The Experts below are selected from a list of 8763 Experts worldwide ranked by ideXlab platform
Lara Leclerc - One of the best experts on this subject based on the ideXlab platform.
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impact of airborne particle size acoustic airflow and Breathing pattern on delivery of nebulized antibiotic into the maxillary sinuses using a realistic human Nasal replica
Pharmaceutical Research, 2014Co-Authors: Lara Leclerc, Jeremie Pourchez, Gerald Aubert, Sandrine Leguellec, L Vecellio, Michele Cottier, Marc DurandAbstract:Purpose Improvement of clinical outcome in patients with sinuses disorders involves targeting delivery of nebulized drug into the maxillary sinuses. We investigated the impact of nebulization conditions (with and without 100 Hz acoustic airflow), particle size (9.9 μm, 2.8 μm, 550 nm and 230 nm) and Breathing pattern (Nasal vs. no Nasal Breathing) on enhancement of aerosol delivery into the sinuses using a realistic Nasal replica developed by our team.
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impact of airborne particle size acoustic airflow and Breathing pattern on delivery of nebulized antibiotic into the maxillary sinuses using a realistic human Nasal replica
Pharmaceutical Research, 2014Co-Authors: Lara Leclerc, Jeremie Pourchez, Gerald Aubert, Sandrine Leguellec, L Vecellio, Michele Cottier, Marc DurandAbstract:Improvement of clinical outcome in patients with sinuses disorders involves targeting delivery of nebulized drug into the maxillary sinuses. We investigated the impact of nebulization conditions (with and without 100 Hz acoustic airflow), particle size (9.9 μm, 2.8 μm, 550 nm and 230 nm) and Breathing pattern (Nasal vs. no Nasal Breathing) on enhancement of aerosol delivery into the sinuses using a realistic Nasal replica developed by our team. After segmentation of the airways by means of high-resolution computed tomography scans, a well-characterized Nasal replica was created using a rapid prototyping technology. A total of 168 intrasinus aerosol depositions were performed with changes of aerosol particle size and Breathing patterns under different nebulization conditions using gentamicin as a marker. The results demonstrate that the fraction of aerosol deposited in the maxillary sinuses is enhanced by use of submicrometric aerosols, e.g. 8.155 ± 1.476 mg/L of gentamicin in the left maxillary sinus for the 2.8 μm particles vs. 2.056 ± 0.0474 for the 550 nm particles. Utilization of 100-Hz acoustic airflow nebulization also produced a 2- to 3-fold increase in drug deposition in the maxillary sinuses (e.g. 8.155 ± 1.476 vs. 3.990 ± 1.690 for the 2.8 μm particles). Our study clearly shows that optimum deposition was achieved using submicrometric particles and 100-Hz acoustic airflow nebulization with no Nasal Breathing. It is hoped that our new respiratory Nasal replica will greatly facilitate the development of more effective delivery systems in the future.
Marc Durand - One of the best experts on this subject based on the ideXlab platform.
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impact of airborne particle size acoustic airflow and Breathing pattern on delivery of nebulized antibiotic into the maxillary sinuses using a realistic human Nasal replica
Pharmaceutical Research, 2014Co-Authors: Lara Leclerc, Jeremie Pourchez, Gerald Aubert, Sandrine Leguellec, L Vecellio, Michele Cottier, Marc DurandAbstract:Purpose Improvement of clinical outcome in patients with sinuses disorders involves targeting delivery of nebulized drug into the maxillary sinuses. We investigated the impact of nebulization conditions (with and without 100 Hz acoustic airflow), particle size (9.9 μm, 2.8 μm, 550 nm and 230 nm) and Breathing pattern (Nasal vs. no Nasal Breathing) on enhancement of aerosol delivery into the sinuses using a realistic Nasal replica developed by our team.
