The Experts below are selected from a list of 25050102 Experts worldwide ranked by ideXlab platform
Yingyeung Yeung - One of the best experts on this subject based on the ideXlab platform.
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catalyst free and metal free electrophilic bromoamidation of unactivated olefins using the n bromosuccinimide sulfonamide protocol
Journal of Organic Chemistry, 2015Co-Authors: Wesley Zongrong Yu, Feng Chen, Yi An Cheng, Yingyeung YeungAbstract:An efficient, catalyst-free, and metal-free bromoamidation of unactivated olefins has been developed. 4-(Trifluoromethyl)benzenesulfonamide and N-Bromosuccinimide were used as the nitrogen and halogen sources, respectively. The methodology is applicable to both cyclic and aliphatic olefins.
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an unexpected 2 3 dihydrofuran derivative ring opening initiated by electrophilic bromination scope and mechanistic study
Journal of Organic Chemistry, 2015Co-Authors: Yi Zhao, Yingchieh Wong, Yingyeung YeungAbstract:An unexpected 2,3-dihydrofuran ring opening process at the C(4)-C(5) bond has been developed. N-Bromosuccinimide and DABCO were used as the electrophilic halogen source and the catalyst, respectively. Mechanistic study indicates that moisture in the solvent might contribute to the reaction. The resulting brominated product could be further oxidized to yield a synthetically valuable 1,2-diketo building block.
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diastereoselective synthesis of functionalized pyrrolidines through n bromosuccinimide induced aziridine ring expansion cascade of cinnamylaziridine
Organic and Biomolecular Chemistry, 2014Co-Authors: Jing Zhou, Yingyeung YeungAbstract:An efficient aziridine ring expansion cascade of cinnamylaziridine has been developed. N-Bromosuccinimide was used as the promoter. The resulting functionalized pyrrolidines are the fundamental units of many useful molecules.
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synthesis of reboxetine intermediate and carnitine acetyltransferase inhibitor via nbs induced electrophilic multicomponent reaction
Journal of Organic Chemistry, 2014Co-Authors: Jing Zhou, Yingyeung YeungAbstract:N-Bromosuccinimide-induced electrophilic multicomponent reaction has been applied to the synthesis of Reboxetine intermediate, a highly potent selective norepinephrine reuptake inhibitor. By simply changing the olefinic partner, the synthesis of a carnitine acetyltransferase inhibitor, which contains a 2,6,6-trisubstituted morpholine system, can be accomplished.
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n bromosuccinimide induced aminocyclization aziridine ring expansion cascade an asymmetric and highly stereoselective approach toward the synthesis of azepane
Organic Letters, 2014Co-Authors: Jing Zhou, Yingyeung YeungAbstract:A novel N-Bromosuccinimide induced aminocyclization–aziridine ring expansion cascade is reported. Substituted azepanes were isolated exclusively in good yields. The azepane products could be transformed into a number of functional molecules including piperidines, a bicyclic amine, and a bridgehead amide.
Jing Zhou - One of the best experts on this subject based on the ideXlab platform.
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diastereoselective synthesis of functionalized pyrrolidines through n bromosuccinimide induced aziridine ring expansion cascade of cinnamylaziridine
Organic and Biomolecular Chemistry, 2014Co-Authors: Jing Zhou, Yingyeung YeungAbstract:An efficient aziridine ring expansion cascade of cinnamylaziridine has been developed. N-Bromosuccinimide was used as the promoter. The resulting functionalized pyrrolidines are the fundamental units of many useful molecules.
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synthesis of reboxetine intermediate and carnitine acetyltransferase inhibitor via nbs induced electrophilic multicomponent reaction
Journal of Organic Chemistry, 2014Co-Authors: Jing Zhou, Yingyeung YeungAbstract:N-Bromosuccinimide-induced electrophilic multicomponent reaction has been applied to the synthesis of Reboxetine intermediate, a highly potent selective norepinephrine reuptake inhibitor. By simply changing the olefinic partner, the synthesis of a carnitine acetyltransferase inhibitor, which contains a 2,6,6-trisubstituted morpholine system, can be accomplished.
