The Experts below are selected from a list of 114 Experts worldwide ranked by ideXlab platform
Ricardo Jorge Dinis-oliveira - One of the best experts on this subject based on the ideXlab platform.
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Portugal’s first major forensic case and the genesis of forensic toxicology: 10 years of research to reconstruct the event
Taylor & Francis Group, 2019Co-Authors: Ricardo Jorge Dinis-oliveiraAbstract:The “Crime of Flores Street” is one of the most famous cases of poisoning to divide public opinion in Portugal in the late 19th century, and it also demonstrated the weaknesses of the Portuguese medicolegal system and attested to the importance of toxicological analysis. Vicente Urbino de Freitas was a prominent doctor, graduating from the Faculty of Medicine of the University of Coimbra in 1875. He later became Professor of Physiology at the Porto Medical-Surgical School and author of a number of books on leprosy. In 1877, he married Maria das Dores Basto Sampaio Freitas, and this was followed by the death of a number of her close relatives in suspicious circumstances, notably her brother José António Sampaio Junior and nephew Mário Guilherme Augusto de Sampaio. This review aims to retell the story of Portugal’s first significant medicolegal case as well as the accompanying judicial drama that gave birth to Forensic Toxicology in Portugal and prompted the medicolegal organization that exists today. This research was carried out over a 10-year period and represents undeniable historical value given the rarity of the facts compiled. At the heart of this forensic case was the use of toxicological analyses in court for which the Chemist António Joaquim Ferreira da Silva played a key role. This toxicological report revealed high concentrations of morphine, delphinine and Narceine in viscera and in Mario’s urine. The Mario’s cause of death was attributed to poisoning by opium alkaloids. Despite the strong judicial evidence, doubts still remains as to whether Vicente Urbino de Freitas was a “monster” or a victim of circumstances and a hapless martyr
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Portugal's first major forensic case and the genesis of forensic toxicology: 10 years of research to reconstruct the event.
Forensic Sciences Research, 2018Co-Authors: Ricardo Jorge Dinis-oliveiraAbstract:The "Crime of Flores Street" is one of the most famous cases of poisoning to divide public opinion in Portugal in the late 19th century, and it also demonstrated the weaknesses of the Portuguese medicolegal system and attested to the importance of toxicological analysis. Vicente Urbino de Freitas was a prominent doctor, graduating from the Faculty of Medicine of the University of Coimbra in 1875. He later became Professor of Physiology at the Porto Medical-Surgical School and author of a number of books on leprosy. In 1877, he married Maria das Dores Basto Sampaio Freitas, and this was followed by the death of a number of her close relatives in suspicious circumstances, notably her brother Jose Antonio Sampaio Junior and nephew Mario Guilherme Augusto de Sampaio. This review aims to retell the story of Portugal's first significant medicolegal case as well as the accompanying judicial drama that gave birth to Forensic Toxicology in Portugal and prompted the medicolegal organization that exists today. This research was carried out over a 10-year period and represents undeniable historical value given the rarity of the facts compiled. At the heart of this forensic case was the use of toxicological analyses in court for which the Chemist Antonio Joaquim Ferreira da Silva played a key role. This toxicological report revealed high concentrations of morphine, delphinine and Narceine in viscera and in Mario's urine. The Mario's cause of death was attributed to poisoning by opium alkaloids. Despite the strong judicial evidence, doubts still remains as to whether Vicente Urbino de Freitas was a "monster" or a victim of circumstances and a hapless martyr.
Wang Li-qing - One of the best experts on this subject based on the ideXlab platform.
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Uncertainty Evaluation of Pericarpium Papaveris Alkaloids in Seasonings by Ultra Performance Liquid Chromatography-Tandem Mass Spectrometry Method
China Condiment, 2013Co-Authors: Wang Li-qingAbstract:Based on JJF1059-1999 about Evaluation and about Expression of Uncertainty Determination,a mathematical model is established to assess the uncertainty of Pericarpium Papaveris alkaloids in seasonings by Ultra Performance Liquid Chromatography-Tandem Mass Spectrometry Method.Quantify and evaluate the uncertainty factors.The results show that when the sample volume is 2.0g,Narceine content is(2.93±0.50)μg/kg,narcotine content is(4.62±0.80)μg/kg,thebaine content is(137.23±2.32)μg/kg,morphine content is(121.58±2.53)μg/kg and codeine content is(182.36±3.05)μg/kg.The evaluation method is reasonable,clear,simple and accurate,which is suitable for the evaluation of uncertainty by Ultra Performance Liquid Chromatography-Tandem Mass Spectrometry Method.
Marc Lamblin - One of the best experts on this subject based on the ideXlab platform.
