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Sean J Pittock - One of the best experts on this subject based on the ideXlab platform.
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Application of 2015 Seronegative Neuromyelitis Optica Spectrum Disorder Diagnostic Criteria for Patients With Myelin Oligodendrocyte Glycoprotein IgG-Associated Disorders.
JAMA neurology, 2020Co-Authors: Amy Kunchok, Eoin P. Flanagan, John J Chen, Brian G Weinshenker, Ruba S. Saadeh, Dean M. Wingerchuk, Sean J PittockAbstract:This study evaluates the proportion of patients with Myelin Oligodendrocyte Glycoprotein IgG–associated disorders who fulfill the seronegative neuromyelitis optica spectrum disorder criteria.
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does area postrema syndrome occur in Myelin Oligodendrocyte Glycoprotein igg associated disorders mogad
Neurology, 2020Co-Authors: Amy Kunchok, Eoin P. Flanagan, John J Chen, Karl N Krecke, Jiraporn Jitprapaikulsan, Sebastian A Lopezchiriboga, Brian G Weinshenker, Sean J PittockAbstract:Myelin Oligodendrocyte Glycoprotein-IgG is a biomarker associated with CNS deMyelinating diseases.1,2 MOGAD and aquaporin-4-IgG–positive neuromyelitis optica spectrum disorder (AQP4-IgG + NMOSD) have overlapping clinical features including optic neuritis and myelitis. However, there are several clinical and radiologic distinguishing features of MOGAD including lack of female predominance, higher incidence of acute disseminated encephalomyelitis (ADEM), higher proportion of bilateral optic neuritis, and T2-signal confined to gray matter and conus involvement in myelitis.1,3,4
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Does area postrema syndrome occur in Myelin Oligodendrocyte Glycoprotein-IgG-associated disorders (MOGAD)?
Neurology, 2019Co-Authors: Amy Kunchok, Eoin P. Flanagan, John J Chen, Karl N Krecke, Jiraporn Jitprapaikulsan, Brian G Weinshenker, A. Sebastian Lopez-chiriboga, Sean J PittockAbstract:Myelin Oligodendrocyte Glycoprotein-IgG is a biomarker associated with CNS deMyelinating diseases.1,2 MOGAD and aquaporin-4-IgG–positive neuromyelitis optica spectrum disorder (AQP4-IgG + NMOSD) have overlapping clinical features including optic neuritis and myelitis. However, there are several clinical and radiologic distinguishing features of MOGAD including lack of female predominance, higher incidence of acute disseminated encephalomyelitis (ADEM), higher proportion of bilateral optic neuritis, and T2-signal confined to gray matter and conus involvement in myelitis.1,3,4
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Myelin Oligodendrocyte Glycoprotein Antibody (MOG-IgG)-Positive Optic Perineuritis
Neuro-ophthalmology (Aeolus Press), 2019Co-Authors: A. Sebastian Lopez-chiriboga, Eoin P. Flanagan, Sean J Pittock, Gregory P. Van Stavern, J. P. Fryer, M. Tariq Bhatti, John J ChenAbstract:Optic perineuritis can be a manifestation of infectious and systemic inflammatory disorders, but the majority of cases are idiopathic. Myelin Oligodendrocyte Glycoprotein (MOG)-IgG-positive optic neuritis has been reported to be associated with optic nerve sheath enhancement. This report describes two MOG-IgG patients with clinical, radiological and therapeutic response consistent with optic perineuritis. MOG-IgG may account for many cases of previously described idiopathic optic perineuritis. Vision loss with optic nerve sheath enhancement on MRI should prompt testing for MOG-IgG.
Amy Kunchok - One of the best experts on this subject based on the ideXlab platform.
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Application of 2015 Seronegative Neuromyelitis Optica Spectrum Disorder Diagnostic Criteria for Patients With Myelin Oligodendrocyte Glycoprotein IgG-Associated Disorders.
JAMA neurology, 2020Co-Authors: Amy Kunchok, Eoin P. Flanagan, John J Chen, Brian G Weinshenker, Ruba S. Saadeh, Dean M. Wingerchuk, Sean J PittockAbstract:This study evaluates the proportion of patients with Myelin Oligodendrocyte Glycoprotein IgG–associated disorders who fulfill the seronegative neuromyelitis optica spectrum disorder criteria.
