immobilization group), whereas other rats in the experimental group were treated with YC-1, an HIF-1α inhibitor (YC-1 group). Additionally, YC-1 (2 mg/mL/day) was administered to each rat for 4 weeks. Bilateral dorsiflexion range of motion (ROM) in the ankle joints was measured each week to evaluate Muscle Contracture. Moreover, hydroxyproline (a parameter for collagen contents) and protein levels of HIF-1α were determined via biochemical analysis. Results Dorsiflexion ROM was significantly smaller in both experimental groups than in the control group at each timepoint, whereas this parameter was significantly greater in the YC-1 group than in the immobilization group after 3 weeks. In addition, the hydroxyproline and HIF-1α protein were significantly greater in the immobilization and YC-1 groups than in the control group at 4 weeks. However, both expressions were significantly smaller in the YC-1 group than in the immobilization group at 4 weeks. Conclusion From these results, the HIF-1α inhibitor may prevent immobilization-induced Muscle fibrosis leading to Muscle Contracture. We surmised that the HIF-1α inhibition is a new therapeutic target for Muscle Contracture in immobilized skeletal Muscle.
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Cyclic Muscle twitch contraction inhibits immobilization-induced Muscle Contracture and fibrosis in rats.
Connective Tissue Research, 2016Co-Authors: Ayana Yoshimura, Jiro Nakano, Junya Sakamoto, Yuichiro Honda, Hideki Kataoka, Minoru OkitaAbstract:We investigated the effects of cyclic Muscle twitch contraction caused by neuromuscular electrical stimulation (NMES) on immobilization-induced Muscle Contracture and fibrosis in rats. Twenty-nine rats were divided into control, immobilization, and immobilization with Muscle contraction groups. The ankle joints of the immobilization and Muscle contraction rats were fixed in full plantar flexion with a plaster cast for 4 weeks. In the Muscle contraction group, cyclic Muscle twitch contraction of the soleus Muscle was induced using a commercial device (1 Hz, 4 ± 2 mA, 60 min/day, 5 times/week) with the ankle joint immobilized. The dorsiflexion range of ankle joint motion in the Muscle contraction group was significantly greater than that in the immobilization group. The expressions of fibrosis-related genes (i.e., hypoxia inducible factor-1α, transforming growth factor-β1, α-smooth Muscle actin, and types I and III collagen) were significantly decreased in the Muscle contraction group compared to the immobilization group. The fluorescence intensities of type I and type III collagen in the perimysium and endomysium in the Muscle contraction group were significantly decreased compared to the immobilization group. These results suggest that cyclic Muscle twitch contraction induced by NMES might alleviate skeletal Muscle fibrosis, reducing immobilization-induced Muscle Contracture.
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Effects of Prolonged Stretching and Thermotherapy on Muscle Contracture of Immobilized Rat Soleus Muscle
2016Co-Authors: Tomoki Origuchi, Toshiro Yoshimura, Minoru OkitaAbstract:Abstract. [Purpose] We examined the effects of prolonged stretching and thermotherapy on Muscle Contracture of immobilized rat soleus Muscles by determining ankle joint range of motion (ROM), collagen fibril arrangement in the endomysium and insoluble collagen content. [Methods] In the experimental group, bilateral ankle joints of each rat were fixed in full plantar flexion with plaster casts for four weeks. Then, the experimental group animals were randomly partitioned into five groups: 1) immobilization alone; and 2) spontaneous recovery, 3) prolonged stretching, 4) thermotherapy, and 5) prolonged stretching immediately following thermotherapy for 2 weeks after cast removal. Prolonged stretching of the soleus Muscle (30 min/day) was conducted by maintaining the dorsiflexion position of the ankle joint. Thermotherapy consisted of immersion of bilateral hindlimbs (20 min/day) in hot wate
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upregulation of interleukin 1β transforming growth factor β1 and hypoxia relate to molecular mechanisms underlying immobilization induced Muscle Contracture
Muscle & Nerve, 2015Co-Authors: Yuichiro Honda, Toshiro Yoshimura, Jiro Nakano, Junya Sakamoto, Hideki Kataoka, Ryo Sasabe, Kyo Goto, Miho Tanaka, Tomoki Origuchi, Minoru OkitaAbstract:Introduction: In this study we investigated the molecular mechanism underlying Muscle Contracture in rats. Methods: The rats were divided into immobilization and control groups, and soleus Muscles of the right and left sides were selected for analyses. Results: The levels of CD11b and α-SMA protein, IL-1β, and TGF-β1 mRNA, and type I and III collagen protein and mRNA were significantly greater in the immobilization group than in the control group at all time-points. HIF-1α mRNA levels were significantly higher in the immobilization group at 4 weeks. Moreover, HIF-1α, α-SMA, and type I collagen levels were significantly higher at 4 weeks than at 1 and 2 weeks in the immobilization group. Conclusions: In the early stages of immobilization, upregulation of IL-1β/TGF-β1 via macrophages may promote fibroblast differentiation that could affect Muscle Contracture. The soleus Muscle became hypoxic in the later stages of immobilization, suggesting that hypoxia influences the progression of Muscle Contracture. Muscle Nerve 52:419–427, 2015
