The Experts below are selected from a list of 36423 Experts worldwide ranked by ideXlab platform
Charles A Nelson - One of the best experts on this subject based on the ideXlab platform.
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assessment of Neurodevelopment nutrition and inflammation from fetal life to adolescence in low resource settings
Pediatrics, 2017Co-Authors: Parminder S Suchdev, Michael J Boivin, Brian W C Forsyth, Michael K Georgieff, Richard L Guerrant, Charles A NelsonAbstract:Efforts to improve child Neurodevelopment are critical to health, equity, and sustainable development, particularly in low-resource settings in the United States and globally. The colliding epidemics of food insecurity, infectious diseases, and noncommunicable diseases interact and impact Neurodevelopment. Understanding the complex relationships between nutrition, inflammation, and Neurodevelopment can inform clinical and public health interventions to improve outcomes. This article reviews key definitions, tools, and considerations for the assessment of nutrition, inflammation, and child Neurodevelopment. The effectiveness of existing assessment tools to reflect status and biology, particularly in relation to each other, and to predict long-term changes in health is examined. The aim of this review is to present the extant evidence, identify critical research gaps, and suggest a research agenda for future longitudinal and intervention studies to address the assessment of nutrition, inflammation, and child Neurodevelopment, particularly in low-resource settings. Despite research gaps, there is a strong relationship between nutrition, inflammation, environmental factors, and child Neurodevelopment, which emphasizes the need to evaluate targeted, early interventions to improve long-term health and well-being.
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Neurodevelopment the impact of nutrition and inflammation during early to middle childhood in low resource settings
Pediatrics, 2017Co-Authors: Chandy C John, Charles A Nelson, Maureen M BlackAbstract:The early to middle childhood years are a critical period for child Neurodevelopment. Nutritional deficiencies, infection, and inflammation are major contributors to impaired child Neurodevelopment in these years, particularly in low-resource settings. This review identifies global research priorities relating to nutrition, infection, and inflammation in early to middle childhood Neurodevelopment. The research priority areas identified include: (1) assessment of how nutrition, infection, or inflammation in the preconception, prenatal, and infancy periods (or interventions in these periods) affect function in early to middle childhood; (2) assessment of whether effects of nutritional interventions vary by poverty or inflammation; (3) determination of the feasibility of preschool- and school-based integrated nutritional interventions; (4) improved assessment of the epidemiology of infection- and inflammation-related Neurodevelopmental impairment (NDI); (5) identification of mechanisms through which infection causes NDI; (6) identification of noninfectious causes of inflammation-related NDI and interventions for causes already identified (eg, environmental factors); and (7) studies on the effects of interactions between nutritional, infectious, and inflammatory factors on Neurodevelopment in early to middle childhood. Areas of emerging importance that require additional study include the effects of maternal Zika virus infection, childhood environmental enteropathy, and alterations in the child’s microbiome on Neurodevelopment in early to middle childhood. Research in these key areas will be critical to the development of interventions to optimize the Neurodevelopmental potential of children worldwide in the early to middle childhood years.
Lourdes Schnaas - One of the best experts on this subject based on the ideXlab platform.
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Prenatal co-exposure to manganese and depression and 24-months Neurodevelopment.
Neurotoxicology, 2017Co-Authors: Teresa Verenice Muñoz-rocha, Lourdes Schnaas, Marcela Tamayo Y Ortiz, Martín Romero, Ivan Pantic, David C. Bellinger, Birgit Claus-henn, Rosalind J. Wright, Robert O. Wright, Martha María Téllez-rojoAbstract:Abstract Background Normal prenatal Neurodevelopment follows stages that are potentially influenced by both chemical and psychosocial environments. Exposure to elevated manganese during this critically vulnerable period has been found to be neurotoxic. Independently, maternal prenatal depression has been associated with subsequent Neurodevelopmental decrements in children. The association between child Neurodevelopment and prenatal co-exposure to manganese and maternal depression has not been sufficiently studied. Methods During pregnancy and at birth, we measured maternal blood and cord blood manganese levels respectively. Maternal depression was assessed in the 3rd trimester of pregnancy using the Edinburgh Depression Scale. Neurodevelopment was evaluated at 24 months of age with the Bayley Scales of Infant Development. A multivariate multiple regression model was used to analyze cognitive, language and motor scores simultaneously for 473 children from the PROGRESS birth cohort in Mexico City. Results Over 25% of our study participants reported having depressive symptoms. 3rd trimester blood manganese as well as depressive symptoms were independently negatively associated with all Neurodevelopment scores in adjusted models. In stratified analyses, the negative association between manganese (maternal as well as cord blood) and 24-month language scores was stronger among women with depressive symptoms. Receptive language was mostly affected. Inverted U-shaped curves were seen for the association between with cord blood manganese and Neurodevelopment scores. Conclusions Our findings are in line with previous studies of manganese and depression neurotoxicity. The prenatal period may be particularly sensitive to manganese and depression co-exposures and should be of interest for public health interventions to promote healthy emotional and nutritional pregnancies.