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does area postrema syndrome occur in Myelin Oligodendrocyte Glycoprotein igg associated disorders mogad
Neurology, 2020Co-Authors: Amy Kunchok, Eoin P. Flanagan, John J Chen, Karl N Krecke, Jiraporn Jitprapaikulsan, Sebastian A Lopezchiriboga, Brian G Weinshenker, Sean J PittockAbstract:Myelin Oligodendrocyte Glycoprotein-IgG is a biomarker associated with CNS deMyelinating diseases.1,2 MOGAD and aquaporin-4-IgG–positive neuromyelitis optica spectrum disorder (AQP4-IgG + NMOSD) have overlapping clinical features including optic neuritis and myelitis. However, there are several clinical and radiologic distinguishing features of MOGAD including lack of female predominance, higher incidence of acute disseminated encephalomyelitis (ADEM), higher proportion of bilateral optic neuritis, and T2-signal confined to gray matter and conus involvement in myelitis.1,3,4
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Does area postrema syndrome occur in Myelin Oligodendrocyte Glycoprotein-IgG-associated disorders (MOGAD)?
Neurology, 2019Co-Authors: Amy Kunchok, Eoin P. Flanagan, John J Chen, Karl N Krecke, Jiraporn Jitprapaikulsan, Brian G Weinshenker, A. Sebastian Lopez-chiriboga, Sean J PittockAbstract:Myelin Oligodendrocyte Glycoprotein-IgG is a biomarker associated with CNS deMyelinating diseases.1,2 MOGAD and aquaporin-4-IgG–positive neuromyelitis optica spectrum disorder (AQP4-IgG + NMOSD) have overlapping clinical features including optic neuritis and myelitis. However, there are several clinical and radiologic distinguishing features of MOGAD including lack of female predominance, higher incidence of acute disseminated encephalomyelitis (ADEM), higher proportion of bilateral optic neuritis, and T2-signal confined to gray matter and conus involvement in myelitis.1,3,4
Christopher Linington - One of the best experts on this subject based on the ideXlab platform.
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Myelin Oligodendrocyte Glycoprotein (MOG): An Archetypal Target for DeMyelinating Autoantibodies in the Central Nervous System
Autoantibodies, 2014Co-Authors: Christopher Linington, Nathali Kaushansky, Katie J. Chapple, Avraham Ben-nunAbstract:Myelin Oligodendrocyte Glycoprotein (MOG) is a dominant target for deMyelinating autoantibodies in multiple sclerosis (MS). Antibody-mediated deMyelination is complement and/or antibody-dependent cell-mediated cytotoxicity (ADCC) dependent. For antibody-mediated deMyelination to occur in the absence of intrathecal synthesis, an initial “hit” is required to disrupt the blood–brain barrier (BBB). Pathogenic MOG-specific antibodies recognize cell surface and largely conformation-dependent epitopes. The prevalence of anti-MOG antibodies in pediatric MS/acute disseminated encephalomyelitis (ADEM) patients suggests these contribute to deMyelination in these diseases. Defining the specificity of deMyelinating autoantibodies in adult patients with MS will drive the development of progressively more sophisticated technologies to manipulate/eliminate pathogenic B-cell responses in human disease.
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Myelin Oligodendrocyte Glycoprotein Gene
Myelin Biology and Disorders, 2004Co-Authors: Danielle Pham-dinh, André Dautigny, Christopher LiningtonAbstract:Publisher Summary Myelin Oligodendrocyte Glycoprotein (MOG) is a protein of great neuroimmunological interest, whose function is not known. This chapter examines the structural functional relationships of MOG in Myelin. Two different strategies are used to clone MOG mRNAs. One uses a mixture of MOG mAbs to screen a rat ƛgt11 expression library, whereas other used degenerate primers developed from the N-terminal amino acid sequence of bovine MOG to screen bovine, rat, and mouse brain ƛgt10 phage libraries. Subsequently, the mouse gene is isolated and its organization characterized. Similar approaches are used to characterize the human MOG cDNA and the human gene. Sequence analyses indicate that the mature protein is highly conserved between species and consists of 218 amino acids comprising a putative signal peptide, an immunoglobulin (Ig)-like N-terminal domain, two highly hydrophobic segments separated by a short hydrophilic loop, and a short hydrophilic C-terminal domain. The presence of two putative membrane-spanning domains, if verified, would make MOG a unique member of the Ig super-gene family (IgSF).
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Myelin Oligodendrocyte Glycoprotein is expressed in the peripheral nervous system of rodents and primates.
Neuroscience letters, 2003Co-Authors: Maria Pagany, Danielle Pham-dinh, François Lachapelle, Maja Jagodic, Tomas Olsson, Anna Schubart, Corinne Bachelin, Anne Baron-van Evercooren, Christopher LiningtonAbstract:The Myelin Oligodendrocyte Glycoprotein (MOG) is a minor CNS Myelin-specific protein that is an important candidate autoantigen in multiple sclerosis. We now report that MOG mRNA transcripts are present in the peripheral nervous system of rodents and primates at levels approximately ten-fold lower than in brain as demonstrated by real time PCR. A major source of this signal are Schwann cells which are also shown to express MOG protein within their cytoplasm in vitro by immunohistochemistry. Expression of MOG by Schwann cells associated with tissue innervation may account for the widespread distribution of low levels of MOG mRNA transcripts, and potentially may provide a source of antigen that can influence the composition and function of the MOG-specific immune repertoire.
