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O B Akinola - One of the best experts on this subject based on the ideXlab platform.

  • diabetes induced prefrontal Nissl Substance deficit and the effects of neem bitter leaf extract treatment
    International Journal of Morphology, 2011
    Co-Authors: O B Akinola, Olaiya G Omotoso, Olufunke O Dosumu, Favour Olotufore
    Abstract:

    La disfuncion cognitiva es presuntamente asociada con un mal manejo de la diabetes mellitus. En este estudio, se presenta el efecto del tratamiento oral combinado con extracto de hoja (CLE) de hoja de neem amarga sobre la corteza prefrontal de ratas Wistar con diabetes. Las ratas Wistar adultas fueron asignadas al azar a uno de los siguientes grupos: control, diabetes (STZ inducida), STZ + CLE, STZ + metformina y CLE. Despues de la eutanasia, los cortes de parafina de la corteza prefrontal se tineron con violeta de cresil rapido, mientras que el malondialdehido (MDA) y la glutation peroxidasa (GPx) fueron analizadas en homogenizados prefrontales. El CLE produce normoglucemia en las ratas hiperglucemicas tratadas. Ademas, las secciones prefrontales tenidas para Nissl no muestran ningun deficit morfologico en todos los grupos excepto en las ratas diabeticas sin tratamiento. En este ultimo caso, hubo una tincion de Nissl debil, mientras que la MDA prefrontal fue significativamente mas alta en comparacion con los grupos de ratas control y las tratadas con CLE (p <0,05). Este estudio mostro que la diabetes mellitus no tratada se asocia con deficit prefrontal de cuerpos de Nissl y estres oxidativo en ratas Wistar. La ausencia de estos deficits en las ratas tratadas CLE, sugiere un efecto neuroprotector del extracto en ratas diabeticas inducidas por estreptozotocina. Esto puede mejorar la funcion cognitiva de la corteza prefrontal en la diabetes mellitus.

  • diabetes induced prefrontal Nissl Substance deficit and the effects of neem bitter leaf extract treatment diabetes inducida por deficit prefrontal de sustancia de Nissl y el efecto del tratamiento con extracto de hoja de neem amargo
    2011
    Co-Authors: Olufunke O Dosumu, Olaiya G Omotoso, O B Akinola
    Abstract:

    ** ** * * AKINOLA, O. B.; OMOTOSO, O. G.; DOSUMU, O. O.; AKINOLA, O. S. & OLOTUFORE, F. Diabetes-Induced prefrontal Nissl Substance deficit and the effects of Neem-Bitter leaf extract treatment. Int. J. Morphol., 29(3):850-856, 2011. SUMMARY: Cognitive dysfunction is reportedly associated with poorly-managed diabetes mellitus. In this study, we report the effect of oral treatment with combined leaf extract (CLE) of neem and bitter leaf on the prefrontal cortex of diabetic Wistar r ats. Adult male Wistar rats were randomized to one of the following groups: control, diabetic (STZ-induced), STZ + CLE, STZ + metformin an d CLE only. At euthanasia, paraffin sections of the prefrontal cortex were stained with cresyl fast violet; while malondialdehyde (MDA) and glutathione peroxidase (GPx) were assayed in prefrontal homogenates. Oral CLE produced normoglycemia in the treated hyperglycaemic rats. Besides, Nissl-stained prefrontal sections showed no morphologic deficits in all the groups except the unt reated diabetic rats. In the latter, there was weak Nissl staining, while prefrontal MDA was significantly high at euthanasia, compare d with the control and CLE-treated rats (P<0.05). This study showed that untreated diabetes mellitus is associated with prefrontal Nissl b ody deficit and oxidative stress in Wistar rats. The absence of these deficits in CLE-treated rats suggests a neuroprotective effect of the extract in streptozotocin-induced diabetic rats. This may improve the cognitive function of the prefrontal cortex in diabetes mellitus.

P C Diegenbach - One of the best experts on this subject based on the ideXlab platform.

  • the use of texture analysis for the discrimination of Nissl Substance in neurons
    Journal of Neuroscience Methods, 1992
    Co-Authors: R B De Heus, P C Diegenbach
    Abstract:

    Structural changes induced by cordotomy in the Nissl Substance of identifiable spinal motoneurons innervating the white musculature of the European eel were quantified with the use of texture features calculated from digitized images. Data were evaluated and the motoneurons classified by using multivariate analysis. The study shows that there are differences in the structural organization of the Nissl Substance of motoneurons taken from control and cordotomized fishes. Distinction could only be made by using texture features, as visual examination of the motoneurons did not reveal any alteration of the studied cellular Substance. Reorganization of the Nissl Substance might be the result of a changed protein metabolism or a changed neuronal activity pattern consequent upon cordotomy. The method employs quick and simple techniques and could be useful in several other neurobiological studies.

