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Bruno Rossion - One of the best experts on this subject based on the ideXlab platform.
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The lateral inferior Occipital Gyrus as a major cortical source of the face-evoked N170: Evidence from simultaneous scalp and intracerebral human recordings
2019Co-Authors: Corentin Jacques, Laurent Koessler, Jacques Jonas, Louis Maillard, Sophie Colnat-coulbois, Bruno RossionAbstract:The onset of a face image leads to a prominent face-selective response in human scalp electroencephalographic (EEG) recordings at Occipital-temporal (OT) scalp sites: the N170. According to a widely held view, the main cortical source generating the N170 lies in the fusiform Gyrus (FG), whereas the posteriorly located inferior Occipital Gyrus (IOG) would rather generate earlier face-selective responses. Here, we report neural responses to faces recorded in an epileptic patient using intracerebral electrodes implanted in the right IOG and above the right lateral FG (LFG). Simultaneous scalp-EEG recording identified the N170 over the right OT scalp region. The latency and amplitude of this scalp N170 were correlated at the single-trial level with the N170 recorded in the lateral IOG, close to the scalp lateral Occipital surface. In addition, a positive component maximal around the latency of the N170 was prominent above the LFG, suggesting the field orientation generated in the LFG is incompatible with a strong contribution of this region to the N170 measured over lateral OT scalp. Altogether, these observations provide evidence that the IOG is a major cortical generator of the face-selective scalp N170, questioning a strict postero-anterior spatio-temporal organization of the human cortical face network.
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The inferior Occipital Gyrus is a major cortical source of the face-evoked N170: Evidence from simultaneous scalp and intracerebral human recordings
Human Brain Mapping, 2019Co-Authors: Corentin Jacques, Laurent Koessler, Jacques Jonas, Louis Maillard, Sophie Colnat-coulbois, Bruno RossionAbstract:The sudden onset of a face image leads to a prominent face‐selective response in human scalp electroencephalographic (EEG) recordings, peaking 170 ms after stimulus onset at occipito–temporal (OT) scalp sites: the N170 (or M170 in magnetoencephalography). According to a widely held view, the main cortical source of the N170 lies in the fusiform Gyrus (FG), whereas the posteriorly located inferior Occipital Gyrus (IOG) would rather generate earlier face‐selective responses. Here, we report neural responses to upright and inverted faces recorded in a unique patient using multicontact intracerebral electrodes implanted in the right IOG and in the OT sulcus above the right lateral FG (LFG). Simultaneous EEG recordings on the scalp identified the N170 over the right OT scalp region. The latency and amplitude of this scalp N170 were correlated at the single‐trial level with the N170 recorded in the lateral IOG, close to the scalp lateral Occipital surface. In addition, a positive component maximal around the latency of the N170 (a P170) was prominent above the internal LFG, whereas this region typically generates an N170 (or “N200”) over its external/ventral surface. This suggests that electrophysiological responses in the LFG manifest as an equivalent dipole oriented mostly along the vertical axis with likely minimal projection to the lateral OT scalp region. Altogether, these observations provide evidence that the IOG is a major cortical generator of the face‐selective scalp N170, qualifying the potential contribution of the FG and questioning a strict serial spatiotemporal organization of the human cortical face network.
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impaired face discrimination in acquired prosopagnosia is associated with abnormal response to individual faces in the right middle fusiform Gyrus
Cerebral Cortex, 2006Co-Authors: Christine Schiltz, Bettina Sorger, Roberto Caldara, Fatima Ahmed, Eugene Mayer, Rainer Goebel, Bruno RossionAbstract:The middle fusiform Gyrus (MFG) and the inferior Occipital Gyrus (IOG) are activated by both detection and identification of faces. Paradoxically, patients with acquired prosopagnosia following lesions to either of these regions in the right hemisphere cannot identify faces, but can still detect faces. Here we acquired functional magnetic resonance imaging (fMRI) data during face processing in a patient presenting a specific deficit in individual face recognition, following lesions encompassing the right IOG. Using an adaptation paradigm we show that the fMRI signal in the rMFG of the patient, while being larger in response to faces as compared to objects, does not differ between conditions presenting identical and distinct faces, in contrast to the larger response to distinct faces observed in controls. These results suggest that individual discrimination of faces critically depends on the integrity of both the rMFG and the rIOG, which may interact through re-entrant cortical connections in the normal brain.
