The Experts below are selected from a list of 318 Experts worldwide ranked by ideXlab platform
Timothy E. Kiehn - One of the best experts on this subject based on the ideXlab platform.
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Mycobacterium haemophilum infection after alemtuzumab treatment.
Emerging infectious diseases, 2008Co-Authors: Mini Kamboj, Eddie Louie, Timothy E. Kiehn, Genovefa A. Papanicolaou, Michael S. Glickman, Kent A. SepkowitzAbstract:To the Editor: The immunosuppressive agent alemtuzumab is a DNA-derived, humanized monoclonal antibody directed against the panlymphocyte, cell-surface antigen CD52 (1). The drug is approved for the treatment of refractory B-cell chronic lymphocytic leukemia (2) and also has been used after stem cell (3) and organ transplantations (4). Alemtuzumab causes profound and prolonged lymphocyte depletion, which results in a variety of complications involving infections (5). However, mycobacteria have rarely been reported to cause infection after alemtuzumab treatment. We describe infections with Mycobacterium haemophilum, a fastidious nontuberculous Mycobacterium, in 2 patients who experienced cutaneous lesions while they received alemtuzumab.
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Mycobacterium haemophilum in Immunocompromised Patients
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2001Co-Authors: Monika K. Shah, Timothy E. Kiehn, Abdelghani Sebti, Susan A. Massarella, Kent A. SepkowitzAbstract:Mycobacterium haemophilum, a recently described pathogen, can cause an array of symptoms in immuno- compromised patients. To date, 90 patients with this infection have been described worldwide. We report our institution's experience with 23 patients who were treated from 1990 through 2000. Fourteen patients had undergone bone marrow transplantation, 5 were infected with human immunodeficiency virus, 3 had he- matologic malignancies, and 1 had no known underlying immunosupression. Clinical syndromes on presen- tation included skin lesions alone in 13 patients, arthritis or osteomyelitis in 4 patients, and lung disease in 6 patients. Although patients with skin or joint involvement had favorable outcomes, 5 of 7 patients with lung infection died. Prolonged courses of multidrug therapy are required for treatment. A diagnosis of M. haemophilum infection must be considered for any immunocompromised patient for whom acid-fast bacilli are identified in a cutaneous, synovial fluid or respiratory sample or for whom granulomas are identified in any pathological specimen.
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Pulmonary nodule due to Mycobacterium haemophilum in an immunocompetent host.
American journal of respiratory and critical care medicine, 1999Co-Authors: Dorothy A. White, Timothy E. Kiehn, Anna Y. Bondoc, Susan A. MassarellaAbstract:We present a case of a pulmonary nodular lesion in an immunocompetent patient documented at open lung biopsy to be due to Mycobacterium haemophilum. This organism has recently been recognized as a cause of disease in immunocompromised patients, presenting predominantly as skin lesions, arthritis, and rarely pneumonia. Because this Mycobacterium is fastidious and difficult to grow without the use of special media and conditions, our case raises the possibility that M. haemophilum could be an underrecognized cause of granulomatous pulmonary lesions and should be considered particularly in cases where smears for acid-fast bacteria are positive but cultures are negative.
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Histologic reactions to cutaneous infections by Mycobacterium haemophilum.
