The Experts below are selected from a list of 8061 Experts worldwide ranked by ideXlab platform
Joseph M Martel - One of the best experts on this subject based on the ideXlab platform.
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tunable Nanostructured Coating for the capture and selective release of viable circulating tumor cells
Advanced Materials, 2015Co-Authors: Eduardo Reategui, Nicola Aceto, Eugene J Lim, James P Sullivan, Anne E Jensen, Mahnaz Zeinali, Joseph M MartelAbstract:Circulating tumor cells (CTCs) are cells shed from the primary tumor and metastatic sites, and can be found at very low frequencies in the peripheral blood of cancer patients.[1] Enumeration of CTCs has been shown to correlate with disease progression in metastatic cancer patients,[2] and recent studies suggest that CTCs can serve as a less invasive biomarker for therapeutic assays.[3] However, the heterogeneity inherent in CTCs[4] suggests that molecular profiling at a single cell level may be necessary to capture the evolution of tumor genotypes during treatment and disease progression.[5] To successfully achieve in-depth interrogation of individual CTCs and identify tumor drivers or secondary mutations,[6] the isolated cells must be intact, viable and free of contaminating cells. On the other hand, bulk analysis of the same CTC population may be desirable for other clinical applications, such as the establishment of CTC cell lines through cell culture for in-vitro drug screening. CTC isolation technologies with such dynamic versatility could serve as a powerful clinical tool.
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tunable Nanostructured Coating for the capture and selective release of viable circulating tumor cells
Advanced Materials, 2015Co-Authors: Eduardo Reategui, Nicola Aceto, Eugene J Lim, James P Sullivan, Anne E Jensen, Mahnaz Zeinali, Joseph M Martel, Alexander J Aranyosi, Steven A CastleberryAbstract:A layer-by-layer gelatin nanoCoating is presented for use as a tunable, dual response biomaterial for the capture and release of circulating tumor cells (CTCs) from cancer patient blood. The entire nanoCoating can be dissolved from the surface of microfluidic devices through biologically compatible temperature shifts. Alternatively, individual CTCs can be released through locally applied mechanical stress.
Eduardo Reategui - One of the best experts on this subject based on the ideXlab platform.
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tunable Nanostructured Coating for the capture and selective release of viable circulating tumor cells
Advanced Materials, 2015Co-Authors: Eduardo Reategui, Nicola Aceto, Eugene J Lim, James P Sullivan, Anne E Jensen, Mahnaz Zeinali, Joseph M MartelAbstract:Circulating tumor cells (CTCs) are cells shed from the primary tumor and metastatic sites, and can be found at very low frequencies in the peripheral blood of cancer patients.[1] Enumeration of CTCs has been shown to correlate with disease progression in metastatic cancer patients,[2] and recent studies suggest that CTCs can serve as a less invasive biomarker for therapeutic assays.[3] However, the heterogeneity inherent in CTCs[4] suggests that molecular profiling at a single cell level may be necessary to capture the evolution of tumor genotypes during treatment and disease progression.[5] To successfully achieve in-depth interrogation of individual CTCs and identify tumor drivers or secondary mutations,[6] the isolated cells must be intact, viable and free of contaminating cells. On the other hand, bulk analysis of the same CTC population may be desirable for other clinical applications, such as the establishment of CTC cell lines through cell culture for in-vitro drug screening. CTC isolation technologies with such dynamic versatility could serve as a powerful clinical tool.
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tunable Nanostructured Coating for the capture and selective release of viable circulating tumor cells
Advanced Materials, 2015Co-Authors: Eduardo Reategui, Nicola Aceto, Eugene J Lim, James P Sullivan, Anne E Jensen, Mahnaz Zeinali, Joseph M Martel, Alexander J Aranyosi, Steven A CastleberryAbstract:A layer-by-layer gelatin nanoCoating is presented for use as a tunable, dual response biomaterial for the capture and release of circulating tumor cells (CTCs) from cancer patient blood. The entire nanoCoating can be dissolved from the surface of microfluidic devices through biologically compatible temperature shifts. Alternatively, individual CTCs can be released through locally applied mechanical stress.
Eugene J Lim - One of the best experts on this subject based on the ideXlab platform.
