The Experts below are selected from a list of 11346 Experts worldwide ranked by ideXlab platform
Mandeep Singh Bakshi - One of the best experts on this subject based on the ideXlab platform.
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nanoshape control tendency of phospholipids and proteins protein nanoparticle composites seeding self aggregation and their applications in bionanotechnology and Nanotoxicology
Journal of Physical Chemistry C, 2011Co-Authors: Mandeep Singh BakshiAbstract:This feature article studies different areas related to phospholipid/protein conjugated nanoparticles ranging from their basic synthetic strategies of shape-directed morphologies to their applications in biodegradable materials and Nanotoxicology. Present research and future directions toward environmental impact, Nanotoxicology, and protein misfolding diseases have been discussed. Phosphilipids, especially anionic ones, and water-soluble proteins show the significant shape-directing ability of both noble and semiconductor nanoparticles under different circumstances. Protein–nanoparticle composites exhibit the unique behavior of seeding, fibrillation, and self-association with possible relevance to amyloidosis or protein misfolding diseases and on the other hand to the synthesis of biodegradable protein films with potential environmental impact. Metal nanoparticles as model air pollutants with a strong tendency for pulmonary surfactants further help us to understand their potential threat to the human res...
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Nanoshape Control Tendency of Phospholipids and Proteins: Protein–Nanoparticle Composites, Seeding, Self-Aggregation, and Their Applications in Bionanotechnology and Nanotoxicology
The Journal of Physical Chemistry C, 2011Co-Authors: Mandeep Singh BakshiAbstract:This feature article studies different areas related to phospholipid/protein conjugated nanoparticles ranging from their basic synthetic strategies of shape-directed morphologies to their applications in biodegradable materials and Nanotoxicology. Present research and future directions toward environmental impact, Nanotoxicology, and protein misfolding diseases have been discussed. Phosphilipids, especially anionic ones, and water-soluble proteins show the significant shape-directing ability of both noble and semiconductor nanoparticles under different circumstances. Protein–nanoparticle composites exhibit the unique behavior of seeding, fibrillation, and self-association with possible relevance to amyloidosis or protein misfolding diseases and on the other hand to the synthesis of biodegradable protein films with potential environmental impact. Metal nanoparticles as model air pollutants with a strong tendency for pulmonary surfactants further help us to understand their potential threat to the human res...
Valerian E. Kagan - One of the best experts on this subject based on the ideXlab platform.
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Nanotoxicology ten years later lights and shadows
Toxicology and Applied Pharmacology, 2016Co-Authors: Anna A Shvedova, Antonio Pietroiusti, Valerian E. KaganAbstract:The mounting societal concerns about possible and maybe even likely adverse effects of nanomaterials are reflected in a large and growing number of publications in the field of Nanotoxicology. Indeed, today's search in PubMed reveals >3700 publications on the subject denoted by (toxic+nanomaterials) - quite a growth over the last decade that began with only two dozens of them up-to 2005.
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Nanotoxicology ten years later: Lights and shadows ☆
Toxicology and applied pharmacology, 2016Co-Authors: Anna A Shvedova, Antonio Pietroiusti, Valerian E. KaganAbstract:The mounting societal concerns about possible and maybe even likely adverse effects of nanomaterials are reflected in a large and growing number of publications in the field of Nanotoxicology. Indeed, today's search in PubMed reveals >3700 publications on the subject denoted by (toxic+nanomaterials) - quite a growth over the last decade that began with only two dozens of them up-to 2005.
Rachel J Errington - One of the best experts on this subject based on the ideXlab platform.
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statistical analysis of nanoparticle dosing in a dynamic cellular system
Nature Nanotechnology, 2011Co-Authors: H D Summers, Paul Rees, Mark D Holton, Rowan M Brown, Sally Claire Chappell, Paul J Smith, Rachel J ErringtonAbstract:The uptake of nanoparticles into cells and their inheritance during cell division is shown to be random, which has implications for dose considerations in drug delivery and Nanotoxicology studies.
