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Michael Muller - One of the best experts on this subject based on the ideXlab platform.
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human Nutrigenomics of gene regulation by dietary fatty acids
Progress in Lipid Research, 2012Co-Authors: Lydia A Afman, Michael MullerAbstract:Nutrigenomics employs high-throughput genomics technologies to unravel how nutrients modulate gene and protein expression and ultimately influence cellular and organism metabolism. The most often-applied genomics technique so far is transcriptomics, which allows quantifying genome-wide changes in gene expression of thousands of genes at the same time in one sample. The performance of gene expression quantification requires sufficient high-quality homogenous cellular material, therefore research in healthy volunteers is restricted to biopsies from easy accessible tissues such as subcutaneous adipose tissue, skeletal muscle and intestinal biopsies or even more easily accessible cells such as peripheral blood mononuclear cells from blood. There is now significant evidence that fatty acids, in particular unsaturated fatty acids, exert many of their effects through modulation of gene transcription by regulating the activity of numerous transcription factors, including nuclear receptors such as peroxisome proliferator activated receptors, liver X receptor and sterol regulatory binding proteins. This review evaluates the human Nutrigenomics studies performed on dietary fat since the initiation of Nutrigenomics research around 10 years ago. Although the number of studies is still limited, all studies clearly suggest that changes in dietary fatty acids intake and composition can have a significant impact on cellular adaptive response capacity by gene transcription changes in humans. This adds important knowledge to our understanding of the strong effects that various fatty acids can have on numerous metabolic and inflammatory pathways, signaling routes and homeostatic control in the cell and ultimately on whole body health. It is important to use and integrate Nutrigenomics in all future nutrition studies to build up the necessary framework for evidence-based nutrition in near future.
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design guidelines for the development of digital Nutrigenomics learning material for heterogeneous target groups
Advances in Physiology Education, 2007Co-Authors: Maria C Busstra, Sander Kersten, Rob Hartog, Michael MullerAbstract:Nutritional genomics, or Nutrigenomics, can be considered as the combination of molecular nutrition and genomics. Students who attend courses in Nutrigenomics differ with respect to their prior kno...
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Nutrigenomics from molecular nutrition to prevention of disease
Journal of The American Dietetic Association, 2006Co-Authors: Lydia A Afman, Michael MullerAbstract:Abstract Until recently, nutrition research concentrated on nutrient deficiencies and impairment of health. The advent of genomics—interpreted broadly as a suite of high throughput technologies for the generation, processing, and application of scientific information about the composition and functions of genomes—has created unprecedented opportunities for increasing our understanding of how nutrients modulate gene and protein expression and ultimately influence cellular and organismal metabolism. Nutritional genomics (Nutrigenomics), the junction between health, diet, and genomics, can be seen as the combination of molecular nutrition and genomics. The diverse tissue and organ-specific effects of bioactive dietary components include gene-expression patterns (transcriptome); organization of the chromatin (epigenome); protein-expression patterns, including posttranslational modifications (proteome); as well as metabolite profiles (metabolome). Nutrigenomics will promote an increased understanding of how nutrition influences metabolic pathways and homeostatic control, how this regulation is disturbed in the early phases of diet-related disease, and the extent to which individual sensitizing genotypes contribute to such diseases. Eventually, Nutrigenomics will lead to evidence-based dietary intervention strategies for restoring health and fitness and for preventing diet-related disease. In this review, we provide a brief overview of Nutrigenomics from our point of view by describing current strategies, future opportunities, and challenges.
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Nutrigenomics goals and strategies
Nature Reviews Genetics, 2003Co-Authors: Michael Muller, Sander KerstenAbstract:Nutrigenomics is the application of high-throughput genomics tools in nutrition research. Applied wisely, it will promote an increased understanding of how nutrition influences metabolic pathways and homeostatic control, how this regulation is disturbed in the early phase of a diet-related disease and to what extent individual sensitizing genotypes contribute to such diseases. Ultimately, Nutrigenomics will allow effective dietary-intervention strategies to recover normal homeostasis and to prevent diet-related diseases.
