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Sumithra S. Devi - One of the best experts on this subject based on the ideXlab platform.
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Efficacy of Ocimum Tenuiflorum essential oil as grain protectant against coleopteran beetle, infesting stored pulses
Journal of Food Science and Technology, 2020Co-Authors: M. L. Bhavya, S. Obulaxmi, Sumithra S. DeviAbstract:In the present investigation, essential oil (EO) of Ocimum Tenuiflorum and its principal constituent (eugenol) was evaluated for its toxicity and mode of action against Callosobruchus maculatus . Furthermore, fumigant toxicity and germination studies on the application of O. Tenuiflorum EO and eugenol against C. maculatus on different pulses was also studied. Fumigant activity studies revealed that EO toxicity was significantly ( p
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efficacy of Ocimum Tenuiflorum essential oil as grain protectant against coleopteran beetle infesting stored pulses
Journal of Food Science and Technology-mysore, 2020Co-Authors: M. L. Bhavya, S. Obulaxmi, Sumithra S. DeviAbstract:In the present investigation, essential oil (EO) of Ocimum Tenuiflorum and its principal constituent (eugenol) was evaluated for its toxicity and mode of action against Callosobruchus maculatus. Furthermore, fumigant toxicity and germination studies on the application of O. Tenuiflorum EO and eugenol against C. maculatus on different pulses was also studied. Fumigant activity studies revealed that EO toxicity was significantly (p < 0.05) influenced by concentration and exposure time. In fumigant toxicity assay without food, O. Tenuiflorum EO and eugenol showed LC50 value of 278.6 and 256.5 µL/L air, respectively, at one hour exposure. Further, O. Tenuiflorum EO displayed fumigant toxicity via inhibiting acetylcholinesterase activity. Pulses treated with O. Tenuiflorum EO showed 70% of C. maculatus mortality at 250 µL/L air concentration after 24 h. Furthermore, these treatments didn’t affect the seed viability of the pulses tested. Hence, the application of O. Tenuiflorum EO has potential scope as a botanical insecticide.
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Ocimum Tenuiflorum oil a potential insecticide against rice weevil with anti acetylcholinesterase activity
Industrial Crops and Products, 2018Co-Authors: M. L. Bhavya, A G S Chandu, Sumithra S. DeviAbstract:Abstract Essential oils are complex secondary metabolites, rich in volatiles, possessing a wide range of biological activities. In recent years, its application as bio-pesticide is receiving renewed attention due to its effective and safe application. In the present study, holy basil (Ocimum Tenuiflorum) essential oil was tested for its insecticidal activity against Sitophilus orzyae (L.), using direct contact application and fumigation procedures. The GC–MS analysis of the O. Tenuiflorum essential oil was also performed to characterize the essential oil. The GC–MS results showed that the major components present in O. Tenuiflorum oil were eugenol and caryophyllene constituting about 70.5% of the total essential oil composition. Fumigant toxicity of essential oil and eugenol standard was assessed at different rates (100-1000 μL/L air) in space fumigation study. Toxicity results revealed that fumigant and contact toxicity of the oils was significantly (p
M. L. Bhavya - One of the best experts on this subject based on the ideXlab platform.
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Efficacy of Ocimum Tenuiflorum essential oil as grain protectant against coleopteran beetle, infesting stored pulses
Journal of Food Science and Technology, 2020Co-Authors: M. L. Bhavya, S. Obulaxmi, Sumithra S. DeviAbstract:In the present investigation, essential oil (EO) of Ocimum Tenuiflorum and its principal constituent (eugenol) was evaluated for its toxicity and mode of action against Callosobruchus maculatus . Furthermore, fumigant toxicity and germination studies on the application of O. Tenuiflorum EO and eugenol against C. maculatus on different pulses was also studied. Fumigant activity studies revealed that EO toxicity was significantly ( p
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efficacy of Ocimum Tenuiflorum essential oil as grain protectant against coleopteran beetle infesting stored pulses
Journal of Food Science and Technology-mysore, 2020Co-Authors: M. L. Bhavya, S. Obulaxmi, Sumithra S. DeviAbstract:In the present investigation, essential oil (EO) of Ocimum Tenuiflorum and its principal constituent (eugenol) was evaluated for its toxicity and mode of action against Callosobruchus maculatus. Furthermore, fumigant toxicity and germination studies on the application of O. Tenuiflorum EO and eugenol against C. maculatus on different pulses was also studied. Fumigant activity studies revealed that EO toxicity was significantly (p < 0.05) influenced by concentration and exposure time. In fumigant toxicity assay without food, O. Tenuiflorum EO and eugenol showed LC50 value of 278.6 and 256.5 µL/L air, respectively, at one hour exposure. Further, O. Tenuiflorum EO displayed fumigant toxicity via inhibiting acetylcholinesterase activity. Pulses treated with O. Tenuiflorum EO showed 70% of C. maculatus mortality at 250 µL/L air concentration after 24 h. Furthermore, these treatments didn’t affect the seed viability of the pulses tested. Hence, the application of O. Tenuiflorum EO has potential scope as a botanical insecticide.
