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Hongkun Zhao - One of the best experts on this subject based on the ideXlab platform.
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equilibrium solubility investigation and preferential solvation of 2 6 dichloro 4 nitroaniline dissolved in four aqueous mixtures of isopropanol acetonitrile n propanol and n methyl 2 pyrrolidone
Journal of Chemical & Engineering Data, 2020Co-Authors: Yanyan Zhou, Jing Wang, Hongkun ZhaoAbstract:Saturated solubilities of 2,6-dichloro-4-nitroaniline in aqueous mixtures of isopropanol, acetonitrile, n-propanol, and N-Methyl-2-Pyrrolidone (NMP) were examined via the shake-flask equilibrium me...
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solubility of terephthaldialdehyde in n methyl 2 pyrrolidone and solid liquid phase equilibrium for ternary systems of terephthalic acid terephthaldialdehyde n n dimethylformamide n methyl 2 pyrrolidone
Journal of Chemical & Engineering Data, 2018Co-Authors: Yu Liu, Jing Wang, Hongkun ZhaoAbstract:The solubility of terephthaldialdehyde in N-Methyl-2-Pyrrolidone (NMP) at temperatures ranging from T = 293.15 to 318.15 K and the mutual solubility for ternary systems of terephthalic acid + terephthaldialdehyde + N,N-dimethylformamide (DMF) and terephthalic acid + terephthaldialdehyde + NMP at T = 298.15, 308.15, and 318.15 K were measured with the technique of isothermal saturation under 101.2 kPa. Six phase diagrams were built on the basis of the determined solubility. There were two solids formed in each ternary system, which were terephthalic acid and terephthaldialdehyde. Each diagram consisted of one cosaturated point, three crystalline areas, and two cosaturated curves. Furthermore, the nonrandom two-liquid mode and Wilson model were used in correlating and calculating the solubility of terephthaldialdehyde in NMP and the mutual solubility data for terephthalic acid + terephthaldialdehyde + DMF/NMP systems. The maximum root-mean-square deviation was 3.58 × 10–3, and maximum value of relative aver...
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determination and modeling of binary and ternary solid liquid phase equilibrium for the systems formed by 1 8 dinitronaphthalene and 1 5 dinitronaphthalene and n methyl 2 pyrrolidone
The Journal of Chemical Thermodynamics, 2016Co-Authors: Yong Xie, Shuo Han, Yang Cong, Jing Wang, Hongkun ZhaoAbstract:Abstract The solubility of 1,8-dinitronaphthalene and 1,5-dinitronaphthalene in N -methyl-2-pyrrolidone at (293.15–343.15) K and the mutual solubility of the ternary 1,5-dinitronaphthalene + 1,8-dinitronaphthalene + N -methyl-2-pyrrolidone mixture at (313.15, 328.15 and 343.15) K were determined experimentally using the isothermal saturation method under atmospheric pressure (101.2 kPa). The solubility of 1,8-dinitronaphthalene in N -methyl-2-pyrrolidone is larger than that of 1,5-dinitronaphthalene. Three isothermal ternary phase diagrams were built according to the measured mutual solubility data. In each ternary phase diagram, there were one co-saturated point, two boundary curves, and three crystalline regions. Two pure solids (pure 1,8-dinitronaphthalene and pure 1,5-dinitronaphthalene) were formed in the ternary system at a given temperature, which were identified by Schreinemaker’s method of wet residue and powder X-ray diffraction (PXRD) pattern. The crystallization region of 1,8-dinitronaphthalene was smaller than that of 1,5-dinitronaphthalene at each temperature. The modified Apelblat equation, λh equation, NRTL model and Wilson model were used to correlate the solubility of 1,8-dinitronaphthalene and 1,5-dinitronaphthalene in N -methyl-2-pyrrolidone; and the NRTL and Wilson models were employed to correlate and calculate the mutual solubility for the ternary 1,5-dinitronaphthalene + 1,8-dinitronaphthalene + N -methyl-2-pyrrolidone system. The largest value of root-mean-square deviation ( RMSD ) was 20.34 × 10 −4 for the binary systems; and 7.38 × 10 −3 for ternary system. The calculated results via these models are all acceptable for the binary and ternary solid-liquid phase equilibrium.