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impact of airborne particle size acoustic airflow and Breathing pattern on delivery of nebulized antibiotic into the maxillary sinuses using a realistic human Nasal replica
Pharmaceutical Research, 2014Co-Authors: Lara Leclerc, Jeremie Pourchez, Gerald Aubert, Sandrine Leguellec, L Vecellio, Michele Cottier, Marc DurandAbstract:Improvement of clinical outcome in patients with sinuses disorders involves targeting delivery of nebulized drug into the maxillary sinuses. We investigated the impact of nebulization conditions (with and without 100 Hz acoustic airflow), particle size (9.9 μm, 2.8 μm, 550 nm and 230 nm) and Breathing pattern (Nasal vs. no Nasal Breathing) on enhancement of aerosol delivery into the sinuses using a realistic Nasal replica developed by our team. After segmentation of the airways by means of high-resolution computed tomography scans, a well-characterized Nasal replica was created using a rapid prototyping technology. A total of 168 intrasinus aerosol depositions were performed with changes of aerosol particle size and Breathing patterns under different nebulization conditions using gentamicin as a marker. The results demonstrate that the fraction of aerosol deposited in the maxillary sinuses is enhanced by use of submicrometric aerosols, e.g. 8.155 ± 1.476 mg/L of gentamicin in the left maxillary sinus for the 2.8 μm particles vs. 2.056 ± 0.0474 for the 550 nm particles. Utilization of 100-Hz acoustic airflow nebulization also produced a 2- to 3-fold increase in drug deposition in the maxillary sinuses (e.g. 8.155 ± 1.476 vs. 3.990 ± 1.690 for the 2.8 μm particles). Our study clearly shows that optimum deposition was achieved using submicrometric particles and 100-Hz acoustic airflow nebulization with no Nasal Breathing. It is hoped that our new respiratory Nasal replica will greatly facilitate the development of more effective delivery systems in the future.
Radan Starcevic - One of the best experts on this subject based on the ideXlab platform.
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the effects of disclosure of sequential rhinomanometry scores on post septoplasty subjective scores of Nasal obstruction a randomised controlled trial
Clinical Otolaryngology, 2012Co-Authors: Tamara Braut, Dubravko Manestar, Marko Velepic, Goran Malvic, Milodar Kujundžic, Matanic D Lender, Radan StarcevicAbstract:Clin. Otolaryngol. 2012, 37, 176–180 Objective: We sought to evaluate the effects of awareness of rhinomanometric results on subjective sensation of Nasal Breathing in patients after septoplasty. Design: Prospective randomised study. Setting: Clinical Hospital Rijeka. Participants: A study of 60 patients (45 M, 15 F) who underwent septoplasty was performed at the ENT Clinic, Clinical Hospital Rijeka. The patients were randomised into two groups; group A was shown their rhinomanometry scores at 3 months postoperatively, while group B remained unaware of their rhinomanometry results. Main outcome measure: The assumption is that in the same settings patients aware of their rhinomanometric results have better performances of their Nasal Obstruction Symptom Evaluation (NOSE) scale and thereby a better quality of life (QOL) after septoplasty. Results: The differences in rhinomanometric results and NOSE scale prior and after septoplasty were statistically significant (P < 0.001), all patients achieving better results after the operation. There was no statistically significant difference in resistance (F = 0.004; P = 0.948) and improvement of rhinomanometry results in postoperative measurements (F = 0.110; P = 0.896) between groups A and B. The symptoms measured by the NOSE scale were the same in both groups preoperatively and 1 month after septoplasty (F = 2.906; P = 0.094). Three months postoperatively in group A, the NOSE scale score was lower (M = 11.67; sd = 12.34) than in group B (M = 27.50; sd = 18.04). Conclusions: The results suggest that disclosing information to patients about their post-septoplasty rhinomanometry results may improve subjective Nasal Breathing, and thus improve their QOL.
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the effects of disclosure of sequential rhinomanometry scores on post septoplasty subjective scores of Nasal obstruction a randomised controlled trial
Clinical Otolaryngology, 2012Co-Authors: Dubravko Manestar, Marko Velepic, Tamara Braut, Goran Malvic, Milodar Kujundžic, Matanic D Lender, Radan StarcevicAbstract:Clin. Otolaryngol. 2012, 37, 176–180 Objective: We sought to evaluate the effects of awareness of rhinomanometric results on subjective sensation of Nasal Breathing in patients after septoplasty. Design: Prospective randomised study. Setting: Clinical Hospital Rijeka. Participants: A study of 60 patients (45 M, 15 F) who underwent septoplasty was performed at the ENT Clinic, Clinical Hospital Rijeka. The patients were randomised into two groups; group A was shown their rhinomanometry scores at 3 months postoperatively, while group B remained unaware of their rhinomanometry results. Main outcome measure: The assumption is that in the same settings patients aware of their rhinomanometric results have better performances of their Nasal Obstruction Symptom Evaluation (NOSE) scale and thereby a better quality of life (QOL) after septoplasty. Results: The differences in rhinomanometric results and NOSE scale prior and after septoplasty were statistically significant (P < 0.001), all patients achieving better results after the operation. There was no statistically significant difference in resistance (F = 0.004; P = 0.948) and improvement of rhinomanometry results in postoperative measurements (F = 0.110; P = 0.896) between groups A and B. The symptoms measured by the NOSE scale were the same in both groups preoperatively and 1 month after septoplasty (F = 2.906; P = 0.094). Three months postoperatively in group A, the NOSE scale score was lower (M = 11.67; sd = 12.34) than in group B (M = 27.50; sd = 18.04). Conclusions: The results suggest that disclosing information to patients about their post-septoplasty rhinomanometry results may improve subjective Nasal Breathing, and thus improve their QOL.
