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Teresa Weber - One of the best experts on this subject based on the ideXlab platform.

  • irritation and allergy patch test analysis of topical treatments commonly used in wound care evaluation on normal and compromised skin
    Journal of The American Academy of Dermatology, 2011
    Co-Authors: Nathan S Trookman, Ronald L Rizer, Teresa Weber
    Abstract:

    Background Topical agents indicated for the treatment of superficial wounds have the potential to cause irritation or allergic contact dermatitis, particularly when applied to an impaired skin barrier. Objective We sought to compare the irritancy potential of 5 topical wound care products commonly used in dermatologic practice on normal and compromised skin. Methods Agents tested included Aquaphor Healing Ointment (AHO) (Beiersdorf Inc, Wilton, CT); bacitracin; Biafine Topical Emulsion (BTE) (OrthoNeutrogena, Los Angeles, CA); Neosporin (Poly/Bac/Neo) (Johnson & Johnson, New Brunswick, NJ); and Polysporin (Poly/Bac) (Johnson & Johnson). Study 1 assessed cumulative irritation using a modified human repeat insult patch test on normal back skin with an induction phase (test materials applied under occlusive patch 9 times at 48- to 72-hour intervals) and a challenge phase (test materials applied to original and naive sites for 48 hours, 12-24 days postinduction). Irritation was graded for erythema and type IV allergy skin responses. Study 2 assessed the acute irritation potential of agents on tape-stripped ("wounded") back skin. Test sites were graded for erythema, transepidermal water loss, and skin color (Chroma Meter a∗) (Minolta, Osaka, Japan) at 48 and 72 hours poststripping. Results In study 1, cumulative irritation testing in 108 subjects classified AHO, bacitracin, Poly/Bac/Neo, and Poly/Bac as "mild," and BTE as "probably mild." In study 2 at 72 hours, mean clinical grading scores were significantly higher for BTE and Poly/Bac/Neo than AHO. Transepidermal water loss and colorimeter a∗ values were significantly lower for AHO and bacitracin compared with BTE. No allergic contact dermatitis was seen in either study. Conclusions Patch test studies demonstrated that BTE showed the greatest irritancy potential in both normal and compromised skin whereas AHO showed the least.

  • Treatment of minor wounds from dermatologic procedures: a comparison of three topical wound care ointments using a laser wound model.
    Journal of the American Academy of Dermatology, 2011
    Co-Authors: Nathan S Trookman, Ronald L Rizer, Teresa Weber
    Abstract:

    Topical antibiotic ointments are commonly used for postoperative wound care after dermatologic procedures such as curettage, electrodessication, or shave removals. Antibiotics have the potential to cause allergic contact dermatitis and increase drug resistance and may not be necessary for the treatment of clean surgical wounds. This study compared the wound healing properties of the topical wound care ointments Aquaphor Healing Ointment (AHO) (Beiersdorf Inc, Wilton, CT), Neosporin (Poly/Bac/Neo) (Johnson & Johnson, New Brunswick, NJ), and Polysporin (Poly/Bac) (Johnson & Johnson) using a laser wound model. In this double-blind study, 4 uniform circular erbium/carbon dioxide laser wounds penetrating to the dermis were made in 20 subjects. Each wound was treated 3 times daily for 18 days with AHO, Poly/Bac/Neo, or Poly/Bac, with one wound left untreated (control). Efficacy and safety were assessed using clinical grading, transepidermal water loss, investigator grading of wound appearance, subjective ranking of wound appearance, and adverse event reporting. Significant improvements in erythema (days 7-18), edema (days 4 and 7), epithelial confluence (days 7-18), and general wound appearance (days 7-18) were observed with AHO compared with Poly/Bac/Neo and Poly/Bac (P ≤ .007). No differences were observed between Poly/Bac/Neo and Poly/Bac for any clinical parameters. The average transepidermal water loss value on day 4 was significantly less with AHO compared with the other treatments (P = .0006). Subjects ranked the treated sites as follows: AHO (best), Poly/Bac, and Poly/Bac/Neo. No adverse events were reported. This was a small pilot study using a laser wound model to replicate minor wounds. AHO demonstrated fast and effective improvements in several wound healing parameters compared with antibiotic-containing treatments. Copyright © 2011 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.