Joshua J. Field - One of the best experts on this subject based on the ideXlab platform.
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Periaqueductal gray (PAG) seed-based functional connectivity (FC) analyses between patients with SCD (SCD) and controls (CN).
2019Co-Authors: Matthew S. Karafin, Guangyu Chen, Nancy J. Wandersee, Amanda M. Brandow, Robert W. Hurley, Pippa Simpson, Doug Ward, Joshua J. FieldAbstract:Left: Images show the results of the two sample t-test pattern of CN (controls, blue) and SCD (patients with sickle cell disease, orange) PAG FC, respectively. Color is coded based on z-score of the significance. Brain regions with warm color represent the positive connection and cold color represents the autocorrelation with PAG regions. Brain regions are numbered: (1) right inferior and superior parietal lobule, (2) left inferior Occipital Gyrus (Brodmann area 17 and 18), and (3) left and right anterior cingulate. Right: In comparison to CN (blue), SCD (orange) demonstrated increased connectivity in (1) right inferior and superior parietal lobule, (2) left inferior Occipital Gyrus (Brodmann area 17 and 18), and decreased connectivity in the (3) left and right anterior cingulate (y-axis = z-score of the significance, x-axis = brain region of interest by number).
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Periaqueductal gray (PAG) seed-based functional connectivity (FC) analyses between patients with SCD with chronic pain (CP) and without chronic pain (NCP).
2019Co-Authors: Matthew S. Karafin, Guangyu Chen, Nancy J. Wandersee, Amanda M. Brandow, Robert W. Hurley, Pippa Simpson, Doug Ward, Joshua J. FieldAbstract:Left: Images show the results of the two sample t-test pattern of NCP (SCD patients without chronic pain, blue) and patients with chronic pain (SCD patients with sickle cell disease and chronic pain, orange) PAG FC, respectively. Color is coded based on z-score of the significance. Brain regions with warm color represent the positive connection and cold color represents the autocorrelation with PAG regions. Brain regions are numbered: (1) right superior temporal Gyrus/ right insula/ right postcentral Gyrus/ right inferior parietal lobule, (2) left lingual Gyrus/ left inferior Occipital Gyrus/ left middle Occipital Gyrus, (3) left middle temporal Gyrus/ left precuneus/ left inferior parietal lobule/ left superior parietal lobule, (4) left and right superior frontal Gyrus (right most)/ medial frontal Gyrus, (5) left supramarginal Gyrus, (6) left superior frontal, (7) left posterior cingulate cortex, (8) right culmen of the cerebellum, and the (9) right middle and superior frontal lobe. Right: In comparison to NCP, patients with chronic pain demonstrated increased connectivity in the (1) right superior temporal Gyrus/ right insula/ right postcentral Gyrus/ right inferior parietal lobule, (4) left and right superior frontal Gyrus (right most)/ medial frontal Gyrus, (5) left supramarginal Gyrus, (6) left superior frontal, (8) right culmen (cerebellum), and the (9) right middle and superior frontal lobe. Decreased connectivity was noted in the (2) left lingual Gyrus/ left inferior Occipital Gyrus/ left middle Occipital Gyrus, (3) left middle temporal Gyrus/ left precuneus/ left inferior parietal lobule/ left superior parietal lobule, and (7) left posterior cingulate cortex (y-axis = z-score of the significance, x-axis = brain region of interest by number).
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Periaqueductal gray (PAG) seed-based functional connectivity (FC) analyses between patients with SCD without chronic pain (NCP) and controls (CN).
