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Constança Simões Barbosa - One of the best experts on this subject based on the ideXlab platform.
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Spinal Neuroschistosomiasis caused by Schistoma mansoni: cases reported in two brothers.
BMC infectious diseases, 2020Co-Authors: Ana Lúcia Coutinho Domingues, Constança Simões Barbosa, Thiago Frederico Andrade Agt, Andréia Braga Mota, Clélia Maria Ribeiro Franco, Rodrigo Loyo, Edmundo Pessoa De Almeida Lopes, Elainne Christine De Souza GomesAbstract:Spinal Neuroschistosomiasis (SN) is one of the most severe clinical presentations of schistosomiasis infection and an ectopic form of the disease caused by any species of Schistosoma. In Brazil, all cases of this clinical manifestation are related to Schistosoma mansoni, the only species present in the country. Although many cases have been reported in various endemic areas in Brazil, this is the first time in the literature that SN is described in two brothers. Two cases of SN were accidentally diagnosed during an epidemiological survey in an urban area endemic for schistosomiasis transmission. Both patients complained of low back pain and muscle weakness in the lower limbs. Sphincter dysfunction and various degrees of paresthesia were also reported. The patients’ disease was classified as hepato-intestinal stage schistosomiasis mansoni at the onset of the chronic form. A positive parasitological stool test for S. mansoni, clinical evidence of myeloradicular damage and exclusion of other causes of damage were the basic criteria for diagnosis. After treatment with praziquantel and corticosteroid, the patients presented an improvement in symptoms, although some complaints persisted. It is important to consider SN when patients come from areas endemic for transmission of schistosomiasis mansoni. Clinical physicians and neurologists should consider this diagnostic hypothesis, because recovery from neurological injuries is directly related to early treatment. As, described here in two brothers, a genetic predisposition may be related to neurological involvement. Primary care physicians should thus try to evaluate family members and close relatives in order to arrive at prompt schistosomiasis diagnosis in asymptomatic individuals and propose treatment in an attempt to avoid progression to SN.
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Spinal Neuroschistosomiasis caused by Schistoma mansoni: cases reported in two brothers
BMC Infectious Diseases, 2020Co-Authors: Ana Lúcia Coutinho Domingues, Constança Simões Barbosa, Thiago Frederico Andrade Agt, Andréia Braga Mota, Clélia Maria Ribeiro Franco, Edmundo Pessoa Lopes, Rodrigo Loyo, Elainne Christine Souza GomesAbstract:Background Spinal Neuroschistosomiasis (SN) is one of the most severe clinical presentations of schistosomiasis infection and an ectopic form of the disease caused by any species of Schistosoma . In Brazil, all cases of this clinical manifestation are related to Schistosoma mansoni , the only species present in the country. Although many cases have been reported in various endemic areas in Brazil, this is the first time in the literature that SN is described in two brothers. Case presentation Two cases of SN were accidentally diagnosed during an epidemiological survey in an urban area endemic for schistosomiasis transmission. Both patients complained of low back pain and muscle weakness in the lower limbs. Sphincter dysfunction and various degrees of paresthesia were also reported. The patients’ disease was classified as hepato-intestinal stage schistosomiasis mansoni at the onset of the chronic form. A positive parasitological stool test for S. mansoni , clinical evidence of myeloradicular damage and exclusion of other causes of damage were the basic criteria for diagnosis. After treatment with praziquantel and corticosteroid, the patients presented an improvement in symptoms, although some complaints persisted. Conclusions It is important to consider SN when patients come from areas endemic for transmission of schistosomiasis mansoni. Clinical physicians and neurologists should consider this diagnostic hypothesis, because recovery from neurological injuries is directly related to early treatment. As, described here in two brothers, a genetic predisposition may be related to neurological involvement. Primary care physicians should thus try to evaluate family members and close relatives in order to arrive at prompt schistosomiasis diagnosis in asymptomatic individuals and propose treatment in an attempt to avoid progression to SN.