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Statistical analysis of nanoparticle dosing in a dynamic cellular system
Nature Nanotechnology, 2011Co-Authors: H D Summers, Paul Rees, Mark D Holton, Sally Claire Chappell, Paul J Smith, M. Rowan Brown, Rachel J ErringtonAbstract:The uptake of nanoparticles into cells and their inheritance during cell division is shown to be random, which has implications for dose considerations in drug delivery and Nanotoxicology studies. The delivery of nanoparticles into cells is important in therapeutic applications^ 1 , 2 , 3 and in Nanotoxicology^ 4 . Nanoparticles are generally targeted to receptors on the surfaces of cells and internalized into endosomes by endocytosis^ 5 , 6 , 7 , 8 , 9 , but the kinetics of the process and the way in which cell division redistributes the particles remain unclear. Here we show that the chance of success or failure of nanoparticle uptake and inheritance is random. Statistical analysis of nanoparticle-loaded endosomes indicates that particle capture is described by an over-dispersed Poisson probability distribution that is consistent with heterogeneous adsorption and internalization. Partitioning of nanoparticles in cell division is random and asymmetric, following a binomial distribution with mean probability of 0.52–0.72. These results show that cellular targeting of nanoparticles is inherently imprecise due to the randomness of nature at the molecular scale, and the statistical framework offers a way to predict nanoparticle dosage for therapy and for the study of nanotoxins.
Anna A Shvedova - One of the best experts on this subject based on the ideXlab platform.
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Nanotoxicology ten years later lights and shadows
Toxicology and Applied Pharmacology, 2016Co-Authors: Anna A Shvedova, Antonio Pietroiusti, Valerian E. KaganAbstract:The mounting societal concerns about possible and maybe even likely adverse effects of nanomaterials are reflected in a large and growing number of publications in the field of Nanotoxicology. Indeed, today's search in PubMed reveals >3700 publications on the subject denoted by (toxic+nanomaterials) - quite a growth over the last decade that began with only two dozens of them up-to 2005.
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Applied Nanotoxicology.
International journal of toxicology, 2016Co-Authors: David W Hobson, David B. Warheit, Stephen M Roberts, Anna A Shvedova, Georgia K Hinkley, Robin C GuyAbstract:Nanomaterials, including nanoparticles and nanoobjects, are being incorporated into everyday products at an increasing rate. These products include consumer products of interest to toxicologists such as pharmaceuticals, cosmetics, food, food packaging, household products, and so on. The manufacturing of products containing or utilizing nanomaterials in their composition may also present potential toxicologic concerns in the workplace. The molecular complexity and composition of these nanomaterials are ever increasing, and the means and methods being applied to characterize and perform useful toxicologic assessments are rapidly advancing. This article includes presentations by experienced toxicologists in the Nanotoxicology community who are focused on the applied aspect of the discipline toward supporting state of the art toxicologic assessments for food products and packaging, pharmaceuticals and medical devices, inhaled nanoparticle and gastrointestinal exposures, and addressing occupational safety and health issues and concerns. This symposium overview article summarizes 5 talks that were presented at the 35th Annual meeting of the American College of Toxicology on the subject of "Applied Nanotechnology."
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Nanotoxicology ten years later: Lights and shadows ☆
Toxicology and applied pharmacology, 2016Co-Authors: Anna A Shvedova, Antonio Pietroiusti, Valerian E. KaganAbstract:The mounting societal concerns about possible and maybe even likely adverse effects of nanomaterials are reflected in a large and growing number of publications in the field of Nanotoxicology. Indeed, today's search in PubMed reveals >3700 publications on the subject denoted by (toxic+nanomaterials) - quite a growth over the last decade that began with only two dozens of them up-to 2005.
Gengmei Xing - One of the best experts on this subject based on the ideXlab platform.
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Molecular toxicity of nanomaterials
Journal of Biomedical Nanotechnology, 2014Co-Authors: Xue-ling Chang, Sheng-tao Yang, Gengmei XingAbstract:With the rapid developments in the fields of nanoscience and nanotechnlogy, more and more nanomaterials and their based consumer products have been used into our daily life. The safety concerns of nanomaterials have been well recognized by the scientific community and the public. Molecular mechanism of interactions between nanomaterials and biosystems is the most essential topic and final core of the biosafety. In the last two decades, Nanotoxicology developed very fast and toxicity phenomena of nanomaterials have been reported. To achieve better understanding and detoxication of nanomaterials, thorough studies of nanotoxicity at molecular level are important. The interactions between nanomaterials and biomolecules have been widely investigated as the first step toward the molecular Nanotoxicology. The consequences of such interactions have been discussed in the literature. Besides this, the chemical mechanism of Nanotoxicology is gaining more attention, which would lead to a better design of nontoxic nanomaterials. In this review, we focus on the molecular Nanotoxicology and explore the toxicity of nanomaterials at molecular level. The molecular level studies of Nanotoxicology are summarized and the published nanotoxicological data are revisited.
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Nanotoxicology are carbon nanotubes safe
Nature Nanotechnology, 2008Co-Authors: Yuliang Zhao, Gengmei Xing, Zhifang ChaiAbstract:The toxicity of carbon nanotubes is the subject of ongoing debate. A preliminary study using a small number of mice shows that they may be safe, but the results should be treated with caution.