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Genetic variation in Myelin Oligodendrocyte Glycoprotein expression and susceptibility to experimental autoimmune encephalomyelitis.
Journal of neuroimmunology, 2003Co-Authors: Maria Pagany, Maja Jagodic, Carole Bourquin, Tomas Olsson, Christopher LiningtonAbstract:Myelin Oligodendrocyte Glycoprotein (MOG) is encoded within the RT1.M region of the rat MHC a susceptibility locus for MOG-induced experimental autoimmune encephalomyelitis (EAE). We report that the enhanced susceptibility of Brown Norway (BN) rats to MOG-EAE is associated with higher expression of MOG mRNA and protein in the nervous system than in the less susceptible Lewis (LEW) strain. MOG mRNA was also detected in the immune system, but there was no correlation with disease susceptibility. These results suggest that differences in the expression of MOG in the target organ, rather than in the immune system may influence susceptibility to MOG-EAE.
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Investigation of Myelin/Oligodendrocyte Glycoprotein membrane topology.
Journal of neurochemistry, 2002Co-Authors: John F. Kroepfl, Christopher Linington, Laura R. Viise, Audra J. Charron, Minnetta V. GardinierAbstract:Myelin/Oligodendrocyte Glycoprotein (MOG) is a CNS-specific integral membrane protein that is an atypical member of the immunoglobulin (Ig) superfamily with two potential transmembrane domains based upon hydropathy analysis. With only one other exception, all lg family members possess a single or no membrane spanning region. In order to analyze MOG membrane topology, we prepared stably transfected cells that express mouse MOG and used three domain-specific antisera to ascertain the localization of these hydrophilic domains. As expected, MOG's glycosylated N-terminal Ig-like domain was identified as extracellular, because membrane permeabilization was not required for immunoreactivity with the MOG 1-125 antiserum. In contrast, both MOG 154-169 and MOG 198-218 antisera stained cells only upon permeabilization. These data indicate that only MOG's N-terminal hydrophobic domain spans the lipid bilayer, and we propose that MOG's C-terminal hydrophobic domain associates with the cytoplasmic face of the plasma membrane. As for MOG's second hydrophobic domain, it is clear that either orientation (transmembrane versus membrane-associated) would be unique among Ig-like proteins, and the implications of our proposed topology for MOG in oligodendroglial plasma membrane are discussed.
John J Chen - One of the best experts on this subject based on the ideXlab platform.
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Application of 2015 Seronegative Neuromyelitis Optica Spectrum Disorder Diagnostic Criteria for Patients With Myelin Oligodendrocyte Glycoprotein IgG-Associated Disorders.
JAMA neurology, 2020Co-Authors: Amy Kunchok, Eoin P. Flanagan, John J Chen, Brian G Weinshenker, Ruba S. Saadeh, Dean M. Wingerchuk, Sean J PittockAbstract:This study evaluates the proportion of patients with Myelin Oligodendrocyte Glycoprotein IgG–associated disorders who fulfill the seronegative neuromyelitis optica spectrum disorder criteria.
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does area postrema syndrome occur in Myelin Oligodendrocyte Glycoprotein igg associated disorders mogad
Neurology, 2020Co-Authors: Amy Kunchok, Eoin P. Flanagan, John J Chen, Karl N Krecke, Jiraporn Jitprapaikulsan, Sebastian A Lopezchiriboga, Brian G Weinshenker, Sean J PittockAbstract:Myelin Oligodendrocyte Glycoprotein-IgG is a biomarker associated with CNS deMyelinating diseases.1,2 MOGAD and aquaporin-4-IgG–positive neuromyelitis optica spectrum disorder (AQP4-IgG + NMOSD) have overlapping clinical features including optic neuritis and myelitis. However, there are several clinical and radiologic distinguishing features of MOGAD including lack of female predominance, higher incidence of acute disseminated encephalomyelitis (ADEM), higher proportion of bilateral optic neuritis, and T2-signal confined to gray matter and conus involvement in myelitis.1,3,4
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Does area postrema syndrome occur in Myelin Oligodendrocyte Glycoprotein-IgG-associated disorders (MOGAD)?