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Does physical exercise influence in the development of neuroeschistosomiasis
Brain research bulletin, 2019Co-Authors: Tiago Pinheiro Vaz De Carvalho, Christina Alves Peixoto, Igor Henrique Rodrigues De Paiva, Rodrigo Moraes Loyo Arcoverde, Wheverton Ricardo Correia Do Nascimento, Luydson Richardson Silva Vasconcelos, Elainne Christine De Souza Gomes, Constança Simões BarbosaAbstract:Abstract Neuroschistosomiasis is a severe form of presentation of schistosomiasis in which Schistosoma spp. affects the central nervous system. This is the first study performed to analyze whether there is any relationship between physical effort and the appearance of Neuroschistosomiasis, through clinical, molecular and immunological evaluations. An experimental controlled study using 64 male Balb/c inbred mice divided into four groups according to presence or absence of S. mansoni infection and submitted to physical effort or resting was conducted. Thirteen weeks after exercise training, S. mansoni DNA was detected in the brain or spinal cord in about 30% of the infected animals moreover, only S. mansoni-positive samples showed positive labeling for S. mansoni antigens in the brain or spinal cord, with a striking reaction inside the microglia. However, the behavioral tests did not show any clinical symptoms of Neuroschistosomiasis in animals submitted to physical effort or in resting. In animals with S. mansoni-positive DNA, immunohistochemical data revealed astrogliosis and microgliosis, elevated IL-10 levels and decreased TNF-α expression. This study demonstrated that isometric exercise does not promote Neuroschistosomiasis, furthermore, ectopic forms of schistosomiasis in the central nervous system were largely asymptomatic and exhibited a Th2 immune response profile. More experimental studies are necessary in order to characterize the pathological process of experimental Neuroschistosomiasis.
Elainne Christine De Souza Gomes - One of the best experts on this subject based on the ideXlab platform.
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Spinal Neuroschistosomiasis caused by Schistoma mansoni: cases reported in two brothers.
BMC infectious diseases, 2020Co-Authors: Ana Lúcia Coutinho Domingues, Constança Simões Barbosa, Thiago Frederico Andrade Agt, Andréia Braga Mota, Clélia Maria Ribeiro Franco, Rodrigo Loyo, Edmundo Pessoa De Almeida Lopes, Elainne Christine De Souza GomesAbstract:Spinal Neuroschistosomiasis (SN) is one of the most severe clinical presentations of schistosomiasis infection and an ectopic form of the disease caused by any species of Schistosoma. In Brazil, all cases of this clinical manifestation are related to Schistosoma mansoni, the only species present in the country. Although many cases have been reported in various endemic areas in Brazil, this is the first time in the literature that SN is described in two brothers. Two cases of SN were accidentally diagnosed during an epidemiological survey in an urban area endemic for schistosomiasis transmission. Both patients complained of low back pain and muscle weakness in the lower limbs. Sphincter dysfunction and various degrees of paresthesia were also reported. The patients’ disease was classified as hepato-intestinal stage schistosomiasis mansoni at the onset of the chronic form. A positive parasitological stool test for S. mansoni, clinical evidence of myeloradicular damage and exclusion of other causes of damage were the basic criteria for diagnosis. After treatment with praziquantel and corticosteroid, the patients presented an improvement in symptoms, although some complaints persisted. It is important to consider SN when patients come from areas endemic for transmission of schistosomiasis mansoni. Clinical physicians and neurologists should consider this diagnostic hypothesis, because recovery from neurological injuries is directly related to early treatment. As, described here in two brothers, a genetic predisposition may be related to neurological involvement. Primary care physicians should thus try to evaluate family members and close relatives in order to arrive at prompt schistosomiasis diagnosis in asymptomatic individuals and propose treatment in an attempt to avoid progression to SN.