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A concise first total synthesis of Narceine imide
Organic & Biomolecular Chemistry, 2007Co-Authors: Marc Lamblin, Axel Couture, Eric Deniau, Pierre GrandclaudonAbstract:A concise and efficient total synthesis of alkaloid Narceine imide is disclosed. The key steps are based upon the sequential construction of the isoindolinone template followed by metalation and coupling with an isoquinolinium salt. Subsequent E1cb elimination enables the creation of the arylmethylene unit with the concomitant formation of the dimethylaminoethyl chain and ultimate deprotection completes the synthesis of the natural product.
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First Total Synthesis of Narceine Imide
Proceedings of The 10th International Electronic Conference on Synthetic Organic Chemistry, 2006Co-Authors: Axel Couture, Eric Deniau, Pierre Grandclaudon, Marc LamblinAbstract:The creeper Fumaria parviflora Lam (Fumariaceae) is widespread in Pakistan where it is commonly known as Pit Papra and where its extracts are used in folk medicine as a blood purifier and as an anthelmintic, as well as in the treatment of skin diseases and diarrhea [1]. The crude alkaloidal extracts have initially indicated the presence of seventeen isoquinoline bases [2] and additionally four enelactams, i.e; Narceine imide (1), fumaramidine (2), fumaramine (3) and fumaridine (4) (Fig. 1) were isolated from the strongly basic ethanolic extracts of dried plant material [3].
Pierre Grandclaudon - One of the best experts on this subject based on the ideXlab platform.
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A concise first total synthesis of Narceine imide
Organic & Biomolecular Chemistry, 2007Co-Authors: Marc Lamblin, Axel Couture, Eric Deniau, Pierre GrandclaudonAbstract:A concise and efficient total synthesis of alkaloid Narceine imide is disclosed. The key steps are based upon the sequential construction of the isoindolinone template followed by metalation and coupling with an isoquinolinium salt. Subsequent E1cb elimination enables the creation of the arylmethylene unit with the concomitant formation of the dimethylaminoethyl chain and ultimate deprotection completes the synthesis of the natural product.
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First Total Synthesis of Narceine Imide
Proceedings of The 10th International Electronic Conference on Synthetic Organic Chemistry, 2006Co-Authors: Axel Couture, Eric Deniau, Pierre Grandclaudon, Marc LamblinAbstract:The creeper Fumaria parviflora Lam (Fumariaceae) is widespread in Pakistan where it is commonly known as Pit Papra and where its extracts are used in folk medicine as a blood purifier and as an anthelmintic, as well as in the treatment of skin diseases and diarrhea [1]. The crude alkaloidal extracts have initially indicated the presence of seventeen isoquinoline bases [2] and additionally four enelactams, i.e; Narceine imide (1), fumaramidine (2), fumaramine (3) and fumaridine (4) (Fig. 1) were isolated from the strongly basic ethanolic extracts of dried plant material [3].
Steven G. Toske - One of the best experts on this subject based on the ideXlab platform.
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Applicability of ultra-performance liquid chromatography-tandem mass spectrometry for heroin profiling
Journal of Chromatography A, 2008Co-Authors: Ira S. Lurie, Steven G. ToskeAbstract:Abstract The applicability of ultra- performance liquid chromatography tandem-mass spectrometry (UPLC-MS/MS) for heroin profiling is described. The coupling of the high separation power of UPLC with the highly selective and sensitive detection of MS/MS is well suited for heroin profiling. An Acquity UPLC BEH C18 1.7 μm particle column (100 mm × 2.1 mm) with binary gradients containing 1% formic acid (pH 2.0) or 10 mM ammonium bicarbonate (pH 10.0)/acetonitrile mixtures was investigated for the profiling. For MS/MS detection, an atmospheric pressure positive electrospray source was employed with multiple reaction monitoring (MRM). MRMs for individual basic impurities were generated for heroin profiling using low and high pH mobile phases, while MRMs for neutral impurities were generated using a high pH mobile phase. Compared to a pH 2.2 mobile phase, the use of a pH 10 mobile phase allowed for significantly greater sample loading, major selectivity differences, and lower MRM sensitivity. UPLC-MS/MS allowed for the highly selective and sensitive detection of many of the targeted solutes in seized heroin exhibits. Basic impurities detected included morphine, codeine, noscapine, papaverine and the previously unreported solutes reticuline, reticuline monoacetate (2 products), reticuline diacetate, Narceine, codamine, laudanidine, cryptopine, laudanosine, and norlaudanosine. Neutral impurities found included N ,3,6-triacetylnormorphine, N -acetylnorcodeine, N -acetylnornarcotine, 3,6-dimethoxy-4-acetyloxy-5-[2-( N -methylacetamido)]-ethylphenanthrene, and cis - n -acetylanhydronorNarceine. The detection of these impurities, at levels as low as 10 −6 % w/w should allow for greatly enhanced heroin profiles.