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Prenatal molybdenum exposure and infant Neurodevelopment in Mexican children
Nutritional neuroscience, 2013Co-Authors: Ruth Argelia Vázquez-salas, Lourdes Schnaas, Mariano E Cebrian, Lizbeth López-carrillo, José A. Menezes-filho, Stephen J. Rothenberg, Gustavo Freitas De Souza Viana, Luisa Torres-sánchezAbstract:Objective To evaluate the association between prenatal exposure to molybdenum (Mo) and infant Neurodevelopment during the first 30 months of life. Methods We selected a random sample of 147 children who participated in a prospective cohort study in four municipalities in the State of Morelos, Mexico. The children were the products of uncomplicated pregnancies with no perinatal asphyxia, with a weight of ≥2 kg at birth, and whose mothers had no history of chronic illnesses. These women were monitored before, during, and after the pregnancy. For each of these children a maternal urine sample was available for at least one trimester of pregnancy, and urine Mo levels were determined by electrothermal atomic absorption spectrometry. Neurodevelopment was evaluated using the psychomotor (PDI) and mental development indices (MDI) of the Bayley scale. Association between prenatal exposure to Mo and infant Neurodevelopment was estimated using generalized mixed effect models. Results The average urinary concentratio...
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prenatal dichlorodiphenyldichloroethylene dde exposure and Neurodevelopment a follow up from 12 to 30 months of age
Neurotoxicology, 2009Co-Authors: Luisa Torressanchez, Lourdes Schnaas, Mariano E Cebrian, Maria Del Carmen Hernandez, Erika Osorio Valencia, Rosa Maria Garcia Hernandez, Lizbeth LopezcarrilloAbstract:In order to evaluate the persistency of the association between DDE and infant Neurodevelopment we assessed mental and psychomotor development between 12 and 30 months of age in an ongoing cohort in Mexico. A total of 270 singleton children without perinatal asphyxia diagnosis, with a birth weight > or =2 kg, mothers>15 years of age with organochlorine maternal serum levels measured at least in one trimester of pregnancy, and who were evaluated at least in two of the four visits at 12, 18, 24 and 30 months of age, were included in this report. The Spanish version of Bayley Scales of Infant Development II (BSID_II; Bayley, 1993) was administered to the children and Psychomotor Development Index (PDI) and Mental Development Index (MDI) were calculated. Information about stimulation at home was measured using the Home Observation of Measurement of the Environment (HOME) at 6 months, and breastfeeding history was obtained through direct interviews with the mothers. Maternal serum DDE levels were determined during pregnancy by means of electron capture gas-liquid chromatography. The association between DDE prenatal exposure and Neurodevelopment was estimated using separate generalized mixed effects models. Our results suggest that the association between prenatal DDE and infant Neurodevelopment does not persist beyond 12 months of age even after adjusting for known risk factors for Neurodevelopment. In addition, we observed an interaction between early home stimulation and mental improvement at 24 and 30 months of age (p<0.001). The association of DDE with infant Neurodevelopment seems to be reversible. However, we cannot rule out that other DDT metabolites may play a role in Neurodevelopment.
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Prenatal dichlorodiphenyldichloroethylene (DDE) exposure and Neurodevelopment: a follow-up from 12 to 30 months of age.