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tunable Nanostructured Coating for the capture and selective release of viable circulating tumor cells
Advanced Materials, 2015Co-Authors: Eduardo Reategui, Nicola Aceto, Eugene J Lim, James P Sullivan, Anne E Jensen, Mahnaz Zeinali, Joseph M MartelAbstract:Circulating tumor cells (CTCs) are cells shed from the primary tumor and metastatic sites, and can be found at very low frequencies in the peripheral blood of cancer patients.[1] Enumeration of CTCs has been shown to correlate with disease progression in metastatic cancer patients,[2] and recent studies suggest that CTCs can serve as a less invasive biomarker for therapeutic assays.[3] However, the heterogeneity inherent in CTCs[4] suggests that molecular profiling at a single cell level may be necessary to capture the evolution of tumor genotypes during treatment and disease progression.[5] To successfully achieve in-depth interrogation of individual CTCs and identify tumor drivers or secondary mutations,[6] the isolated cells must be intact, viable and free of contaminating cells. On the other hand, bulk analysis of the same CTC population may be desirable for other clinical applications, such as the establishment of CTC cell lines through cell culture for in-vitro drug screening. CTC isolation technologies with such dynamic versatility could serve as a powerful clinical tool.
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tunable Nanostructured Coating for the capture and selective release of viable circulating tumor cells
Advanced Materials, 2015Co-Authors: Eduardo Reategui, Nicola Aceto, Eugene J Lim, James P Sullivan, Anne E Jensen, Mahnaz Zeinali, Joseph M Martel, Alexander J Aranyosi, Steven A CastleberryAbstract:A layer-by-layer gelatin nanoCoating is presented for use as a tunable, dual response biomaterial for the capture and release of circulating tumor cells (CTCs) from cancer patient blood. The entire nanoCoating can be dissolved from the surface of microfluidic devices through biologically compatible temperature shifts. Alternatively, individual CTCs can be released through locally applied mechanical stress.
Chuanxian Ding - One of the best experts on this subject based on the ideXlab platform.
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tribological behaviour of Nanostructured al2o3 3 wt tio2 Coating against steel in dry sliding
Tribology Letters, 2004Co-Authors: Yi Zeng, Chuanxian Ding, Pingyu ZhengAbstract:Nanostructured and conventional Al2O3-3 wt% TiO2 Coatings were deposited by atmospheric plasma spraying. The wear and friction properties of both Coatings against a steel ball under dry friction conditions were examined. It was found that the wear resistance of the Nanostructured Al2O3-3 wt% TiO2 Coating was superior to that of the corresponding conventional counterpart. The improvement in wear resistance of the Nanostructured Coating was attributed to its higher toughness and cohesion strength between splats. As for the Nanostructured Coating, the wear mechanism was mainly adhesion with micro-abrasion at low loads (20 N). At high loads (80 N), the wear of the Nanostructured Coating was controlled by plastic deformation and associated delamination along the splat boundaries, which was similar to that of the conventional Coating at low loads. However, the failure of the conventional Coating was predominantly brittle fracture within the splats and delamination between splats at high loads.
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characterization of alumina 3 wt titania Coating prepared by plasma spraying of Nanostructured powders
Journal of The European Ceramic Society, 2004Co-Authors: Yi Zeng, Chuanxian DingAbstract:Abstract Nanostructured and conventional alumina–3 wt.% titania Coatings were deposited by air plasma spraying (APS). The microstructure and phase composition of the Coatings were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM) and transmission electron microscopy (TEM). Mechanical properties including hardness, adhesion strength, crack extension force (GC) and sliding wear rate were measured. Equiaxed α-Al2O3 grains were observed in the Nanostructured Al2O3–3 wt.% TiO2 Coating and the diameter of α-Al2O3 grains were about 150 to 700 nm in size. The microhardness of both kinds of Coating was similar and about 820 HV0.2. However, the adhesion strength and crack extension force of the Nanostructured Coating increased by 33 and 80%, respectively, as compared with those of the conventional Coating. The wear rate of the Nanostructured Coating was lower than that of the conventional Coating. The results were explained in terms of characteristics of the powders and microstructure of the Coatings.
