The Experts below are selected from a list of 393 Experts worldwide ranked by ideXlab platform
Xinhua Cao - One of the best experts on this subject based on the ideXlab platform.
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terminal molecular isomer effect on supramolecular self assembly system based on Naphthalimide Derivative and its sensing application for mercury ii and iron iii ions
Langmuir, 2018Co-Authors: Xinhua Cao, Na Zhao, Aiping Gao, Qianqian Ding, Xueping ChangAbstract:A series of Naphthalimide Derivative gelators (G-o, G-m, and G-p) with three molecular isomers as their terminal groups were designed and synthesized. Only G-m and G-p could form stable organogels in some solvents including methanol, acetonitrile, n-hexane, toluene, ethanol, DMSO, DMF, and mixed solvents of acetonitrile/H2O (1/1, v/v). The different self-assembly structures were obtained from the self-assembly process of G-o, G-m, and G-p such as structures like a Chinese chestnut formed by irregular micrometer pieces, microbelts, and microbelt structures mingled with the bird’s nest structures which exhibited different surface hydrophobicity with water contact angles of 121–139° due to their different intermolecular noncovalent interactions. To our surprise, G-p acetonitrile solution emitted 492 nm light with a red-shift of 72 nm compared with that emitted from G-o and G-m acetonitrile solution under 350 nm light excitation. Three gelators showed different detection abilities toward metal ions. G-o did n...
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supramolecular self assembly system based on Naphthalimide boric acid ester Derivative for detection of organic amine
Sensors and Actuators B-chemical, 2018Co-Authors: Xinhua Cao, Na Zhao, Aiping Gao, Qianqian Ding, Qiangshan JingAbstract:Abstract Two new gelators (N12 and N18) containing Naphthalimides group were designed and synthesized which the C-4 of Naphthalimide Derivative was modified by isopropoxyboronic acid ester. The two gelators could form gels in different solvents, and different structures were formed and exhibited hydrophobicity. The self-assembly processes of gelator were investigated by UV–vis, fluorescence, infrared spectroscopy, field emission scanning electron microscope (FE-SEM), X-ray diffraction, NMR spectrum and contact angle experiments in detail. The gelator in solution or gel state could emit blue light which response to some organic amine, and the fluorescence of gelator was quenched. The fluorescence of gelator could be recovered after acid was added again. Take Et3N for instance, the association constant (K) between N12 and Et3N was calculated to be 3.75 × 103 M−1 and the gelator N12 could detect Et3N in solution with the detection limit of 4.77 × 10−7 M. This research would expand the supramolecular self-assembly materials application in sensor field and offer a new detection method for organic amines.
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Terminal Molecular Isomer-Effect on Supramolecular Self-Assembly System Based on Naphthalimide Derivative and Its Sensing Application for Mercury(II) and Iron(III) Ions
2018Co-Authors: Xinhua Cao, Na Zhao, Aiping Gao, Qianqian Ding, Xueping ChangAbstract:A series of Naphthalimide Derivative gelators (G-o, G-m, and G-p) with three molecular isomers as their terminal groups were designed and synthesized. Only G-m and G-p could form stable organogels in some solvents including methanol, acetonitrile, n-hexane, toluene, ethanol, DMSO, DMF, and mixed solvents of acetonitrile/H2O (1/1, v/v). The different self-assembly structures were obtained from the self-assembly process of G-o, G-m, and G-p such as structures like a Chinese chestnut formed by irregular micrometer pieces, microbelts, and microbelt structures mingled with the bird’s nest structures which exhibited different surface hydrophobicity with water contact angles of 121–139° due to their different intermolecular noncovalent interactions. To our surprise, G-p acetonitrile solution emitted 492 nm light with a red-shift of 72 nm compared with that emitted from G-o and G-m acetonitrile solution under 350 nm light excitation. Three gelators showed different detection abilities toward metal ions. G-o did not have any ability for sensitive and selective detection toward any ion. In contrast, G-m and G-p could sensitively and selectively detect Hg2+ and Fe3+. The detection limits for Fe3+ and Hg 2+ by G-m were 4.76 × 10–5 M and 7.01 × 10–6 M with the corresponding association constants (K) of 1.64 × 104 and 3.79 × 104 M–1, respectively. The detection limits for Fe3+ and Hg2+ by G-p were 3.26 × 10–5 and 1.77 × 10–6 M with the corresponding K of 1.44 × 105 and 1.99 × 104 M–1, respectively. More interestingly, the back-titration of SCN– could distinguish Hg2+ from Fe3+. At the same time, xerogels G-m and G-p also exhibited responsiveness toward Fe3+ and Hg2+ through fluorescence changes. The photophysical properties, gel formation, hierarchical structures, surface wettability, and their function in this self-assembly system could be tuned through the molecular isomer effect. This work provides a new research paradigm for molecular isomer tuned supramolecular self-assembly materials from noncovalent interaction to molecular function
Hiroyuki Saimoto - One of the best experts on this subject based on the ideXlab platform.