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Does physical exercise influence in the development of neuroeschistosomiasis
Brain research bulletin, 2019Co-Authors: Tiago Pinheiro Vaz De Carvalho, Christina Alves Peixoto, Igor Henrique Rodrigues De Paiva, Rodrigo Moraes Loyo Arcoverde, Wheverton Ricardo Correia Do Nascimento, Luydson Richardson Silva Vasconcelos, Elainne Christine De Souza Gomes, Constança Simões BarbosaAbstract:Abstract Neuroschistosomiasis is a severe form of presentation of schistosomiasis in which Schistosoma spp. affects the central nervous system. This is the first study performed to analyze whether there is any relationship between physical effort and the appearance of Neuroschistosomiasis, through clinical, molecular and immunological evaluations. An experimental controlled study using 64 male Balb/c inbred mice divided into four groups according to presence or absence of S. mansoni infection and submitted to physical effort or resting was conducted. Thirteen weeks after exercise training, S. mansoni DNA was detected in the brain or spinal cord in about 30% of the infected animals moreover, only S. mansoni-positive samples showed positive labeling for S. mansoni antigens in the brain or spinal cord, with a striking reaction inside the microglia. However, the behavioral tests did not show any clinical symptoms of Neuroschistosomiasis in animals submitted to physical effort or in resting. In animals with S. mansoni-positive DNA, immunohistochemical data revealed astrogliosis and microgliosis, elevated IL-10 levels and decreased TNF-α expression. This study demonstrated that isometric exercise does not promote Neuroschistosomiasis, furthermore, ectopic forms of schistosomiasis in the central nervous system were largely asymptomatic and exhibited a Th2 immune response profile. More experimental studies are necessary in order to characterize the pathological process of experimental Neuroschistosomiasis.
Teresa Cristina Abreu Ferrari - One of the best experts on this subject based on the ideXlab platform.
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Neuroschistosomiasis: clinical symptoms and pathogenesis
The Lancet. Neurology, 2011Co-Authors: Teresa Cristina Abreu Ferrari, Paulo Roberto R. MoreiraAbstract:Neuroschistosomiasis, referring to schistosomal involvement of the CNS, when symptomatic, is a severe disorder in which prognosis depends largely on early diagnosis and treatment. It is an underdiagnosed disorder, but has been increasingly reported in populations in endemic areas and in tourists. CNS involvement can occur at any time during schistosomal infection. Both the brain and the spinal cord can be affected. Schistosoma mansoni and Schistosoma haematobium usually cause myelopathy, whereas Schistosoma japonicum usually causes encephalic disease. There are substantial differences in the pathogenesis, clinical presentation, and outcome of the neurological disorder, depending on the phase and clinical form of schistosomiasis in which it occurs.
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Identification and characterization of immune complexes in the cerebrospinal fluid of patients with spinal cord schistosomiasis
Journal of Neuroimmunology, 2010Co-Authors: Teresa Cristina Abreu Ferrari, Luciana Costa Faria, Tatiane S. Vilaça, Cristiane Rodrigues Correa, Alfredo M. GoesAbstract:The pathogenesis of Neuroschistosomiasis is largely unknown. Available evidence suggests that it depends on the presence of parasite eggs in the nervous tissue and on the host's immune response. We investigated the presence of immune complexes (ICs) in the cerebrospinal fluid (CSF) of four patients with spinal cord schistosomiasis (SCS), and performed their characterization. ICs containing soluble egg antigen of Schistosoma mansoni (SEA) were found in the CSF of all the SCS patients. To our knowledge, this is the first evidence of ICs containing schistosomal antigens in the CSF of patients with SCS. Further studies are necessary to confirm our findings and investigate the possible roles of ICs in the pathogenesis of this disease.
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A laboratory test for the diagnosis of Neuroschistosomiasis.
Neurological research, 2010Co-Authors: Teresa Cristina Abreu FerrariAbstract:Abstract Objective: To provide a general description of the studies on spinal cord schistosomiasis that our team has developed in Brazil, with an emphasis on how we have planned the investigations and managed the problems. Methods: Schistosoma mansoni is endemic in extensive areas in Brazil. We review the subject and discuss the design, development and initial evaluation of a diagnostic cerebrospinal fluid enzyme-linked immunoassay test for spinal cord schistosomiasis. Results: Since the late 1980s, several clinical investigations have led to a better understanding of the natural history of this disorder and an improved characterization of its clinical presentations. Spinal cord schistosomiasis is a severe condition that typically presents as an acute/subacute low cord syndrome generally associated with the involvement of the cauda equina roots. Cerebrospinal fluid examination usually shows an inflammatory pattern, and MRI demonstrates findings of an inflammatory spinal cord lesion. Its diagnosis is large...
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Clinical characterization of Neuroschistosomiasis due to Schistosoma mansoni and its treatment.