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investigation of the thermomechanical properties of a plasma sprayed Nanostructured zirconia Coating
Journal of The European Ceramic Society, 2003Co-Authors: Huang Chen, Xiaming Zhou, Chuanxian DingAbstract:Abstract Yttria partially stabilized Nanostructured zirconia Coatings were deposited by atmospherical plasma spraying (APS). The microstructure of the as-sprayed Nanostructured Coating was characterized with Scanning electronic microscopy (SEM), Transmission electron microscopy (TEM), X-ray diffraction (XRD) and Raman spectrum (RS). The laser-flash diffusivity method and push-rod method were used to examine the thermomechanical properties of the Nanostructured zirconia Coatings. The results obtained indicated that the plasma-sprayed zirconia Coating possessed nano-structure and its average grain size was about 73 nm. The average thermal expansion coefficients of the Nanostructured Coating at the first thermal cycle and second thermal cycle from room temperature to 1200 °C are 11.0 and 11.6×10−6 °C−1, respectively. The thermal diffusivity of the Nanostructured zirconia Coating was 1.80–2.54×10−3 cm2/s between 200 and 1200 °C. The microhardness of the Nanostructured zirconia Coating was 8.6 GPa, which was 1.6 times as large as that of traditional zirconia Coating.
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tribological properties of Nanostructured and conventional wc co Coatings deposited by plasma spraying
Thin Solid Films, 2001Co-Authors: Ken Yukimura, Chuanxian Ding, Pingyu ZhangAbstract:Abstract Nanostructured and conventional WC–Co Coatings were deposited by vacuum plasma spraying. The wear and friction properties of the two Coatings against alumina under dry friction conditions were comparatively studied. It was found that the wear resistance of the Nanostructured WC–Co Coating is superior to that of conventional WC–Co Coatings, especially under high load conditions. The improved wear resistance of the Nanostructured Coating is attributed to its higher hardness and toughness. The wear mechanism of the Nanostructured WC–Co Coating is plastic deformation with slight surface fracture, whilst that of a conventional WC–Co Coating is the initial removal of a binder phase followed by fragmentation or uprooting of carbide grains. Their tribological properties are discussed in relation to the microstructure of the two Coatings. It is concluded the decomposition is a fatal factor influencing the wear resistance of thermal sprayed Nanostructured WC–Co Coatings.
Hui Chen - One of the best experts on this subject based on the ideXlab platform.
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Research on the Wear Properties of HVOF Sprayed Nanostructured WC-17Co Coatings
Advanced Materials Research, 2012Co-Authors: Guo Qing Gou, Hui Chen, Nan Huang, Yan Liu, Li Chun MengAbstract:Nanostructured WC-17Co Coating was prepared by means of High Velocity Oxygen Flame (HVOF) technique. When eroded with quartz sand, the erosion wear resistance of Nanostructured Coating is better than that of 1Cr13. The loss of Co-rich phase dominates the main failure mechanism, following with minor peeling of WC particles.
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effect of wc grain size on the abrasive wear resistance of hvof spraying wc co Coatings
Advanced Materials Research, 2010Co-Authors: Yue Yang, Hui ChenAbstract:Three different WC grain size powder were used to prepare WC-Co Coatings employing HVOF technique. The effect of WC grain size on the abrasive wear resistance and failure mechanism were analyzed. The results show that the abrasive wear resistance increases with the decrease of WC grain size. Nanostructured Coating is high in surface plasticity. It can only be pressed out of prints, the opportunity of cutting is small. Micro-cutting wear dominates the main abrasive wear mechanism of Nanostructured Coating.
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characteristics of nano particles and their effect on the formation of nanostructures in air plasma spraying wc 17co Coating
Surface & Coatings Technology, 2009Co-Authors: Hui Chen, Mingjing TuAbstract:Abstract WC–17Co Nanostructured Coating was prepared by means of air plasma spraying technology. Microstructures and compositions of the nano WC–Co powder and Coating were analyzed using SEM (Scanning Electron Microscopy), and XRD (X-ray Diffraction), etc. The average grain size of the Coating was measured using XRD. The mechanism of nanostructure formation and the properties of the Nanostructured Coating were investigated. The results show that the size of original particles is about 50–500 nm. Finer sub-particles of 2–5 nm are found to exist in the original particles. These sub-particles can act as crystallization nuclei and make the grains much finer during the plasma spraying process, which is beneficial to the formation of nanostructure in the Coating. Both amorphous and Nanostructured phases can be identified in the Coating. The Nanostructured Coating is mainly composed of WC, W 2 C and some amorphous phases. The Nanostructured WC–Co Coating has a good mechanical property combination. Nanostructured Coating possesses good combination properties of micro-hardness, fracture toughness and bonding strength.
