The Experts below are selected from a list of 28125 Experts worldwide ranked by ideXlab platform
Hugh H Tilson - One of the best experts on this subject based on the ideXlab platform.
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methodological challenges in monitoring new treatments for rare diseases lessons from the cryopyrin associated periodic syndrome registry
Orphanet Journal of Rare Diseases, 2013Co-Authors: Hugh H Tilson, Paola Primatesta, D Kim, B Rauer, Philip N Hawkins, Hal M Hoffman, Jasmin B Kuemmerledeschner, Tom Van Der Poll, Ulrich A WalkerAbstract:Background: The Cryopyrin-Associated Periodic Syndromes (CAPS) are a group of rare hereditary autoinflammatory diseases and encompass Familial Cold Autoinflammatory Syndrome (FCAS), Muckle-Wells Syndrome (MWS), and Neonatal Onset Multisystem Inflammatory Disease (NOMID). Canakinumab is a monoclonal antibody directed against IL-1 beta and approved for CAPS patients but requires post-approval monitoring due to low and short exposures during the licensing process. Creative approaches to Observational Methodology are needed, harnessing novel registry strategies to ensure Health Care Provider reporting and patient monitoring. Methods: A web-based registry was set up to collect information on long-term safety and effectiveness of canakinumab for CAPS. Results: Starting in November 2009, this registry enrolled 241 patients in 43 centers and 13 countries by December 31, 2012. One-third of the enrolled population was aged < 18; the overall population is evenly divided by gender. Enrolment is ongoing for children. Conclusions: Innovative therapies in orphan diseases require post-approval structures to enable in depth understanding of safety and natural history of disease. The rarity and distribution of such diseases and unpredictability of treatment require innovative methods for enrolment and follow-up. Broad international practicebased recruitment and web-based data collection are practical.
M. Teresa Anguera - One of the best experts on this subject based on the ideXlab platform.
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Teacher-student -task -interactions in a motor skills programme for an adolescent boy with autism spectrum disorder: a systematic observation study (Interacción profesor-alumno-tarea en un programa de desarrollo de capacidades motrices en un adolesce
Journal for the Study of Education and Development, 2020Co-Authors: Daniel Lapresa, Ianire Gutiérrez, Alicia Pérez-de-albéniz, Patricia Merino, M. Teresa AngueraAbstract:This study illustrates the potential offered by Observational Methodology for analysing spontaneous behaviours and interactions by students with autism spectrum disorder (ASD). We present a case st...
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A log-linear analysis of efficiency in elite basketball applied to Observational Methodology:
International Journal of Sports Science & Coaching, 2019Co-Authors: Roberto Alsasua, Daniel Lapresa, Javier Arana, M. Teresa AngueraAbstract:Although the full potential of Observational Methodology is realized through diachronic analyses, synchronic analyses can be used to investigate associations between categorical variables. Log-line...
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Use of effective play-space by U12 FC Barcelona players: an Observational study combining lag sequential analysis and T-pattern detection
International Journal of Performance Analysis in Sport, 2018Co-Authors: Daniel Lapresa, Mario Amatria, Javier Arana, Ángel Del Río, M. Teresa AngueraAbstract:This Observational Methodology study had a substantive and a methodological aim. The substantive aim was to analyse the use of overall and effective play-space (EP-S) in the construction of offensive sequences ending in a shot by under-12 (U12) FC Barcelona (FCB) players. Analysis of EP-S helps to contextualise play in terms of a player’s relationship with the ball and other players on the pitch. The data analysed corresponded to all the matches played by FCB during an international U12 tournament. The reliability and generalisability of the data were confirmed. The methodological aim was to illustrate the complementary use of two of the most common diachronic techniques in Observational Methodology: lag sequential analysis and T-pattern detection. The software for both techniques (GSEQ and Theme, respectively) is free. The patterns detected for the use of space in general and EP-S using both techniques show that FCB’s U12 team exhibits certain features of play that the senior team is well known for, namely, elaborate play; frequent use of the wings to widen the area of play and press forward to ultimately break through the last line of defense; and recovery of the ball in forward positions within the EP-S of both teams, enabling rapid completion of sequences ending in a shot. We also detected behaviours that reflect a playing style adapted to the smaller size of the pitch used in 7-a-side soccer (e.g. the use of distant shots from within the rival team’s EP-S).