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determination and prediction of solid liquid phase equilibrium for quaternary system of terephthalic acid isophthalic acid phthalic acid n methyl 2 pyrrolidone at 303 15k and 313 15k
Fluid Phase Equilibria, 2015Co-Authors: Shuo Han, Jian Wang, Ganbing Yao, Yun Hao Zhong, Hongkun ZhaoAbstract:Abstract Solid–liquid phase equilibrium and solubility data for quaternary system of terephthalic acid + isophthalic acid + phthalic acid + N-Methyl-2-Pyrrolidone at 303.15 K and 313.15 K were determined by Schreinemakers’ method of wet residue under atmosphere pressure. Based on the measured solubility, the quaternary phase diagrams were constructed at the two studied temperatures according to the Janeck method. At each temperature, the quaternary phase diagram includes three crystallization regions of pure solid, three co-saturated curves and one eutectic point. The three pure solids are phthalic acid, adduct of isophthalic acid with N-Methyl-2-Pyrrolidone (the mole ratio of isophthalic acid to N-Methyl-2-Pyrrolidone is 1:2), adduct of terephthalic acid with N-Methyl-2-Pyrrolidone (the mole ratio of terephthalic acid to N-Methyl-2-Pyrrolidone is 1:2), which are confirmed by the method of Schreinemakers’ wet residue. The crystallization region of adduct of terephthalic acid with N-Methyl-2-Pyrrolidone is larger than those of phthalic acid and adduct of isophthalic acid with N-Methyl-2-Pyrrolidone. Furthermore, the quaternary solid–liquid phase equilibrium were predicted by NRTL model. The calculated quaternary phase diagrams agreed well with experimental data.
Santos Otin - One of the best experts on this subject based on the ideXlab platform.
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analysis of n n dialkylamide or 1 methyl 2 pyrrolidone 1 chloroalkane or α ω dichloroalkane mixtures in terms of group contribution
Thermochimica Acta, 2009Co-Authors: Pilar Garciagimenez, Elisa Langa, Jose Martinez F Lopez, Santos OtinAbstract:Abstract The experimental vapour–liquid equilibria, VLE, excess molar Gibbs energies, G m E , and excess molar enthalpies, H m E , determined previously for the systems N,N-dimethylformamide, or N,N-dimethylacetamide, or 1-methyl-2-pyrrolidone + 1-chlorobutane, or +1-chlorohexane, or +1-chlorooctane, or +1,2-dichloroethane, or +1,4-dichlorobutane, or +1,6-dichlorohexane, are examined using the DISQUAC group contribution model. The dispersive and quasi-chemical interchange parameters for the contacts chloro-amide in the mixtures with N,N-dialkylamide or 1-methyl-2-pyrrolidone with chloro- or α,ω-dichloroalkane were calculated. The model reproduces quite well the experimental data.
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excess enthalpies and isothermal vapour liquid equilibria of 1 methyl 2 pyrrolidone 1 chloroalkane or α ω dichloroalkane mixtures
The Journal of Chemical Thermodynamics, 2008Co-Authors: Pilar Garciagimenez, Inmaculada Velasco, Jose F Martinezlopez, Manuela Artal, Santos OtinAbstract:Abstract Excess enthalpies H m E at T = (298.15 and 308.15) K have been measured for liquid (1-methyl-2-pyrrolidone + 1-chlorobutane, or +1-chlorohexane, or +1-chlorooctane, or +1,2-dichloroethane, or +1,4-dichlorobutane, or +1,6-dichlorohexane) and isothermal (vapor + liquid) equilibria (VLE) at T = (313.15, 323.15, and 333.15) K are reported for (1-methyl-2-pyrrolidone + 1-chlorobutane, or +1-chlorohexane, or +1,2-dichloroethane). The VLE data were reduced using the Redlich–Kister equation taking into consideration the vapour-phase imperfection in terms of 2nd molar virial coefficients.
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densities and isothermal compressibilities at pressures up to 20 mpa of the systems 1 methyl 2 pyrrolidone 1 chloroalkane or α ω dichloroalkane
Journal of Chemical & Engineering Data, 2008Co-Authors: Pilar Garciagimenez, Sofia T Blanco, Inmaculada Velasco, Santos OtinAbstract:Densities of pure 1-methyl-2-pyrrolidone were measured at (288.15, 298.15, 308.15, and 318.15) K at pressures up to 20 MPa, and from them isothermal compressibilities were obtained. Densities for 1-methyl-2-pyrrolidone + 1-chlorobutane, or + 1-chlorohexane, or + 1-chlorooctane, or + 1,2-dichloroethane, or + 1,4-dichlorobutane, or + 1,6-dichlorohexane at 298.15 K and at pressures up to 20 MPa were measured, and isothermal compressibilities were obtained.
Pilar Garciagimenez - One of the best experts on this subject based on the ideXlab platform.
