The Experts below are selected from a list of 240 Experts worldwide ranked by ideXlab platform
Robert F. Miller - One of the best experts on this subject based on the ideXlab platform.
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Patterns of Ga-67 citrate accumulation in Human Immunodeficiency Virus positive patients with and without Mycobacterium avium intracellulare Infection
Clinical Radiology, 1995Co-Authors: J.r. Buscombe, P. Buttery, Robert F. MillerAbstract:Infection with Mycobacterium avium intracellulaire (MAI) is an increasingly important problem in patients infected with Human Immunodeficiency Virus (HIV). The objective of this study was to identify whether specific patterns of accumulation of Ga-67 citrate occur in HIV antibody positive patients with disseminated MAI Infection. A retrospective review of Ga-67 scinigraphy was performed in 18 HIV antibody positive patients with MAI and 20 HIV antibody positive patients without MAI (who acted as a control group). A wide range of abnormalities was seen in both groups of patients and no single abnormality was diagnostic of MAI. However MAI was likely (sensitivity 89%, specificity 70%) in the presence of two or more of the following; accumulation of Ga-67 in lymph nodes, paranasal sinuses or colon or reduced uptake in the bone marrow. No specific abnormality on Ga-67 scintigraphy in HIV antibody positive patients enables a diagnosis of MAI to be made. Subtle and non specific abnormalities of Ga-67 may be the only scintigraphic evidence of active, Mycobacterium avium intracellulare Infection.
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Indium-111-Labeled Polyclonal Human Immunoglobulin: Identifying Focal Infection in Patients Positive for Human Immunodeficiency Virus
The Journal of Nuclear Medicine, 1993Co-Authors: J.r. Buscombe, Wim J.g. Oyen, Alison D. Grant, Roland A. M. J. Claessens, J.w.m. Van Der Meer, F.h.m. Corstens, Robert F. MillerAbstract:Pooled human immunoglobulin labeled with indium-111 (111lnHlgG) was used to identify the presence and extent of Infection in patients positive for human immunodeficiency virus (HIV), presenting with either symptoms and/or signs of acute chest Infection or with pyrexia without localizing signs or symptoms. Fifty-five studies were performed in 51 patients with suspected chest Infection or pyrexia without localizing signs. Of these, 1111n-HIgG identified intrapulmonary accumulation in 17 patients with Pneumocystis carinii pneumonia, eight with bacterial pneu monia, five with cytomegalovirus pneumonia, three with pulmo nary Mycobacterium avium intracellulare Infection and one with a fungal pneumonia. There was no intrapulmonary accumulation of 111ln-HlgG in five patients with bronchopulmonary Kaposi’s sarcoma and in three patients with intrathoracic lymphoma. Quantification of lung/heart activity was significantly increased (p < 0.05) in patients with active chest Infection compared with those with intrapulmonary tumor or no active lung pathology. Indium-111 -HlgG scintigraphy also localized at 14 sites of extrapulmonary Infection, including six patients with colitis. There were no false-negative studies but false-positive uptake was seen in four studies. These results confirm that 111ln-HlgG cor rectly identifies the presence and extent of Infection in patients positive for HIV antibody.
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Mycobacterium Avium-Intracellulare Infection in the acquired immunodeficiency syndrome.
British Journal of Hospital Medicine, 1991Co-Authors: A Scoular, P French, Robert F. MillerAbstract:Disseminated Infection with Mycobacterium avium and M. intracellulare (MAI) is increasingly recognized as a significant contributor to both increased illness and death in patients with acquired immunodeficiency syndrome. Early reports of treatment of MAI were disappointing but recent studies have shown that combination antimycobacterial therapy may provide symptomatic relief and an improvement in mycobacteraemia.
Robert G. Phelps - One of the best experts on this subject based on the ideXlab platform.
