The Experts below are selected from a list of 2214 Experts worldwide ranked by ideXlab platform
Seid Mahdi Jafari - One of the best experts on this subject based on the ideXlab platform.
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Nanoencapsulation of phase change materials pcms and their applications in various fields for energy storage and management
Advances in Colloid and Interface Science, 2020Co-Authors: Elham Alehosseini, Seid Mahdi JafariAbstract:Today, the use of phase change materials (PCMs) with remarkable properties for energy storage and development of engineering systems is an extremely important topic, due to enhanced demand for energy consumption. PCMs could be generally subdivided into solid-liquid, liquid-gas, solid-gas, and solid-solid groups. It should be noted that since there is no single excellent PCM that comprises all the suitable physical, chemical, kinetic, thermal, and economic properties, PCMs could be improved by incorporating some additives, modifying PCM structures, and optimizing the storage systems. Nanoencapsulation of PCMs, as an effective technique, can increase their thermal conductivity, barricades their leak during the melting operation, and their possible interactions with the surrounding matrix. Furthermore, there are several methods for fabricating nanocapsules loaded with PCMs including chemical (i.e., emulsion polymerization, mini-emulsion polymerization, in situ polymerization, and interfacial polymerization), physicochemical (sol-gel entrapment), and physicomechanical techniques (electrohydrodynamic processes). Accordingly, the energy storage and release of nanoencapsulated PCMs has been become an important field in many applications such as electronic devices, food industry, buildings, solar energy storage, heat exchangers, packed bed designs, space systems, textiles, etc. This study has been focused on various PCMs, their Nanoencapsulation methods, phase change fibers, as well as their potential applications in energy storing and management goals in various fields.
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Nanoencapsulation of carotenoids within lipid based nanocarriers
Journal of Controlled Release, 2019Co-Authors: Hadis Rostamabadi, Seid Reza Falsafi, Seid Mahdi JafariAbstract:Carotenoids, as promising functional components in human diet, are gaining immense importance todays. Apart from their pivotal importance in photosynthetic organisms or as natural pigments, they are typically referred to as health-promotional ingredients, which offer several beneficial attributes. However, their sensitivity against environmental and process stresses, low-water solubility, as well as low-bioavailability are the most shortfalls restricting pharmaceutical/food carotenoid applications. In this regard, lipid-based nano-delivery cargos i.e. nano-liposomal vehicles, surfactant-based nano-carriers, nano-emulsions, nano-structured lipid carriers (NLCs), and solid lipid nano-particles (SLNs), as safe and attractive nanocarriers, are proving to be a potent platform for protection of carotenoids against challenging conditions along with offering an efficient controlled release. Nonetheless, the development of such delivery systems needs comprehensive understanding of physicochemical attributes of carotenoids and their specialized carriers, effective variables, delivery mechanisms, specific shortfalls of each delivery system, as well as recent nano-encapsulation advancements. To address these issues, the present review is attempting to cover the novel advances in Nanoencapsulation of carotenoids principally based on lipid-based nanocarriers with an emphasis on the factors affecting the bioaccessibility of carotenoids in such nanocarriers, together with their challenges and upcoming evolutions.
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Nanoencapsulation of hydrophobic and low soluble food bioactive compounds within different nanocarriers
Food Hydrocolloids, 2019Co-Authors: Atefe Rezaei, Milad Fathi, Seid Mahdi JafariAbstract:Abstract There are many hydrophobic or poorly soluble nutrients and bioactive compounds which are essential for human health, such as phenolic compounds, carotenoids, essential oils, essential fatty acids, and insoluble vitamins. The low bioavailability and sustainability of these compounds are the main challenges for their use in the pharmaceuticae and food industries. Nanoencapsulation can be a favourable approach for protecting hydrophobic food bioactive compounds against unsuitable circumstances and enhance their bioavailability. In this review, several Nanoencapsulation delivery systems for hydrophobic compounds, such as inclusion complexes through cyclodextrins, amylose, and yeast cells, nanogels, nanoemulsions, nanofibers, nanosponges, nanoliposomes, and nanoparticles made with lipids and biopolymers are discussed. Also, the toxicity and safety aspects of the nanocarriers loaded with hydrophobic food bioactive compounds has been covered. Different studies on encapsulation of hydrophobic food bioactives have shown that by incorporating them into sophisticated nanocarriers, promising and favourable results can be achieved such improvement in water solubility, antioxidant and other health-promoting properties, in vitro gastrointestinal release profile, and better protection against process and environment harsh conditions such as light, oxygen, high temperatures, humidity, etc.