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analysis of n n dialkylamide or 1 methyl 2 pyrrolidone 1 chloroalkane or α ω dichloroalkane mixtures in terms of group contribution
Thermochimica Acta, 2009Co-Authors: Pilar Garciagimenez, Elisa Langa, Jose Martinez F Lopez, Santos OtinAbstract:Abstract The experimental vapour–liquid equilibria, VLE, excess molar Gibbs energies, G m E , and excess molar enthalpies, H m E , determined previously for the systems N,N-dimethylformamide, or N,N-dimethylacetamide, or 1-methyl-2-pyrrolidone + 1-chlorobutane, or +1-chlorohexane, or +1-chlorooctane, or +1,2-dichloroethane, or +1,4-dichlorobutane, or +1,6-dichlorohexane, are examined using the DISQUAC group contribution model. The dispersive and quasi-chemical interchange parameters for the contacts chloro-amide in the mixtures with N,N-dialkylamide or 1-methyl-2-pyrrolidone with chloro- or α,ω-dichloroalkane were calculated. The model reproduces quite well the experimental data.
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excess enthalpies and isothermal vapour liquid equilibria of 1 methyl 2 pyrrolidone 1 chloroalkane or α ω dichloroalkane mixtures
The Journal of Chemical Thermodynamics, 2008Co-Authors: Pilar Garciagimenez, Inmaculada Velasco, Jose F Martinezlopez, Manuela Artal, Santos OtinAbstract:Abstract Excess enthalpies H m E at T = (298.15 and 308.15) K have been measured for liquid (1-methyl-2-pyrrolidone + 1-chlorobutane, or +1-chlorohexane, or +1-chlorooctane, or +1,2-dichloroethane, or +1,4-dichlorobutane, or +1,6-dichlorohexane) and isothermal (vapor + liquid) equilibria (VLE) at T = (313.15, 323.15, and 333.15) K are reported for (1-methyl-2-pyrrolidone + 1-chlorobutane, or +1-chlorohexane, or +1,2-dichloroethane). The VLE data were reduced using the Redlich–Kister equation taking into consideration the vapour-phase imperfection in terms of 2nd molar virial coefficients.
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densities and isothermal compressibilities at pressures up to 20 mpa of the systems 1 methyl 2 pyrrolidone 1 chloroalkane or α ω dichloroalkane
Journal of Chemical & Engineering Data, 2008Co-Authors: Pilar Garciagimenez, Sofia T Blanco, Inmaculada Velasco, Santos OtinAbstract:Densities of pure 1-methyl-2-pyrrolidone were measured at (288.15, 298.15, 308.15, and 318.15) K at pressures up to 20 MPa, and from them isothermal compressibilities were obtained. Densities for 1-methyl-2-pyrrolidone + 1-chlorobutane, or + 1-chlorohexane, or + 1-chlorooctane, or + 1,2-dichloroethane, or + 1,4-dichlorobutane, or + 1,6-dichlorohexane at 298.15 K and at pressures up to 20 MPa were measured, and isothermal compressibilities were obtained.
Jing Wang - One of the best experts on this subject based on the ideXlab platform.
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equilibrium solubility investigation and preferential solvation of 2 6 dichloro 4 nitroaniline dissolved in four aqueous mixtures of isopropanol acetonitrile n propanol and n methyl 2 pyrrolidone
Journal of Chemical & Engineering Data, 2020Co-Authors: Yanyan Zhou, Jing Wang, Hongkun ZhaoAbstract:Saturated solubilities of 2,6-dichloro-4-nitroaniline in aqueous mixtures of isopropanol, acetonitrile, n-propanol, and N-Methyl-2-Pyrrolidone (NMP) were examined via the shake-flask equilibrium me...
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solubility of terephthaldialdehyde in n methyl 2 pyrrolidone and solid liquid phase equilibrium for ternary systems of terephthalic acid terephthaldialdehyde n n dimethylformamide n methyl 2 pyrrolidone
Journal of Chemical & Engineering Data, 2018Co-Authors: Yu Liu, Jing Wang, Hongkun ZhaoAbstract:The solubility of terephthaldialdehyde in N-Methyl-2-Pyrrolidone (NMP) at temperatures ranging from T = 293.15 to 318.15 K and the mutual solubility for ternary systems of terephthalic acid + terephthaldialdehyde + N,N-dimethylformamide (DMF) and terephthalic acid + terephthaldialdehyde + NMP at T = 298.15, 308.15, and 318.15 K were measured with the technique of isothermal saturation under 101.2 kPa. Six phase diagrams were built on the basis of the determined solubility. There were two solids formed in each ternary system, which were terephthalic acid and terephthaldialdehyde. Each diagram consisted of one cosaturated point, three crystalline areas, and two cosaturated curves. Furthermore, the nonrandom two-liquid mode and Wilson model were used in correlating and calculating the solubility of terephthaldialdehyde in NMP and the mutual solubility data for terephthalic acid + terephthaldialdehyde + DMF/NMP systems. The maximum root-mean-square deviation was 3.58 × 10–3, and maximum value of relative aver...