Acta Tropica, 2008Co-Authors: Teresa Cristina Abreu Ferrari, Paulo Roberto R. Moreira, Aloísio Sales Da CunhaAbstract:The involvement of the central nervous system (CNS) by Schistosoma mansoni may or may not cause clinical manifestations. When symptomatic, Neuroschistosomiasis mansoni (NSM) is one of the most severe presentations of this infection. The neurological manifestations are due to numerous granulomas grouped in confined areas of the spinal cord or the brain. Considering the symptomatic form, myelopathy is far more frequent than the cerebral disease. Spinal cord NSM presents as a low cord syndrome of acute/subacute progression usually associated with involvement of the cauda esquina roots. Lower limbs pain, weakness and sensory disturbance, and autonomic dysfunctions, particularly bladder dysfunction, are often present. Cerebrospinal fluid (CSF) examination generally shows an inflammatory pattern with or without eosinophils and/or IgG against schistosomal antigens. Magnetic resonance imaging (MRI) demonstrates signs of inflammatory myelopathy. Cerebral NSM presents as a slow-expanding intracranial tumor-like lesion. Its clinical manifestations are variable and depend on the increased intracranial pressure and on the site of the lesion. The diagnosis of spinal cord NSM is based on clinical evidence whereas the cerebral disease is usually diagnosed by biopsy of the nervous tissue. There is no consensus on the treatment of NSM. We discuss the literature data on this topic, and suggest a therapeutic approach based on our experience with 69 spinal cord NSM patients who have been followed up by a long period of time. Outcome is largely dependent on early treatment, particularly in the medullar disorder, and is better in cerebral NSM.
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Involvement of central nervous system in the schistosomiasis.
Memorias Do Instituto Oswaldo Cruz, 2004Co-Authors: Teresa Cristina Abreu FerrariAbstract:The involvement of the central nervous system (CNS) by schistosomes may or may not determine clinical manifestations. When symptomatic, Neuroschistosomiasis (NS) is one of the most severe presentations of schistosomal infection. Considering the symptomatic form, cerebral involvement is almost always due to Schistosoma japonicum and the spinal cord disease, caused by S. mansoni or S. haematobium. Available evidence suggests that NS depends basically on the presence of parasite eggs in the nervous tissue and on the host immune response. The patients with cerebral NS usually have the clinical manifestations of increased intracranial pressure associated with focal neurological signs; and those with schistosomal myeloradiculopathy (SMR) present rapidly progressing symptoms of myelitis involving the lower cord, usually in association with the involvement of the cauda esquina roots. The diagnosis of cerebral NS is established by biopsy of the nervous tissue and SMR is usually diagnosed according to a clinical criterion. Antischistosomal drugs, corticosteroids and surgery are the resourses available for treating NS. The outcome is variable and is better in cerebral disease.
Ana Lúcia Coutinho Domingues - One of the best experts on this subject based on the ideXlab platform.
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Spinal Neuroschistosomiasis caused by Schistoma mansoni: cases reported in two brothers
BMC Infectious Diseases, 2020Co-Authors: Ana Lúcia Coutinho Domingues, Constança Simões Barbosa, Thiago Frederico Andrade Agt, Andréia Braga Mota, Clélia Maria Ribeiro Franco, Edmundo Pessoa Lopes, Rodrigo Loyo, Elainne Christine Souza GomesAbstract:Background Spinal Neuroschistosomiasis (SN) is one of the most severe clinical presentations of schistosomiasis infection and an ectopic form of the disease caused by any species of Schistosoma . In Brazil, all cases of this clinical manifestation are related to Schistosoma mansoni , the only species present in the country. Although many cases have been reported in various endemic areas in Brazil, this is the first time in the literature that SN is described in two brothers. Case presentation Two cases of SN were accidentally diagnosed during an epidemiological survey in an urban area endemic for schistosomiasis transmission. Both patients complained of low back pain and muscle weakness in the lower limbs. Sphincter dysfunction and various degrees of paresthesia were also reported. The patients’ disease was classified as hepato-intestinal stage schistosomiasis mansoni at the onset of the chronic form. A positive parasitological stool test for S. mansoni , clinical evidence of myeloradicular damage and exclusion of other causes of damage were the basic criteria for diagnosis. After treatment with praziquantel and corticosteroid, the patients presented an improvement in symptoms, although some complaints persisted. Conclusions It is important to consider SN when patients come from areas endemic for transmission of schistosomiasis mansoni. Clinical physicians and neurologists should consider this diagnostic hypothesis, because recovery from neurological injuries is directly related to early treatment. As, described here in two brothers, a genetic predisposition may be related to neurological involvement. Primary care physicians should thus try to evaluate family members and close relatives in order to arrive at prompt schistosomiasis diagnosis in asymptomatic individuals and propose treatment in an attempt to avoid progression to SN.