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Ocimum Tenuiflorum oil a potential insecticide against rice weevil with anti acetylcholinesterase activity
Industrial Crops and Products, 2018Co-Authors: M. L. Bhavya, A G S Chandu, Sumithra S. DeviAbstract:Abstract Essential oils are complex secondary metabolites, rich in volatiles, possessing a wide range of biological activities. In recent years, its application as bio-pesticide is receiving renewed attention due to its effective and safe application. In the present study, holy basil (Ocimum Tenuiflorum) essential oil was tested for its insecticidal activity against Sitophilus orzyae (L.), using direct contact application and fumigation procedures. The GC–MS analysis of the O. Tenuiflorum essential oil was also performed to characterize the essential oil. The GC–MS results showed that the major components present in O. Tenuiflorum oil were eugenol and caryophyllene constituting about 70.5% of the total essential oil composition. Fumigant toxicity of essential oil and eugenol standard was assessed at different rates (100-1000 μL/L air) in space fumigation study. Toxicity results revealed that fumigant and contact toxicity of the oils was significantly (p
Meghana S. Kamble - One of the best experts on this subject based on the ideXlab platform.
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STUDIES ON ISOLATION AND EVALUATION OF Ocimum Tenuiflorum LINN SEED MUCILAGE
Journal of Drug Delivery and Therapeutics, 2012Co-Authors: Meghana S. KambleAbstract:ABSTRACT Plant products serves as an alternative to synthetic products because of local accessibility, eco-friendly nature and lower prices compared to important synthetic products. Natural gums and mucilages have been widely explored as pharmaceutical excipient. The present study was undertaken to isolate and evaluate mucilage from the seeds of Ocimum Tenuiflorum Linn and explore its use as a pharmaceutical excipient. Various methods of mucilage extraction were tried and simple, economical and optimum method was developed. Physicochemical properties of Ocimum seed mucilage such as pH, Charring, Swelling Ratio, Bulk and Tapped Densities, Carr's Index and Hausner’s Ratio, Viscosity, Angle of Repose were studied.
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Evaluation of Binding Property of Ocimum Tenuiflorum Linn. Seed Mucilage Isolated By Defatting Method.
Journal of Biomedical and Pharmaceutical Research, 2012Co-Authors: Meghana S. KambleAbstract:In the present study Ocimum Tenuiflorum Linn seed mucilage was evaluated to determine if it posseses the tablet binding property. For this purpose the seed mucilage was used in different concentrations as binder in the formulations and compared with tablet prepared with starch as binder. Six tablet formulations were prepared in which F1 to F5 contained 1-5 % Ocimum seed mucilage and F6 contained 5 % starch. These tablets were evaluated for hardness, thickness, friability, disintegration, content uniformity, in vitro drug release. The results indicated that mucilage is required in less concentration to give equivalent binding effect produced by starch in 5 %. Thus Ocimum seed mucilage shows potential to use as binder in tablet formulations in lesser concentration than starch which may the cut cost of formulation to some extent. KEYWORDS: Tablet binder, seed mucilage, defatting method, Ocimum Tenuiflorum
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Research Article Pharmaceutical Characterization of Ocimum Tenuiflorum Linn. Seed Mucilage as Superdisintegrant
2012Co-Authors: Meghana S. Kamble, Satish D. Mendake, Pravin P. Aute, Suraj S. Mane, Varsha G. Borwandkar, Omkar R. Mane, Pravin D. ChaudhariAbstract:The aim of the present work was to evaluate the superdisintegrant property of Ocimum Tenuiflorum Linn. seed mucilage in the formulation of mouth dissolving tablets. The Ocimum Tenuiflorum Linn. seed mucilage was isolated by defatting with petroleum ether and then soaked in distilled water. Ocimum Tenuiflorum Linn. seed mucilage alone, crosspovidone alone and different combination of Ocimum Tenuiflorum Linn. seed mucilage with crospovidone and sodium starch glycolate were evaluated for disintegrant property. Glimepiride, an anti-diabetic drug was selected as a model drug in present study. Nineteen formulations of mouth dissolving tablets were prepared and evaluated for various pre-compression, post compression properties and in-vitro drug release. The formulation F10 was found to be optimum with in-vitro disintegration time 32 sec. and 91.89% drug release in 45 min. Ocimum Tenuiflorum Linn. seed mucilage alone did not show superdisintegrant property however it gives good results when combined with crospovidone. It shows potential of superdisintegrant activity in combination with other commercially available superdisintegrant agents. The partial replacement of the semi synthetic and synthetic superdisintegrants by the eco-friendly natural polymers will lead to development of economic formulations.