Dubravko Manestar - One of the best experts on this subject based on the ideXlab platform.
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the effects of disclosure of sequential rhinomanometry scores on post septoplasty subjective scores of Nasal obstruction a randomised controlled trial
Clinical Otolaryngology, 2012Co-Authors: Tamara Braut, Dubravko Manestar, Marko Velepic, Goran Malvic, Milodar Kujundžic, Matanic D Lender, Radan StarcevicAbstract:Clin. Otolaryngol. 2012, 37, 176–180 Objective: We sought to evaluate the effects of awareness of rhinomanometric results on subjective sensation of Nasal Breathing in patients after septoplasty. Design: Prospective randomised study. Setting: Clinical Hospital Rijeka. Participants: A study of 60 patients (45 M, 15 F) who underwent septoplasty was performed at the ENT Clinic, Clinical Hospital Rijeka. The patients were randomised into two groups; group A was shown their rhinomanometry scores at 3 months postoperatively, while group B remained unaware of their rhinomanometry results. Main outcome measure: The assumption is that in the same settings patients aware of their rhinomanometric results have better performances of their Nasal Obstruction Symptom Evaluation (NOSE) scale and thereby a better quality of life (QOL) after septoplasty. Results: The differences in rhinomanometric results and NOSE scale prior and after septoplasty were statistically significant (P < 0.001), all patients achieving better results after the operation. There was no statistically significant difference in resistance (F = 0.004; P = 0.948) and improvement of rhinomanometry results in postoperative measurements (F = 0.110; P = 0.896) between groups A and B. The symptoms measured by the NOSE scale were the same in both groups preoperatively and 1 month after septoplasty (F = 2.906; P = 0.094). Three months postoperatively in group A, the NOSE scale score was lower (M = 11.67; sd = 12.34) than in group B (M = 27.50; sd = 18.04). Conclusions: The results suggest that disclosing information to patients about their post-septoplasty rhinomanometry results may improve subjective Nasal Breathing, and thus improve their QOL.
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the effects of disclosure of sequential rhinomanometry scores on post septoplasty subjective scores of Nasal obstruction a randomised controlled trial
Clinical Otolaryngology, 2012Co-Authors: Dubravko Manestar, Marko Velepic, Tamara Braut, Goran Malvic, Milodar Kujundžic, Matanic D Lender, Radan StarcevicAbstract:Clin. Otolaryngol. 2012, 37, 176–180 Objective: We sought to evaluate the effects of awareness of rhinomanometric results on subjective sensation of Nasal Breathing in patients after septoplasty. Design: Prospective randomised study. Setting: Clinical Hospital Rijeka. Participants: A study of 60 patients (45 M, 15 F) who underwent septoplasty was performed at the ENT Clinic, Clinical Hospital Rijeka. The patients were randomised into two groups; group A was shown their rhinomanometry scores at 3 months postoperatively, while group B remained unaware of their rhinomanometry results. Main outcome measure: The assumption is that in the same settings patients aware of their rhinomanometric results have better performances of their Nasal Obstruction Symptom Evaluation (NOSE) scale and thereby a better quality of life (QOL) after septoplasty. Results: The differences in rhinomanometric results and NOSE scale prior and after septoplasty were statistically significant (P < 0.001), all patients achieving better results after the operation. There was no statistically significant difference in resistance (F = 0.004; P = 0.948) and improvement of rhinomanometry results in postoperative measurements (F = 0.110; P = 0.896) between groups A and B. The symptoms measured by the NOSE scale were the same in both groups preoperatively and 1 month after septoplasty (F = 2.906; P = 0.094). Three months postoperatively in group A, the NOSE scale score was lower (M = 11.67; sd = 12.34) than in group B (M = 27.50; sd = 18.04). Conclusions: The results suggest that disclosing information to patients about their post-septoplasty rhinomanometry results may improve subjective Nasal Breathing, and thus improve their QOL.
Jason P Kirkness - One of the best experts on this subject based on the ideXlab platform.