Neurotoxicology, 2009Co-Authors: Luisa Torres-sánchez, Lourdes Schnaas, Mariano E Cebrian, Maria Del Carmen Hernandez, Erika Osorio Valencia, Rosa Maria Garcia Hernandez, Lizbeth López-carrilloAbstract:In order to evaluate the persistency of the association between DDE and infant Neurodevelopment we assessed mental and psychomotor development between 12 and 30 months of age in an ongoing cohort in Mexico. A total of 270 singleton children without perinatal asphyxia diagnosis, with a birth weight > or =2 kg, mothers>15 years of age with organochlorine maternal serum levels measured at least in one trimester of pregnancy, and who were evaluated at least in two of the four visits at 12, 18, 24 and 30 months of age, were included in this report. The Spanish version of Bayley Scales of Infant Development II (BSID_II; Bayley, 1993) was administered to the children and Psychomotor Development Index (PDI) and Mental Development Index (MDI) were calculated. Information about stimulation at home was measured using the Home Observation of Measurement of the Environment (HOME) at 6 months, and breastfeeding history was obtained through direct interviews with the mothers. Maternal serum DDE levels were determined during pregnancy by means of electron capture gas-liquid chromatography. The association between DDE prenatal exposure and Neurodevelopment was estimated using separate generalized mixed effects models. Our results suggest that the association between prenatal DDE and infant Neurodevelopment does not persist beyond 12 months of age even after adjusting for known risk factors for Neurodevelopment. In addition, we observed an interaction between early home stimulation and mental improvement at 24 and 30 months of age (p
Lizbeth López-carrillo - One of the best experts on this subject based on the ideXlab platform.
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Prenatal molybdenum exposure and infant Neurodevelopment in Mexican children
Nutritional neuroscience, 2013Co-Authors: Ruth Argelia Vázquez-salas, Lourdes Schnaas, Mariano E Cebrian, Lizbeth López-carrillo, José A. Menezes-filho, Stephen J. Rothenberg, Gustavo Freitas De Souza Viana, Luisa Torres-sánchezAbstract:Objective To evaluate the association between prenatal exposure to molybdenum (Mo) and infant Neurodevelopment during the first 30 months of life. Methods We selected a random sample of 147 children who participated in a prospective cohort study in four municipalities in the State of Morelos, Mexico. The children were the products of uncomplicated pregnancies with no perinatal asphyxia, with a weight of ≥2 kg at birth, and whose mothers had no history of chronic illnesses. These women were monitored before, during, and after the pregnancy. For each of these children a maternal urine sample was available for at least one trimester of pregnancy, and urine Mo levels were determined by electrothermal atomic absorption spectrometry. Neurodevelopment was evaluated using the psychomotor (PDI) and mental development indices (MDI) of the Bayley scale. Association between prenatal exposure to Mo and infant Neurodevelopment was estimated using generalized mixed effect models. Results The average urinary concentratio...
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Prenatal dichlorodiphenyldichloroethylene (DDE) exposure and Neurodevelopment: a follow-up from 12 to 30 months of age.
Neurotoxicology, 2009Co-Authors: Luisa Torres-sánchez, Lourdes Schnaas, Mariano E Cebrian, Maria Del Carmen Hernandez, Erika Osorio Valencia, Rosa Maria Garcia Hernandez, Lizbeth López-carrilloAbstract:In order to evaluate the persistency of the association between DDE and infant Neurodevelopment we assessed mental and psychomotor development between 12 and 30 months of age in an ongoing cohort in Mexico. A total of 270 singleton children without perinatal asphyxia diagnosis, with a birth weight > or =2 kg, mothers>15 years of age with organochlorine maternal serum levels measured at least in one trimester of pregnancy, and who were evaluated at least in two of the four visits at 12, 18, 24 and 30 months of age, were included in this report. The Spanish version of Bayley Scales of Infant Development II (BSID_II; Bayley, 1993) was administered to the children and Psychomotor Development Index (PDI) and Mental Development Index (MDI) were calculated. Information about stimulation at home was measured using the Home Observation of Measurement of the Environment (HOME) at 6 months, and breastfeeding history was obtained through direct interviews with the mothers. Maternal serum DDE levels were determined during pregnancy by means of electron capture gas-liquid chromatography. The association between DDE prenatal exposure and Neurodevelopment was estimated using separate generalized mixed effects models. Our results suggest that the association between prenatal DDE and infant Neurodevelopment does not persist beyond 12 months of age even after adjusting for known risk factors for Neurodevelopment. In addition, we observed an interaction between early home stimulation and mental improvement at 24 and 30 months of age (p
Mariano E Cebrian - One of the best experts on this subject based on the ideXlab platform.