The American journal of surgical pathology, 1999Co-Authors: Klaus J. Busam, Timothy E. Kiehn, Stacy P. Salob, Patricia L. MyskowskiAbstract:Mycobacterium haemophilum is an emerging pathogen in immunocompromised patients. We report the clinical and histologic findings of 16 skin biopsies from 11 patients with culture-proven infections by M. haemophilum. The patients had leukemia or non-Hodgkin's lymphoma. Ten of them had undergone bone marrow transplantation. When the skin biopsy specimens were taken, a portion of the skin was simultaneously submitted to a microbiology laboratory for cultures. The remaining skin was processed routinely. Acid-fast bacilli were found in 11 of 16 lesions. The number of histologically detectable organisms was typically low: nine biopsies had fewer than three bacilli per 50 oil immersion fields. The most common histologic pattern was a mixed suppurative and granulomatous reaction (7 of 16 biopsies). Four biopsies showed well-formed epithelioid granulomas. Two showed necrosis, one of which was ulcerated. One lesion was a subcutaneous abscess. Two biopsies showed a mixed lichenoid and granulomatous dermatitis. In one of them, the granulomatous reaction was focal and small. One biopsy lacked a granulomatous tissue reaction altogether; it showed an interface dermatitis, a perivascular and periadnexal lymphocytic infiltrate, and necrotizing lymphocytic small vessel vasculitis. A subsequent biopsy from the same patient additionally showed a focal granulomatous reaction. Our observation that infections by M. haemophilum can present with nongranulomatous or pauci-granulomatous reactions without necrosis is of note. Failure to suspect mycobacterial infection in such reactions contributes to probable underreporting of M. haemophilum and to misdiagnoses. Furthermore, our findings emphasize the importance of simultaneous biopsies for culture and histology in immunocompromised patients.
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Mycobacterium haemophilum infections in bone marrow transplant recipients.
Transplantation, 1995Co-Authors: Mary H. White, Timothy E. Kiehn, Esperanza B. Papadopoulos, Trudy N. Small, Donald ArmstrongAbstract:The purpose of this study was to describe the clinical presentation, treatment, and outcome of Mycobacterium haemophilum infection in patients undergoing bone marrow transplantation at a cancer center. Bone marrow transplant recipients with M haemophilum infection were identified upon culture of the organism by implementing the organism's unique requirements for growth. This report of the patients' clinical and immunologic course is based on a retrospective chart review. Two distinctly different presentations of M haemophilum infection were observed. Three patients presented with cutaneous lesions, typical of those seen in previous reports of the infection. Two others developed pulmonary disease only. All patients received directed therapy against M haemophilum, but respiratory failure developed in the patients with pneumonia and they died. The remaining 3 patients survived and are free of infection. These are the only reported cases of M haemophilum infection in bone marrow transplant recipients. Early diagnosis obtained through biopsy and special request for culture conditions conducive to the growth of the organism may decrease morbidity and mortality, particularly in patients with pulmonary disease.
Jun Hee Woo - One of the best experts on this subject based on the ideXlab platform.
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case of pyomyositis due to Mycobacterium haemophilum in a renal transplant recipient
Journal of Clinical Microbiology, 2007Co-Authors: Eunyoung Jang, Sangoh Lee, Seongho Choi, Heungsup Sung, Mina Kim, Bum Joon Kim, Sangho Choi, Yang Soo Kim, Jun Hee WooAbstract:We report a case of pyomyositis due to Mycobacterium haemophilum in a renal transplant recipient. M. haemophilum was identified by PCR-mediated sequence analysis of the heat shock protein gene in the DNA of the specimen. The patient was successfully treated with repeated surgical debridement and prolonged antimycobacterial therapy.
Ron Read - One of the best experts on this subject based on the ideXlab platform.
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Mycobacterium haemophilum osteomyelitis: case report and review of the literature
BMC Infectious Diseases, 2006Co-Authors: Sameer Elsayed, Ron ReadAbstract:Background Mycobacterium haemophilum is a slow-growing, fastidious, iron-requiring microorganism that, relative to other non-tuberculous mycobacterial species, has rarely been documented as a cause of human infection. This microorganism appears to be acquired via environmental exposure although its natural habitat and mode of acquisition are unknown. It has primarily been implicated as a cause of ulcerating cutaneous or subcutaneous nodular skin lesions, particularly in immunocompromised patients, although infections at extracutaneous sites have also been described. Osteomyelitis, while rarely documented, appears to be an important complication of infection with M. haemophilum in these patients. Case presentation We describe a unique case of culture-confirmed M. haemophilum osteomyelitis in an adult woman with polycythemia vera and review the world literature on bone infections due to this organism. Conclusion Mycobacterium haemophilum is an important but infrequently encountered cause of osteomyelitis in immunocompromised patients, often requiring months to years of medical therapy, with or without surgery, to effect a clinical cure.