Wentao Zhang - One of the best experts on this subject based on the ideXlab platform.
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a possible prediction of dystocia at the time of cesarean delivery gluteal Muscle Contracture a single center experience from china
Medicine, 2020Co-Authors: Tian You, Bei Yang, Xintao Zhang, Shiyou Ren, Lu Bai, Fujia Jiao, Xiaocheng Jiang, Siyao Guan, Wentao ZhangAbstract:The study assessed the pelvic dimensions by computed tomography (CT) performed for gluteal Muscle Contracture women, and evaluated the impact of malformations on several essential obstetric parameters.The CT pelvimetry was retrospectively performed in 25 gluteal Muscle Contracture women selected consecutively whether they had delivery history or not. Among the pelvic inlet plane, the mid plane and the outlet plane, 12 indicators including the transverse diameter of the pelvic inlet, the conjugate vera, the diagonal conjugate, the biischial diameter, the anteroposterior diameter of the middle pelvis, transverse outlet, the posterior sagittal diameter of outlet, the conjugate of the outlet, the anterior sagittal diameter of the outlet, the curvature and length of the sacrum, the angle of pubic arch were collected.Finally, the mean age of these women was 26.6 ± 5.0 years. Most pelvises had anteroposterior elliptical appearance in inlet and size of the female pelvis. The most statistically different and most clinically significant indicator was the biischial diameter, gluteal Muscle Contracture women were 95.6 ± 9.3 mm and the normal women from other study were 105.0 ± 7.9 mm, the comparison showed a significant difference (P < .001).Generally, most gluteal Muscle Contracture women had features of anthropoid pelvis which were quite different from normal Chinese female. These results may serve as a basis for future studies to assess its utility and prognostic value for a safe vaginal delivery in gluteal Muscle Contracture women.
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arthroscopic revision release of gluteal Muscle Contracture after failed primary open surgery
International Orthopaedics, 2017Co-Authors: Tian You, Xintao Zhang, Xiaocheng Jiang, Zuru Liang, Dadi Jin, Wentao ZhangAbstract:The treatment of gluteal Muscle Contracture (GMC) after failed primary open release surgery has rarely been reported in the literature. GMC is a troublesome health problem in some developing countries, and it can result in the limitation of patients’ hip function, leading to the development of inferiority complexes. The aim of this study is to evaluate the effect of arthroscopic revision surgery after failed primary open release on patients with GMC. A total of 278 hips of 140 patients who underwent arthroscopic revision procedures after failed primary open surgeries were gathered from the department files. All patients were treated using a “three-step” arthroscopic release procedure by the same surgeon group. The mean follow-up for the 136 patients was 38.9 months. There was significant difference (P < 0.05) between the patients’ mean post-revision and pre-operative results on the Harris scoring system. Unreleased Contracture tissues that needed revision operations included the gluteus maximus, tensor fasciae latae Muscle, and gluteus medius in all patients, and the gluteus minimus and hip capsule in 11.0% and 8.1% of patients, respectively. Short-term complications included subcutaneous bruising of the abdomen in 11 patients, extensive ecchymosis in the lateral thigh in 12 patients, and a transient reduction of Muscle strength in all patients. No complications involving postoperative incision infection, nerve and blood vessel damage, or positive Trendelenburg sign occurred. Symptoms of hip snapping and limitation of range of motion (ROM), combined with a positive Trendelenburg sign in two patients after the primary open surgery, were all resolved except for the Trendelenburg sign through arthroscopic revision release. The overall satisfaction rate of the revision operations was 90.4%. The three-step arthroscopic release procedure is effective for failed primary open GMC surgeries as shown by improved post-operative function and patient satisfaction regardless of which primary procedure was performed.