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an overview of specialized equipment for Nanoencapsulation of food ingredients
2019Co-Authors: Elham Assadpour, Seid Mahdi JafariAbstract:Abstract One of the main challenges in the food and nutraceutical fields is the potential risks arising from nanomaterial fabrication and consumption. On the other hand, many recent research activities have shown that nanocarriers loaded with food bioactive ingredients can be a promising strategy to safely and successfully deliver these nutraceuticals into the body. Therefore, developing green and facile approaches to produce healthy nanostructures, suitable for bioactive Nanoencapsulation, is very essential. High-energy techniques or so-called top-down methods are effective technologies to generate different biobased structures in submicron or nanometer scale. These include electrospinning/spraying, nanospray drying, nano-/microfluidics, high-pressure homogenization, microfluidization, high-intensity ultrasonication, and some other less common techniques. This chapter gives a brief overview of these technologies and more details and coverage of recent studies for each specialized equipment that have been provided in the following chapters of this book.
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a systematic review on Nanoencapsulation of food bioactive ingredients and nutraceuticals by various nanocarriers
Critical Reviews in Food Science and Nutrition, 2019Co-Authors: Elham Assadpour, Seid Mahdi JafariAbstract:Today, there is an ever-growing interest on natural food ingredients both by consumers and producers in the food industry. In fact, people are looking for those products in the market which are free from artificial and synthetic additives and can promote their health. These food bioactive ingredients should be formulated in such a way that protects them against harsh process and environmental conditions and safely could be delivered to the target organs and cells. Nanoencapsulation is a perfect strategy for this situation and there have been many studies in recent years for Nanoencapsulation of food components and nutraceuticals by different technologies. In this review paper, our main goal is firstly to have an overview of Nanoencapsulation techniques applicable to food ingredients in a systematic classification, i.e., lipid-based nanocarriers, nature-inspired nanocarriers, special-equipment-based nanocarriers, biopolymer nanocarriers, and other miscellaneous nanocarriers. Then, application of these cutting-edge nanocarriers for different nutraceuticals including phenolic compounds and antioxidants, natural food colorants, antimicrobial agents and essential oils, vitamins, minerals, flavors, fish oils and essential fatty acids will be discussed along with presenting some examples in each field.
Milad Fathi - One of the best experts on this subject based on the ideXlab platform.
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Nanoencapsulation of hydrophobic and low soluble food bioactive compounds within different nanocarriers
Food Hydrocolloids, 2019Co-Authors: Atefe Rezaei, Milad Fathi, Seid Mahdi JafariAbstract:Abstract There are many hydrophobic or poorly soluble nutrients and bioactive compounds which are essential for human health, such as phenolic compounds, carotenoids, essential oils, essential fatty acids, and insoluble vitamins. The low bioavailability and sustainability of these compounds are the main challenges for their use in the pharmaceuticae and food industries. Nanoencapsulation can be a favourable approach for protecting hydrophobic food bioactive compounds against unsuitable circumstances and enhance their bioavailability. In this review, several Nanoencapsulation delivery systems for hydrophobic compounds, such as inclusion complexes through cyclodextrins, amylose, and yeast cells, nanogels, nanoemulsions, nanofibers, nanosponges, nanoliposomes, and nanoparticles made with lipids and biopolymers are discussed. Also, the toxicity and safety aspects of the nanocarriers loaded with hydrophobic food bioactive compounds has been covered. Different studies on encapsulation of hydrophobic food bioactives have shown that by incorporating them into sophisticated nanocarriers, promising and favourable results can be achieved such improvement in water solubility, antioxidant and other health-promoting properties, in vitro gastrointestinal release profile, and better protection against process and environment harsh conditions such as light, oxygen, high temperatures, humidity, etc.
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protein based delivery systems for the Nanoencapsulation of food ingredients
Comprehensive Reviews in Food Science and Food Safety, 2018Co-Authors: Milad Fathi, Francesco Donsi, David Julian McclementsAbstract:Many proteins possess functional attributes that make them suitable for the encapsulation of bioactive agents, such as nutraceuticals and pharmaceuticals. This article reviews the state of the art of protein-based Nanoencapsulation approaches. The physicochemical principles underlying the major techniques for the fabrication of nanoparticles, nanogels, and nanofibers from animal, botanical, and recombinant proteins are described. Protein modification approaches that can be used to extend their functionality in these nanocarrier systems are also described, including chemical, physical, and enzymatic treatments. The encapsulation, retention, protection, and release of bioactive agents in different protein-based nanocarriers are discussed. Finally, some of the major challenges in the design and fabrication of protein-based delivery systems are highlighted.