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simultaneous determination of three pesticide adjuvant residues in plant derived agro products using liquid chromatography tandem mass spectrometry
Journal of Chromatography A, 2017Co-Authors: Zejun Jiang, Xiaolin Cao, Hua Shao, Fen Jin, A Abd M Elaty, Jing WangAbstract:Abstract Herein, an accurate and reliable isotope-labelled internal standard method was developed and validated for simultaneous determination of three polar pesticide adjuvants, namely 2-pyrrolidone, N-Methyl-2-Pyrrolidone, and N-ethyl-2-pyrrolidone in plant-derived agro-products. Matrices, including apple, cabbage, tomato, cucumber, rice, and wheat were extracted with a modified quick, easy, cheap, effective, rugged, and safe “QuEChERS” method and purified with a new clean-up sorbent (Z-Sep). A hydrophilic interaction liquid chromatography column (HILIC), exhibiting a lipophilic-hydrophilic character, was used to separate the three analytes over 10 min using liquid chromatography–tandem mass spectrometry (LC–MS/MS). Matrix effects in various matrices were evaluated and an isotope-labelled internal standard method was employed to compensate for ion enhancement/suppression effects. At three fortification levels (2.0, 5.0, and 20.0 μg/kg), the mean recoveries ranged from 78.5 to 112.1% with relative standard deviations (RSDs)
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determination and modeling of binary and ternary solid liquid phase equilibrium for the systems formed by 1 8 dinitronaphthalene and 1 5 dinitronaphthalene and n methyl 2 pyrrolidone
The Journal of Chemical Thermodynamics, 2016Co-Authors: Yong Xie, Shuo Han, Yang Cong, Jing Wang, Hongkun ZhaoAbstract:Abstract The solubility of 1,8-dinitronaphthalene and 1,5-dinitronaphthalene in N -methyl-2-pyrrolidone at (293.15–343.15) K and the mutual solubility of the ternary 1,5-dinitronaphthalene + 1,8-dinitronaphthalene + N -methyl-2-pyrrolidone mixture at (313.15, 328.15 and 343.15) K were determined experimentally using the isothermal saturation method under atmospheric pressure (101.2 kPa). The solubility of 1,8-dinitronaphthalene in N -methyl-2-pyrrolidone is larger than that of 1,5-dinitronaphthalene. Three isothermal ternary phase diagrams were built according to the measured mutual solubility data. In each ternary phase diagram, there were one co-saturated point, two boundary curves, and three crystalline regions. Two pure solids (pure 1,8-dinitronaphthalene and pure 1,5-dinitronaphthalene) were formed in the ternary system at a given temperature, which were identified by Schreinemaker’s method of wet residue and powder X-ray diffraction (PXRD) pattern. The crystallization region of 1,8-dinitronaphthalene was smaller than that of 1,5-dinitronaphthalene at each temperature. The modified Apelblat equation, λh equation, NRTL model and Wilson model were used to correlate the solubility of 1,8-dinitronaphthalene and 1,5-dinitronaphthalene in N -methyl-2-pyrrolidone; and the NRTL and Wilson models were employed to correlate and calculate the mutual solubility for the ternary 1,5-dinitronaphthalene + 1,8-dinitronaphthalene + N -methyl-2-pyrrolidone system. The largest value of root-mean-square deviation ( RMSD ) was 20.34 × 10 −4 for the binary systems; and 7.38 × 10 −3 for ternary system. The calculated results via these models are all acceptable for the binary and ternary solid-liquid phase equilibrium.
Joanna Pichor - One of the best experts on this subject based on the ideXlab platform.
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synthesis and anticonvulsant activity of new n 4 arylpiperazin 1 yl alkyl derivatives of 3 phenyl pyrrolidine 2 5 dione
European Journal of Medicinal Chemistry, 2009Co-Authors: Jolanta Obniska, Krzysztof Kaminski, Dorota Skrzynska, Joanna PichorAbstract:Abstract In the present study, on the development of new anticonvulsants, the series of N -[(4-arylpiperazin-1-yl)-alkyl]-3-(2-methylphenyl)- ( 8a – e , 10a – h ) and 3-(2-trifluoromethyl-phenyl)-pyrrolidine-2,5-diones ( 9a – e , 11a – i ) were synthesized and tested for anticonvulsant activity using the maximal electroshock (MES), subcutaneous pentylenetetrazole (scPTZ) screens. Their neurotoxicity were determined applying the rotorod test. In this series, the most active were N -[(4-phenylpiperazin-1-yl)-methyl]-3-(2-trifluoromethylphenyl)-pyrrolidine-2,5-dione ( 9a ) with the ED 50 = 20.78 mg/kg, when given orally to rats and N -[3-{4-(3-trifluoromethylphenyl)-piperazin-1-yl}-propyl]-3-(2-trifluoromethylphenyl)-pyrrolidine-2,5-dione ( 11i ) with the ED 50 = 132.13 mg/kg after intraperitoneally injection to mice.