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congenital heart disease in adolescents with gluteal Muscle Contracture
Medicine, 2015Co-Authors: Tian You, Xintao Zhang, Zhengang Zha, Wentao ZhangAbstract:Gluteal Muscle Contracture (GMC), presented with hip abduction and external rotation when crouching, is common in several ethnicities, particularly in Chinese. It remains unclear that the reasons why these children are weak and have no choice to accept repeated intramuscular injection. Here, we found some unique cases which may be useful to explain this question. We describe a series of special GMC patients, who are accompanied with congenital heart disease (CHD). These cases were first observed in preoperative examinations of a patient with atrial septal defect (ASD), which was proved by chest X-ray and cardiac ultrasound. From then on, we gradually identified additional 3 GMC patients with CHD. The original patient with ASD was sent to cardiosurgery department to repair atrial septal first and received arthroscopic surgery later. While the other 3 were cured postoperative of ventricular septal defect (VSD), tetralogy of fallot (TOF), patent ductus arteriosus (PDA), respectively, and had surgery directly. The study gives us 3 proposals: (1) as to CHD children, it is essential to decrease the use of intramuscular injection, (2) paying more attention to cardiac examination especially cardiac ultrasound in perioperative period, and (3) taking 3D-CT to reconstruct gluteal Muscles for observing Contracture bands clearly in preoperation. However, more larger series of patients are called for to confirm these findings.
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roles of tgf β smad signaling pathway in pathogenesis and development of gluteal Muscle Contracture
Connective Tissue Research, 2015Co-Authors: Xintao Zhang, Tian You, Xiaopeng Tian, Honglei Zhang, Qi Zhu, Wentao ZhangAbstract:AbstractPurpose of the study: Gluteal Muscle Contracture (GMC) is a chronic fibrotic disease of gluteal Muscles which is characterized by excessive deposition of collagen in the extracellular matrix. Transforming growth factor (TGF)-βs have been shown to play an important role in the progression of GMC. However, the underlying mechanisms are not entirely clear. We sought to explore the expression of TGF-β/Smad pathway proteins and their downstream targets in gluteal Muscle Contracture disease.Materials and methods: The expression levels of collagens type I/III, TGF-β1, Smad2/3/4/7 and PAI-1 (plasminogen activator inhibitor type 1) in gluteal Muscle contraction (GMC) patients were measured using immunohistochemistry, reverse transcription and polymerase chain reaction (RT-PCR) and western blot assays.Results: The expressions of collagens type I/III and TGF-β1 were significantly increased in the contraction band compared with unaffected Muscle. In addition, R-Smad phosphorylation and Smad4 protein expressio...
Xintao Zhang - One of the best experts on this subject based on the ideXlab platform.