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Nanoencapsulation of food ingredients using carbohydrate based delivery systems
Trends in Food Science and Technology, 2014Co-Authors: Milad Fathi, Angel Martin, David Julian McclementsAbstract:Natural and modified polysaccharides are promising vehicles for nano- and micro-encapsulation of active food ingredients. This article reviews the state of the art of carbohydrate-based delivery systems for utilization in the food, pharmaceutical and other industries. Initially, an overview of the different kinds of carbohydrates used to assemble delivery systems is given, including starch, cellulose, pectin, guar gum, chitosan, alginate, dextrin, cyclodextrins, new sources of native gums, and their combinations and chemically modified forms. Their molecular and physicochemical properties, functional performance, and advantages and disadvantages for encapsulation are given. Various approaches for fabrication of carbohydrate-based delivery systems are then discussed, including coacervation, spray drying, electrospinning, electrospray, supercritical fluid, emulsion-diffusion, reverse micelle, emulsion-droplet coalescence, emulsification/solvent evaporation, salting-out, ultrasonication and high pressure homogenization. The biological fate of carbohydrate nanocarriers during digestion, absorption, metabolism and excretion are discussed, and some notes about their bioavailability and potential toxicity are provided. Finally, the functional performances of different carbohydrate-based delivery systems are discussed, and future developments are highlighted.
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Nanoencapsulation of food ingredients using lipid based delivery systems
Trends in Food Science and Technology, 2012Co-Authors: Milad Fathi, M R Mozafari, Mohebbat MohebbiAbstract:Nanoencapsulation allows protection of the sensitive bioactive food ingredients from unfavorable environmental conditions, eradication of incompatibilities, solubilization, or masking of unpleasant taste or odor. This paper reviews the present state of the art of lipid based carriers including nanoemulsions, nanoliposomes, solid lipid nanoparticles (SLNs) and novel generation of encapsulation system namely nanostructure lipid carriers (NLCs) regarding their production method, physicochemical properties, functionalities, stabilization techniques, potential advantages and limitations and delivery mechanisms. In the last section, mathematical models for predication of bioactive release kinetics from lipid based nanocarriers, which can be applied for optimization of encapsulation systems, are presented and some future developments in the area of Nanoencapsulation are discussed.
Hyeon Gyu Lee - One of the best experts on this subject based on the ideXlab platform.
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Improving the water solubility and antimicrobial activity of silymarin by Nanoencapsulation
Colloids and Surfaces B: Biointerfaces, 2017Co-Authors: Ji-soo Lee, Da Young Hong, Eun Suh Kim, Hyeon Gyu LeeAbstract:Abstract The aims of this study were to improve the water solubility and antimicrobial activity of milk thistle silymarin by Nanoencapsulation and to assess the functions of silymarin nanoparticle-containing film as an antimicrobial food-packaging agent. Silymarin nanoparticles were prepared using water-soluble chitosan (WCS) and poly-γ-glutamic acid (γ-PGA). As the WCS and silymarin concentrations increased, particle size and polydispersity index (PDI) significantly increased. Nanoencapsulation significantly improved the water solubility of silymarin 7.7-fold. Antimicrobial activity of silymarin was effectively improved when silymarin was entrapped within the nanocapsule compared to when it was not entrapped. Films incorporating silymarin nanoparticles had better antimicrobial activity than films incorporating free silymarin. The results suggest that silymarin nanoparticles have applications in antimicrobial food additives and food packing.