Marie-claude Vohl - One of the best experts on this subject based on the ideXlab platform.
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Nutrigenomics perspectives from registered dietitians a report from the quebec wide e consultation on Nutrigenomics among registered dietitians
Journal of Human Nutrition and Dietetics, 2014Co-Authors: Hubert Cormier, Bénédicte L. Tremblay, Ann-marie Paradis, Véronique Garneau, Sophie Desroches, Julie Robitaille, Marie-claude VohlAbstract:Background Not all healthcare professionals are familiar with Nutrigenomics. However, they recognise that Nutrigenomics has great potential for the development of preventive health approaches. The present study aimed to provide an overall picture of the current situation about Nutrigenomics in the practice of registered dietitians (RDs) from the province of Quebec (Canada). Methods Three hundred and seventy-three RDs members of the Ordre professionnel des dietetistes du Quebec completed an online survey that included 34 questions, most of which were closed-ended questions. Results Overall, 76.9% of RDs knew about Nutrigenomics. Among RDs with <5 years of experience, 49.2% knew about genetic testing related to nutrition compared to 11.7% for RDs with over 25 years of experience. Currently, 75.9% of RDs working in clinical nutrition in the public sector consider that they do not have the basic knowledge to integrate Nutrigenomics in their practice compared to 62.9% for RDs in private practice. When asked about main limitations of genetic testing related to nutrition, RDs considered that genetic testing does not consider the other determinants of health, that genetic testing and their results have poor accuracy, and that there is a lack of scientific evidence. Concerns remained about ethical and legal aspects and its difficult application as a result of poor understanding and/or interpretation by professionals and/or customers. The high costs of these tests were also noted as a limitation. Conclusions Registered dietitians know and are interested in Nutrigenomics, especially those with less experience, although they do not feel adequately qualified to integrate findings from Nutrigenomics into their practice.
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Nutrigenomics - perspectives from registered dietitians: a report from the Quebec-wide e-consultation on Nutrigenomics among registered dietitians.
Journal of Human Nutrition and Dietetics, 2014Co-Authors: Hubert Cormier, Bénédicte L. Tremblay, Ann-marie Paradis, Véronique Garneau, Sophie Desroches, Julie Robitaille, Marie-claude VohlAbstract:Background Not all healthcare professionals are familiar with Nutrigenomics. However, they recognise that Nutrigenomics has great potential for the development of preventive health approaches. The present study aimed to provide an overall picture of the current situation about Nutrigenomics in the practice of registered dietitians (RDs) from the province of Quebec (Canada). Methods Three hundred and seventy-three RDs members of the Ordre professionnel des dietetistes du Quebec completed an online survey that included 34 questions, most of which were closed-ended questions. Results Overall, 76.9% of RDs knew about Nutrigenomics. Among RDs with
Lynnette R Ferguson - One of the best experts on this subject based on the ideXlab platform.
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Research in Nutrigenomics and potential applications
2020Co-Authors: Lynnette R FergusonAbstract:Aim: Nutrigenomics reflects gene–diet interactions. In recent years, the science of Nutrigenomics has become more sophisticated. We seek to answer the question as to what this might mean for the dietetics profession. Methods: We have critically reviewed recent developments in the area, and considered the importance of new business opportunities being opened up, which exploit the full potential of Nutrigenomics for dietitians. Results: Whereas early business models sold genetic test results through direct-to-consumer testing, new business initiatives move dietitians to a central role. This now provides a robust framework that can inform dietitians in their practice. Conclusion: This field represents an important advance for dietitians.