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mir 29a is a potential protective factor for fibrogenesis in gluteal Muscle Contracture
Physiological Research, 2020Co-Authors: Ri Zhou, Xintao Zhang, Shiyou Ren, Weiyan ZhangAbstract:Circulating miRNAs have been proposed as the effective diagnostic biomarkers for muscular fibrosis-associated diseases. However, circulating biomarkers for early diagnosis of Contracture Muscles are limited in gluteal Muscle Contracture (GMC) patients. Here we sought to explore the abnormally expressed miRNAs in plasma and contraction bands of GMC patients. The results showed miR-29a-3p expression in plasma and contraction bands tissue was significantly reduced in GMC patients compared with normal control. Cell viability and levels of proliferation-associated protein cyclin D1 and cyclin-dependent-kinase 2 (CDK2) were powerfully inhibited by miR-29a mimics and enhanced by miR-29a inhibitor compared with negative control. Furthermore, miR-29a mimics effectively impeded, while miR-29a inhibitor enhanced the expression of collagen I and collagen III, followed by the secretion of transforming growth factor beta1 (TGF-beta1), TGF-beta3 and connective tissue growth factor (CTGF) in primary human contraction bands (CB) fibroblasts. The miR-29a-3p negatively regulated the expression of TGF-beta1 through binding to the 3´ UTR region of SERPINH1 (encoding heat shock protein HSP47), but had no effect on Smad2 activity. The miR-29a-3p was inversely correlated with HSP47 in contraction bands tissue from GMC patients. Collectively, miR-29a was notably depressed and regulated cell viability and fibrosis by directly targeting HSP47 in GMC, which suggest that circulating miR-29a might be a potential biomarker for early diagnosis and provides a novel therapeutic target for GMC.
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a possible prediction of dystocia at the time of cesarean delivery gluteal Muscle Contracture a single center experience from china
Medicine, 2020Co-Authors: Tian You, Bei Yang, Xintao Zhang, Shiyou Ren, Lu Bai, Fujia Jiao, Xiaocheng Jiang, Siyao Guan, Wentao ZhangAbstract:The study assessed the pelvic dimensions by computed tomography (CT) performed for gluteal Muscle Contracture women, and evaluated the impact of malformations on several essential obstetric parameters.The CT pelvimetry was retrospectively performed in 25 gluteal Muscle Contracture women selected consecutively whether they had delivery history or not. Among the pelvic inlet plane, the mid plane and the outlet plane, 12 indicators including the transverse diameter of the pelvic inlet, the conjugate vera, the diagonal conjugate, the biischial diameter, the anteroposterior diameter of the middle pelvis, transverse outlet, the posterior sagittal diameter of outlet, the conjugate of the outlet, the anterior sagittal diameter of the outlet, the curvature and length of the sacrum, the angle of pubic arch were collected.Finally, the mean age of these women was 26.6 ± 5.0 years. Most pelvises had anteroposterior elliptical appearance in inlet and size of the female pelvis. The most statistically different and most clinically significant indicator was the biischial diameter, gluteal Muscle Contracture women were 95.6 ± 9.3 mm and the normal women from other study were 105.0 ± 7.9 mm, the comparison showed a significant difference (P < .001).Generally, most gluteal Muscle Contracture women had features of anthropoid pelvis which were quite different from normal Chinese female. These results may serve as a basis for future studies to assess its utility and prognostic value for a safe vaginal delivery in gluteal Muscle Contracture women.
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arthroscopic revision release of gluteal Muscle Contracture after failed primary open surgery
International Orthopaedics, 2017Co-Authors: Tian You, Xintao Zhang, Xiaocheng Jiang, Zuru Liang, Dadi Jin, Wentao ZhangAbstract:The treatment of gluteal Muscle Contracture (GMC) after failed primary open release surgery has rarely been reported in the literature. GMC is a troublesome health problem in some developing countries, and it can result in the limitation of patients’ hip function, leading to the development of inferiority complexes. The aim of this study is to evaluate the effect of arthroscopic revision surgery after failed primary open release on patients with GMC. A total of 278 hips of 140 patients who underwent arthroscopic revision procedures after failed primary open surgeries were gathered from the department files. All patients were treated using a “three-step” arthroscopic release procedure by the same surgeon group. The mean follow-up for the 136 patients was 38.9 months. There was significant difference (P < 0.05) between the patients’ mean post-revision and pre-operative results on the Harris scoring system. Unreleased Contracture tissues that needed revision operations included the gluteus maximus, tensor fasciae latae Muscle, and gluteus medius in all patients, and the gluteus minimus and hip capsule in 11.0% and 8.1% of patients, respectively. Short-term complications included subcutaneous bruising of the abdomen in 11 patients, extensive ecchymosis in the lateral thigh in 12 patients, and a transient reduction of Muscle strength in all patients. No complications involving postoperative incision infection, nerve and blood vessel damage, or positive Trendelenburg sign occurred. Symptoms of hip snapping and limitation of range of motion (ROM), combined with a positive Trendelenburg sign in two patients after the primary open surgery, were all resolved except for the Trendelenburg sign through arthroscopic revision release. The overall satisfaction rate of the revision operations was 90.4%. The three-step arthroscopic release procedure is effective for failed primary open GMC surgeries as shown by improved post-operative function and patient satisfaction regardless of which primary procedure was performed.