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The Specificity of Observational Studies in Physical Activity and Sports Sciences: Moving Forward in Mixed Methods Research and Proposals for Achieving Quantitative and Qualitative Symmetry.
Frontiers in psychology, 2017Co-Authors: M. Teresa Anguera, Oleguer Camerino, Marta Castañer, Pedro Sánchez-algarra, Anthony J. OnwuegbuzieAbstract:Mixed methods studies are been increasingly applied to a diversity of fields. In this paper, we discuss the growing use—and enormous potential—of mixed methods research in the field of sport and physical activity. A second aim is to contribute to strengthening the characteristics of mixed methods research by showing how systematic observation offers rigor within a flexible framework that can be applied to a wide range of situations. Observational Methodology is characterized by high scientific rigor and flexibility throughout its different stages and allows the objective study of spontaneous behavior in natural settings, with no external influence. Mixed methods researchers need to take bold yet thoughtful decisions regarding both substantive and procedural issues. We present three fundamental and complementary ideas to guide researchers in this respect: we show why studies of sport and physical activity that use a mixed methods research approach should be included in the field of mixed methods research, we highlight the numerous possibilities offered by Observational Methodology in this field through the transformation of descriptive data into quantifiable code matrices, and we discuss possible solutions for achieving true integration of qualitative and quantitative findings.
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Application of logistic regression models in Observational Methodology: game formats in grassroots football in initiation into football
Anales De Psicologia, 2016Co-Authors: Daniel Lapresa, M. Teresa Anguera, Javier Arana, J.ignacio Pérez-castellanos, Mario AmatriaAbstract:El presente trabajo constituye un ejemplo de las posibilidades de utilizacion de modelos de regresion logistica -multiple y simple- en el ambito de la metodologia observacional y mas concretamente en su aplicacion a la actividad fisica y el deporte. La ejemplificacion se concreta en un estudio que pretende discriminar que modalidad de juego (futbol 3 o futbol 5) constituye una propuesta mas adaptada a las posibilidades del nino de 6 a 8 anos. La satisfaccion de ambos objetivos -metodologico y disciplinar- se satisface mediante un modelo de regresion logistica multiple, que va a analizar en que modalidad el nino obtiene un desempeno espacial de mayor calidad; y tres modelos de regresion logistica simple, que van a aportar informacion relevante acerca de en que modalidad de futbol el nino obtiene un desempeno tecnico-tactico mas eficaz y adaptado
Stephen Scott - One of the best experts on this subject based on the ideXlab platform.
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Observational attachment theory based parenting measures predict children s attachment narratives independently from social learning theory based measures
Attachment & Human Development, 2014Co-Authors: Carla Matias, Thomas G Oconnor, Annabel Futh, Stephen ScottAbstract:Conceptually and methodologically distinct models exist for assessing quality of parent-child relationships, but few studies contrast competing models or assess their overlap in predicting developmental outcomes. Using Observational Methodology, the current study examined the distinctiveness of attachment theory-based and social learning theory-based measures of parenting in predicting two key measures of child adjustment: security of attachment narratives and social acceptance in peer nominations. A total of 113 5-6-year-old children from ethnically diverse families participated. Parent-child relationships were rated using standard paradigms. Measures derived from attachment theory included sensitive responding and mutuality; measures derived from social learning theory included positive attending, directives, and criticism. Child outcomes were independently-rated attachment narrative representations and peer nominations. Results indicated that Attachment theory-based and Social Learning theory-based measures were modestly correlated; nonetheless, parent-child mutuality predicted secure child attachment narratives independently of social learning theory-based measures; in contrast, criticism predicted peer-nominated fighting independently of attachment theory-based measures. In young children, there is some evidence that attachment theory-based measures may be particularly predictive of attachment narratives; however, no single model of measuring parent-child relationships is likely to best predict multiple developmental outcomes. Assessment in research and applied settings may benefit from integration of different theoretical and methodological paradigms.