  • Irritation and allergy patch test analysis of topical treatments commonly used in wound care: evaluation on normal and compromised skin.
    Journal of the American Academy of Dermatology, 2011
    Co-Authors: Nathan S Trookman, Ronald L Rizer, Teresa Weber
    Abstract:

    Topical agents indicated for the treatment of superficial wounds have the potential to cause irritation or allergic contact dermatitis, particularly when applied to an impaired skin barrier. We sought to compare the irritancy potential of 5 topical wound care products commonly used in dermatologic practice on normal and compromised skin. Agents tested included Aquaphor Healing Ointment (AHO) (Beiersdorf Inc, Wilton, CT); bacitracin; Biafine Topical Emulsion (BTE) (OrthoNeutrogena, Los Angeles, CA); Neosporin (Poly/Bac/Neo) (Johnson & Johnson, New Brunswick, NJ); and Polysporin (Poly/Bac) (Johnson & Johnson). Study 1 assessed cumulative irritation using a modified human repeat insult patch test on normal back skin with an induction phase (test materials applied under occlusive patch 9 times at 48- to 72-hour intervals) and a challenge phase (test materials applied to original and naïve sites for 48 hours, 12-24 days postinduction). Irritation was graded for erythema and type IV allergy skin responses. Study 2 assessed the acute irritation potential of agents on tape-stripped ("wounded") back skin. Test sites were graded for erythema, transepidermal water loss, and skin color (Chroma Meter a∗) (Minolta, Osaka, Japan) at 48 and 72 hours poststripping. In study 1, cumulative irritation testing in 108 subjects classified AHO, bacitracin, Poly/Bac/Neo, and Poly/Bac as "mild," and BTE as "probably mild." In study 2 at 72 hours, mean clinical grading scores were significantly higher for BTE and Poly/Bac/Neo than AHO. Transepidermal water loss and colorimeter a∗ values were significantly lower for AHO and bacitracin compared with BTE. No allergic contact dermatitis was seen in either study. Patch test studies demonstrated that BTE showed the greatest irritancy potential in both normal and compromised skin whereas AHO showed the least. Copyright © 2010 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.

Nathan S Trookman - One of the best experts on this subject based on the ideXlab platform.

  • irritation and allergy patch test analysis of topical treatments commonly used in wound care evaluation on normal and compromised skin
    Journal of The American Academy of Dermatology, 2011
    Co-Authors: Nathan S Trookman, Ronald L Rizer, Teresa Weber
    Abstract:

    Background Topical agents indicated for the treatment of superficial wounds have the potential to cause irritation or allergic contact dermatitis, particularly when applied to an impaired skin barrier. Objective We sought to compare the irritancy potential of 5 topical wound care products commonly used in dermatologic practice on normal and compromised skin. Methods Agents tested included Aquaphor Healing Ointment (AHO) (Beiersdorf Inc, Wilton, CT); bacitracin; Biafine Topical Emulsion (BTE) (OrthoNeutrogena, Los Angeles, CA); Neosporin (Poly/Bac/Neo) (Johnson & Johnson, New Brunswick, NJ); and Polysporin (Poly/Bac) (Johnson & Johnson). Study 1 assessed cumulative irritation using a modified human repeat insult patch test on normal back skin with an induction phase (test materials applied under occlusive patch 9 times at 48- to 72-hour intervals) and a challenge phase (test materials applied to original and naive sites for 48 hours, 12-24 days postinduction). Irritation was graded for erythema and type IV allergy skin responses. Study 2 assessed the acute irritation potential of agents on tape-stripped ("wounded") back skin. Test sites were graded for erythema, transepidermal water loss, and skin color (Chroma Meter a∗) (Minolta, Osaka, Japan) at 48 and 72 hours poststripping. Results In study 1, cumulative irritation testing in 108 subjects classified AHO, bacitracin, Poly/Bac/Neo, and Poly/Bac as "mild," and BTE as "probably mild." In study 2 at 72 hours, mean clinical grading scores were significantly higher for BTE and Poly/Bac/Neo than AHO. Transepidermal water loss and colorimeter a∗ values were significantly lower for AHO and bacitracin compared with BTE. No allergic contact dermatitis was seen in either study. Conclusions Patch test studies demonstrated that BTE showed the greatest irritancy potential in both normal and compromised skin whereas AHO showed the least.

