The Experts below are selected from a list of 135 Experts worldwide ranked by ideXlab platform
Deborah Vela - One of the best experts on this subject based on the ideXlab platform.
-
current status of the role of stem cells in Myocardial Biology and repair
Cardiovascular Pathology, 2011Co-Authors: Maximilian L Buja, Deborah VelaAbstract:Abstract The purpose of this article is to present an analysis of current knowledge and understanding of the role of stem cells in Myocardial Biology and Myocardial repair following injury. This rapidly evolving field has assumed relevance for the understanding, diagnosis, and treatment of heart failure.
Maximilian L Buja - One of the best experts on this subject based on the ideXlab platform.
-
current status of the role of stem cells in Myocardial Biology and repair
Cardiovascular Pathology, 2011Co-Authors: Maximilian L Buja, Deborah VelaAbstract:Abstract The purpose of this article is to present an analysis of current knowledge and understanding of the role of stem cells in Myocardial Biology and Myocardial repair following injury. This rapidly evolving field has assumed relevance for the understanding, diagnosis, and treatment of heart failure.
Albert J. Sinusas - One of the best experts on this subject based on the ideXlab platform.
-
Advances in radionuclide molecular imaging in Myocardial Biology
Journal of Nuclear Cardiology, 2010Co-Authors: Alan R. Morrison, Albert J. SinusasAbstract:Molecular imaging is a new and evolving field that employs a targeted approach to noninvasively assess biologic processes in vivo. By assessing key elements in specific cellular processes prior to irreversible end-organ damage, molecular tools will allow for earlier detection and intervention, improving management and outcomes associated with cardiovascular diseases. The goal of those working to expand this field is not just to provide diagnostic and prognostic information, but rather to guide an individual’s pharmacological, cell-based, or genetic therapeutic regimen. This article will review molecular imaging tools in the context of our current understanding of biological processes of the myocardium, including angiogenesis, ventricular remodeling, inflammation, and apoptosis. The focus will be on radiotracer-based molecular imaging modalities with an emphasis on clinical application. Though this field is still in its infancy and may not be fully ready for widespread use, molecular imaging of Myocardial Biology has begun to show promise of clinical utility in acute and chronic ischemia, acute Myocardial infarction, congestive heart failure, as well as in more global inflammatory and immune-mediated responses in the heart-like myocarditis and allogeneic cardiac transplant rejection. With continued research and development, molecular imaging promises to be an important tool for the optimization of cardiovascular care.
-
new molecular imaging targets to characterize Myocardial Biology
Cardiology Clinics, 2009Co-Authors: Alan R. Morrison, Albert J. SinusasAbstract:Molecular imaging represents a targeted approach to noninvasively assess biologic (both physiologic and pathologic) processes in vivo. Ideally the goal of molecular imaging is not just to provide diagnostic and prognostic information based on identification of the molecular events associated with a pathologic process but rather to guide individually tailored pharmacologic, cell-based, or genetic therapeutic regimens. This article reviews the recent advances in Myocardial molecular imaging in the context of the cardiovascular processes of angiogenesis, apoptosis, inflammation, and ventricular remodeling. The focus is on radiotracer-based single photon emission computed tomography and positron emission tomography molecular imaging approaches.
Piero Anversa - One of the best experts on this subject based on the ideXlab platform.
-
Regenerating new heart with stem cells
Journal of Clinical Investigation, 2013Co-Authors: Piero Anversa, Jan Kajstura, Marcello Rota, Annarosa LeriAbstract:This article discusses current understanding of Myocardial Biology, emphasizing the regeneration potential of the adult human heart and the mechanisms involved. In the last decade, a novel conceptual view has emerged. The heart is no longer considered a postmitotic organ, but is viewed as a self-renewing organ characterized by a resident stem cell compartment responsible for tissue homeostasis and cardiac repair following injury. Additionally, HSCs possess the ability to transdifferentiate and acquire the cardiomyocyte, vascular endothelial, and smooth muscle cell lineages. Both cardiac and hematopoietic stem cells may be used therapeutically in an attempt to reverse the devastating consequences of chronic heart failure of ischemic and nonischemic origin.
-
role of cardiac stem cells in cardiac pathophysiology a paradigm shift in human Myocardial Biology
Circulation Research, 2011Co-Authors: Annarosa Leri, Jan Kajstura, Piero AnversaAbstract:For nearly a century, the human heart has been viewed as a terminally differentiated postmitotic organ in which the number of cardiomyocytes is established at birth, and these cells persist throughout the lifespan of the organ and organism. However, the discovery that cardiac stem cells live in the heart and differentiate into the various cardiac cell lineages has changed profoundly our understanding of Myocardial Biology. Cardiac stem cells regulate myocyte turnover and condition Myocardial recovery after injury. This novel information imposes a reconsideration of the mechanisms involved in Myocardial aging and the progression of cardiac hypertrophy to heart failure. Similarly, the processes implicated in the adaptation of the infarcted heart have to be dissected in terms of the critical role that cardiac stem cells and myocyte regeneration play in the restoration of Myocardial mass and ventricular function. Several categories of cardiac progenitors have been described but, thus far, the c-kit–positive c...
-
Mechanisms of Myocardial Regeneration
Trends in Cardiovascular Medicine, 2011Co-Authors: Annarosa Leri, Jan Kajstura, Piero AnversaAbstract:Traditionally, the adult heart has been viewed as a terminally differentiated postmitotic organ in which the number of cardiomyocytes is established at birth and these cells persist throughout the life span of the organ and organism. However, the discovery that cardiac stem cells live in the heart and differentiate into the various cardiac cell lineages has dramatically changed our understanding of Myocardial Biology. Deciphering the biological processes that lead to myocyte renewal is a challenging task. Cardiac regeneration may be accomplished by (1) commitment of multipotent stem cells that generate all specialized lineages within the parenchyma, (2) activation of unipotent progenitors with restricted differentiation potential, (3) replication of pre-existing differentiated cells, (4) transdifferentiation of exogenous progenitors that undergo plastic conversion into cells different from the organ of origin, and (5) dedifferentiation of cardiomyocytes that re-enter the cell cycle and divide. These multiple mechanisms of cell growth may act in concert to regenerate complex structures and restore the function of the target organ.
S Wilson M D Colucci - One of the best experts on this subject based on the ideXlab platform.
-
the effects of norepinephrine on Myocardial Biology implications for the therapy of heart failure
Clinical Cardiology, 1998Co-Authors: S Wilson M D ColucciAbstract:Increased sympathetic nervous system (SNS) activity in patients with heart failure may help to support cardiovascular function. However, increased SNS activity. particularly if prolonged, may exert deleterious effects on cardiovascular structure and function by stimulating pathologic Myocardial remodeling. In vitro, norepinephrine mimics many features of Myocardial remodeling, including hypertrophy of individual myocytes and reinduction of fetal genes. Furthermore, stimulation of the beta-adrenergic pathway has been shown to stimulate apoptosis of cardiac myocytes in vitro, in rats infused with isoproterenol, and in mice that overexpress the stimulatory G-protein, G s . Thus, increased SNS activity, acting via beta-adrenergic receptors. may play an important role in the progression of Myocardial failure by acting directly on myocytes and other cell types in the heart to regulate fundamental biologic properties such as growth, apoptosis, and the composition of the extracellular matrix. This thesis provides a mechanism by which beta-adrenergic antagonists may inhibit or reverse pathologic remodeling, improve Myocardial structure and function, and prolong patient survival.
