The Experts below are selected from a list of 23967 Experts worldwide ranked by ideXlab platform
M. Rabbani - One of the best experts on this subject based on the ideXlab platform.
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The effects of spironolactone on morphine withdrawal induced memory loss by the Object Recognition Task method in mice
Research in Pharmaceutical Sciences, 2009Co-Authors: Azadeh Mesripour, Valiollah Hajhashemi, M. RabbaniAbstract:Previous reports showed that elevated levels of glucocorticoids following morphine withdrawal play an important role in memory impairment. In addition, glucocorticoid receptor (GR) inhibitors improved memory perfor-mance in morphine withdrawal mice. Since mineralocorticoid receptor (MR) and GRs complement each other, the aim of the current study was to evaluate the effects of spironolactone on memory performance after withdrawal in morphine dependent mice. To assess memory performance, the Object Recognition Task was used. Novel Object Recognition Task was carried out in a square wooden open-field apparatus using Objects. The test was comprised of three sections: habituation for 15 min, first trial for 12 min and test trial for 5 min. In this learning paradigm, the difference in exploration between a previously seen Object and a novel Object is taken as an index of memory performance (Recognition index, RI). Male mice were made dependent by increasing doses of morphine (30-90 mg/kg) subcutaneously twice daily for three days. Withdrawal was elicited either by injection of naloxone (0.1 mg/kg) 3 h after last morphine injection or spontaneously 4 h after the last dose of morphine on the third day. Spironolactone (50, 100 mg/kg) was used subcutaneously before the first trial and the effects were compared with control values. After naloxone precipitated withdrawal spironolactone at 50 and 100 mg/kg improved RI to 10.8% ± 6.0 and 24.0% ± 6.1 which were significantly different from vehicle (RI=-24.1 % ± 6.6, P
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the effects of spironolactone on morphine withdrawal induced memory loss by the Object Recognition Task method in mice
Research in Pharmaceutical Sciences, 2009Co-Authors: Azadeh Mesripour, Valiollah Hajhashemi, M. RabbaniAbstract:Previous reports showed that elevated levels of glucocorticoids following morphine withdrawal play an important role in memory impairment. In addition, glucocorticoid receptor (GR) inhibitors improved memory perfor-mance in morphine withdrawal mice. Since mineralocorticoid receptor (MR) and GRs complement each other, the aim of the current study was to evaluate the effects of spironolactone on memory performance after withdrawal in morphine dependent mice. To assess memory performance, the Object Recognition Task was used. Novel Object Recognition Task was carried out in a square wooden open-field apparatus using Objects. The test was comprised of three sections: habituation for 15 min, first trial for 12 min and test trial for 5 min. In this learning paradigm, the difference in exploration between a previously seen Object and a novel Object is taken as an index of memory performance (Recognition index, RI). Male mice were made dependent by increasing doses of morphine (30-90 mg/kg) subcutaneously twice daily for three days. Withdrawal was elicited either by injection of naloxone (0.1 mg/kg) 3 h after last morphine injection or spontaneously 4 h after the last dose of morphine on the third day. Spironolactone (50, 100 mg/kg) was used subcutaneously before the first trial and the effects were compared with control values. After naloxone precipitated withdrawal spironolactone at 50 and 100 mg/kg improved RI to 10.8% ± 6.0 and 24.0% ± 6.1 which were significantly different from vehicle (RI=-24.1 % ± 6.6, P<0.05). Following spontaneous withdrawal, spironolactone at 50 mg/kg improved RI to 18.0% ± 13.0 that differed significantly from vehicle (RI=-20.8% ± 11.4, P<0.01). Results of these experiments show that MRs may play an important role in the Recognition memory impairment following morphine withdrawal in mice.
Pascale Schumann-bard - One of the best experts on this subject based on the ideXlab platform.