2019Co-Authors: Matthew S. Karafin, Guangyu Chen, Nancy J. Wandersee, Amanda M. Brandow, Robert W. Hurley, Pippa Simpson, Doug Ward, Joshua J. FieldAbstract:Left: Images show the results of the two sample t-test pattern of CN (controls, blue) and SCD without chronic pain (patients with sickle cell disease and no chronic pain, orange) PAG FC, respectively. Color is coded based on z-score of the significance. Brain regions with warm color represent the positive connection and cold color represents the autocorrelation with PAG regions. Brain regions are numbered: (1) Left and right Cuneus/ left inferior Occipital Gyrus (brodmann area 18)/ left middle Occipital Gyrus/ left and right lingual Gyrus, and (2) Left and right superior frontal Gyrus. Right: In comparison to CN, NCP demonstrated increased connectivity only in the (1) Left and right Cuneus/ left inferior Occipital Gyrus (brodmann area 18)/ left middle Occipital Gyrus/ left and right lingual Gyrus, and decreased connectivity of the (2) Left and right superior frontal Gyrus (y-axis = z-score of the significance, x-axis = brain region of interest by number).
Qinglin Zhang - One of the best experts on this subject based on the ideXlab platform.
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Resting-state functional magnetic resonance study of primary open-angle glaucoma based on voxelwise brain network degree centrality.
Neuroscience letters, 2019Co-Authors: Qinglin Zhang, Lu Yang, Yongqiang Shu, Chan Xiong, Yulian Pang, Xianjun Zeng, Xu ZhangAbstract:Abstract Objective To investigate alterations in the functional brain networks of patients with primary open-angle glaucoma (POAG) by using the resting-state functional magnetic resonance imaging (fMRI) voxelwise degree centrality (DC) method. Materials and methods Thirteen patients with POAG and thirteen healthy subjects were recruited for this study, and each participant underwent a rs-fMRI scan. The voxelwise DC method was used to assess the features of spontaneous brain activity. The differences in the mean DC across brain regions between the POAG group and the healthy control group were analyzed, and the correlations between the DC values of altered brain regions and various clinical ophthalmic parameters were analyzed in the POAG group. Results Compared with healthy controls, patients with POAG exhibited significantly decreased DC values of the left superior frontal Gyrus and the left postcentral Gyrus as well as significantly increased DC values of the left superior Occipital Gyrus. In POAG patients, the DC value of the left superior Occipital Gyrus was significantly positively correlated with age (r = 0.571, P = 0.042) and negatively correlated with the intraocular pressure of the right eye (r=-0.625, P = 0.022). The DC value of the left superior frontal Gyrus was significantly positively correlated with the right eye average cup-to-disc ratio (r = 0.683, P = 0.010), vertical cup-to-disc ratio (r = 0.779, P = 0.002), and pattern standard deviation (r = 0.567, P = 0.043). Conclusion The results showed that altered DC values in three brain regions may reflect the underlying pathological mechanisms of POAG. Decreased DC values of the left superior Occipital Gyrus could be useful imaging markers for determining the extent of brain damage in POAG patients compared to healthy subjects.
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an illustrated heuristic prototype facilitates scientific inventive problem solving a functional magnetic resonance imaging study
Consciousness and Cognition, 2015Co-Authors: Dandan Tong, Wenfu Li, Wenjing Yang, Chaoying Tang, Lei Zhang, Yan Tian, Meng Zhang, Qinglin ZhangAbstract:Many scientific inventions (SI) throughout history were inspired by heuristic prototypes (HPs). For instance, an event or piece of knowledge similar to displaced water from a tub inspired Archimedes' principle. However, the neural mechanisms underlying this insightful problem solving are not very clear. Thus, the present study explored the neural correlates used to solve SI problems facilitated by HPs. Each HP had two versions: a literal description with an illustration (LDI) and a literal description with no illustration (LDNI). Thirty-two participants were divided randomly into these two groups. Blood oxygenation level-dependent fMRI contrasts between LDI and LDNI groups were measured. Greater activity in the right middle Occipital Gyrus (RMOG, BA19), right precentral Gyrus (RPCG, BA4), and left middle frontal Gyrus (LMFG, BA46) were found within the LDI group as compared to the LDNI group. We discuss these results in terms cognitive functions within these regions related to problem solving and memory retrieval. (C) 2015 Elsevier Inc. All rights reserved.
