The Experts below are selected from a list of 312 Experts worldwide ranked by ideXlab platform
Loren Laine - One of the best experts on this subject based on the ideXlab platform.
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Systematic review: the hepatotoxicity of Non-Steroidal Anti-Inflammatory Drugs.
Alimentary pharmacology & therapeutics, 2004Co-Authors: Joel H. Rubenstein, Loren LaineAbstract:SUMMARY 1 Background: Non-Steroidal Anti-Inflammatory Drugs have been implicated in reports of liver injury. However, the precise risk of Non-Steroidal Anti-Inflammatory Drugs for this rare complication is unknown. Aim: To review systematically the published literature ofpopulation-basedepidemiological studies reportingthe incidence or comparative risk of Non-Steroidal antiinflammatory Drugs for liver injury resulting in clinically significant events, defined as hospitalization or death. Data extraction: Duplicate extraction of the methodological quality, design, source, population, years studied, particular Non-Steroidal Anti-Inflammatory Drugs studied, definitions, patient counts and follow-up, and the adjustment for confounders. Results: Seven articles met inclusion criteria. The comparative risk of liver injury resulting in hospitalization for current Non-Steroidal Anti-Inflammatory drug users compared with past Non-Steroidal antiinflammatory drug users ranged from 1.2 to 1.7, but none was statistically significant. The incidence of liver injury resulting in hospitalization ranged from 3.1 to 23.4/100 000 patient-years of current use of nonsteroidal Anti-Inflammatory Drugs, with an excess risk compared with past Non-Steroidal Anti-Inflammatory Drugs users of 4.8‐8.6/100 000 patient-years of exposure. There were zero deaths from liver injury associated with Non-Steroidal Anti-Inflammatory Drugs use in over 396 392 patient-years of cumulative exposure. Conclusion: These findings allow for the possibility of a small increase in the risk of clinically relevant hepatotoxicity with Non-Steroidal Anti-Inflammatory Drugs use, but do not document that such a risk occurs.
Richard V. Heatley - One of the best experts on this subject based on the ideXlab platform.
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Helicobacter pylori associated chronic gastritis and peptic ulceration in patients taking non‐steroidal anti‐inflammatory Drugs
Alimentary pharmacology & therapeutics, 2007Co-Authors: T. M. Shallcross, B. J. Rathbone, J. I. Wyatt, Richard V. HeatleyAbstract:Helicobacter pylori is now recognized as a frequent cause of histological chronic gastritis, and this has radically changed our understanding of this common condition. In the light of these developments, the traditional view that Non-Steroidal Anti-Inflammatory Drugs are one of the common 'environmental' causes of chronic gastritis has been re-examined. Gastric mucosal biopsies have been studied from 430 patients undergoing routine upper gastrointestinal endoscopy, 99 of whom had recently been taking Non-Steroidal Anti-Inflammatory Drugs. No significant association was found between the use of these Drugs and either the presence of chronic gastritis or the frequency of colonization with H. pylori, although there was a strong association (P less than 0.0001) between H. pylori and gastritis. Non-Steroidal Anti-Inflammatory Drugs appear, however, to modify the inflammatory process in the gastric body, leading to a lower frequency of atrophic gastritis (P less than 0.05). The majority of peptic ulcers were associated with H. pylori irrespective of Non-Steroidal Anti-Inflammatory drug use, but there was a higher frequency of H. pylori negative ulceration in the patients who had used these agents (P less than 0.04). Peptic ulceration was uncommon in the absence of either H. pylori or recent Non-Steroidal Anti-Inflammatory drug use.
Jaime Ribeiro-filho - One of the best experts on this subject based on the ideXlab platform.
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Inclusion Complexes of Non-Steroidal Anti-Inflammatory Drugs with Cyclodextrins: A Systematic Review.
Biomolecules, 2021Co-Authors: Gustavo Marinho Miranda, Vitória Ohana Ramos E Santos, Jonatas Reis Bessa, Yanna C. F. Teles, Sètondji Cocou Modeste Alexandre Yahouédéhou, Marilda Souza Goncalves, Jaime Ribeiro-filhoAbstract:Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) are one of the most widely used classes of medicines in the treatment of inflammation, fever, and pain. However, evidence has demonstrated that these Drugs can induce significant toxicity. In the search for innovative strategies to overcome NSAID-related problems, the incorporation of Drugs into cyclodextrins (CDs) has demonstrated promising results. This study aims to review the impact of cyclodextrin incorporation on the biopharmaceutical and pharmacological properties of Non-Steroidal Anti-Inflammatory Drugs. A systematic search for papers published between 2010 and 2020 was carried out using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) protocol and the following search terms: "Complexation"; AND "Cyclodextrin"; AND "Non-Steroidal Anti-Inflammatory drug". A total of 24 different NSAIDs, 12 types of CDs, and 60 distinct inclusion complexes were identified, with meloxicam and β-CD appearing in most studies. The results of the present review suggest that CDs are drug delivery systems capable of improving the pharmacological and biopharmaceutical properties of Non-Steroidal Anti-Inflammatory Drugs.