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Time decay of Object, place and temporal order memory in a paradigm assessing simultaneously episodic-like memory components in mice
Behavioural Brain Research, 2015Co-Authors: Hassina Belblidia, Abdelmalek Abdelouadoud, Christelle Jozet-alves, Hélène Dumas, Thomas Freret, Marianne Leger, Pascale Schumann-bardAbstract:A common trait of numerous memory disorders is the impairment of episodic memory. Episodic memory is a delay-dependant memory, especially associating three components, the "what", "where" and "when" of a unique event. To investigate underlying mechanisms of such memory, several tests, mainly based on Object exploration behaviour, have been set up in rodents. Recently, a three-trial Object Recognition Task has been proposed to evaluate simultaneously the different components of episodic-like memory in rodents. However, to date, the time course of each memory component in this paradigm is not known. We characterised here the time course of memory decay in adult mice during the three-trial Object Recognition Task, with inter-trial interval (ITI) ranging from 1 h to 4 h. We found that, with 1 hand 2 h, but not 4h ITI, mice spent more time to explore the displaced "old Object" relative to the displaced "recent Object", reflecting memory for "what and when". Concomitantly, animals exhibited more exploration time for the displaced "old Object" relative to the stationary "old Object", reflecting memory for "what and where". These results provide strong evidence that mice establish an integrated memory for unique experience consisting of the "what", "where" and "when" that can persist until 2 h ITI. (C) 2015 Elsevier B.V. All rights reserved.
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Time decay of Object, place and temporal order memory in a paradigm assessing simultaneously episodic-like memory components in mice.
Behavioural Brain Research, 2015Co-Authors: Hassina Belblidia, Abdelmalek Abdelouadoud, Christelle Jozet-alves, Hélène Dumas, Thomas Freret, Marianne Leger, Pascale Schumann-bardAbstract:Abstract A common trait of numerous memory disorders is the impairment of episodic memory. Episodic memory is a delay-dependant memory, especially associating three components, the “what”, “where” and “when” of a unique event. To investigate underlying mechanisms of such memory, several tests, mainly based on Object exploration behaviour, have been set up in rodents. Recently, a three-trial Object Recognition Task has been proposed to evaluate simultaneously the different components of episodic-like memory in rodents. However, to date, the time course of each memory component in this paradigm is not known. We characterised here the time course of memory decay in adult mice during the three-trial Object Recognition Task, with inter-trial interval (ITI) ranging from 1 h to 4 h. We found that, with 1 h and 2 h, but not 4 h ITI, mice spent more time to explore the displaced “old Object” relative to the displaced “recent Object”, reflecting memory for “what and when”. Concomitantly, animals exhibited more exploration time for the displaced “old Object” relative to the stationary “old Object”, reflecting memory for “what and where”. These results provide strong evidence that mice establish an integrated memory for unique experience consisting of the “what”, “where” and “when” that can persist until 2 h ITI.
Robert W. Mccarley - One of the best experts on this subject based on the ideXlab platform.
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learning and memory are impaired in the Object Recognition Task during metestrus diestrus and after sleep deprivation
Behavioural Brain Research, 2018Co-Authors: Joshua Cordeira, Sai Saroja Kolluru, Heather Rosenblatt, Robert E Strecker, Robert W. MccarleyAbstract:Abstract Females are an under-represented research model and the mechanisms through which sleep loss impairs cognition are not clear. Since levels of reproductive hormones and the estrous cycle are sensitive to sleep loss and necessary for learning and memory, we hypothesized that sleep deprivation impacts learning and memory in female mice by interfering with the estrous cycle. We used the Object Recognition Task to assess learning and memory in female mice during separate phases of the estrous cycle and after sleep loss. Mice in metestrus/diestrus attended to sample Objects less than mice in proestrus/estrus during Object acquisition, the first phase of the Object Recognition Task. Subsequently, during the Recognition phase of the Task, only mice in proestrus/estrus displayed a preference for the novel Object. Sleep deprivation for 12 h immediately before the Object Recognition Task reduced time attending to sample Objects and novel Object preference for mice in proestrus/estrus, without changing length of the estrous cycle. These results show that sleep deprived mice in proestrus/estrus had learning deficits and memory impairments, like mice in metestrus/diestrus. Since sleep deprivation did not disrupt the estrous cycle, however, results did not support the hypothesis. Cognitive impairments due to acute sleep loss were not due to alterations to the estrous cycle.