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congenital heart disease in adolescents with gluteal Muscle Contracture
Medicine, 2015Co-Authors: Tian You, Xintao Zhang, Zhengang Zha, Wentao ZhangAbstract:Gluteal Muscle Contracture (GMC), presented with hip abduction and external rotation when crouching, is common in several ethnicities, particularly in Chinese. It remains unclear that the reasons why these children are weak and have no choice to accept repeated intramuscular injection. Here, we found some unique cases which may be useful to explain this question. We describe a series of special GMC patients, who are accompanied with congenital heart disease (CHD). These cases were first observed in preoperative examinations of a patient with atrial septal defect (ASD), which was proved by chest X-ray and cardiac ultrasound. From then on, we gradually identified additional 3 GMC patients with CHD. The original patient with ASD was sent to cardiosurgery department to repair atrial septal first and received arthroscopic surgery later. While the other 3 were cured postoperative of ventricular septal defect (VSD), tetralogy of fallot (TOF), patent ductus arteriosus (PDA), respectively, and had surgery directly. The study gives us 3 proposals: (1) as to CHD children, it is essential to decrease the use of intramuscular injection, (2) paying more attention to cardiac examination especially cardiac ultrasound in perioperative period, and (3) taking 3D-CT to reconstruct gluteal Muscles for observing Contracture bands clearly in preoperation. However, more larger series of patients are called for to confirm these findings.
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roles of tgf β smad signaling pathway in pathogenesis and development of gluteal Muscle Contracture
Connective Tissue Research, 2015Co-Authors: Xintao Zhang, Tian You, Xiaopeng Tian, Honglei Zhang, Qi Zhu, Wentao ZhangAbstract:AbstractPurpose of the study: Gluteal Muscle Contracture (GMC) is a chronic fibrotic disease of gluteal Muscles which is characterized by excessive deposition of collagen in the extracellular matrix. Transforming growth factor (TGF)-βs have been shown to play an important role in the progression of GMC. However, the underlying mechanisms are not entirely clear. We sought to explore the expression of TGF-β/Smad pathway proteins and their downstream targets in gluteal Muscle Contracture disease.Materials and methods: The expression levels of collagens type I/III, TGF-β1, Smad2/3/4/7 and PAI-1 (plasminogen activator inhibitor type 1) in gluteal Muscle contraction (GMC) patients were measured using immunohistochemistry, reverse transcription and polymerase chain reaction (RT-PCR) and western blot assays.Results: The expressions of collagens type I/III and TGF-β1 were significantly increased in the contraction band compared with unaffected Muscle. In addition, R-Smad phosphorylation and Smad4 protein expressio...
Zhang Wentao - One of the best experts on this subject based on the ideXlab platform.