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guide and position of the international society of nutrigenetics Nutrigenomics on personalised nutrition part 1 fields of precision nutrition
Journal of Nutrigenetics and Nutrigenomics, 2016Co-Authors: Lynnette R Ferguson, Hooman Allayee, Ulf Gorman, Raffaele De Caterina, Martin Kohlmeier, Chandan Prasad, Myungsook Choi, Rui Curi, D A De LuisAbstract:Diversity in the genetic profile between individuals and specific ethnic groups affects nutrient requirements, metabolism and response to nutritional and dietary interventions. Indeed, individuals respond differently to lifestyle interventions (diet, physical activity, smoking, etc.). The sequencing of the human genome and subsequent increased knowledge regarding human genetic variation is contributing to the emergence of personalized nutrition. These advances in genetic science are raising numerous questions regarding the mode that precision nutrition can contribute solutions to emerging problems in public health, by reducing the risk and prevalence of nutrition-related diseases. Current views on personalized nutrition encompass omics technologies (Nutrigenomics, transcriptomics, epigenomics, foodomics, metabolomics, metagenomics, etc.), functional food development and challenges related to legal and ethical aspects, application in clinical practice, and population scope, in terms of guidelines and epidemiological factors. In this context, precision nutrition can be considered as occurring at three levels: (1) conventional nutrition based on general guidelines for population groups by age, gender and social determinants; (2) individualized nutrition that adds phenotypic information about the person's current nutritional status (e.g. anthropometry, biochemical and metabolic analysis, physical activity, among others), and (3) genotype-directed nutrition based on rare or common gene variation. Research and appropriate translation into medical practice and dietary recommendations must be based on a solid foundation of knowledge derived from studies on nutrigenetics and Nutrigenomics. A scientific society, such as the International Society of Nutrigenetics/Nutrigenomics (ISNN), internationally devoted to the study of nutrigenetics/Nutrigenomics, can indeed serve the commendable roles of (1) promoting science and favoring scientific communication and (2) permanently working as a 'clearing house' to prevent disqualifying logical jumps, correct or stop unwarranted claims, and prevent the creation of unwarranted expectations in patients and in the general public. In this statement, we are focusing on the scientific aspects of disciplines covering nutrigenetics and Nutrigenomics issues. Genetic screening and the ethical, legal, social and economic aspects will be dealt with in subsequent statements of the Society. (Less)
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Research in Nutrigenomics and potential applications to practice
Nutrition & Dietetics, 2012Co-Authors: Lynnette R Ferguson, Matthew P. G. BarnettAbstract:Aim: Nutrigenomics reflects gene–diet interactions. In recent years, the science of Nutrigenomics has become more sophisticated. We seek to answer the question as to what this might mean for the dietetics profession. Methods: We have critically reviewed recent developments in the area, and considered the importance of new business opportunities being opened up, which exploit the full potential of Nutrigenomics for dietitians. Results: Whereas early business models sold genetic test results through direct-to-consumer testing, new business initiatives move dietitians to a central role. This now provides a robust framework that can inform dietitians in their practice. Conclusion: This field represents an important advance for dietitians.
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Nutrigenetics, Nutrigenomics, and Selenium
Frontiers in Genetics, 2011Co-Authors: Lynnette R Ferguson, Nishi KarunasingheAbstract:Selenium (Se) is an important micronutrient that, as a component of selenoproteins, influences oxidative and inflammatory processes. Its’ levels vary considerably, with different ethnic and geographic population groups showing varied conditions, ranging from frank Se deficiencies to toxic effects. An optimum Se level is essential for the maintenance of homeostasis, and this optimum may vary according to life stage, general state of health and genotype. Nutrigenetic studies of different Se levels, in the presence of genetic variants in selenoproteins, suggest that an effective dietary Se intake for one individual may be very different from that for others. However, we are just starting to learn the significance of various genes in selenoprotein pathways, functional variants in these, and how to combine such data from genes into pathways, alongside dietary intake or serum levels of Se. Advances in systems biology, genetics and genomics technologies, including genetic/genomic, epigenetic/epigenomic, transcriptomic, proteomic and metabolomic information, start to make it feasible to assess a comprehensive spectrum of the biological activity of Se. Such nutrigenomic approaches may prove very sensitive biomarkers of optimal Se status at the individual or population level. The premature cessation of a major human Se intervention trial has led to considerable controversy as to the value of Se supplementation at the population level. New websites provide convenient links to current information on methodologies available for nutrigenetics and Nutrigenomics. These new technologies will increasingly become an essential tool in optimising the level of Se and other micronutrients for optimal health, in individuals and in population groups. However, definitive proof of such effects will require very large collaborative studies, international agreement on study design and innovative approaches to data analysis.