Olaiya G Omotoso - One of the best experts on this subject based on the ideXlab platform.

  • diabetes induced prefrontal Nissl Substance deficit and the effects of neem bitter leaf extract treatment
    International Journal of Morphology, 2011
    Co-Authors: O B Akinola, Olaiya G Omotoso, Olufunke O Dosumu, Favour Olotufore
    Abstract:

    La disfuncion cognitiva es presuntamente asociada con un mal manejo de la diabetes mellitus. En este estudio, se presenta el efecto del tratamiento oral combinado con extracto de hoja (CLE) de hoja de neem amarga sobre la corteza prefrontal de ratas Wistar con diabetes. Las ratas Wistar adultas fueron asignadas al azar a uno de los siguientes grupos: control, diabetes (STZ inducida), STZ + CLE, STZ + metformina y CLE. Despues de la eutanasia, los cortes de parafina de la corteza prefrontal se tineron con violeta de cresil rapido, mientras que el malondialdehido (MDA) y la glutation peroxidasa (GPx) fueron analizadas en homogenizados prefrontales. El CLE produce normoglucemia en las ratas hiperglucemicas tratadas. Ademas, las secciones prefrontales tenidas para Nissl no muestran ningun deficit morfologico en todos los grupos excepto en las ratas diabeticas sin tratamiento. En este ultimo caso, hubo una tincion de Nissl debil, mientras que la MDA prefrontal fue significativamente mas alta en comparacion con los grupos de ratas control y las tratadas con CLE (p <0,05). Este estudio mostro que la diabetes mellitus no tratada se asocia con deficit prefrontal de cuerpos de Nissl y estres oxidativo en ratas Wistar. La ausencia de estos deficits en las ratas tratadas CLE, sugiere un efecto neuroprotector del extracto en ratas diabeticas inducidas por estreptozotocina. Esto puede mejorar la funcion cognitiva de la corteza prefrontal en la diabetes mellitus.

  • diabetes induced prefrontal Nissl Substance deficit and the effects of neem bitter leaf extract treatment diabetes inducida por deficit prefrontal de sustancia de Nissl y el efecto del tratamiento con extracto de hoja de neem amargo
    2011
    Co-Authors: Olufunke O Dosumu, Olaiya G Omotoso, O B Akinola
    Abstract:

    ** ** * * AKINOLA, O. B.; OMOTOSO, O. G.; DOSUMU, O. O.; AKINOLA, O. S. & OLOTUFORE, F. Diabetes-Induced prefrontal Nissl Substance deficit and the effects of Neem-Bitter leaf extract treatment. Int. J. Morphol., 29(3):850-856, 2011. SUMMARY: Cognitive dysfunction is reportedly associated with poorly-managed diabetes mellitus. In this study, we report the effect of oral treatment with combined leaf extract (CLE) of neem and bitter leaf on the prefrontal cortex of diabetic Wistar r ats. Adult male Wistar rats were randomized to one of the following groups: control, diabetic (STZ-induced), STZ + CLE, STZ + metformin an d CLE only. At euthanasia, paraffin sections of the prefrontal cortex were stained with cresyl fast violet; while malondialdehyde (MDA) and glutathione peroxidase (GPx) were assayed in prefrontal homogenates. Oral CLE produced normoglycemia in the treated hyperglycaemic rats. Besides, Nissl-stained prefrontal sections showed no morphologic deficits in all the groups except the unt reated diabetic rats. In the latter, there was weak Nissl staining, while prefrontal MDA was significantly high at euthanasia, compare d with the control and CLE-treated rats (P<0.05). This study showed that untreated diabetes mellitus is associated with prefrontal Nissl b ody deficit and oxidative stress in Wistar rats. The absence of these deficits in CLE-treated rats suggests a neuroprotective effect of the extract in streptozotocin-induced diabetic rats. This may improve the cognitive function of the prefrontal cortex in diabetes mellitus.

Olufunke O Dosumu - One of the best experts on this subject based on the ideXlab platform.