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Mycobacterium haemophilum osteomyelitis: case report and review of the literature.
BMC infectious diseases, 2006Co-Authors: Sameer Elsayed, Ron ReadAbstract:Mycobacterium haemophilum is a slow-growing, fastidious, iron-requiring microorganism that, relative to other non-tuberculous mycobacterial species, has rarely been documented as a cause of human infection. This microorganism appears to be acquired via environmental exposure although its natural habitat and mode of acquisition are unknown. It has primarily been implicated as a cause of ulcerating cutaneous or subcutaneous nodular skin lesions, particularly in immunocompromised patients, although infections at extracutaneous sites have also been described. Osteomyelitis, while rarely documented, appears to be an important complication of infection with M. haemophilum in these patients. We describe a unique case of culture-confirmed M. haemophilum osteomyelitis in an adult woman with polycythemia vera and review the world literature on bone infections due to this organism. Mycobacterium haemophilum is an important but infrequently encountered cause of osteomyelitis in immunocompromised patients, often requiring months to years of medical therapy, with or without surgery, to effect a clinical cure.
Robyn G Langham - One of the best experts on this subject based on the ideXlab platform.
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Recurrent Mycobacterium haemophilum in a renal transplant recipient
Nephrology, 2014Co-Authors: Kathryn Ducharlet, Caitlin Murphy, Sven-jean Tan, Karen M. Dwyer, David Goodman, Craig A Aboltins, John Daffy, Robyn G LanghamAbstract:Mycobacterium haemophilum is a rare isolate of non-tuberculous Mycobacterium which has been reported to affect immunocompromised patients. We report a case of a 32-year-old renal transplant patient with M. haemophilum infection initially involving his left sinus which was treated with appropriate antimicrobial therapy for thirteen months. Two weeks after cessation of antibiotics the infection rapidly recurred in his skin and soft tissues of his hands and feet. This case highlights the difficult diagnostic and therapeutic implications of atypical infections in transplant patients. To our knowledge this is the first reported case of relapsed M. haemophilum infection in a renal transplant recipient.
Donald Armstrong - One of the best experts on this subject based on the ideXlab platform.
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Mycobacterium haemophilum infections in bone marrow transplant recipients.
Transplantation, 1995Co-Authors: Mary H. White, Timothy E. Kiehn, Esperanza B. Papadopoulos, Trudy N. Small, Donald ArmstrongAbstract:The purpose of this study was to describe the clinical presentation, treatment, and outcome of Mycobacterium haemophilum infection in patients undergoing bone marrow transplantation at a cancer center. Bone marrow transplant recipients with M haemophilum infection were identified upon culture of the organism by implementing the organism's unique requirements for growth. This report of the patients' clinical and immunologic course is based on a retrospective chart review. Two distinctly different presentations of M haemophilum infection were observed. Three patients presented with cutaneous lesions, typical of those seen in previous reports of the infection. Two others developed pulmonary disease only. All patients received directed therapy against M haemophilum, but respiratory failure developed in the patients with pneumonia and they died. The remaining 3 patients survived and are free of infection. These are the only reported cases of M haemophilum infection in bone marrow transplant recipients. Early diagnosis obtained through biopsy and special request for culture conditions conducive to the growth of the organism may decrease morbidity and mortality, particularly in patients with pulmonary disease.
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Clinical and Epidemiologic Characteristics of Mycobacterium haemophilum, an Emerging Pathogen in Immunocompromised Patients
Annals of internal medicine, 1994Co-Authors: Walter L. Straus, Timothy E. Kiehn, Stephen M. Ostroff, Daniel B. Jernigan, Emilia Mia Sordillo, Donald Armstrong, Natalie Boone, Nancy Schneider, James O. Kilburn, Vella A. SilcoxAbstract:Objective: To describe 13 infections caused by Mycobacterium haemophilum. Design: Identification of patients by microbiologic record review, followed by medical record review and a case–control stu...