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nutrigenetics and Nutrigenomics viewpoints on the current status and applications in nutrition research and practice
Journal of Nutrigenetics and Nutrigenomics, 2011Co-Authors: Michael Fenech, Ahmed Elsohemy, Leah E Cahill, Lynnette R Ferguson, Tapaeruariki C French, John A Milner, Michelle Zucker, Michael Buckley, Leah J Cosgrove, Trevor LockettAbstract:Nutrigenetics and Nutrigenomics hold much promise for providing better nutritional advice to the public generally, genetic subgroups and individuals. Because nutrigenetics and Nutrigenomics require a deep understanding of nutrition, genetics and biochemistry and ever new ‘omic’ technologies, it is often difficult, even for educated professionals, to appreciate their relevance to the practice of preventive approaches for optimising health, delaying onset of disease and diminishing its severity. This review discusses (i) the basic concepts, technical terms and technology involved in nutrigenetics and Nutrigenomics; (ii) how this emerging knowledge can be applied to optimise health, prevent and treat diseases; (iii) how to read, understand and interpret nutrigenetic and nutrigenomic research results, and (iv) how this knowledge may potentially transform nutrition and dietetic practice, and the implications of such a transformation. This is in effect an up-to-date overview of the various aspects of nutrigenetics and Nutrigenomics relevant to health practitioners who are seeking a better understanding of this new frontier in nutrition research and its potential application to dietetic practice.
David Castle - One of the best experts on this subject based on the ideXlab platform.
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The Personal and the Public in Nutrigenomics
Nutrition and Genomics, 2020Co-Authors: David CastleAbstract:Publisher Summary Nutrigenomics is the study of the intersection of nutrition and genetics. Nutrigenomics presents an interesting, real-life case for considering persistent themes in human genomics about the relationship between individual people, the groups they belong to, their societies, and the human population as a whole. Nutrigenomics research has been translated into direct-to-consumer applications. These commercial products and services focus on empowering people by individualizing and privatizing genomic technologies. The focus on personalization raises questions whether public health applications of Nutrigenomics might be forthcoming. This chapter reviews personalization of Nutrigenomics as a knowledge translation focus of the Human Genome Project. The potential for preventative nutrigenomic applications in a public health model is also discussed in the chapter, with some potential nutrigenomic applications. The chapter concludes with some reflections on how public health Nutrigenomics can be implemented and evaluated.