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Learning and memory are impaired in the Object Recognition Task during metestrus/diestrus and after sleep deprivation.
Behavioural Brain Research, 2017Co-Authors: Joshua Cordeira, Sai Saroja Kolluru, Heather Rosenblatt, Robert E Strecker, Robert W. MccarleyAbstract:Abstract Females are an under-represented research model and the mechanisms through which sleep loss impairs cognition are not clear. Since levels of reproductive hormones and the estrous cycle are sensitive to sleep loss and necessary for learning and memory, we hypothesized that sleep deprivation impacts learning and memory in female mice by interfering with the estrous cycle. We used the Object Recognition Task to assess learning and memory in female mice during separate phases of the estrous cycle and after sleep loss. Mice in metestrus/diestrus attended to sample Objects less than mice in proestrus/estrus during Object acquisition, the first phase of the Object Recognition Task. Subsequently, during the Recognition phase of the Task, only mice in proestrus/estrus displayed a preference for the novel Object. Sleep deprivation for 12 h immediately before the Object Recognition Task reduced time attending to sample Objects and novel Object preference for mice in proestrus/estrus, without changing length of the estrous cycle. These results show that sleep deprived mice in proestrus/estrus had learning deficits and memory impairments, like mice in metestrus/diestrus. Since sleep deprivation did not disrupt the estrous cycle, however, results did not support the hypothesis. Cognitive impairments due to acute sleep loss were not due to alterations to the estrous cycle.
Azadeh Mesripour - One of the best experts on this subject based on the ideXlab platform.
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The effects of spironolactone on morphine withdrawal induced memory loss by the Object Recognition Task method in mice
Research in Pharmaceutical Sciences, 2009Co-Authors: Azadeh Mesripour, Valiollah Hajhashemi, M. RabbaniAbstract:Previous reports showed that elevated levels of glucocorticoids following morphine withdrawal play an important role in memory impairment. In addition, glucocorticoid receptor (GR) inhibitors improved memory perfor-mance in morphine withdrawal mice. Since mineralocorticoid receptor (MR) and GRs complement each other, the aim of the current study was to evaluate the effects of spironolactone on memory performance after withdrawal in morphine dependent mice. To assess memory performance, the Object Recognition Task was used. Novel Object Recognition Task was carried out in a square wooden open-field apparatus using Objects. The test was comprised of three sections: habituation for 15 min, first trial for 12 min and test trial for 5 min. In this learning paradigm, the difference in exploration between a previously seen Object and a novel Object is taken as an index of memory performance (Recognition index, RI). Male mice were made dependent by increasing doses of morphine (30-90 mg/kg) subcutaneously twice daily for three days. Withdrawal was elicited either by injection of naloxone (0.1 mg/kg) 3 h after last morphine injection or spontaneously 4 h after the last dose of morphine on the third day. Spironolactone (50, 100 mg/kg) was used subcutaneously before the first trial and the effects were compared with control values. After naloxone precipitated withdrawal spironolactone at 50 and 100 mg/kg improved RI to 10.8% ± 6.0 and 24.0% ± 6.1 which were significantly different from vehicle (RI=-24.1 % ± 6.6, P
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the effects of spironolactone on morphine withdrawal induced memory loss by the Object Recognition Task method in mice
Research in Pharmaceutical Sciences, 2009Co-Authors: Azadeh Mesripour, Valiollah Hajhashemi, M. RabbaniAbstract:Previous reports showed that elevated levels of glucocorticoids following morphine withdrawal play an important role in memory impairment. In addition, glucocorticoid receptor (GR) inhibitors improved memory perfor-mance in morphine withdrawal mice. Since mineralocorticoid receptor (MR) and GRs complement each other, the aim of the current study was to evaluate the effects of spironolactone on memory performance after withdrawal in morphine dependent mice. To assess memory performance, the Object Recognition Task was used. Novel Object Recognition Task was carried out in a square wooden open-field apparatus using Objects. The test was comprised of three sections: habituation for 15 min, first trial for 12 min and test trial for 5 min. In this learning paradigm, the difference in exploration between a previously seen Object and a novel Object is taken as an index of memory performance (Recognition index, RI). Male mice were made dependent by increasing doses of morphine (30-90 mg/kg) subcutaneously twice daily for three days. Withdrawal was elicited either by injection of naloxone (0.1 mg/kg) 3 h after last morphine injection or spontaneously 4 h after the last dose of morphine on the third day. Spironolactone (50, 100 mg/kg) was used subcutaneously before the first trial and the effects were compared with control values. After naloxone precipitated withdrawal spironolactone at 50 and 100 mg/kg improved RI to 10.8% ± 6.0 and 24.0% ± 6.1 which were significantly different from vehicle (RI=-24.1 % ± 6.6, P<0.05). Following spontaneous withdrawal, spironolactone at 50 mg/kg improved RI to 18.0% ± 13.0 that differed significantly from vehicle (RI=-20.8% ± 11.4, P<0.01). Results of these experiments show that MRs may play an important role in the Recognition memory impairment following morphine withdrawal in mice.
