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Charles W. Bourque - One of the best experts on this subject based on the ideXlab platform.

  • Osmoreception in magnocellular Neurosecretory Cells: from single channels to secretion
    Trends in Neurosciences, 1994
    Co-Authors: Stéphane H. R. Oliet, Charles W. Bourque
    Abstract:

    Abstract Recognizing that osmotic pressure is a principal factor controlling antidiuresis, Verney introduced the term ‘osmoreceptor' to designate the mysterious cerebral structures that regulate vasopressin release from the posterior pituitary. While hormone secretion from the neurohypophysis is influenced by synaptic inputs from other osmoresponsive neurons, magnocellular Neurosecretory Cells currently provide our most comprehensive model of signal detection in an osmoreceptor.

  • Functional N-Methyl-D-Aspartate and Non-N-Methyl-D-Aspartate Receptors are Expressed by Rat Supraoptic Neurosecretory Cells in vitro
    Journal of Neuroendocrinology, 1991
    Co-Authors: Bin Hu, Charles W. Bourque
    Abstract:

    A considerable amount of evidence has accumulated to support a role for excitatory glutamatergic transmission in the regulation of the hypothalamo-neurohypophysial system. Glutamate immunoreactivity has been found in axon terminals forming asymmetric synapses on to magnocellular Neurosecretory Cells and kynurenic acid, a broad spectrum glutamate receptor antagonist inhibits 1) spontaneous electrical activity in vivo, 2) excitatory postsynaptic potentials in hypothalamic slices, and 3) osmotically-evoked vasopressin release from hypothalamic explants. While this provides strong evidence for glutamatergic regulation of hypothalamic magnocellular Neurosecretory Cells, the subtypes of glutamate receptors expressed by these Cells have not been defined. We have, therefore, obtained current and voltage clamp recordings from supraoptic magnocellular Neurosecretory Cells in vitro to investigate the functional and pharmacological properties of their glutamate receptors. Application of micromolar concentrations of L-glutamate, or of the agonists kainate, quisqualate and N-methyl-D-aspartate (NMDA), produced reversible and dose-dependent depolarizations in all Cells tested. These responses were mediated by postsynaptic receptors since they persisted during chemical synaptic blockade with Ca2 + -free or tetrodotoxin-containing solutions. The inward current induced by NMDA showed a marked Mg2+-sensitive voltage dependence, and was blocked by D, L-2-amino-5-phosphonovalerate. In contrast, currents induced by kainate and quisqualate showed linear current-voltage properties and were antagonized by 6-cyano-7-nitroquinoxaline-2,3-dione. We conclude that both NMDA and non-NMDA receptors are expressed by magnocellular Neurosecretory Cells of the rat supraoptic nucleus.

Huang Hui - One of the best experts on this subject based on the ideXlab platform.

  • ULTRASTRUCTURE OF Neurosecretory Cells IN THE PROTOCEREBRUM OF Scylla serrata
    Marine Sciences, 2003
    Co-Authors: Huang Hui
    Abstract:

    Three types of Neurosecretory Cells in the protocerebrum of Scylla serrata were observed using the transmission electron microscope.TypeⅠCells are50～120μm in diameter with many vacuole and few Neurosecretory granule.TypeⅡCells are30～60μmin diameter with developed organelle and various Neurosecretory granule.and TypeⅢCells are15～20μm in diameter with feworganelle and abundant Neurosecretory granule of electron-sparse.The characters of the Neurosecretory Cells in the protocerebrum of Scylla serrata provide the morphological evidence for its lower status during the evolution.

  • Study on the Histology of the Neurosecretory Cells in the Brain of Scylla serrata
    Journal of Xiamen University, 2001
    Co-Authors: Huang Hui
    Abstract:

    The types and distribution of Neurosecretory Cells in the brain of Scylla serrata were investigated with histological method and immunohistochemical method. According to the form of the Cells and the features of the nucleus and cytoplasm, the Neurosecretory Cells in the brain were divided into three types. A diagram of their distribution was also afforded.

Jaideep S Bains - One of the best experts on this subject based on the ideXlab platform.

Sabine Schäfer - One of the best experts on this subject based on the ideXlab platform.

  • Neurosecretory Cells in the honeybee brain and suboesophageal ganglion show FMRFamide‐like immunoreactivity
    The Journal of comparative neurology, 1991
    Co-Authors: Stefan B. Eichmüller, Martin Hammer, Sabine Schäfer
    Abstract:

    Immunocytochemical analysis of the brain and suboesophageal ganglion of the honeybee Apis mellifera L. was combined with Lucifer Yellow backfilling from the corpora cardiaca and intracellular staining of single neurons. It is shown that more than one third of the Cells that display FMRFamide-like immunoreactivity (F-LI) project to the corpora cardiaca, suggesting they are Neurosecretory. Among the ca. 120 median Neurosecretory Cells (MNCs) in the pars intercerebralis about 32 show F-LI. The number of immunoreactive MNCs is highly variable and may depend on age and/or diet. Seven of at least 40 lateral Neurosecretory Cells display F-LI. They project through the brain via the medial branch of the bipartite nervus corporis cardiaci II. In the suboesophageal ganglion three types of immunoreactive Neurosecretory Cells were identified. Together with the median and the lateral Neurosecretory Cells in the brain these Cells project through a single pair of nerves into the corpora cardiaca suggesting that the nervus corporis cardiaci (NCC) of the honeybee is a fusion of NCC I, II, and III described in other insects.

Ulf Bickmeyer - One of the best experts on this subject based on the ideXlab platform.

  • LOCUST MEDIAL Neurosecretory Cells IN VITRO: MORPHOLOGY, ELECTROPHYSIOLOGICAL PROPERTIES AND EFFECTS OF TEMPERATURE
    The Journal of Experimental Biology, 1993
    Co-Authors: Wolfgang Rössler, Ulf Bickmeyer
    Abstract:

    The medial Neurosecretory Cells of the pars intercerebralis in the protocerebrum of larval and adult locusts (Locusta migratoria) were cultured in a chemically defined serum-free culture medium. The morphology of the Cells was investigated by light microscopy and the electrophysiological properties were studied using the patch-clamp technique in the whole-cell configuration. The dissociated Neurosecretory Cells grew new processes under these conditions and were maintained in culture for up to 2 months. The percentage of Cells showing outgrowth was significantly higher in third-instar larvae than in instars 4 and 5 and adults. A primary axonal stump promoted a unipolar cell morphology; in other cases, most Neurosecretory Cells became multipolar. The presence of glial Cells in undissociated groups of Neurosecretory Cells improved outgrowth and the formation of neurite bundles. A considerable number of the recorded Cells showed spiking activity in response to depolarization. The influences of temperature on spike frequency, duration and amplitude as well as on membrane potential and ionic currents were investigated. The results suggest that temperature may directly affect the function of Neurosecretory Cells.