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Intellectual Property and Nutrigenomics
Health law review, 2008Co-Authors: David CastleAbstract:Introduction Evidence for the connection between good nutritional regimens and healthy living comes from many quarters: personal testimony, folk wisdom, cross-cultural comparisons, dietetics, naturopathy and other health care modalities, and clinical epidemiology. On the face of it, recommendations to eat fruits and vegetables each day, but not eat a daily pound of butter, are over-determined by available evidence. Yet this might just be literally on the face of it, since many of the strongest associations between diet and heath are based on contestable food recall data paired with phenotypic information drawn from memories, retrospective studies and secondary uses of clinical data. During the short histories of evidence-based medicine and the nutritional sciences this is how it has been: in a sense everyone knows about healthy eating, but explaining what that means in scientific terms has been difficult to achieve. Two methodological advances in the biological and medical sciences have, since the f950s, dramatically changed the evidence base for understanding diet-health interactions. The first is that the biological and medical sciences have become increasingly experimental, and the second is the shift to a molecular focus. The result is the development of molecular, experimental nutritional sciences, (1) and the advent of the Human Genome Project and molecular genetics. (2) One can now begin to point to causal explanations about the underlying mechanisms that make some diets appear to be healthier than others. More significantly, human genomics and genetics are beginning to reveal how diet and health are linked not only through the physiological activity of nutrients, but that nutrients are involved in the cascade of events beginning with gene regulation and expression. Nutrigenomics lies at the crossroads of these major developments in the nutritional sciences and human genomics and genetics, and it is also developing at a time when the commercialization of research is an expected outcome of research funding. Technology transfer of bench science to publicly accessible applications is a high priority for universities and their funders who coordinate with private sector companies and investors to bring new products and services to market. Nutrigenomics is a growing field of innovative research and development, it has opened a new field of environmental genomics research, (3) and represents a novel and potentially high-value proposition recognized already by private sector interests. Accordingly, proprietary interest in Nutrigenomics has resulted in a number of patents being issued, or existing patents being licensed for use in Nutrigenomics applications. The purpose of this paper is to give an overview of the status of intellectual property rights, particularly patents, in the emerging field of Nutrigenomics. It is not a formal and exhaustive review of all Nutrigenomics patents, licensing activity, and estimation of market capitalization. Rather, the approach taken here involves the characterization of a few representative patents in Nutrigenomics to shed light on the kind of patenting activity in the field. Next follows a discussion about the role of patents in genomics and biotechnology innovation, and highlights some of the claims made about the impact that patents have on innovation and markets. These considerations lead to a short discussion of the impact of patents in Nutrigenomics. In recognition of the criticism directed toward patenting in genomics and genetics, this paper concludes with a preliminary evaluation of effects of strategic patent uses in Nutrigenomics. Patenting Activity in Nutrigenomics There are three main types of conventional patenting activity and one wild-card type that are of interest in Nutrigenomics. The three conventional types are: patents on genes, gene variants or methods of detecting gene variants; patents for bioactive food compounds; and patents on proprietary methods for analyzing gene-nutrient associations using computer supported algorithms. …
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Genomic Nutritional Profiling: Innovation and Regulation in Nutrigenomics
Minnesota journal of law science & technology, 2007Co-Authors: David CastleAbstract:Hippocrates advised to let food be your medicine, but he could not have anticipated the quagmire of ethical and legal issues that would arise with the advent of nutritional genomics. Nutrigenomics is a fast-evolving field that straddles the foodmedicine distinction in order to understand the genetic underpinnings of the effects of nutrient metabolism on health. The core idea behind this emerging field is that nutrients in our food interact with our genes in ways that are typically benign, but can also be deleterious in other circumstances.1 These harmful interactions are implicated in the development of major chronic diseases. Given that individuals have slightly different genetic constitutions and different diets, and given that the interaction generates a spectrum of outcomes, the science of Nutrigenomics faces an enormous analytical task to identify and categorize nutrient-gene interactions and elucidate the interactions’ contribution to disease. Nevertheless, the intent is to provide, as soon as possible, scientifically grounded predictions about the consequences of Nutrigenomics to the public. Like other nascent fields arising from the Human Genome Project, such as pharmacogenomics,2 Nutrigenomics must meet
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ethical legal and social issues in Nutrigenomics the challenges of regulating service delivery and building health professional capacity
Mutation Research, 2007Co-Authors: David Castle, Nola M RiesAbstract:Nutrigenomics, the conjunction of molecular nutrition with human genomics, is among the first publicly available applications of the human genome project. Nutrigenomics raises ethical, legal and social issues particularly with respect to how the public may access nutrigenetic tests and associated nutritional and lifestyle advice. Current regulatory controversy focuses on potential harms associated with direct-to-consumer (DTC) marketing of nutrigenetic tests and especially the need to protect consumers from unreliable tests, false claims and unproven dietary supplements. Nutrigenomics does, however, offer the potential of important health benefits for some individuals. The regulation of nutrigenomic services is slowly evolving, but there is little indication of increased professional capacity to support service delivery. Primary care physicians have minimal training in nutrition and genetics, and medical geneticists are in high demand and short supply. Dietetic practitioners are experts in nutrition science and interest in Nutrigenomics is growing among members of this professional group. However, as with physicians, dietetics practitioners would require considerable training to bring Nutrigenomics into their practice capacity. A downside of regulatory restrictions on direct consumer access to Nutrigenomics companies is that responsible businesses may be hindered in meeting emergent public demand while health care professional groups have not yet developed capacity to provide Nutrigenomics services.