Hassina Belblidia - One of the best experts on this subject based on the ideXlab platform.
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Time decay of Object, place and temporal order memory in a paradigm assessing simultaneously episodic-like memory components in mice
Behavioural Brain Research, 2015Co-Authors: Hassina Belblidia, Abdelmalek Abdelouadoud, Christelle Jozet-alves, Hélène Dumas, Thomas Freret, Marianne Leger, Pascale Schumann-bardAbstract:A common trait of numerous memory disorders is the impairment of episodic memory. Episodic memory is a delay-dependant memory, especially associating three components, the "what", "where" and "when" of a unique event. To investigate underlying mechanisms of such memory, several tests, mainly based on Object exploration behaviour, have been set up in rodents. Recently, a three-trial Object Recognition Task has been proposed to evaluate simultaneously the different components of episodic-like memory in rodents. However, to date, the time course of each memory component in this paradigm is not known. We characterised here the time course of memory decay in adult mice during the three-trial Object Recognition Task, with inter-trial interval (ITI) ranging from 1 h to 4 h. We found that, with 1 hand 2 h, but not 4h ITI, mice spent more time to explore the displaced "old Object" relative to the displaced "recent Object", reflecting memory for "what and when". Concomitantly, animals exhibited more exploration time for the displaced "old Object" relative to the stationary "old Object", reflecting memory for "what and where". These results provide strong evidence that mice establish an integrated memory for unique experience consisting of the "what", "where" and "when" that can persist until 2 h ITI. (C) 2015 Elsevier B.V. All rights reserved.
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Time decay of Object, place and temporal order memory in a paradigm assessing simultaneously episodic-like memory components in mice.
Behavioural Brain Research, 2015Co-Authors: Hassina Belblidia, Abdelmalek Abdelouadoud, Christelle Jozet-alves, Hélène Dumas, Thomas Freret, Marianne Leger, Pascale Schumann-bardAbstract:Abstract A common trait of numerous memory disorders is the impairment of episodic memory. Episodic memory is a delay-dependant memory, especially associating three components, the “what”, “where” and “when” of a unique event. To investigate underlying mechanisms of such memory, several tests, mainly based on Object exploration behaviour, have been set up in rodents. Recently, a three-trial Object Recognition Task has been proposed to evaluate simultaneously the different components of episodic-like memory in rodents. However, to date, the time course of each memory component in this paradigm is not known. We characterised here the time course of memory decay in adult mice during the three-trial Object Recognition Task, with inter-trial interval (ITI) ranging from 1 h to 4 h. We found that, with 1 h and 2 h, but not 4 h ITI, mice spent more time to explore the displaced “old Object” relative to the displaced “recent Object”, reflecting memory for “what and when”. Concomitantly, animals exhibited more exploration time for the displaced “old Object” relative to the stationary “old Object”, reflecting memory for “what and where”. These results provide strong evidence that mice establish an integrated memory for unique experience consisting of the “what”, “where” and “when” that can persist until 2 h ITI.