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Spinal Neuroschistosomiasis caused by Schistoma mansoni: cases reported in two brothers.
BMC infectious diseases, 2020Co-Authors: Ana Lúcia Coutinho Domingues, Constança Simões Barbosa, Thiago Frederico Andrade Agt, Andréia Braga Mota, Clélia Maria Ribeiro Franco, Rodrigo Loyo, Edmundo Pessoa De Almeida Lopes, Elainne Christine De Souza GomesAbstract:Spinal Neuroschistosomiasis (SN) is one of the most severe clinical presentations of schistosomiasis infection and an ectopic form of the disease caused by any species of Schistosoma. In Brazil, all cases of this clinical manifestation are related to Schistosoma mansoni, the only species present in the country. Although many cases have been reported in various endemic areas in Brazil, this is the first time in the literature that SN is described in two brothers. Two cases of SN were accidentally diagnosed during an epidemiological survey in an urban area endemic for schistosomiasis transmission. Both patients complained of low back pain and muscle weakness in the lower limbs. Sphincter dysfunction and various degrees of paresthesia were also reported. The patients’ disease was classified as hepato-intestinal stage schistosomiasis mansoni at the onset of the chronic form. A positive parasitological stool test for S. mansoni, clinical evidence of myeloradicular damage and exclusion of other causes of damage were the basic criteria for diagnosis. After treatment with praziquantel and corticosteroid, the patients presented an improvement in symptoms, although some complaints persisted. It is important to consider SN when patients come from areas endemic for transmission of schistosomiasis mansoni. Clinical physicians and neurologists should consider this diagnostic hypothesis, because recovery from neurological injuries is directly related to early treatment. As, described here in two brothers, a genetic predisposition may be related to neurological involvement. Primary care physicians should thus try to evaluate family members and close relatives in order to arrive at prompt schistosomiasis diagnosis in asymptomatic individuals and propose treatment in an attempt to avoid progression to SN.
José Roberto Lambertucci - One of the best experts on this subject based on the ideXlab platform.
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Schistosoma mansoni granulomas in the skeletal striated muscles in the murine model of Neuroschistosomiasis: histological findings.
Memorias do Instituto Oswaldo Cruz, 2020Co-Authors: Thiago Andre Alves Fidelis, Paulo Marcos Zech Coelho, Geraldo Brasileiro-filho, Patrícia Martins Parreiras, Neusa Araújo, Marco Vinícius Chaud, Denicezar Angelo Baldo, Nelson Brancaccio Dos Santos, José Roberto LambertucciAbstract:Schistosomiasis mansoni presents many clinical manifestations during migration of schistosomes in their hosts, including diarrhea, hepatomegaly, splenomegaly, liver abscesses, skinlesions, brain tumors and myeloradiculopathy. No lesions have been reported in skeletal striated muscles due to schistosomiasis mansoni in the literature. This short communication reports the histopathological findings on skeletal musculature in a murine model of neuroeschistosomiasis mansoni. Lesions were found in the tongue, masseter muscle, buccinator muscle, digastric muscle and temporalis muscle. Worm recovery was carried out to confirm the infection. We describe here, for the first time in the literature, injuries in the skeletal musculature due to Schistosoma mansoni nfection.
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Characterisation of ocular involvement in an experimental model of Neuroschistosomiasis mansoni.
Memorias do Instituto Oswaldo Cruz, 2019Co-Authors: Thiago Andre Alves Fidelis, Paulo Marcos Zech Coelho, Geraldo Brasileiro-filho, Helena Hollanda Santos, Daniel Vitor Vasconcelos-santos, Patrícia Martins Parreiras, Neusa Araújo, Marco Vinícius Chaud, José Roberto LambertucciAbstract:The Global Burden of Disease Study 2010 listed schistosomiasis among the leading 100 causes of death in Brazil, responsible for 3.6% of the estimated total of deaths globally. Eye and adnexa are very rarely affected by schistosomiasis mansoni, with limited documentation of ocular pathology in this setting. This short communication reports ocular histolopathological findings in a murine model of Neuroschistosomiasis mansoni. Lesions were found in the bulbar conjunctiva, lacrimal gland, choroid and corneoscleral limbus.