  • diabetes induced prefrontal Nissl Substance deficit and the effects of neem bitter leaf extract treatment
    International Journal of Morphology, 2011
    Co-Authors: O B Akinola, Olaiya G Omotoso, Olufunke O Dosumu, Favour Olotufore
    Abstract:

    La disfuncion cognitiva es presuntamente asociada con un mal manejo de la diabetes mellitus. En este estudio, se presenta el efecto del tratamiento oral combinado con extracto de hoja (CLE) de hoja de neem amarga sobre la corteza prefrontal de ratas Wistar con diabetes. Las ratas Wistar adultas fueron asignadas al azar a uno de los siguientes grupos: control, diabetes (STZ inducida), STZ + CLE, STZ + metformina y CLE. Despues de la eutanasia, los cortes de parafina de la corteza prefrontal se tineron con violeta de cresil rapido, mientras que el malondialdehido (MDA) y la glutation peroxidasa (GPx) fueron analizadas en homogenizados prefrontales. El CLE produce normoglucemia en las ratas hiperglucemicas tratadas. Ademas, las secciones prefrontales tenidas para Nissl no muestran ningun deficit morfologico en todos los grupos excepto en las ratas diabeticas sin tratamiento. En este ultimo caso, hubo una tincion de Nissl debil, mientras que la MDA prefrontal fue significativamente mas alta en comparacion con los grupos de ratas control y las tratadas con CLE (p <0,05). Este estudio mostro que la diabetes mellitus no tratada se asocia con deficit prefrontal de cuerpos de Nissl y estres oxidativo en ratas Wistar. La ausencia de estos deficits en las ratas tratadas CLE, sugiere un efecto neuroprotector del extracto en ratas diabeticas inducidas por estreptozotocina. Esto puede mejorar la funcion cognitiva de la corteza prefrontal en la diabetes mellitus.

  • diabetes induced prefrontal Nissl Substance deficit and the effects of neem bitter leaf extract treatment diabetes inducida por deficit prefrontal de sustancia de Nissl y el efecto del tratamiento con extracto de hoja de neem amargo
    2011
    Co-Authors: Olufunke O Dosumu, Olaiya G Omotoso, O B Akinola
    Abstract:

    ** ** * * AKINOLA, O. B.; OMOTOSO, O. G.; DOSUMU, O. O.; AKINOLA, O. S. & OLOTUFORE, F. Diabetes-Induced prefrontal Nissl Substance deficit and the effects of Neem-Bitter leaf extract treatment. Int. J. Morphol., 29(3):850-856, 2011. SUMMARY: Cognitive dysfunction is reportedly associated with poorly-managed diabetes mellitus. In this study, we report the effect of oral treatment with combined leaf extract (CLE) of neem and bitter leaf on the prefrontal cortex of diabetic Wistar r ats. Adult male Wistar rats were randomized to one of the following groups: control, diabetic (STZ-induced), STZ + CLE, STZ + metformin an d CLE only. At euthanasia, paraffin sections of the prefrontal cortex were stained with cresyl fast violet; while malondialdehyde (MDA) and glutathione peroxidase (GPx) were assayed in prefrontal homogenates. Oral CLE produced normoglycemia in the treated hyperglycaemic rats. Besides, Nissl-stained prefrontal sections showed no morphologic deficits in all the groups except the unt reated diabetic rats. In the latter, there was weak Nissl staining, while prefrontal MDA was significantly high at euthanasia, compare d with the control and CLE-treated rats (P<0.05). This study showed that untreated diabetes mellitus is associated with prefrontal Nissl b ody deficit and oxidative stress in Wistar rats. The absence of these deficits in CLE-treated rats suggests a neuroprotective effect of the extract in streptozotocin-induced diabetic rats. This may improve the cognitive function of the prefrontal cortex in diabetes mellitus.

R B De Heus - One of the best experts on this subject based on the ideXlab platform.

  • the use of texture analysis for the discrimination of Nissl Substance in neurons
    Journal of Neuroscience Methods, 1992
    Co-Authors: R B De Heus, P C Diegenbach
    Abstract:

    Structural changes induced by cordotomy in the Nissl Substance of identifiable spinal motoneurons innervating the white musculature of the European eel were quantified with the use of texture features calculated from digitized images. Data were evaluated and the motoneurons classified by using multivariate analysis. The study shows that there are differences in the structural organization of the Nissl Substance of motoneurons taken from control and cordotomized fishes. Distinction could only be made by using texture features, as visual examination of the motoneurons did not reveal any alteration of the studied cellular Substance. Reorganization of the Nissl Substance might be the result of a changed protein metabolism or a changed neuronal activity pattern consequent upon cordotomy. The method employs quick and simple techniques and could be useful in several other neurobiological studies.