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n bromosuccinimide induced aminocyclization aziridine ring expansion cascade an asymmetric and highly stereoselective approach toward the synthesis of azepane
Organic Letters, 2014Co-Authors: Jing Zhou, Yingyeung YeungAbstract:A novel N-Bromosuccinimide induced aminocyclization–aziridine ring expansion cascade is reported. Substituted azepanes were isolated exclusively in good yields. The azepane products could be transformed into a number of functional molecules including piperidines, a bicyclic amine, and a bridgehead amide.
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n bromosuccinimide promoted one pot synthesis of guanidine scope and mechanism
Organic Letters, 2011Co-Authors: Ling Zhou, Jing Zhou, Yingyeung YeungAbstract:A novel electrophilic one-pot guanidine synthesis has been developed using an olefin, a cyanimide, an amine, and N-Bromosuccinimide. A number of guanidine derivatives were prepared with good to excellent yields. An rTRTVI precursor was also prepared based on this useful process.
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n bromosuccinimide initiated one pot synthesis of imidazoline
ChemInform, 2011Co-Authors: Ling Zhou, Jing Zhou, Jie Chen, Yingyeung YeungAbstract:One-pot reaction of alkenes nitriles, amines and NBS proceeds mostly stereoselectively leading to imidazolines from the (Z)-alkenes and to the trans-bromoamidines from (E)-substrates.
Runtao Li - One of the best experts on this subject based on the ideXlab platform.
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triphenylphosphine n bromosuccinimide mediated chemoselective cyclodehydration of diols
ChemInform, 2015Co-Authors: Shuo Zhao, Tieming Cheng, You Wu, Runtao LiAbstract:1,4-Diols [e.g. (I)] undergo cyclodehydration and give tetrahydrofurans [e.g. (II)] when 1 equiv.
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triphenylphosphine n bromosuccinimide mediated chemoselective cyclodehydration of diols
Synthesis, 2015Co-Authors: Shuo Zhao, Tieming Cheng, You Wu, Runtao LiAbstract:A triphenylphosphine– N -bromosuccinimide mediated chemoselective cyclodehydration of diols is presented for the synthesis of polysubstituted tetrahydrofurans. 1,4-Diols and their derivatives can be rapidly cyclized to furnish tetrahydrofurans in high yields with one equivalent of Ph 3 P/NBS. Higher amount of Ph 3 P/NBS leads to the formation of dibromobutanes.
Qiaohong Zhang - One of the best experts on this subject based on the ideXlab platform.
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n bromosuccinimide as an oxidant for the transition metal free synthesis of 2 aminobenzoxazoles from benzoxazoles and secondary amines
Organic and Biomolecular Chemistry, 2014Co-Authors: Xiaoe Wang, Daqian Xu, Chengxia Miao, Qiaohong ZhangAbstract:A facile and transition-metal-free method was developed through merging the ring opening of benzoxazoles with secondary amines and N-Bromosuccinimide (NBS) mediated oxidative cyclization toward the synthesis of 2-aminobenzoxazoles. NBS was selected as a powerful oxidant in the oxidative cyclization of ring-opening amidines to provide the desirable 2-aminobenzoxazoles in excellent yields (up to 94%).
Wei Yu - One of the best experts on this subject based on the ideXlab platform.
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n bromosuccinimide mediated radical cyclization of 3 arylallyl azides synthesis of 3 substituted quinolines
Advanced Synthesis & Catalysis, 2015Co-Authors: Weixia Wang, Qingzhao Zhang, Zhanshan Li, Tianqi Zhang, Wei Zhang, Wei YuAbstract:Visible light irradiation of N-Bromosuccinimide serves as an effective means to convert methyl 2-(azidomethyl)-3-arylpropenoates and 2-(azidomethyl)-3-arylacrylonitriles to the corresponding iminyl radicals via a-hydrogen abstraction and subsequent extrusion of dinitrogen. Thus formed iminyl radicals then undergo intramolecular ortho attack on the aryl ring, affording methyl quinoline- 3-carboxylates and quinoline-3-carbonitriles respectively.