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a novel 1 8 Naphthalimide Derivative with an open space for an anion unique fluorescence behaviour depending on the binding anion s electrophilic properties
Chemical Communications, 2015Co-Authors: Hironori Izawa, Shoji Nishino, Masato Sumita, Masaaki Akamatsu, Kenji Morihashi, Shinsuke Ifuku, Minoru Morimoto, Hiroyuki SaimotoAbstract:We have designed a novel 1,8-Naphthalimide Derivative with an open space for an anion. Computational calculation has predicted that the space could trap various anion species and photo-induced charge transfer depending on the anion's electrophilic properties. Indeed, the fluorescence behaviour of the 1,8-Naphthalimide Derivative complexes with each anion is consistent with the computational prediction.
Xueping Chang - One of the best experts on this subject based on the ideXlab platform.
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terminal molecular isomer effect on supramolecular self assembly system based on Naphthalimide Derivative and its sensing application for mercury ii and iron iii ions
Langmuir, 2018Co-Authors: Xinhua Cao, Na Zhao, Aiping Gao, Qianqian Ding, Xueping ChangAbstract:A series of Naphthalimide Derivative gelators (G-o, G-m, and G-p) with three molecular isomers as their terminal groups were designed and synthesized. Only G-m and G-p could form stable organogels in some solvents including methanol, acetonitrile, n-hexane, toluene, ethanol, DMSO, DMF, and mixed solvents of acetonitrile/H2O (1/1, v/v). The different self-assembly structures were obtained from the self-assembly process of G-o, G-m, and G-p such as structures like a Chinese chestnut formed by irregular micrometer pieces, microbelts, and microbelt structures mingled with the bird’s nest structures which exhibited different surface hydrophobicity with water contact angles of 121–139° due to their different intermolecular noncovalent interactions. To our surprise, G-p acetonitrile solution emitted 492 nm light with a red-shift of 72 nm compared with that emitted from G-o and G-m acetonitrile solution under 350 nm light excitation. Three gelators showed different detection abilities toward metal ions. G-o did n...
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Terminal Molecular Isomer-Effect on Supramolecular Self-Assembly System Based on Naphthalimide Derivative and Its Sensing Application for Mercury(II) and Iron(III) Ions
2018Co-Authors: Xinhua Cao, Na Zhao, Aiping Gao, Qianqian Ding, Xueping ChangAbstract:A series of Naphthalimide Derivative gelators (G-o, G-m, and G-p) with three molecular isomers as their terminal groups were designed and synthesized. Only G-m and G-p could form stable organogels in some solvents including methanol, acetonitrile, n-hexane, toluene, ethanol, DMSO, DMF, and mixed solvents of acetonitrile/H2O (1/1, v/v). The different self-assembly structures were obtained from the self-assembly process of G-o, G-m, and G-p such as structures like a Chinese chestnut formed by irregular micrometer pieces, microbelts, and microbelt structures mingled with the bird’s nest structures which exhibited different surface hydrophobicity with water contact angles of 121–139° due to their different intermolecular noncovalent interactions. To our surprise, G-p acetonitrile solution emitted 492 nm light with a red-shift of 72 nm compared with that emitted from G-o and G-m acetonitrile solution under 350 nm light excitation. Three gelators showed different detection abilities toward metal ions. G-o did not have any ability for sensitive and selective detection toward any ion. In contrast, G-m and G-p could sensitively and selectively detect Hg2+ and Fe3+. The detection limits for Fe3+ and Hg 2+ by G-m were 4.76 × 10–5 M and 7.01 × 10–6 M with the corresponding association constants (K) of 1.64 × 104 and 3.79 × 104 M–1, respectively. The detection limits for Fe3+ and Hg2+ by G-p were 3.26 × 10–5 and 1.77 × 10–6 M with the corresponding K of 1.44 × 105 and 1.99 × 104 M–1, respectively. More interestingly, the back-titration of SCN– could distinguish Hg2+ from Fe3+. At the same time, xerogels G-m and G-p also exhibited responsiveness toward Fe3+ and Hg2+ through fluorescence changes. The photophysical properties, gel formation, hierarchical structures, surface wettability, and their function in this self-assembly system could be tuned through the molecular isomer effect. This work provides a new research paradigm for molecular isomer tuned supramolecular self-assembly materials from noncovalent interaction to molecular function
Xiaobing Zhang - One of the best experts on this subject based on the ideXlab platform.