  • Treatment of minor wounds from dermatologic procedures: a comparison of three topical wound care ointments using a laser wound model.
    Journal of The American Academy of Dermatology, 2011
    Co-Authors: Nathan S Trookman, Ronald L Rizer, Teresa M. Weber
    Abstract:

    Background Topical antibiotic ointments are commonly used for postoperative wound care after dermatologic procedures such as curettage, electrodessication, or shave removals. Antibiotics have the potential to cause allergic contact dermatitis and increase drug resistance and may not be necessary for the treatment of clean surgical wounds. Objective This study compared the wound healing properties of the topical wound care ointments Aquaphor Healing Ointment (AHO) (Beiersdorf Inc, Wilton, CT), Neosporin (Poly/Bac/Neo) (Johnson & Johnson, New Brunswick, NJ), and Polysporin (Poly/Bac) (Johnson & Johnson) using a laser wound model. Methods In this double-blind study, 4 uniform circular erbium/carbon dioxide laser wounds penetrating to the dermis were made in 20 subjects. Each wound was treated 3 times daily for 18 days with AHO, Poly/Bac/Neo, or Poly/Bac, with one wound left untreated (control). Efficacy and safety were assessed using clinical grading, transepidermal water loss, investigator grading of wound appearance, subjective ranking of wound appearance, and adverse event reporting. Results Significant improvements in erythema (days 7-18), edema (days 4 and 7), epithelial confluence (days 7-18), and general wound appearance (days 7-18) were observed with AHO compared with Poly/Bac/Neo and Poly/Bac ( P ≤ .007). No differences were observed between Poly/Bac/Neo and Poly/Bac for any clinical parameters. The average transepidermal water loss value on day 4 was significantly less with AHO compared with the other treatments ( P  = .0006). Subjects ranked the treated sites as follows: AHO (best), Poly/Bac, and Poly/Bac/Neo. No adverse events were reported. Limitations This was a small pilot study using a laser wound model to replicate minor wounds. Conclusions AHO demonstrated fast and effective improvements in several wound healing parameters compared with antibiotic-containing treatments.

  • Treatment of minor wounds from dermatologic procedures: a comparison of three topical wound care ointments using a laser wound model.
    Journal of the American Academy of Dermatology, 2011
    Co-Authors: Nathan S Trookman, Ronald L Rizer, Teresa Weber
    Abstract:

    Topical antibiotic ointments are commonly used for postoperative wound care after dermatologic procedures such as curettage, electrodessication, or shave removals. Antibiotics have the potential to cause allergic contact dermatitis and increase drug resistance and may not be necessary for the treatment of clean surgical wounds. This study compared the wound healing properties of the topical wound care ointments Aquaphor Healing Ointment (AHO) (Beiersdorf Inc, Wilton, CT), Neosporin (Poly/Bac/Neo) (Johnson & Johnson, New Brunswick, NJ), and Polysporin (Poly/Bac) (Johnson & Johnson) using a laser wound model. In this double-blind study, 4 uniform circular erbium/carbon dioxide laser wounds penetrating to the dermis were made in 20 subjects. Each wound was treated 3 times daily for 18 days with AHO, Poly/Bac/Neo, or Poly/Bac, with one wound left untreated (control). Efficacy and safety were assessed using clinical grading, transepidermal water loss, investigator grading of wound appearance, subjective ranking of wound appearance, and adverse event reporting. Significant improvements in erythema (days 7-18), edema (days 4 and 7), epithelial confluence (days 7-18), and general wound appearance (days 7-18) were observed with AHO compared with Poly/Bac/Neo and Poly/Bac (P ≤ .007). No differences were observed between Poly/Bac/Neo and Poly/Bac for any clinical parameters. The average transepidermal water loss value on day 4 was significantly less with AHO compared with the other treatments (P = .0006). Subjects ranked the treated sites as follows: AHO (best), Poly/Bac, and Poly/Bac/Neo. No adverse events were reported. This was a small pilot study using a laser wound model to replicate minor wounds. AHO demonstrated fast and effective improvements in several wound healing parameters compared with antibiotic-containing treatments. Copyright © 2011 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.