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Prenatal molybdenum exposure and infant Neurodevelopment in Mexican children
Nutritional neuroscience, 2013Co-Authors: Ruth Argelia Vázquez-salas, Lourdes Schnaas, Mariano E Cebrian, Lizbeth López-carrillo, José A. Menezes-filho, Stephen J. Rothenberg, Gustavo Freitas De Souza Viana, Luisa Torres-sánchezAbstract:Objective To evaluate the association between prenatal exposure to molybdenum (Mo) and infant Neurodevelopment during the first 30 months of life. Methods We selected a random sample of 147 children who participated in a prospective cohort study in four municipalities in the State of Morelos, Mexico. The children were the products of uncomplicated pregnancies with no perinatal asphyxia, with a weight of ≥2 kg at birth, and whose mothers had no history of chronic illnesses. These women were monitored before, during, and after the pregnancy. For each of these children a maternal urine sample was available for at least one trimester of pregnancy, and urine Mo levels were determined by electrothermal atomic absorption spectrometry. Neurodevelopment was evaluated using the psychomotor (PDI) and mental development indices (MDI) of the Bayley scale. Association between prenatal exposure to Mo and infant Neurodevelopment was estimated using generalized mixed effect models. Results The average urinary concentratio...
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prenatal dichlorodiphenyldichloroethylene dde exposure and Neurodevelopment a follow up from 12 to 30 months of age
Neurotoxicology, 2009Co-Authors: Luisa Torressanchez, Lourdes Schnaas, Mariano E Cebrian, Maria Del Carmen Hernandez, Erika Osorio Valencia, Rosa Maria Garcia Hernandez, Lizbeth LopezcarrilloAbstract:In order to evaluate the persistency of the association between DDE and infant Neurodevelopment we assessed mental and psychomotor development between 12 and 30 months of age in an ongoing cohort in Mexico. A total of 270 singleton children without perinatal asphyxia diagnosis, with a birth weight > or =2 kg, mothers>15 years of age with organochlorine maternal serum levels measured at least in one trimester of pregnancy, and who were evaluated at least in two of the four visits at 12, 18, 24 and 30 months of age, were included in this report. The Spanish version of Bayley Scales of Infant Development II (BSID_II; Bayley, 1993) was administered to the children and Psychomotor Development Index (PDI) and Mental Development Index (MDI) were calculated. Information about stimulation at home was measured using the Home Observation of Measurement of the Environment (HOME) at 6 months, and breastfeeding history was obtained through direct interviews with the mothers. Maternal serum DDE levels were determined during pregnancy by means of electron capture gas-liquid chromatography. The association between DDE prenatal exposure and Neurodevelopment was estimated using separate generalized mixed effects models. Our results suggest that the association between prenatal DDE and infant Neurodevelopment does not persist beyond 12 months of age even after adjusting for known risk factors for Neurodevelopment. In addition, we observed an interaction between early home stimulation and mental improvement at 24 and 30 months of age (p<0.001). The association of DDE with infant Neurodevelopment seems to be reversible. However, we cannot rule out that other DDT metabolites may play a role in Neurodevelopment.
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Prenatal dichlorodiphenyldichloroethylene (DDE) exposure and Neurodevelopment: a follow-up from 12 to 30 months of age.