Thomas M Macdonald - One of the best experts on this subject based on the ideXlab platform.
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association of upper gastrointestinal toxicity of non steroidal anti inflammatory Drugs with continued exposure cohort study
BMJ, 1997Co-Authors: Thomas M Macdonald, S V Morant, G C Robinson, Mark Mcgilchrist, F. E. Murray, Michael J. Shield, Denis G. McdevittAbstract:OBJECTIVES: To determine the profile of risk of upper gastrointestinal toxicity during continuous treatment with, and after cessation of, Non-Steroidal Anti-Inflammatory Drugs. DESIGN: Cohort study with a prospectively constructed, population based, record linkage database containing details of exposure to all community dispensed Non-Steroidal Anti-Inflammatory Drugs and also all admissions to hospital for upper gastrointestinal diagnoses. SETTING: The population of Tayside, Scotland. SUBJECTS: 52,293 subjects aged 50 and over who received one or more Non-Steroidal Anti-Inflammatory between 1 January 1989 and 31 December 1991 and 73,792 subjects who did not receive one during the same period (controls). MAIN OUTCOME MEASURES: Admission to hospital for upper gastrointestinal bleeding and perforation, and admission for other upper gastrointestinal diagnoses. RESULTS: About 2% of the Non-Steroidal Anti-Inflammatory cohort were admitted with an upper gastrointestinal event during the study period compared with 1.4% of controls. The risk of admission for upper gastrointestinal haemorrhage and perforation was constant during continuous Non-Steroidal Anti-Inflammatory exposure and carried over after the end of exposure. The results were similar for admissions for all upper gastrointestinal events. CONCLUSION: This study provides evidence that Non-Steroidal Anti-Inflammatory toxicity persists with continuous exposure. There seems to be carryover toxicity after the end of prescribing. These findings have implications for the management of patients requiring Non-Steroidal Anti-Inflammatory Drugs.
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Non-Steroidal Anti-Inflammatory Drugs and Acute Appendicitis: A Case-Control Study
Side Effects of Anti-Inflammatory Drugs IV, 1997Co-Authors: K. S. Vaidya, Mark Mcgilchrist, F. E. Murray, Denis G. Mcdevitt, A. Macgregor, J. M. M. Evans, Ad Mcmahon, G. White, Thomas M MacdonaldAbstract:A recent study using patient recall has suggested that use of Non-Steroidal Anti-Inflammatory Drugs is associated with an increased risk of appendicitis.
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topical non steroidal anti inflammatory Drugs and admission to hospital for upper gastrointestinal bleeding and perforation a record linkage case control study
BMJ, 1995Co-Authors: Josie M M Evans, Mark Mcgilchrist, F. E. Murray, Denis G. Mcdevitt, G. White, Alex D Mcmahon, Thomas M MacdonaldAbstract:Abstract Objective: To evaluate the relation between topically applied Non-Steroidal Anti-Inflammatory Drugs and upper gastrointestinal bleeding and perforation. Design: A case-control study with 1103 patients admitted to hospital for upper gastrointestinal bleeding or perforation between January 1990 and December 1992 (cases). Two different control groups were used, with six community controls and with two hospital controls for each case. Previous exposure to topical and oral Non-Steroidal Anti-Inflammatory Drugs and ulcer healing Drugs was assessed. Study population--The population of 319465 people who were resident in Tayside and were registered with a Tayside general practitioner between January 1989 and October 1994. A record linkage database containing all data on hospital events and dispensed Drugs between 1989 and 1992 was used for this population. Main outcome measures: Unadjusted and adjusted odds ratios of exposure in those admitted to hospital compared with controls. Results: Significant unadjusted associations were detected between all three classes of drug and upper gastrointestinal complications. The significant association detected for topical Non-Steroidal Anti-Inflammatory Drugs was no longer evident in analyses which adjusted for the confounding effect of concomitant exposure to oral anti-inflammatories and ulcer healing Drugs (odds ratio=1.45; 95% confidence interval 0.84 to 2.50 with community controls; 1.06; 0.60 to 1.88 with hospital controls). Conclusion: In this study topical Non-Steroidal Anti-Inflammatory Drugs were not significantly associated with upper gastrointestinal bleeding and perforation after adjustment for the confounding effects of concomitant use of oral anti-inflammatories and ulcer healing Drugs.
John M. Pezzuto - One of the best experts on this subject based on the ideXlab platform.
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Non-Steroidal Anti-Inflammatory Drugs in cancer treatment
Expert Opinion on Therapeutic Patents, 2002Co-Authors: Muriel Cuendet, John M. PezzutoAbstract:Epidemiological studies have demonstrated that Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), which are potent cyclooxygenase (COX) inhibitors, mediate cancer preventive and tumour regressive effe...