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an efficient two photon ratiometric fluorescent probe platform for dual channel imaging of lysosomes in living cells and tissues
Sensors and Actuators B-chemical, 2017Co-Authors: Liyi Zhou, Qianqian Wang, Haifei Wang, Hongyan Sun, Xiaobing ZhangAbstract:Abstract In contrast to one-photon microscopy, two-photon probe-based fluorescence imaging can provide improved three-dimensional spatial localization and increased imaging depth. Therefore, the development of new functional two-photon fluorescent dye has attracted great attention. Herein, we have adopted the fluorescence resonance energy transfer (FRET) strategy to design a unique type of two-photon ratiometric fluorescent probe platform. Specifically, a two-photon fluorophore (D-π-A-structured Naphthalimide Derivative) and a rhodamine B fluorophore are directly connected by a flexible piperidine linker. We further used this platform to develop a new type of two-photon ratiometric fluorescent probe, NRLys, for lysosomal pH detection and bioimaging. The experiments demonstrated that the NRLys is a reliable and specific probe for labeling lysosomes in living cells and tissues with two well-resolved emission peaks separated by 60 nm. The probe showed high ratiometric imaging resolution and deep-tissue imaging depth of over 180 μm. Based on the above results, we expect that the new platform may prompt the development of a wide variety of two-photon ratiometric fluorescent probes application in biological systems.
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Efficient Two-Photon Fluorescent Probe for Glutathione S‑Transferase Detection and Imaging in Drug-Induced Liver Injury Sample
2017Co-Authors: Jing Zhang, Xiaobing Zhang, Zhen Jin, Hong-min Meng, Hong-wen Liu, Tanggang Deng, Shan Yao, Lili FengAbstract:Drug-induced liver injury (DILI) is a potential complication of any prescribed medication. So far, the diagnosis of DILI is still a clinical challenge due to the lack of efficient diagnosis method. Glutathione S-transferase (GST), with a high concentration in liver cytosol, can reduce toxicity and facilitate urinary excretion by catalyzing the conjugation of glutathione (GSH) with reactive metabolites in liver. When liver is seriously damaged, GST and GSH will be released into plasma from liver cytosol, which caused a lower GST activity in liver cytosol. Therefore, monitoring the level of GST activity in liver tissue may be a potential strategy for diagnosis of DILI. Here, we reported a two-photon probe P-GST for GST activity detection for the first time. In the proposed design, a donor-π-acceptor (D-π-A) structured Naphthalimide Derivative with efficient two-photon properties was chosen as the fluorescent group, and a 2,4-dinitrobenzenesulfonate group was employed as the GST recognition unit, which also acted as the fluorescence quencher. In the present of GST and GSH, the recognition unit was removed and the fluorophore was released, causing a 40-fold enhancement of fluorescence signal with a detection limit of 35 ng/mL. At last, P-GST was successfully applied in two-photon imaging of GST in cells and DILI samples, which demonstrated its practical application in complex biosystems as a potential method for diagnosis of DILI
Hironori Izawa - One of the best experts on this subject based on the ideXlab platform.
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a novel 1 8 Naphthalimide Derivative with an open space for an anion unique fluorescence behaviour depending on the binding anion s electrophilic properties
Chemical Communications, 2015Co-Authors: Hironori Izawa, Shoji Nishino, Masato Sumita, Masaaki Akamatsu, Kenji Morihashi, Shinsuke Ifuku, Minoru Morimoto, Hiroyuki SaimotoAbstract:We have designed a novel 1,8-Naphthalimide Derivative with an open space for an anion. Computational calculation has predicted that the space could trap various anion species and photo-induced charge transfer depending on the anion's electrophilic properties. Indeed, the fluorescence behaviour of the 1,8-Naphthalimide Derivative complexes with each anion is consistent with the computational prediction.