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improving solubility stability and cellular uptake of resveratrol by Nanoencapsulation with chitosan and γ poly glutamic acid
Colloids and Surfaces B: Biointerfaces, 2016Co-Authors: Young Ok Jeon, Ji-soo Lee, Hyeon Gyu LeeAbstract:Resveratrol (RES), a polyphenolic compound found in grape skins, is a potent antioxidant with broad health benefits. However, its utilization in food has been limited by its poor water solubility, instability, and low bioavailability. The purpose of this study is to improve the solubility, stability, and cellular uptake of RES by Nanoencapsulation using chitosan (CS) and γ-poly (glutamic acid) (γ-PGA). The size of nanoparticles significantly decreases with a decrease in the CS/γ-PGA ratio (p<0.05). The nanoparticle size with CS/γ-PGA ratio of 5 was 100-150nm. The entrapment efficiency and UV-light protection effect significantly increases (p<0.05), with an increase in the CS and γ-PGA concentration. The solubility of RES increases 3.2 and 4.2 times before and after lyophilization by Nanoencapsulation, respectively. Compared with non-nanoencapsulated RES, the nanoencapsulated RES tends to maintain its solubility and antioxidant activity during storage. CS/γ-PGA Nanoencapsulation was able to significantly enhance the transport of RES across a Caco-2 cell monolayer (p<0.05). The highest cellular uptake was found for nanoparticles prepared with 0.5mg/mL CS and 0.1mg/mL γ-PGA, which showed the highest solubility and antioxidant activity during storage. Therefore, CS/γ-PGA Nanoencapsulation is found to be a potentially valuable technique for improving the solubility, stability, and cellular uptake of RES.
Ulrich F Schaefer - One of the best experts on this subject based on the ideXlab platform.
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Nanoencapsulation in lipid core nanocapsules controls mometasone furoate skin permeability rate and its penetration to the deeper skin layers
Skin Pharmacology and Physiology, 2014Co-Authors: Ana Melero, Adriana Raffin Pohlmann, Silvia Stanisçuaski Guterres, Aline Ferreira Ourique, Ruy Carlos Ruver Beck, Clausmichael Lehr, Ulrich F SchaeferAbstract:Aims: The influence of Nanoencapsulation of mometasone furoate (MF) in poly(e-caprolactone) lipid-core nanocapsules (LNC) on its in vitro human skin permeation and penetration was evaluated. Methods: Semisolid formulations were prepared by increasing the viscosity of LNC using a carbomer (Carbopol® Ultrez at 0.5% w/v). Two complementary techniques (the static Franz diffusion cell model and the Saarbrucken penetration model) were used to evaluate skin permeation/penetration. Results: The drug release rate was decreased by Nanoencapsulation. The skin permeability of MF was controlled by the Nanoencapsulation as well as by increasing the viscosity. Furthermore, the formulation containing the nanoencapsulated MF controlled the amount of drug reaching the deeper skin layers without changing its accumulation in the stratum corneum. Conclusion: This formulation is suitable for prolonged treatment of skin disorders which should avoid systemic absorption.
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improved photostability and reduced skin permeation of tretinoin development of a semisolid nanomedicine
European Journal of Pharmaceutics and Biopharmaceutics, 2011Co-Authors: Aline Ferreira Ourique, Adriana Raffin Pohlmann, Cristiane De Bona Da Silva, Ana Melero, Ulrich F Schaefer, Silvia S Guterres, Clausmichael Lehr, Karlheinz Kostka, Ruy Carlos Ruver BeckAbstract:The aims of this work were to increase the photostability and to reduce the skin permeation of tretinoin through Nanoencapsulation. Tretinoin is widely used in the topical treatment of various dermatological diseases such as acne, psoriasis, skin cancer, and photoaging. Tretinoin-loaded lipid-core polymeric nanocapsules were prepared by interfacial deposition of a preformed polymer. Carbopol hydrogels containing nanoencapsulated tretinoin presented a pH value of 6.08±0.14, a drug content of 0.52±0.01 mg g(-1), pseudoplastic rheological behavior, and higher spreadability than a marketed formulation. Hydrogels containing nanoencapsulated tretinoin demonstrated a lower photodegradation (24.17±3.49%) than the formulation containing the non-encapsulated drug (68.64±2.92%) after 8h of ultraviolet A irradiation. The half-life of the former was seven times higher than the latter. There was a decrease in the skin permeability coefficient of the drug by Nanoencapsulation, independently of the dosage form. The liquid suspension and the semisolid form provided K(p)=0.31±0.15 and K(p)=0.33±0.01 cm s(-1), respectively (p≤0.05), while the samples containing non-encapsulated tretinoin showed K(p)=1.80±0.27 and K(p)=0.73±0.12 cm s(-1) for tretinoin solution and hydrogel, respectively. Lag time was increased two times by Nanoencapsulation, meaning that the drug is retained for a longer time on the skin surface.