  • Irritation and allergy patch test analysis of topical treatments commonly used in wound care: evaluation on normal and compromised skin.
    Journal of the American Academy of Dermatology, 2011
    Co-Authors: Nathan S Trookman, Ronald L Rizer, Teresa Weber
    Abstract:

    Topical agents indicated for the treatment of superficial wounds have the potential to cause irritation or allergic contact dermatitis, particularly when applied to an impaired skin barrier. We sought to compare the irritancy potential of 5 topical wound care products commonly used in dermatologic practice on normal and compromised skin. Agents tested included Aquaphor Healing Ointment (AHO) (Beiersdorf Inc, Wilton, CT); bacitracin; Biafine Topical Emulsion (BTE) (OrthoNeutrogena, Los Angeles, CA); Neosporin (Poly/Bac/Neo) (Johnson & Johnson, New Brunswick, NJ); and Polysporin (Poly/Bac) (Johnson & Johnson). Study 1 assessed cumulative irritation using a modified human repeat insult patch test on normal back skin with an induction phase (test materials applied under occlusive patch 9 times at 48- to 72-hour intervals) and a challenge phase (test materials applied to original and naïve sites for 48 hours, 12-24 days postinduction). Irritation was graded for erythema and type IV allergy skin responses. Study 2 assessed the acute irritation potential of agents on tape-stripped ("wounded") back skin. Test sites were graded for erythema, transepidermal water loss, and skin color (Chroma Meter a∗) (Minolta, Osaka, Japan) at 48 and 72 hours poststripping. In study 1, cumulative irritation testing in 108 subjects classified AHO, bacitracin, Poly/Bac/Neo, and Poly/Bac as "mild," and BTE as "probably mild." In study 2 at 72 hours, mean clinical grading scores were significantly higher for BTE and Poly/Bac/Neo than AHO. Transepidermal water loss and colorimeter a∗ values were significantly lower for AHO and bacitracin compared with BTE. No allergic contact dermatitis was seen in either study. Patch test studies demonstrated that BTE showed the greatest irritancy potential in both normal and compromised skin whereas AHO showed the least. Copyright © 2010 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.

Matthew L Cooper - One of the best experts on this subject based on the ideXlab platform.

  • The cytotoxic effects of commonly used topical antimicrobial agents on human fibroblasts and keratinocytes.
    Journal of Trauma-injury Infection and Critical Care, 1991
    Co-Authors: Matthew L Cooper, Julie A. Laxer, John F Hansbrough
    Abstract:

    This study evaluated the cytotoxicity of commonly used topical agents to human dermal fibroblasts and epidermal keratinocytes, which play a prominent role in wound healing. The effects of these topical agents were assessed using two separate assays for the fibroblasts--tritiated thymidine incorporation and the uptake of a vital dye (neutral red). Keratinocytes were evaluated with the neutral red assay. Serial dilutions of each of 10 commonly used topical agents produced decreases in both the uptake of neutral red and the incorporation of thymidine at clinically relevant doses. Only Neosporin G.U. irrigant showed no significant difference compared with controls in the assays for both the fibroblasts and the keratinocytes. Careful attention must be paid to which agent is used in the clinical setting, since many of these can have profound effects on cells that influence wound healing.