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Arthroscopic revision release of gluteal Muscle Contracture after failed primary open surgery
INTERNATIONAL ORTHOPAEDICS, 2017Co-Authors: Zhang Xintao, Jiang Xiaocheng, He Feilin, Liang Zuru, You Tian, Jin Dadi, Zhang WentaoAbstract:Purpose The treatment of gluteal Muscle Contracture (GMC) after failed primary open release surgery has rarely been reported in the literature. GMC is a troublesome health problem in some developing countries, and it can result in the limitation of patients' hip function, leading to the development of inferiority complexes. The aim of this study is to evaluate the effect of arthroscopic revision surgery after failed primary open release on patients with GMC. Methods A total of 278 hips of 140 patients who underwent arthroscopic revision procedures after failed primary open surgeries were gathered from the department files. All patients were treated using a "three-step" arthroscopic release procedure by the same surgeon group. Results The mean follow-up for the 136 patients was 38.9 months. There was significant difference (P < 0.05) between the patients' mean post-revision and pre-operative results on the Harris scoring system. Unreleased Contracture tissues that needed revision operations included the gluteus maximus, tensor fasciae latae Muscle, and gluteus medius in all patients, and the gluteus minimus and hip capsule in 11.0% and 8.1% of patients, respectively. Short-term complications included subcutaneous bruising of the abdomen in 11 patients, extensive ecchymosis in the lateral thigh in 12 patients, and a transient reduction of Muscle strength in all patients. No complications involving postoperative incision infection, nerve and blood vessel damage, or positive Trendelenburg sign occurred. Symptoms of hip snapping and limitation of range of motion (ROM), combined with a positive Trendelenburg sign in two patients after the primary open surgery, were all resolved except for the Trendelenburg sign through arthroscopic revision release. The overall satisfaction rate of the revision operations was 90.4%. Conclusions The three-step arthroscopic release procedure is effective for failed primary open GMC surgeries as shown by improved post-operative function and patient satisfaction regardless of which primary procedure was performed.Medical Scientific Research Foundation of Guangdong Province, China [A2015560, A2016517]SCI(E)ARTICLE81521-15264
Tian You - One of the best experts on this subject based on the ideXlab platform.
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a possible prediction of dystocia at the time of cesarean delivery gluteal Muscle Contracture a single center experience from china
Medicine, 2020Co-Authors: Tian You, Bei Yang, Xintao Zhang, Shiyou Ren, Lu Bai, Fujia Jiao, Xiaocheng Jiang, Siyao Guan, Wentao ZhangAbstract:The study assessed the pelvic dimensions by computed tomography (CT) performed for gluteal Muscle Contracture women, and evaluated the impact of malformations on several essential obstetric parameters.The CT pelvimetry was retrospectively performed in 25 gluteal Muscle Contracture women selected consecutively whether they had delivery history or not. Among the pelvic inlet plane, the mid plane and the outlet plane, 12 indicators including the transverse diameter of the pelvic inlet, the conjugate vera, the diagonal conjugate, the biischial diameter, the anteroposterior diameter of the middle pelvis, transverse outlet, the posterior sagittal diameter of outlet, the conjugate of the outlet, the anterior sagittal diameter of the outlet, the curvature and length of the sacrum, the angle of pubic arch were collected.Finally, the mean age of these women was 26.6 ± 5.0 years. Most pelvises had anteroposterior elliptical appearance in inlet and size of the female pelvis. The most statistically different and most clinically significant indicator was the biischial diameter, gluteal Muscle Contracture women were 95.6 ± 9.3 mm and the normal women from other study were 105.0 ± 7.9 mm, the comparison showed a significant difference (P < .001).Generally, most gluteal Muscle Contracture women had features of anthropoid pelvis which were quite different from normal Chinese female. These results may serve as a basis for future studies to assess its utility and prognostic value for a safe vaginal delivery in gluteal Muscle Contracture women.