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Category-selective attention modulates unconscious processes in the middle Occipital Gyrus
Consciousness and Cognition, 2013Co-Authors: Shen Tu, Ulla Martens, Qinglin ZhangAbstract:Abstract Many studies have revealed the top-down modulation (spatial attention, attentional load, etc.) on unconscious processing. However, there is little research about how category-selective attention could modulate the unconscious processing. In the present study, using functional magnetic resonance imaging (fMRI), the results showed that category-selective attention modulated unconscious face/tool processing in the middle Occipital Gyrus (MOG). Interestingly, MOG effects were of opposed direction for face and tool processes. During unconscious face processing, activation in MOG decreased under the face-selective attention compared with tool-selective attention. This result was in line with the predictive coding theory. During unconscious tool processing, however, activation in MOG increased under the tool-selective attention compared with face-selective attention. The different effects might be ascribed to an interaction between top-down category-selective processes and bottom-up processes in the partial awareness level as proposed by Kouider, De Gardelle, Sackur, and Dupoux (2010) . Specifically, we suppose an “excessive activation” hypothesis.
Matthew S. Karafin - One of the best experts on this subject based on the ideXlab platform.
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Periaqueductal gray (PAG) seed-based functional connectivity (FC) analyses between patients with SCD (SCD) and controls (CN).
2019Co-Authors: Matthew S. Karafin, Guangyu Chen, Nancy J. Wandersee, Amanda M. Brandow, Robert W. Hurley, Pippa Simpson, Doug Ward, Joshua J. FieldAbstract:Left: Images show the results of the two sample t-test pattern of CN (controls, blue) and SCD (patients with sickle cell disease, orange) PAG FC, respectively. Color is coded based on z-score of the significance. Brain regions with warm color represent the positive connection and cold color represents the autocorrelation with PAG regions. Brain regions are numbered: (1) right inferior and superior parietal lobule, (2) left inferior Occipital Gyrus (Brodmann area 17 and 18), and (3) left and right anterior cingulate. Right: In comparison to CN (blue), SCD (orange) demonstrated increased connectivity in (1) right inferior and superior parietal lobule, (2) left inferior Occipital Gyrus (Brodmann area 17 and 18), and decreased connectivity in the (3) left and right anterior cingulate (y-axis = z-score of the significance, x-axis = brain region of interest by number).
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Periaqueductal gray (PAG) seed-based functional connectivity (FC) analyses between patients with SCD with chronic pain (CP) and without chronic pain (NCP).