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Morbidity of schistosomiasis mansoni in the state of
2016Co-Authors: Minas Gerais Brazil, Sílvio Roberto Sousa-pereira, Ra Costa Drummond, Luciana Cristina, Santos Silva, Ronaldo Santos Do Amaral, Carlos Maurício Antunes, José Roberto LambertucciAbstract:myeloradiculopathy has been implemented in the state of Minas Gerais by the local Health Department. The state was divided in 28 regional health centers and the local representatives have been trained to identify and direct patients with hepatosplenic schistosomiasis and Neuroschistosomiasis to a reference center in Belo Horizonte, the capital of the state of Minas Gerais. Seventy five patients with hepatosplenic schistosomiasis and 54 with schistoso-mal myeloradiculopathy have been referred and examined in the reference center in a period of time of 3 years. Schistosomal myeloradiculopathy should be emphasized because the number of cases reported is increasing rapidly and when timely diagnosed and treated, they respond promptly to treatment. Left untreated, they die or become invalid for life. In our view, the time has come for more active investigation of the different aspects of morbidity caused by schistosomiasis mansoni in Brazil. Key words: schistosomiasis- hepatosplenic schistosomiasis- Neuroschistosomiasis- magnetic resonance imaging-myeloradiculopathy It has been estimated that 4 to 6 million people are infected by Schistosoma mansoni in Brazil and that the states of Minas Gerais and Bahia concentrate 70 % of the cases. Based on two national surveys of schistosomiasi
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Brain schistosomiasis in mice experimentally infected with Schistosoma mansoni
Revista da Sociedade Brasileira de Medicina Tropical, 2014Co-Authors: José Roberto Lambertucci, Thiago Andre Alves Fidelis, Thiago A. Pereira, Paulo Marcos Zech Coelho, Neuza Araujo, Márcia Maria De Souza, Geraldo Brasileiro Filho, Fausto Edmundo Lima Pereira, Carlos AntunesAbstract:Introduction: Human Neuroschistosomiasis has been reported in the literature, but the possibility of modeling Neuroschistosomiasis in mice is controversial. Methods: In two research laboratories in Brazil that maintain the Schistosoma mansoni life cycle in rodents, two mice developed signs of brain disease (hemiplegia and spinning), and both were autopsied. Results: S. mansoni eggs, both with and without granuloma formation, were observed in the brain and meninges of both mice by optical microscopy. Conclusions: This is the first description of eggs in the brains of symptomatic mice that were experimentally infected with S. mansoni. An investigation of experimental Neuroschistosomiasis is now feasible.
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Neuroschistosomiasis mansoni: literature review and guidelines.
The neurologist, 2012Co-Authors: Thiago Cardoso Vale, Sílvio Roberto Sousa-pereira, João Gabriel Ramos Ribas, José Roberto LambertucciAbstract:BACKGROUND Schistosomiasis is a tropical disease caused by worms of the genus Schistosoma. It is endemic in the Caribbean Islands, the middle east, eastern Asia, South America, and Africa. In nonendemic areas, physicians should be aware of this condition in travelers returning from endemic areas and in immigrants. The main disease-causing species are Schistosoma haematobium, Schistosoma mansoni, and Schistosoma japonicum. Neuroschistosomiasis is an ectopic form of the disease that is mainly associated with S. japonicum infection. Involvement of the central nervous system (CNS) in S. mansoni infection is neglected and underestimated. Neuroschistosomiasis mansoni can be classified into cerebral, spinal, and encephalomyelitic forms in the course of an acute or chronic infection. REVIEW SUMMARY We review the CNS involvement by S. mansoni infection with an emphasis on life cycle, epidemiology, pathophysiology and immunology, clinical manifestations, diagnostic criteria, differential diagnosis, current treatment guidelines, and prognosis. CONCLUSIONS Although an underreported CNS infection, found mainly in underdeveloped countries, Neuroschistosomiasis mansoni still causes significant incapacity and morbidity. Hence, neurologists should become familiar with this infection worldwide and include it in the differential diagnosis of CNS involvement in travelers returning from endemic areas and in immigrants.