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science society and the supermarket the opportunities and challenges of Nutrigenomics
2006Co-Authors: David Castle, Cheryl Cline, Abdallah S Daar, Charoula Tsamis, Peter A SingerAbstract:Preface. Acknowledgments. 1 NUTRITIONAL GENOMICS: OPPORTUNITIES AND CHALLENGES. 1.1 Introduction. 1.2 What is Nutritional Genomics? 1.3 Methodology and Approach of this Book. 1.4 Opportunities and Challenges for Nutrigenomics. 1.4.1 Improved health. 1.4.2 Personalized dietary advice. 1.4.3 Improved diet. 1.4.4 More development of health-enhancing food products. 1.4.5 Consumer empowerment. 1.4.6 Reducing health disparities. 1.4.7 Health care savings. 1.5 Challenges and a Road Map of This Book. References. 2 THE SCIENCE OF Nutrigenomics AND NUTRIGENETICS. 2.1 Introduction. 2.2 The Scientific Context. 2.2.1 Nutrigenomics. 2.2.2 Nutrigenetics. 2.3 The Case of MTHFR. 2.4 Room for Improvement. 2.4.1 Study design. 2.4.2 Epigenetics. 2.4.3 SNPs and haplotypes. 2.4.4 Dietary intake assessment. 2.4.5 Biomarkers. 2.4.6 Susceptibility and predictions. 2.4.7 Analytical and clinical validity. 2.4.8 Clinical utility. 2.5 Science and Technology Assessment. 2.6 Conclusion. References. 3 THE ETHICS OF NUTRIGENOMIC TESTS AND INFORMATION. 3.1 Introduction. 3.2 Ethical Principles. 3.3 Nutrigenomics Testing in the Clinical Setting. 3.3.1 Informed consent. 3.3.2 Confidentiality. 3.3.3 Secondary information. 3.3.4 Families. 3.3.5 Genetic testing of children and adolescents. 3.4 Use of Nutrigenomics Information for Research. 3.5 Use of Nutrigenomics Information by Private Third Parties. 3.5.1 Insurance. 3.5.2 Employment. 3.5.3 Legal and social responses to fears of discrimination. 3.6 Conclusion. References. 4 ALTERNATIVES FOR NUTRIGENOMIC SERVICE DELIVERY. 4.1 Introduction. 4.2 Considerations for Nutrigenomic Service Delivery. 4.2.1 Strength of the science. 4.2.2 Regulatory environment. 4.2.3 Human resource capacity and professional competence. 4.2.4 Funding policy. 4.2.5 Professional politics and culture. 4.2.6 Consumers and patients. 4.3 Four Alternative Models. 4.3.1 Consumer model. 4.3.2 Health practitioner model. 4.3.3 Blended models. 4.3.4 Public health model. 4.4 Conclusion. References. 5 Nutrigenomics AND THE REGULATION OF HEALTH CLAIMS FOR FOODS AND DRUGS. 5.1 Introduction. 5.1.1 Genetic tests, service delivery, and genetic antidiscrimination. 5.2 Food Categories: Functional Foods, Nutraceuticals, Medicinal Foods, and Dietary Supplements. 5.2.1 Functional foods. 5.2.2 Nutraceuticals. 5.2.3 Medical or medicinal foods. 5.2.4 Dietary supplements. 5.3 Health-Related Claims Associated with Foods Compared to Drugs. 5.3.1 Structure-function claims. 5.3.2 Health claims. 5.3.3 Medical food claims. 5.3.4 Disease risk reduction claims. 5.4 Nutrigenomic Information and the Regulation of Foods Compared to Drugs. 5.4.1 The regulation of foods. 5.4.2 The regulation of drugs. 5.5 Food and Drug Regulations in Japan, the United States, and Canada. 5.5.1 Japan. 5.5.2 United States. 5.5.3 Canada. 5.6 Conclusion. References. 6 Nutrigenomics: JUSTICE, EQUITY, AND ACCESS. 6.1 Introduction. 6.2 Industrialized Country Context. 6.2.1 Individualized nutrigenomic testing. 6.2.2 Population-based Nutrigenomics. 6.3 Developing Country Context. 6.3.1 Individualized nutrigenomic testing. 6.4 Nutrigenomics and Intellectual Property. 6.4.1 An issue of access to scientific information. 6.5 Conclusion. References. 7 CONCLUSIONS AND RECOMMENDATIONS. 7.1 Introduction. 7.1.1 Nutrigenomic science. 7.1.2 Nutrigenomics and health information management. 7.1.3 Nutrigenomic service delivery. 7.1.4 Regulation of Nutrigenomics. 7.1.5 Access and equity. 7.2 A Final Word. Index.