2019Co-Authors: Matthew S. Karafin, Guangyu Chen, Nancy J. Wandersee, Amanda M. Brandow, Robert W. Hurley, Pippa Simpson, Doug Ward, Joshua J. FieldAbstract:Left: Images show the results of the two sample t-test pattern of NCP (SCD patients without chronic pain, blue) and patients with chronic pain (SCD patients with sickle cell disease and chronic pain, orange) PAG FC, respectively. Color is coded based on z-score of the significance. Brain regions with warm color represent the positive connection and cold color represents the autocorrelation with PAG regions. Brain regions are numbered: (1) right superior temporal Gyrus/ right insula/ right postcentral Gyrus/ right inferior parietal lobule, (2) left lingual Gyrus/ left inferior Occipital Gyrus/ left middle Occipital Gyrus, (3) left middle temporal Gyrus/ left precuneus/ left inferior parietal lobule/ left superior parietal lobule, (4) left and right superior frontal Gyrus (right most)/ medial frontal Gyrus, (5) left supramarginal Gyrus, (6) left superior frontal, (7) left posterior cingulate cortex, (8) right culmen of the cerebellum, and the (9) right middle and superior frontal lobe. Right: In comparison to NCP, patients with chronic pain demonstrated increased connectivity in the (1) right superior temporal Gyrus/ right insula/ right postcentral Gyrus/ right inferior parietal lobule, (4) left and right superior frontal Gyrus (right most)/ medial frontal Gyrus, (5) left supramarginal Gyrus, (6) left superior frontal, (8) right culmen (cerebellum), and the (9) right middle and superior frontal lobe. Decreased connectivity was noted in the (2) left lingual Gyrus/ left inferior Occipital Gyrus/ left middle Occipital Gyrus, (3) left middle temporal Gyrus/ left precuneus/ left inferior parietal lobule/ left superior parietal lobule, and (7) left posterior cingulate cortex (y-axis = z-score of the significance, x-axis = brain region of interest by number).
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Periaqueductal gray (PAG) seed-based functional connectivity (FC) analyses between patients with SCD without chronic pain (NCP) and controls (CN).
2019Co-Authors: Matthew S. Karafin, Guangyu Chen, Nancy J. Wandersee, Amanda M. Brandow, Robert W. Hurley, Pippa Simpson, Doug Ward, Joshua J. FieldAbstract:Left: Images show the results of the two sample t-test pattern of CN (controls, blue) and SCD without chronic pain (patients with sickle cell disease and no chronic pain, orange) PAG FC, respectively. Color is coded based on z-score of the significance. Brain regions with warm color represent the positive connection and cold color represents the autocorrelation with PAG regions. Brain regions are numbered: (1) Left and right Cuneus/ left inferior Occipital Gyrus (brodmann area 18)/ left middle Occipital Gyrus/ left and right lingual Gyrus, and (2) Left and right superior frontal Gyrus. Right: In comparison to CN, NCP demonstrated increased connectivity only in the (1) Left and right Cuneus/ left inferior Occipital Gyrus (brodmann area 18)/ left middle Occipital Gyrus/ left and right lingual Gyrus, and decreased connectivity of the (2) Left and right superior frontal Gyrus (y-axis = z-score of the significance, x-axis = brain region of interest by number).
Motomi Toichi - One of the best experts on this subject based on the ideXlab platform.
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bidirectional electric communication between the inferior Occipital Gyrus and the amygdala during face processing
Human Brain Mapping, 2017Co-Authors: Wataru Sato, Takanori Kochiyama, Shota Uono, Kazumi Matsuda, Keiko Usui, Naotaka Usui, Yushi Inoue, Motomi ToichiAbstract:Faces contain multifaceted information that is important for human communication. Neuroimaging studies have revealed face-specific activation in multiple brain regions, including the inferior Occipital Gyrus (IOG) and amygdala; it is often assumed that these regions constitute the neural network responsible for the processing of faces. However, it remains unknown whether and how these brain regions transmit information during face processing. This study investigated these questions by applying dynamic causal modeling of induced responses to human intracranial electroencephalography data recorded from the IOG and amygdala during the observation of faces, mosaics, and houses in upright and inverted orientations. Model comparisons assessing the experimental effects of upright faces versus upright houses and upright faces versus upright mosaics consistently indicated that the model having face-specific bidirectional modulatory effects between the IOG and amygdala was the most probable. The experimental effect between upright versus inverted faces also favored the model with bidirectional modulatory effects between the IOG and amygdala. The spectral profiles of modulatory effects revealed both same-frequency (e.g., gamma–gamma) and cross-frequency (e.g., theta–gamma) couplings. These results suggest that the IOG and amygdala communicate rapidly with each other using various types of oscillations for the efficient processing of faces. Hum Brain Mapp, 2017. © 2017 Wiley Periodicals, Inc.
