The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform
Shyamprasad Kodimule - One of the best experts on this subject based on the ideXlab platform.
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sub acute and acute toxicity of ferula asafoetida and silybum marianum Formulation and effect of the Formulation on delaying gastric emptying
BMC Complementary and Alternative Medicine, 2019Co-Authors: Ramanaiah Illuri, Sudeep Heggar Venkataramana, David Daguet, Shyamprasad KodimuleAbstract:Delayed gastric emptying play an important role in the pathology of functional dyspepsia. Owing to their functional attributes in alleviating the gastrointestinal disorders, single or polyherbal Formulations have gained attention to treat the symptoms of functional dyspepsia. We have investigated the safety and efficacy of a Novel Formulation of Ferula asafoetida oleo resin and standardized Silybum marianum extract (Asdamarin). The effect of asdamarin on delayed gastric emptying was investigated in Sprague Dawley rats using phenol red method. The acute and sub-acute oral toxicity was evaluated in wistar rats following OECD guidelines 425 and 407 respectively. The data were analyzed by one-way ANOVA using GraphPad Prism 5.0 software. Oral administration of Asdamarin dose-dependently improved the delay in gastric emptying as evident from the significant increase in the gastrointestinal transit time (p < 0.001). The LD50 of asdamarin was estimated to be more than 2000 mg/kg. Further, in the 28-day sub-acute toxicity study, the administration of 250, 500 and 1000 mg/kg of Asdamarin did not significantly altered the feed and water consuption, body weight change, biochemical and haematological parameters compared to control animals. Macroscopic and histopathological examination of vital organs revealed no toxic signs. The preliminary data from the present study provides the first evidence on the possible effectiveness of Novel Formulation of F. Asafoatida and S. marianum extracts in alleviating the associated symptoms of functional dyspepsia. The toxicity data indicated that Asdamarin can be considered safe up to 1000 mg/kg dose.
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sub acute and acute toxicity of ferula asafoetida and silybum marianum Formulation and effect of the Formulation on delaying gastric emptying
BMC Complementary and Alternative Medicine, 2019Co-Authors: Ramanaiah Illuri, Sudeep Heggar Venkataramana, David Daguet, Shyamprasad KodimuleAbstract:Delayed gastric emptying play an important role in the pathology of functional dyspepsia. Owing to their functional attributes in alleviating the gastrointestinal disorders, single or polyherbal Formulations have gained attention to treat the symptoms of functional dyspepsia. We have investigated the safety and efficacy of a Novel Formulation of Ferula asafoetida oleo resin and standardized Silybum marianum extract (Asdamarin). The effect of asdamarin on delayed gastric emptying was investigated in Sprague Dawley rats using phenol red method. The acute and sub-acute oral toxicity was evaluated in wistar rats following OECD guidelines 425 and 407 respectively. The data were analyzed by one-way ANOVA using GraphPad Prism 5.0 software. Oral administration of Asdamarin dose-dependently improved the delay in gastric emptying as evident from the significant increase in the gastrointestinal transit time (p < 0.001). The LD50 of asdamarin was estimated to be more than 2000 mg/kg. Further, in the 28-day sub-acute toxicity study, the administration of 250, 500 and 1000 mg/kg of Asdamarin did not significantly altered the feed and water consuption, body weight change, biochemical and haematological parameters compared to control animals. Macroscopic and histopathological examination of vital organs revealed no toxic signs. The preliminary data from the present study provides the first evidence on the possible effectiveness of Novel Formulation of F. Asafoatida and S. marianum extracts in alleviating the associated symptoms of functional dyspepsia. The toxicity data indicated that Asdamarin can be considered safe up to 1000 mg/kg dose.
Gleb B Sukhorukov - One of the best experts on this subject based on the ideXlab platform.