Hubert Cormier - One of the best experts on this subject based on the ideXlab platform.
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Nutrigenomics perspectives from registered dietitians a report from the quebec wide e consultation on Nutrigenomics among registered dietitians
Journal of Human Nutrition and Dietetics, 2014Co-Authors: Hubert Cormier, Bénédicte L. Tremblay, Ann-marie Paradis, Véronique Garneau, Sophie Desroches, Julie Robitaille, Marie-claude VohlAbstract:Background Not all healthcare professionals are familiar with Nutrigenomics. However, they recognise that Nutrigenomics has great potential for the development of preventive health approaches. The present study aimed to provide an overall picture of the current situation about Nutrigenomics in the practice of registered dietitians (RDs) from the province of Quebec (Canada). Methods Three hundred and seventy-three RDs members of the Ordre professionnel des dietetistes du Quebec completed an online survey that included 34 questions, most of which were closed-ended questions. Results Overall, 76.9% of RDs knew about Nutrigenomics. Among RDs with <5 years of experience, 49.2% knew about genetic testing related to nutrition compared to 11.7% for RDs with over 25 years of experience. Currently, 75.9% of RDs working in clinical nutrition in the public sector consider that they do not have the basic knowledge to integrate Nutrigenomics in their practice compared to 62.9% for RDs in private practice. When asked about main limitations of genetic testing related to nutrition, RDs considered that genetic testing does not consider the other determinants of health, that genetic testing and their results have poor accuracy, and that there is a lack of scientific evidence. Concerns remained about ethical and legal aspects and its difficult application as a result of poor understanding and/or interpretation by professionals and/or customers. The high costs of these tests were also noted as a limitation. Conclusions Registered dietitians know and are interested in Nutrigenomics, especially those with less experience, although they do not feel adequately qualified to integrate findings from Nutrigenomics into their practice.
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Nutrigenomics - perspectives from registered dietitians: a report from the Quebec-wide e-consultation on Nutrigenomics among registered dietitians.
Journal of Human Nutrition and Dietetics, 2014Co-Authors: Hubert Cormier, Bénédicte L. Tremblay, Ann-marie Paradis, Véronique Garneau, Sophie Desroches, Julie Robitaille, Marie-claude VohlAbstract:Background Not all healthcare professionals are familiar with Nutrigenomics. However, they recognise that Nutrigenomics has great potential for the development of preventive health approaches. The present study aimed to provide an overall picture of the current situation about Nutrigenomics in the practice of registered dietitians (RDs) from the province of Quebec (Canada). Methods Three hundred and seventy-three RDs members of the Ordre professionnel des dietetistes du Quebec completed an online survey that included 34 questions, most of which were closed-ended questions. Results Overall, 76.9% of RDs knew about Nutrigenomics. Among RDs with