Neurology, 2019Co-Authors: Amy Kunchok, Eoin P. Flanagan, John J Chen, Karl N Krecke, Jiraporn Jitprapaikulsan, Brian G Weinshenker, A. Sebastian Lopez-chiriboga, Sean J PittockAbstract:Myelin Oligodendrocyte Glycoprotein-IgG is a biomarker associated with CNS deMyelinating diseases.1,2 MOGAD and aquaporin-4-IgG–positive neuromyelitis optica spectrum disorder (AQP4-IgG + NMOSD) have overlapping clinical features including optic neuritis and myelitis. However, there are several clinical and radiologic distinguishing features of MOGAD including lack of female predominance, higher incidence of acute disseminated encephalomyelitis (ADEM), higher proportion of bilateral optic neuritis, and T2-signal confined to gray matter and conus involvement in myelitis.1,3,4
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Myelin Oligodendrocyte Glycoprotein Antibody (MOG-IgG)-Positive Optic Perineuritis
Neuro-ophthalmology (Aeolus Press), 2019Co-Authors: A. Sebastian Lopez-chiriboga, Eoin P. Flanagan, Sean J Pittock, Gregory P. Van Stavern, J. P. Fryer, M. Tariq Bhatti, John J ChenAbstract:Optic perineuritis can be a manifestation of infectious and systemic inflammatory disorders, but the majority of cases are idiopathic. Myelin Oligodendrocyte Glycoprotein (MOG)-IgG-positive optic neuritis has been reported to be associated with optic nerve sheath enhancement. This report describes two MOG-IgG patients with clinical, radiological and therapeutic response consistent with optic perineuritis. MOG-IgG may account for many cases of previously described idiopathic optic perineuritis. Vision loss with optic nerve sheath enhancement on MRI should prompt testing for MOG-IgG.
Eoin P. Flanagan - One of the best experts on this subject based on the ideXlab platform.
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Application of 2015 Seronegative Neuromyelitis Optica Spectrum Disorder Diagnostic Criteria for Patients With Myelin Oligodendrocyte Glycoprotein IgG-Associated Disorders.
JAMA neurology, 2020Co-Authors: Amy Kunchok, Eoin P. Flanagan, John J Chen, Brian G Weinshenker, Ruba S. Saadeh, Dean M. Wingerchuk, Sean J PittockAbstract:This study evaluates the proportion of patients with Myelin Oligodendrocyte Glycoprotein IgG–associated disorders who fulfill the seronegative neuromyelitis optica spectrum disorder criteria.
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does area postrema syndrome occur in Myelin Oligodendrocyte Glycoprotein igg associated disorders mogad
Neurology, 2020Co-Authors: Amy Kunchok, Eoin P. Flanagan, John J Chen, Karl N Krecke, Jiraporn Jitprapaikulsan, Sebastian A Lopezchiriboga, Brian G Weinshenker, Sean J PittockAbstract:Myelin Oligodendrocyte Glycoprotein-IgG is a biomarker associated with CNS deMyelinating diseases.1,2 MOGAD and aquaporin-4-IgG–positive neuromyelitis optica spectrum disorder (AQP4-IgG + NMOSD) have overlapping clinical features including optic neuritis and myelitis. However, there are several clinical and radiologic distinguishing features of MOGAD including lack of female predominance, higher incidence of acute disseminated encephalomyelitis (ADEM), higher proportion of bilateral optic neuritis, and T2-signal confined to gray matter and conus involvement in myelitis.1,3,4
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Does area postrema syndrome occur in Myelin Oligodendrocyte Glycoprotein-IgG-associated disorders (MOGAD)?
Neurology, 2019Co-Authors: Amy Kunchok, Eoin P. Flanagan, John J Chen, Karl N Krecke, Jiraporn Jitprapaikulsan, Brian G Weinshenker, A. Sebastian Lopez-chiriboga, Sean J PittockAbstract:Myelin Oligodendrocyte Glycoprotein-IgG is a biomarker associated with CNS deMyelinating diseases.1,2 MOGAD and aquaporin-4-IgG–positive neuromyelitis optica spectrum disorder (AQP4-IgG + NMOSD) have overlapping clinical features including optic neuritis and myelitis. However, there are several clinical and radiologic distinguishing features of MOGAD including lack of female predominance, higher incidence of acute disseminated encephalomyelitis (ADEM), higher proportion of bilateral optic neuritis, and T2-signal confined to gray matter and conus involvement in myelitis.1,3,4
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Myelin Oligodendrocyte Glycoprotein Antibody (MOG-IgG)-Positive Optic Perineuritis
Neuro-ophthalmology (Aeolus Press), 2019Co-Authors: A. Sebastian Lopez-chiriboga, Eoin P. Flanagan, Sean J Pittock, Gregory P. Van Stavern, J. P. Fryer, M. Tariq Bhatti, John J ChenAbstract:Optic perineuritis can be a manifestation of infectious and systemic inflammatory disorders, but the majority of cases are idiopathic. Myelin Oligodendrocyte Glycoprotein (MOG)-IgG-positive optic neuritis has been reported to be associated with optic nerve sheath enhancement. This report describes two MOG-IgG patients with clinical, radiological and therapeutic response consistent with optic perineuritis. MOG-IgG may account for many cases of previously described idiopathic optic perineuritis. Vision loss with optic nerve sheath enhancement on MRI should prompt testing for MOG-IgG.