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Pseudogaucher Cells in Cutaneous Mycobacterium Avium Intracellulare Infection
American Journal of Dermatopathology, 1999Co-Authors: Hirshel Kahn, Robert G. PhelpsAbstract:We report on a patient infected with human immunodeficiency virus, and with cutaneous Mycobacterium avium intracellulare, in whom many cells with abundant reticulated cytoplasm resembling the characteristic cells of Gauchers disease ("pseudogaucher cells") were noted within the dermal infiltrate on
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Pseudogaucher cells in cutaneous Mycobacterium avium intracellulare Infection: report of a case.
American Journal of Dermatopathology, 1999Co-Authors: Hirshel Kahn, Robert G. PhelpsAbstract:We report on a patient infected with human immunodeficiency virus, and with cutaneous Mycobacterium avium intracelluare, in whom many cells with abundant reticulated cytoplasm resembling the characteristic cells of Gauchers disease (pseudogaucher cells) were noted within the dermal infiltrate on biopsy. Although pseudogaucher cells have been reported in association with M. avium intracellulare Infection in extracutaneous sites, this is, to our knowledge the first report of cutaneous pseudogaucher cells in the skin.
P A Pizzo - One of the best experts on this subject based on the ideXlab platform.
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Defining the population of human immunodeficiency virus-infected children at risk for Mycobacterium Avium-Intracellulare Infection
The Journal of Pediatrics, 1992Co-Authors: L L Lewis, K M Butler, R N Husson, B U Mueller, C L Fowler, S M Steinberg, P A PizzoAbstract:We reviewed the 22 cases of Mycobacterium Avium-Intracellulare (MAI) Infection that occurred among 196 human immunodeficiency virus-infected children seen at the National Cancer Institute Pediatric Branch from December 1986 through April 1991, and an additional 65 charts from children with cultures negative for MAI. All patients with proven MAI were receiving antiretroviral therapy with zidovudine, dideoxyinosine, or a combination of zidovudine and dideoxycytidine. All patients had disseminated MAI Infection, except one adolescent who had only evidence of localized lymphadenitis. All cases of MAI but one were diagnosed before death. The overall incidence of MAI was 11% in our patients but increased to 24% in patients whose absolute CD4 cell counts were 3 . Symptoms most commonly associated with MAI Infection included recurrent fever (86% of patients), weight loss or failure to thrive (64%), neutropenia (55%), night sweats (32%), and abdominal pain (27%). Children infected with MAI had a mean CD4 percentage of 2% (range, 0% to 7%) and a mean absolute CD4 count of 12 cells/mm 3 (range, 0 to 48 cells/mm 3 ), significantly lower than in the remainder of the clinic population or the group of children with cultures negative for MAI. Of 20 patients with MAI Infection who were tested, 10 had measurable p24 antigen with a mean value 939 pg/ml (range, 77 to 3270 pg/ml) compared with 19 of 59 patients without MAI Infection in whom the mean positive value was 413 pg/ml. There was no difference in survival time between those children with documented MAI Infection (median survival time, 45.5 weeks) and those with similarly low CD4 counts and cultures negative for MAI (median survival time, 50.4 weeks). Future improvements in therapeutic options may make screening of pediatric human immunodeficiency virus-infected patients with low CD4 counts a reasonable plan.
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Defining the population of human immunodeficiency virus-infected children at risk for Mycobacterium Avium-Intracellulare Infection.