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influence of Breathing route on upper airway lining liquid surface tension in humans
The Journal of Physiology, 2006Co-Authors: Manisha Verma, John R. Wheatley, Terence C. Amis, Margaret Setopoon, Jason P KirknessAbstract:We have recently demonstrated that the severity of sleep-disordered Breathing in obstructive sleep apnoea hypopnoea syndrome (OSAHS) can be reduced by lowering the surface tension (gamma) of the upper airway lining liquid (UAL). Morning xerostomia (related to oral Breathing during sleep) is reported by most OSAHS patients. In the present study we examine relationships between Breathing route, oral mucosal 'wetness' and the gamma of UAL. We studied eight healthy subjects (age, 25 +/- 5 years [mean +/- S.D.]; body-mass index, 23 +/- 2 kg m(-2)) during a 120 min challenge of both Nasal-only Breathing (mouth taped) and oral-only Breathing (nose clip), each on a separate day (randomized). Both oral mucosal 'wetness' (5 s contact gravimetric absorbent paper strip method) and the gamma ('pull-off' force technique) of 0.2 microl samples of UAL obtained from the posterior pharyngeal wall were measured at 15 min intervals (mouth tape removed and replaced as required). Upper airway mucosal 'wetness' increased during 120 min of Nasal Breathing from 4.0 +/- 0.4 (mean +/- S.E.M.) to 5.3 +/- 0.3 microl (5 s)(-1) but decreased from 4.5 +/- 0.4 to 0.1 +/- 0.2 microl (5 s)(-1) with oral Breathing (both P < 0.001, repeated-measures ANOVA, Tukey's multiple comparison test, post hoc test). Concurrently, the gamma of UAL decreased from 59.3 +/- 2.2 to 51.8 +/- 0.98 mN m(-1) with Nasal Breathing but increased from 64.4 +/- 2.7 to 77.4 +/- 1.1 mN m(-1) with oral Breathing (P < 0.001). For the group and all conditions studied, gamma of UAL values strongly correlated with upper airway mucosal 'wetness' (correlation coefficient, r2 = -0.34, P < 0.001; linear regression). We conclude that oral Breathing increases and Nasal Breathing decreases the gamma of UAL in healthy subjects during wakefulness. We speculate that Nasal Breathing in OSAHS patients during sleep may promote a low gamma of UAL that may contribute to reducing the severity of sleep-disordered Breathing.
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surface tension of upper airway mucosal lining liquid in obstructive sleep apnea hypopnea syndrome
Sleep, 2005Co-Authors: Jason P Kirkness, John R. Wheatley, Melanie Madronio, Rosie Stavrinou, Terence C. AmisAbstract:STUDY OBJECTIVES: The obstructive sleep apnea hypopnea syndrome (OSAHS) is a disorder characterized by repetitive closure and reopening of the upper airway during sleep. Upper airway luminal patency is influenced by the surface tension (gamma) acting within the liquid layer lining the upper airway. The aim of the present study was to examine the gamma of upper airway mucosal lining liquid (UAL) in both healthy subjects and patients with OSAHS before and after sleep. DESIGN: Measurements were performed before (PM) and after (AM) an overnight polysomnographic study. SETTING: Sleep laboratory. PARTICIPANTS: We studied 11 healthy adults (5 men, 6 women) and 15 patients with OSAHS (14 men, 1 woman). INTERVENTIONS: None. MEASUREMENTS AND RESULTS: The gamma of UAL ("pull-off' force technique, pooled PM and AM samples) in patients with OSAHS was increased (59.9 [53.8, 58.8] mN/m; mean [95% confidence interval]) compared with healthy subjects (56.3 [57.7, 62.1] mN/m; linear mixed effects models; P =.05). In both groups there was no significant difference between PM (56.6 [53.7, 59.5] mN/m for healthy subjects, 60.1 [57.9, 62.3] mN/m for the patients with OSAHS) and AM (56.1 [51.8, 60.4] mN/m and 59.6 [57.4, 61.8] mN/m, respectively) samples for gamma of UAL and salivary flow rate (5 minutes unstimulated collection; PM =0.53 [0.22, 0.84] mL/minute for healthy subjects, 0.38 [0.22, 0.54] mL/minute for OSAHS; AM=0.39 [0.23, 0.55] mL/minute and 0.32 [0.2, 0.44] mL/minute). However, the occurrence of Nasal Breathing during sleep was associated with a fall in gamma of UAL overnight (r2 = 0.15, P < .05). CONCLUSION: Patients with OSAHS have normal salivary flow rate but an increased gamma of UAL. In both healthy subjects and OSAHS patients, Nasal Breathing during sleep was associated with an overnight fall in the gamma of UAL.