Ulrich A Walker - One of the best experts on this subject based on the ideXlab platform.
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methodological challenges in monitoring new treatments for rare diseases lessons from the cryopyrin associated periodic syndrome registry
Orphanet Journal of Rare Diseases, 2013Co-Authors: Hugh H Tilson, Paola Primatesta, D Kim, B Rauer, Philip N Hawkins, Hal M Hoffman, Jasmin B Kuemmerledeschner, Tom Van Der Poll, Ulrich A WalkerAbstract:Background: The Cryopyrin-Associated Periodic Syndromes (CAPS) are a group of rare hereditary autoinflammatory diseases and encompass Familial Cold Autoinflammatory Syndrome (FCAS), Muckle-Wells Syndrome (MWS), and Neonatal Onset Multisystem Inflammatory Disease (NOMID). Canakinumab is a monoclonal antibody directed against IL-1 beta and approved for CAPS patients but requires post-approval monitoring due to low and short exposures during the licensing process. Creative approaches to Observational Methodology are needed, harnessing novel registry strategies to ensure Health Care Provider reporting and patient monitoring. Methods: A web-based registry was set up to collect information on long-term safety and effectiveness of canakinumab for CAPS. Results: Starting in November 2009, this registry enrolled 241 patients in 43 centers and 13 countries by December 31, 2012. One-third of the enrolled population was aged < 18; the overall population is evenly divided by gender. Enrolment is ongoing for children. Conclusions: Innovative therapies in orphan diseases require post-approval structures to enable in depth understanding of safety and natural history of disease. The rarity and distribution of such diseases and unpredictability of treatment require innovative methods for enrolment and follow-up. Broad international practicebased recruitment and web-based data collection are practical.
Andrew D. Bersten - One of the best experts on this subject based on the ideXlab platform.
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diaphragm and peripheral muscle thickness on ultrasound intra rater reliability and variability of a Methodology using non standard recumbent positions
Respirology, 2011Co-Authors: Claire E Baldwin, Jenny Davida Paratz, Andrew D. BerstenAbstract:Background and objective: Reliable measurement of diaphragm and peripheral muscle thickness, using diagnostic ultrasound, has only been validated in the erect posture. However, in many clinical populations, including critically ill patients, the erect posture presents logistic difficulties. This study aimed to validate ultrasound measurement of diaphragm and peripheral muscle thickness in the recumbent position. Methods: An Observational Methodology of repeated but blind ultrasound and anthropometric measurements was applied, to assess inta-rater reliability. Thirteen healthy volunteers (aged 20-73 years) participated. A pneumotachograph was used to target lung volume, as diaphragm thickness was measured from ultrasound at end-expiration, and both 25% and 50% of inspiratory capacity, while semi-recumbent. The thicknesses of the mid-upper arm, mid-forearm and mid-thigh musculature were also measured bilaterally while supine. Results: Diaphragm thickness could be reliably measured at end-expiration (intra-class correlation coefficient (ICC) = 0.990, 95% confidence interval: 0.918-0.998), 25% of inspiratory capacity (ICC = 0.959 (0.870-0.988)) and 50% of inspiratory capacity (ICC = 0.994 (0.980-0.998)). Peripheral muscle thickness measurements were also reliable (ICC = 0.998-1.0). Supine anthropometric measurements of limb segment lengths and girths were highly reproducible. Conclusions: This ultrasound technique has good reliability in recumbent positions, making it useful for application to clinical populations when the erect posture is not practical. Recumbent postures may affect the reliability of diaphragm and peripheral muscle thickness measured with ultrasound. While usually performed erect, patients may not tolerate this posture. We demonstrated that recumbent positions can be used to reliably measure diaphragm and peripheral muscle thickness, and that imaging sites can be accurately located supine.