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influence of Nanoencapsulation on human skin transport of flufenamic acid
Skin Pharmacology and Physiology, 2006Co-Authors: J Luengo, Clausmichael Lehr, Karlheinz Kostka, Barbara Weiss, Marc Schneider, Alexander Ehlers, Frank Stracke, Karsten Konig, Ulrich F SchaeferAbstract:The effect of the inclusion of flufenamic acid in poly(lactide-co-glycolide) nanoparticles on the transport of flufenamic acid into excised human skin was investigated. Penetration and permeation data were acquired using two different in vitro test systems: the Saarbrucken penetration model, where the skin acts as its own receptor medium, and the Franz diffusion cell, where the receptor medium is a buffer solution. For the stratum corneum, no differences were found between nanoencapsulated and free drug. Drug accumulation in the deeper skin layers and drug transport across human epidermis were slightly delayed for the nanoencapsulated drug compared to the free drug after shorter incubation times ( 12 h), the nanoencapsulated drug showed a statistically significantly enhanced transport and accumulation (p < 0.05). Additionally, nanoencapsulated flufenamic acid was visualized by multiphoton fluorescence microscopy. Particles were found homogeneously distributed on the skin surface and within the dermatoglyphs, but no nanoparticles were detected within or between the corneocytes.
C Anandharamakrishnan - One of the best experts on this subject based on the ideXlab platform.
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Nanoencapsulation of green tea catechins by electrospraying technique and its effect on controlled release and in vitro permeability
Journal of Food Engineering, 2017Co-Authors: C Anandharamakrishnan, Anu J Bhushani, Nawneet K KurreyAbstract:Abstract Zein, a biocompatible, biodegradable macromolecule was employed for Nanoencapsulation of green tea catechins by electrospraying technique. For this, the electrohydrodynamic behavior of zein solution was studied and the effective electrospraying concentration of zein was optimized. Later, the influence of Nanoencapsulation and core-to-wall ratio on the gastrointestinal stability and permeability of green tea catechins were investigated. Among the various concentrations of zein studied (i.e. 1%–40% w/w), 5% w/w zein solution yielded spherical, monodisperse nanoparticles with mean diameter of 157 ± 36 nm. Nanoencapsulates with 1:50 core-to-wall ratio had highest encapsulation efficiency compared to 1:10 and 1:05 core-to-wall ratio samples. The nanoencapsulated catechins had significantly improved in-vitro gastrointestinal stability and Caco-2 cell monolayer permeability compared to unencapsulated catechins. Further, 1:50 and 1:10 samples possessed higher permeability of catechins compared to 1:05 nanoencapsulates. Hence, the study provides a one-step approach for production of green tea catechin nanoencapsulates with sustained release and enhanced permeability properties.
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techniques for Nanoencapsulation of food ingredients
2013Co-Authors: C AnandharamakrishnanAbstract:Nanoencapsulation of Food Bioactive Compounds.- Techniques for Formation of Nanoemulsions.- Bioactive Entrapment using Lipid-based Nanocarrier Technology.- Liquid Based Nanoencapsulation Techniques.- Electro-spraying and Electro-spinning technique for Nanoencapsulation.- Drying techniques for Nanoencapsulation.- Applications of food grade Nanoemulsion.- Characterization of nanoparticles.- Safety and Regulations - Current Scenario and Scope.
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Nanoencapsulation Techniques for Food Bioactive Components: A Review
Food and Bioprocess Technology, 2013Co-Authors: P. N. Ezhilarasi, P. Karthik, N. Chhanwal, C AnandharamakrishnanAbstract:The protection and controlled release of bioactive compounds at the right time and the right place can be implemented by encapsulation. Nanoencapsulation remains to be the one of the most promising technologies having the feasibility to entrap bioactive compounds. Nanoencapsulation of bioactive compounds has versatile advantages for targeted site-specific delivery and efficient absorption through cells. However, researches in the application of nanotechnology in the food industry have been very limited and there are only a few review articles that explored the Nanoencapsulation technology. This review focuses on the various Nanoencapsulation techniques such as emulsification, coacervation, inclusion, complexation nanoprecipitation, emulsification–solvent evaporation, and supercritical fluid for food ingredients. Drying techniques such as spray drying and freeze drying for stabilization of nanoparticles are also discussed. Current state of knowledge, limitations of these techniques, and recent trends are also discussed. Finally, safety and regulatory issues in the Nanoencapsulation of bioactive compounds are also highlighted.