Neurotoxicology, 2009Co-Authors: Luisa Torres-sánchez, Lourdes Schnaas, Mariano E Cebrian, Maria Del Carmen Hernandez, Erika Osorio Valencia, Rosa Maria Garcia Hernandez, Lizbeth López-carrilloAbstract:In order to evaluate the persistency of the association between DDE and infant Neurodevelopment we assessed mental and psychomotor development between 12 and 30 months of age in an ongoing cohort in Mexico. A total of 270 singleton children without perinatal asphyxia diagnosis, with a birth weight > or =2 kg, mothers>15 years of age with organochlorine maternal serum levels measured at least in one trimester of pregnancy, and who were evaluated at least in two of the four visits at 12, 18, 24 and 30 months of age, were included in this report. The Spanish version of Bayley Scales of Infant Development II (BSID_II; Bayley, 1993) was administered to the children and Psychomotor Development Index (PDI) and Mental Development Index (MDI) were calculated. Information about stimulation at home was measured using the Home Observation of Measurement of the Environment (HOME) at 6 months, and breastfeeding history was obtained through direct interviews with the mothers. Maternal serum DDE levels were determined during pregnancy by means of electron capture gas-liquid chromatography. The association between DDE prenatal exposure and Neurodevelopment was estimated using separate generalized mixed effects models. Our results suggest that the association between prenatal DDE and infant Neurodevelopment does not persist beyond 12 months of age even after adjusting for known risk factors for Neurodevelopment. In addition, we observed an interaction between early home stimulation and mental improvement at 24 and 30 months of age (p
Luisa Torres-sánchez - One of the best experts on this subject based on the ideXlab platform.
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Prenatal molybdenum exposure and infant Neurodevelopment in Mexican children
Nutritional neuroscience, 2013Co-Authors: Ruth Argelia Vázquez-salas, Lourdes Schnaas, Mariano E Cebrian, Lizbeth López-carrillo, José A. Menezes-filho, Stephen J. Rothenberg, Gustavo Freitas De Souza Viana, Luisa Torres-sánchezAbstract:Objective To evaluate the association between prenatal exposure to molybdenum (Mo) and infant Neurodevelopment during the first 30 months of life. Methods We selected a random sample of 147 children who participated in a prospective cohort study in four municipalities in the State of Morelos, Mexico. The children were the products of uncomplicated pregnancies with no perinatal asphyxia, with a weight of ≥2 kg at birth, and whose mothers had no history of chronic illnesses. These women were monitored before, during, and after the pregnancy. For each of these children a maternal urine sample was available for at least one trimester of pregnancy, and urine Mo levels were determined by electrothermal atomic absorption spectrometry. Neurodevelopment was evaluated using the psychomotor (PDI) and mental development indices (MDI) of the Bayley scale. Association between prenatal exposure to Mo and infant Neurodevelopment was estimated using generalized mixed effect models. Results The average urinary concentratio...
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Prenatal dichlorodiphenyldichloroethylene (DDE) exposure and Neurodevelopment: a follow-up from 12 to 30 months of age.
Neurotoxicology, 2009Co-Authors: Luisa Torres-sánchez, Lourdes Schnaas, Mariano E Cebrian, Maria Del Carmen Hernandez, Erika Osorio Valencia, Rosa Maria Garcia Hernandez, Lizbeth López-carrilloAbstract:In order to evaluate the persistency of the association between DDE and infant Neurodevelopment we assessed mental and psychomotor development between 12 and 30 months of age in an ongoing cohort in Mexico. A total of 270 singleton children without perinatal asphyxia diagnosis, with a birth weight > or =2 kg, mothers>15 years of age with organochlorine maternal serum levels measured at least in one trimester of pregnancy, and who were evaluated at least in two of the four visits at 12, 18, 24 and 30 months of age, were included in this report. The Spanish version of Bayley Scales of Infant Development II (BSID_II; Bayley, 1993) was administered to the children and Psychomotor Development Index (PDI) and Mental Development Index (MDI) were calculated. Information about stimulation at home was measured using the Home Observation of Measurement of the Environment (HOME) at 6 months, and breastfeeding history was obtained through direct interviews with the mothers. Maternal serum DDE levels were determined during pregnancy by means of electron capture gas-liquid chromatography. The association between DDE prenatal exposure and Neurodevelopment was estimated using separate generalized mixed effects models. Our results suggest that the association between prenatal DDE and infant Neurodevelopment does not persist beyond 12 months of age even after adjusting for known risk factors for Neurodevelopment. In addition, we observed an interaction between early home stimulation and mental improvement at 24 and 30 months of age (p