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time course of gamma band oscillation associated with face processing in the inferior Occipital Gyrus and fusiform Gyrus a combined fmri and meg study
Human Brain Mapping, 2017Co-Authors: Shota Uono, Wataru Sato, Takanori Kochiyama, Yasutaka Kubota, Reiko Sawada, Sayaka Yoshimura, Motomi ToichiAbstract:Debate continues over whether the inferior Occipital Gyrus (IOG) or the fusiform Gyrus (FG) represents the first stage of face processing and what role these brain regions play. We investigated this issue by combining functional magnetic resonance imaging (fMRI) and magnetoencephalography (MEG) in normal adults. Participants passively observed upright and inverted faces and houses. First, we identified the IOG and FG as face-specific regions using fMRI. We applied beamforming source reconstruction and time–frequency analysis to MEG source signals to reveal the time course of gamma-band activations in these regions. The results revealed that the right IOG showed higher gamma-band activation in response to upright faces than to upright houses at 100 ms from the stimulus onset. Subsequently, the right FG showed greater gamma-band response to upright faces versus upright houses at around 170 ms. The gamma-band activation in the right IOG and right FG was larger in response to inverted faces than to upright faces at the later time window. These results suggest that (1) the gamma-band activities occurs rapidly first in the IOG and next in the FG and (2) the gamma-band activity in the right IOG at later time stages is involved in configuration processing for faces. Hum Brain Mapp, 2016. © 2016 Wiley Periodicals, Inc.
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rapid gamma oscillations in the inferior Occipital Gyrus in response to eyes
Scientific Reports, 2016Co-Authors: Wataru Sato, Takanori Kochiyama, Shota Uono, Kazumi Matsuda, Keiko Usui, Naotaka Usui, Yushi Inoue, Motomi ToichiAbstract:Eyes are an indispensable communication medium for human social interactions. Although previous neuroscientific evidence suggests the activation of the inferior Occipital Gyrus (IOG) during eye processing, the temporal profile of this activation remains unclear. To investigate this issue, we analyzed intracranial electroencephalograms of the IOG during the presentation of eyes and mosaics, in either averted or straight directions. Time–frequency statistical parametric mapping analyses revealed greater gamma-band activation in the right IOG beginning at 114 ms in response to eyes relative to mosaics, irrespective of their averted or straight direction. These results suggest that gamma oscillations in the right IOG are involved in the early stages of eye processing, such as eye detection.
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Rapid, high-frequency, and theta-coupled gamma oscillations in the inferior Occipital Gyrus during face processing
Cortex; a journal devoted to the study of the nervous system and behavior, 2014Co-Authors: Wataru Sato, Takanori Kochiyama, Shota Uono, Kazumi Matsuda, Keiko Usui, Yushi Inoue, Motomi ToichiAbstract:Neuroimaging studies have found greater activation in the inferior Occipital Gyrus (IOG), or Occipital face area, in response to faces relative to non-facial stimuli. However, the temporal, frequency, and functional profiles of IOG activity during face processing remain unclear. Here, this issue was investigated by recording intracranial field potentials in the IOG during the presentation of faces, mosaics, and houses in upright and inverted orientations. Time-frequency statistical parametric mapping analyses revealed greater gamma-band activation in the IOG beginning at 110 msec and covering 40-300 Hz in response to upright faces relative to upright houses and mosaics. Phase-amplitude cross-frequency coupling analyses revealed more evident theta-gamma couplings at 115-256 msec during the processing of upright faces as compared with that of upright houses and mosaics. Comparable gamma-band activity was observed during the processing of inverted and upright faces at about 100-200 msec, but weaker activity and different coupling with theta-band activity after 200 msec. These patterns of activity were more evident in the right than in the left IOG. These results, together with other evidence on neural communication, suggest that broadband gamma oscillations in the right IOG conduct rapid and multistage (i.e., both featural and configural) face processing in collaboration with theta oscillations transmitted from other brain regions.