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Novel Formulation of chlorhexidine spheres and sustained release with multilayered encapsulation
ACS Applied Materials & Interfaces, 2016Co-Authors: Dong Luo, Saroash Shahid, Rory M Wilson, Michael J Cattell, Gleb B SukhorukovAbstract:This work demonstrates the synthesis of new chlorhexidine polymorphs with controlled morphology and symmetry, which were used as a template for layer-by-layer (LbL) encapsulation. LbL self-assembly of oppositely charged polyelectrolytes onto the drug surface was used in the current work, as an efficient method to produce a carrier with high drug content, improved drug solubility and sustained release. Coprecipitation of the chlorhexidine polymorphs was performed using chlorhexidine diacetate and calcium chloride solutions. Porous interconnected chlorhexidine spheres were produced by tuning the concentration of calcium chloride. The size of these drug colloids could be further controlled from 5.6 μm to over 20 μm (diameter) by adjusting the coprecipitation temperature. The chlorhexidine content in the spheres was determined to be as high as 90%. These particles were further stabilized by depositing 3.5 bilayers of poly(allylamine hydrochloride) (PAH) and polystyrenesulfonate (PSS) on the surface. In vitro ...
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Novel Formulation of Chlorhexidine Spheres and Sustained Release with Multilayered Encapsulation
2016Co-Authors: Dong Luo, Saroash Shahid, Rory M Wilson, Michael J. Cattell, Gleb B SukhorukovAbstract:This work demonstrates the synthesis of new chlorhexidine polymorphs with controlled morphology and symmetry, which were used as a template for layer-by-layer (LbL) encapsulation. LbL self-assembly of oppositely charged polyelectrolytes onto the drug surface was used in the current work, as an efficient method to produce a carrier with high drug content, improved drug solubility and sustained release. Coprecipitation of the chlorhexidine polymorphs was performed using chlorhexidine diacetate and calcium chloride solutions. Porous interconnected chlorhexidine spheres were produced by tuning the concentration of calcium chloride. The size of these drug colloids could be further controlled from 5.6 μm to over 20 μm (diameter) by adjusting the coprecipitation temperature. The chlorhexidine content in the spheres was determined to be as high as 90%. These particles were further stabilized by depositing 3.5 bilayers of poly(allylamine hydrochloride) (PAH) and polystyrenesulfonate (PSS) on the surface. In vitro release kinetics of chlorhexidine capsules showed that the multilayer shells could prolong the release, which was further demonstrated by characterizing the remaining chlorhexidine capsules with SEM and confocal microscopy. The new chlorhexidine polymorph and LbL coating has created Novel chlorhexidine Formulations. Further modification to the chlorhexidine polymorph structure is possible to achieve both sustained and stimuli responsive release, which will enhance its clinical performance in medicine and dentistry
Ramanaiah Illuri - One of the best experts on this subject based on the ideXlab platform.
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sub acute and acute toxicity of ferula asafoetida and silybum marianum Formulation and effect of the Formulation on delaying gastric emptying
BMC Complementary and Alternative Medicine, 2019Co-Authors: Ramanaiah Illuri, Sudeep Heggar Venkataramana, David Daguet, Shyamprasad KodimuleAbstract:Delayed gastric emptying play an important role in the pathology of functional dyspepsia. Owing to their functional attributes in alleviating the gastrointestinal disorders, single or polyherbal Formulations have gained attention to treat the symptoms of functional dyspepsia. We have investigated the safety and efficacy of a Novel Formulation of Ferula asafoetida oleo resin and standardized Silybum marianum extract (Asdamarin). The effect of asdamarin on delayed gastric emptying was investigated in Sprague Dawley rats using phenol red method. The acute and sub-acute oral toxicity was evaluated in wistar rats following OECD guidelines 425 and 407 respectively. The data were analyzed by one-way ANOVA using GraphPad Prism 5.0 software. Oral administration of Asdamarin dose-dependently improved the delay in gastric emptying as evident from the significant increase in the gastrointestinal transit time (p < 0.001). The LD50 of asdamarin was estimated to be more than 2000 mg/kg. Further, in the 28-day sub-acute toxicity study, the administration of 250, 500 and 1000 mg/kg of Asdamarin did not significantly altered the feed and water consuption, body weight change, biochemical and haematological parameters compared to control animals. Macroscopic and histopathological examination of vital organs revealed no toxic signs. The preliminary data from the present study provides the first evidence on the possible effectiveness of Novel Formulation of F. Asafoatida and S. marianum extracts in alleviating the associated symptoms of functional dyspepsia. The toxicity data indicated that Asdamarin can be considered safe up to 1000 mg/kg dose.