  • Effects of topical antimicrobial agents on the human neutrophil respiratory burst
    Archives of Surgery, 1991
    Co-Authors: John F Hansbrough, R L Zapata-sirvent, Matthew L Cooper
    Abstract:

    • The neutrophil oxidative burst plays an important role in killing intracellular microorganisms. We studied the effects of topical antimicrobial agents on the N -formyl-l-methionyl-l-leucyl-l-phenylalanine–stimulated oxidative burst of human peripheral blood neutrophils, using a flow cytometric assay. Mafenide acetate, sulfadiazine silver, gentamicin sulfate, neomycin sulfate–polymyxin B sulfate (Neosporin GU Irrigant), acetic acid, amphotericin B, and povidone-iodine inhibited the neutrophil oxidative burst at or below clinical concentrations, while 0.25% modified diluted sodium hypochlorite (Dakin's) solution caused cell death. Bacitracin–polymyxin B sulfate (Polysporin) greatly augmented the respiratory burst; this effect was due to the bacitracin component. Diluted gentamicin and acetic acid also augmented intracellular hydrogen peroxide production, but to a lesser extent than Polysporin. Inhibition of the respiratory burst of neutrophils might be considered when these agents are used for topical wound care, although clinical correlates of these effects have not been determined. ( Arch Surg. 1991;126:603-608)

  • Cytotoxicity to cultured human keratinocytes of topical antimicrobial agents
    Journal of Surgical Research, 1990
    Co-Authors: Matthew L Cooper, Tanya J. Foreman, Steven T. Boyce, John F Hansbrough, David H. Frank
    Abstract:

    Abstract Cultured skin grafts administered clinically for closure of burn wounds may be contacted by topically applied antimicrobial agents. A study was performed to assess whether commonly used topical antimicrobial agents are toxic to cultured human keratinocytes (HK) in vitro . Serum-free MCDB 153 culture medium containing Neosporin G.U. irrigant (Neomycin, 40 μg/ml-polymyxin B sulfate, 200 units/ml) and a standard tissue culture antimicrobial agent of penicillin (10,000 units/ml)-streptomycin (10,000 μg/ml)-amphotericin B (25 μg/ml) had no effect on the keratinocyte growth rates when compared to standard MCDB 153 medium without antibiotics. Medium containing Sulfamylon (mafenide acetate, 0.85%), Polysporin (polymyxin B sulfate, 1 × 10 4 units/ml-bacitracin, 500 units/ml), gentamicin sulfate (0.1%), modified Dakins solution (25%), and acetic acid (0.25%) all showed statistically significant ( P

  • Cytotoxicity to cultured human keratinocytes of topical antimicrobial agents
    Journal of Surgical Research, 1990
    Co-Authors: Matthew L Cooper, Tanya J. Foreman, Steven T. Boyce, John F Hansbrough, David H. Frank
    Abstract:

    Cultured skin grafts administered clinically for closure of burn wounds may be contacted by topically applied antimicrobial agents. A study was performed to assess whether commonly used topical antimicrobial agents are toxic to cultured human keratinocytes (HK) in vitro. Serum-free MCDB 153 culture medium containing Neosporin G.U. irrigant (Neomycin, 40 micrograms/ml-polymyxin B sulfate, 200 units/ml) and a standard tissue culture antimicrobial agent of penicillin (10,000 units/ml)-streptomycin (10,000 micrograms/ml)-amphotericin B (25 micrograms/ml) had no effect on the keratinocyte growth rates when compared to standard MCDB 153 medium without antibiotics. Medium containing Sulfamylon (mafenide acetate, 0.85%), Polysporin (polymyxin B sulfate, 1 x 10(4) units/ml-bacitracin, 500 units/ml), gentamicin sulfate (0.1%), modified Dakins solution (25%), and acetic acid (0.25%) all showed statistically significant (P less than 0.01) decreases in keratinocyte growth rates. This data suggests that commonly applied antimicrobials may not be appropriate for cultured grafts in the concentrations that are used clinically.

John F Hansbrough - One of the best experts on this subject based on the ideXlab platform.