The Journal of pediatrics, 1992Co-Authors: L L Lewis, K M Butler, R N Husson, B U Mueller, C L Fowler, S M Steinberg, P A PizzoAbstract:We reviewed the 22 cases of Mycobacterium Avium-Intracellulare (MAI) Infection that occurred among 196 human immunodeficiency virus-infected children seen at the National Cancer Institute Pediatric Branch from December 1986 through April 1991, and an additional 65 charts from children with cultures negative for MAI. All patients with proven MAI were receiving antiretroviral therapy with zidovudine, dideoxyinosine, or a combination of zidovudine and dideoxycytidine. All patients had disseminated MAI Infection, except one adolescent who had only evidence of localized lymphadenitis. All cases of MAI but one were diagnosed before death. The overall incidence of MAI was 11% in our patients but increased to 24% in patients whose absolute CD4 cell counts were < 100 cells/mm3. Symptoms most commonly associated with MAI Infection included recurrent fever (86% of patients), weight loss or failure to thrive (64%), neutropenia (55%), night sweats (32%), and abdominal pain (27%). Children infected with MAI had a mean CD4 percentage of 2% (range, 0% to 7%) and a mean absolute CD4 count of 12 cells/mm3 (range, 0 to 48 cells/mm3), significantly lower than in the remainder of the clinic population or the group of children with cultures negative for MAI. Of 20 patients with MAI Infection who were tested, 10 had measurable p24 antigen with a mean value 939 pg/ml (range, 77 to 3270 pg/ml) compared with 19 of 59 patients without MAI Infection in whom the mean positive value was 413 pg/ml. There was no difference in survival time between those children with documented MAI Infection (median survival time, 45.5 weeks) and those with similarly low CD4 counts and cultures negative for MAI (median survival time, 50.4 weeks). Future improvements in therapeutic options may make screening of pediatric human immunodeficiency virus-infected patients with low CD4 counts a reasonable plan.
Jay R Mcdonald - One of the best experts on this subject based on the ideXlab platform.
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Mycobacterium Avium-Intracellularecellulitis occurring with septic arthritis after joint injection: a case report
BMC Infectious Diseases, 2007Co-Authors: David M Murdoch, Jay R McdonaldAbstract:Background Cellulitis caused by Mycobacterium Avium-Intracellulare has rarely been described. Mycobacterium Avium-Intracellulare is a rare cause of septic arthritis after intra-articular injection, though the causative role of injection is difficult to ascertain in such cases. Case presentation A 57-year-old with rheumatoid arthritis treated with prednisone and azathioprine developed bilateral painful degenerative shoulder arthritis. After corticosteroid injections into both acromioclavicular joints, he developed bilateral cellulitis centered over the injection sites. Skin biopsy showed non-caseating granulomas, and culture grew Mycobacterium Avium-Intracellulare . Joint aspiration also revealed Mycobacterium Avium-Intracellulare Infection. Conclusion Although rare, skin and joint Infections caused by Mycobacterium Avium-Intracellulare should be considered in any immunocompromised host, particularly after intra-articular injection. Stains for acid-fast bacilli may be negative in pathologic samples even in the presence of Infection; cultures of tissue specimens should always be obtained.
Hirshel Kahn - One of the best experts on this subject based on the ideXlab platform.
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Pseudogaucher Cells in Cutaneous Mycobacterium Avium Intracellulare Infection
American Journal of Dermatopathology, 1999Co-Authors: Hirshel Kahn, Robert G. PhelpsAbstract:We report on a patient infected with human immunodeficiency virus, and with cutaneous Mycobacterium avium intracellulare, in whom many cells with abundant reticulated cytoplasm resembling the characteristic cells of Gauchers disease ("pseudogaucher cells") were noted within the dermal infiltrate on
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Pseudogaucher cells in cutaneous Mycobacterium avium intracellulare Infection: report of a case.
American Journal of Dermatopathology, 1999Co-Authors: Hirshel Kahn, Robert G. PhelpsAbstract:We report on a patient infected with human immunodeficiency virus, and with cutaneous Mycobacterium avium intracelluare, in whom many cells with abundant reticulated cytoplasm resembling the characteristic cells of Gauchers disease (pseudogaucher cells) were noted within the dermal infiltrate on biopsy. Although pseudogaucher cells have been reported in association with M. avium intracellulare Infection in extracutaneous sites, this is, to our knowledge the first report of cutaneous pseudogaucher cells in the skin.