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sub acute and acute toxicity of ferula asafoetida and silybum marianum Formulation and effect of the Formulation on delaying gastric emptying
BMC Complementary and Alternative Medicine, 2019Co-Authors: Ramanaiah Illuri, Sudeep Heggar Venkataramana, David Daguet, Shyamprasad KodimuleAbstract:Delayed gastric emptying play an important role in the pathology of functional dyspepsia. Owing to their functional attributes in alleviating the gastrointestinal disorders, single or polyherbal Formulations have gained attention to treat the symptoms of functional dyspepsia. We have investigated the safety and efficacy of a Novel Formulation of Ferula asafoetida oleo resin and standardized Silybum marianum extract (Asdamarin). The effect of asdamarin on delayed gastric emptying was investigated in Sprague Dawley rats using phenol red method. The acute and sub-acute oral toxicity was evaluated in wistar rats following OECD guidelines 425 and 407 respectively. The data were analyzed by one-way ANOVA using GraphPad Prism 5.0 software. Oral administration of Asdamarin dose-dependently improved the delay in gastric emptying as evident from the significant increase in the gastrointestinal transit time (p < 0.001). The LD50 of asdamarin was estimated to be more than 2000 mg/kg. Further, in the 28-day sub-acute toxicity study, the administration of 250, 500 and 1000 mg/kg of Asdamarin did not significantly altered the feed and water consuption, body weight change, biochemical and haematological parameters compared to control animals. Macroscopic and histopathological examination of vital organs revealed no toxic signs. The preliminary data from the present study provides the first evidence on the possible effectiveness of Novel Formulation of F. Asafoatida and S. marianum extracts in alleviating the associated symptoms of functional dyspepsia. The toxicity data indicated that Asdamarin can be considered safe up to 1000 mg/kg dose.
Christophe Baudouin - One of the best experts on this subject based on the ideXlab platform.
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polyquad preserved travoprost timolol benzalkonium chloride bak preserved travoprost timolol and latanoprost timolol in fixed combinations a rabbit ocular surface study
Advances in Therapy, 2011Co-Authors: Hong Liang, Francoise Brignolebaudouin, Aude Pauly, Luisa Riancho, Christophe BaudouinAbstract:Introduction The aim of this study was to use a validated acute rabbit model to test the toxicity of a Novel Formulation of fixed-combination travoprost 0.004%/timolol 0.5% ophthalmic solution, which contains the antimicrobial preservative polyquaternium-1 (PQ), compared with the commercial Formulation of fixed combinations travoprost 0.004%/timolol 0.5% ophthalmic solution and latanoprost 0.005%/timolol 0.5% ophthalmic solution, which both contain the preservative benzalkonium chloride (BAK).
Luisa Riancho - One of the best experts on this subject based on the ideXlab platform.
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polyquad preserved travoprost timolol benzalkonium chloride bak preserved travoprost timolol and latanoprost timolol in fixed combinations a rabbit ocular surface study
Advances in Therapy, 2011Co-Authors: Hong Liang, Francoise Brignolebaudouin, Aude Pauly, Luisa Riancho, Christophe BaudouinAbstract:Introduction The aim of this study was to use a validated acute rabbit model to test the toxicity of a Novel Formulation of fixed-combination travoprost 0.004%/timolol 0.5% ophthalmic solution, which contains the antimicrobial preservative polyquaternium-1 (PQ), compared with the commercial Formulation of fixed combinations travoprost 0.004%/timolol 0.5% ophthalmic solution and latanoprost 0.005%/timolol 0.5% ophthalmic solution, which both contain the preservative benzalkonium chloride (BAK).