  • The cytotoxic effects of commonly used topical antimicrobial agents on human fibroblasts and keratinocytes.
    Journal of Trauma-injury Infection and Critical Care, 1991
    Co-Authors: Matthew L Cooper, Julie A. Laxer, John F Hansbrough
    Abstract:

    This study evaluated the cytotoxicity of commonly used topical agents to human dermal fibroblasts and epidermal keratinocytes, which play a prominent role in wound healing. The effects of these topical agents were assessed using two separate assays for the fibroblasts--tritiated thymidine incorporation and the uptake of a vital dye (neutral red). Keratinocytes were evaluated with the neutral red assay. Serial dilutions of each of 10 commonly used topical agents produced decreases in both the uptake of neutral red and the incorporation of thymidine at clinically relevant doses. Only Neosporin G.U. irrigant showed no significant difference compared with controls in the assays for both the fibroblasts and the keratinocytes. Careful attention must be paid to which agent is used in the clinical setting, since many of these can have profound effects on cells that influence wound healing.

  • Effects of topical antimicrobial agents on the human neutrophil respiratory burst
    Archives of Surgery, 1991
    Co-Authors: John F Hansbrough, R L Zapata-sirvent, Matthew L Cooper
    Abstract:

    • The neutrophil oxidative burst plays an important role in killing intracellular microorganisms. We studied the effects of topical antimicrobial agents on the N -formyl-l-methionyl-l-leucyl-l-phenylalanine–stimulated oxidative burst of human peripheral blood neutrophils, using a flow cytometric assay. Mafenide acetate, sulfadiazine silver, gentamicin sulfate, neomycin sulfate–polymyxin B sulfate (Neosporin GU Irrigant), acetic acid, amphotericin B, and povidone-iodine inhibited the neutrophil oxidative burst at or below clinical concentrations, while 0.25% modified diluted sodium hypochlorite (Dakin's) solution caused cell death. Bacitracin–polymyxin B sulfate (Polysporin) greatly augmented the respiratory burst; this effect was due to the bacitracin component. Diluted gentamicin and acetic acid also augmented intracellular hydrogen peroxide production, but to a lesser extent than Polysporin. Inhibition of the respiratory burst of neutrophils might be considered when these agents are used for topical wound care, although clinical correlates of these effects have not been determined. ( Arch Surg. 1991;126:603-608)

  • Cytotoxicity to cultured human keratinocytes of topical antimicrobial agents
    Journal of Surgical Research, 1990
    Co-Authors: Matthew L Cooper, Tanya J. Foreman, Steven T. Boyce, John F Hansbrough, David H. Frank
    Abstract:

    Abstract Cultured skin grafts administered clinically for closure of burn wounds may be contacted by topically applied antimicrobial agents. A study was performed to assess whether commonly used topical antimicrobial agents are toxic to cultured human keratinocytes (HK) in vitro . Serum-free MCDB 153 culture medium containing Neosporin G.U. irrigant (Neomycin, 40 μg/ml-polymyxin B sulfate, 200 units/ml) and a standard tissue culture antimicrobial agent of penicillin (10,000 units/ml)-streptomycin (10,000 μg/ml)-amphotericin B (25 μg/ml) had no effect on the keratinocyte growth rates when compared to standard MCDB 153 medium without antibiotics. Medium containing Sulfamylon (mafenide acetate, 0.85%), Polysporin (polymyxin B sulfate, 1 × 10 4 units/ml-bacitracin, 500 units/ml), gentamicin sulfate (0.1%), modified Dakins solution (25%), and acetic acid (0.25%) all showed statistically significant ( P

  • Cytotoxicity to cultured human keratinocytes of topical antimicrobial agents
    Journal of Surgical Research, 1990
    Co-Authors: Matthew L Cooper, Tanya J. Foreman, Steven T. Boyce, John F Hansbrough, David H. Frank
    Abstract:

    Cultured skin grafts administered clinically for closure of burn wounds may be contacted by topically applied antimicrobial agents. A study was performed to assess whether commonly used topical antimicrobial agents are toxic to cultured human keratinocytes (HK) in vitro. Serum-free MCDB 153 culture medium containing Neosporin G.U. irrigant (Neomycin, 40 micrograms/ml-polymyxin B sulfate, 200 units/ml) and a standard tissue culture antimicrobial agent of penicillin (10,000 units/ml)-streptomycin (10,000 micrograms/ml)-amphotericin B (25 micrograms/ml) had no effect on the keratinocyte growth rates when compared to standard MCDB 153 medium without antibiotics. Medium containing Sulfamylon (mafenide acetate, 0.85%), Polysporin (polymyxin B sulfate, 1 x 10(4) units/ml-bacitracin, 500 units/ml), gentamicin sulfate (0.1%), modified Dakins solution (25%), and acetic acid (0.25%) all showed statistically significant (P less than 0.01) decreases in keratinocyte growth rates. This data suggests that commonly applied antimicrobials may not be appropriate for cultured grafts in the concentrations that are used clinically.

D Regmi - One of the best experts on this subject based on the ideXlab platform.

  • An evaluation of merocel and Neosporin impregnated ribbon gauze packs in patients following nasal surgery: a prospective randomised trial
    2016
    Co-Authors: Rr Joshi, A Nepal, Thapa S Chhetri, Tb Panta, D Regmi
    Abstract:

    Background: Packs are placed following nasal surgeries to arrest haemorrhage, to prevent septal haematoma and synechie formation. Despite Merocel, a tampon constructed from a foam polymer of hydroxylated polyvinyl acetate, which is less abrasive and hence associated with the less pain, we still use Neosporine Impregnated Ribbon Gauze (NIRG). Objective: To compare Merocel and the Neosporine Impregnated Ribbon gauze (NIRG) packs in regards to the post-operative pain levels caused by them and their ability to prevent haemorrhage, crusting and synechie. Methods: The nose was packed after surgery either with the Merocel pack or Neosporin Impregnated Ribbon Gauze (NIRG) according to the randomisation. The pain score was noted on the Visual analog score while packs were in situ and again immediately after the pack removal. The haemorrhage, crusting and synechie were noted if present. Results: Among 106 patients, 61 were male and 45 were female. In Merocel group there were 51 patients and in NIRG group 55. The mean pain score for merocel was 4.15 while in situ and 3.66 immediately after removal where as mean pain score for NIRG was 6 while in situ and 3.78 immediately after removals. Post-operative crusting and synechie were seen relatively more in NIRG pack group. Conclusion: Merocel is superior in terms of both patient comfort and pain

  • An evaluation of merocel and Neosporin impregnated ribbon gauze packs in patients following nasal surgery: a prospective randomised trial
    Health Renaissance, 2012
    Co-Authors: Rr Joshi, Tb Panta, Ashwini Kumar Nepal, S Thapa Chhetri, S Bhandary, D Regmi
    Abstract:

    Background: Packs are placed following nasal surgeries to arrest haemorrhage, to prevent septal haematoma and synechie formation. Despite Merocel, a tampon constructed from a foam polymer of hydroxylated polyvinyl acetate , which is less abrasive and hence associated with the less pain, we still use Neosporine Impregnated Ribbon Gauze (NIRG). Objective: To compare Merocel and the Neosporine Impregnated Ribbon gauze (NIRG) packs in regards to the post-operative pain levels caused by them and their ability to prevent haemorrhage, crusting and synechie. Methods: The nose was packed after surgery either with the Merocel pack or Neosporin Impregnated Ribbon Gauze (NIRG) according to the randomisation. The pain score was noted on the Visual analog score while packs were in situ and again immediately after the pack removal. The haemorrhage, crusting and synechie were noted if present. Results: Among 106 patients, 61 were male and 45 were female. In Merocel group there were 51 patients and in NIRG group 55. The mean pain score for merocel was 4.15 while in situ and 3.66 immediately after removal where as mean pain score for NIRG was 6 while in situ and 3.78 immediately after removals. Post-operative crusting and synechie were seen relatively more in NIRG pack group. Conclusion: Merocel is superior in terms of both patient comfort and pain. DOI: http://dx.doi.org/10.3126/hren.v10i1.6004 HREN 2012; 10(1): 30-34