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arthroscopic revision release of gluteal Muscle Contracture after failed primary open surgery
International Orthopaedics, 2017Co-Authors: Tian You, Xintao Zhang, Xiaocheng Jiang, Zuru Liang, Dadi Jin, Wentao ZhangAbstract:The treatment of gluteal Muscle Contracture (GMC) after failed primary open release surgery has rarely been reported in the literature. GMC is a troublesome health problem in some developing countries, and it can result in the limitation of patients’ hip function, leading to the development of inferiority complexes. The aim of this study is to evaluate the effect of arthroscopic revision surgery after failed primary open release on patients with GMC. A total of 278 hips of 140 patients who underwent arthroscopic revision procedures after failed primary open surgeries were gathered from the department files. All patients were treated using a “three-step” arthroscopic release procedure by the same surgeon group. The mean follow-up for the 136 patients was 38.9 months. There was significant difference (P < 0.05) between the patients’ mean post-revision and pre-operative results on the Harris scoring system. Unreleased Contracture tissues that needed revision operations included the gluteus maximus, tensor fasciae latae Muscle, and gluteus medius in all patients, and the gluteus minimus and hip capsule in 11.0% and 8.1% of patients, respectively. Short-term complications included subcutaneous bruising of the abdomen in 11 patients, extensive ecchymosis in the lateral thigh in 12 patients, and a transient reduction of Muscle strength in all patients. No complications involving postoperative incision infection, nerve and blood vessel damage, or positive Trendelenburg sign occurred. Symptoms of hip snapping and limitation of range of motion (ROM), combined with a positive Trendelenburg sign in two patients after the primary open surgery, were all resolved except for the Trendelenburg sign through arthroscopic revision release. The overall satisfaction rate of the revision operations was 90.4%. The three-step arthroscopic release procedure is effective for failed primary open GMC surgeries as shown by improved post-operative function and patient satisfaction regardless of which primary procedure was performed.
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congenital heart disease in adolescents with gluteal Muscle Contracture
Medicine, 2015Co-Authors: Tian You, Xintao Zhang, Zhengang Zha, Wentao ZhangAbstract:Gluteal Muscle Contracture (GMC), presented with hip abduction and external rotation when crouching, is common in several ethnicities, particularly in Chinese. It remains unclear that the reasons why these children are weak and have no choice to accept repeated intramuscular injection. Here, we found some unique cases which may be useful to explain this question. We describe a series of special GMC patients, who are accompanied with congenital heart disease (CHD). These cases were first observed in preoperative examinations of a patient with atrial septal defect (ASD), which was proved by chest X-ray and cardiac ultrasound. From then on, we gradually identified additional 3 GMC patients with CHD. The original patient with ASD was sent to cardiosurgery department to repair atrial septal first and received arthroscopic surgery later. While the other 3 were cured postoperative of ventricular septal defect (VSD), tetralogy of fallot (TOF), patent ductus arteriosus (PDA), respectively, and had surgery directly. The study gives us 3 proposals: (1) as to CHD children, it is essential to decrease the use of intramuscular injection, (2) paying more attention to cardiac examination especially cardiac ultrasound in perioperative period, and (3) taking 3D-CT to reconstruct gluteal Muscles for observing Contracture bands clearly in preoperation. However, more larger series of patients are called for to confirm these findings.
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roles of tgf β smad signaling pathway in pathogenesis and development of gluteal Muscle Contracture
Connective Tissue Research, 2015Co-Authors: Xintao Zhang, Tian You, Xiaopeng Tian, Honglei Zhang, Qi Zhu, Wentao ZhangAbstract:AbstractPurpose of the study: Gluteal Muscle Contracture (GMC) is a chronic fibrotic disease of gluteal Muscles which is characterized by excessive deposition of collagen in the extracellular matrix. Transforming growth factor (TGF)-βs have been shown to play an important role in the progression of GMC. However, the underlying mechanisms are not entirely clear. We sought to explore the expression of TGF-β/Smad pathway proteins and their downstream targets in gluteal Muscle Contracture disease.Materials and methods: The expression levels of collagens type I/III, TGF-β1, Smad2/3/4/7 and PAI-1 (plasminogen activator inhibitor type 1) in gluteal Muscle contraction (GMC) patients were measured using immunohistochemistry, reverse transcription and polymerase chain reaction (RT-PCR) and western blot assays.Results: The expressions of collagens type I/III and TGF-β1 were significantly increased in the contraction band compared with unaffected Muscle. In addition, R-Smad phosphorylation and Smad4 protein expressio...