K.p. Sastry - One of the best experts on this subject based on the ideXlab platform.
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Influence of Different Doses of Vermicompost on Growth of Herb Ocimum Tenuiflorum var. CIM-Ayu
Research Journal of Pharmacy and Technology, 2017Co-Authors: A. Ranganadha Reddy, R. Bharath Kumar, M. Deepthi, K.p. SastryAbstract:Experimental studies were conducted to study the influence of various inorganic and organic components (nutrients) with different combinations of vermicompost concentrations against the species of Ocimum Tenuiflorum var. CIM-Ayu at CIMAP, Research Centre, and Hyderabad during October 2010 to May, 2011. These studies were focus on the integrated nutrient management for production of higher herb in the species Ocimum Tenuiflorum variety CIM-AYU. In the first phase experimental studies-six different levels of vermicompost (0–3.0 tons/ha) were applied and the observations were made against the with application of 3.0 tons of vermicompost per hectare resulted in better growth in Ocimum Tenuiflorum variety CIM-AYU. Similarly a significant improvement in the number of leaves per plant was noticed due to vermicompost application. The considerable amount of increase in plant weight was noticed due to application of three tons of vermicompost per hectare/s. Naturally occurring organic biofertilizer vermicompost contains 1.5–2.5% Nitrogen, 0.9–1.7% Phosphorus, 1.5–2.4% Potash, 0.5–1.0% Calcium, 0.2–0.3% Magnesium, 0.4–0.5% Sulphur.
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Experimental studies on Influence of different doses of Vermicompost on essential oil yield of Ocimum Tenuiflorum var. CIM-Ayu
Research Journal of Pharmacy and Technology, 2016Co-Authors: A. Ranganadha Reddy, R. Bharath Kumar, M. Deepthi, T.c. Venkateswarulu, M. Indira, D. Ramyakrishna, K.p. SastryAbstract:Vermicompost is a naturally occurring organic biofertilizer and it contains 1.5 – 2.5 % Nitrogen, 0.9 – 1.7 % Phosphorus, 1.5 – 2.4 % Potash, 0.5 – 1.0 % Calcium, 0.2 – 0.3 % Magnesium, 0.4 - 0.5 % Sulphur. Ocimum Tenuiflorum yields aromatic oil containing eugenol (71.3%). The present study focused on the influence of different doses of vermicompost on the essential oil yield of Ocimum Tenuiflorum var. CIM-Ayu. In the experiment, six different doses of vermicompost (0- 3.0 tons/ha) was applied and during the course of investigation the essential oil from the herbs was collected at two different stages (i.e. at 45, 90 days after planting) and it was noticed that the essential content did not follow any particular pattern. Similarly, the chemical constituents of the oil were not influenced by the treatments. It was also observed that reduction in plant height and number of tillers/clump that was manifested in reduced herb yield was compensated by a higher oil concentration in the leaves. The highest content of Eugenol, was reported in addition to Methyl Eugenol, Beta Elemene and Caryophyllene.
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Experimental Studies on effect of Vermicompost and NPK on Essential oil yield of Ocimum Tenuiflorum var. CIM-Ayu
Research Journal of Pharmacy and Technology, 2015Co-Authors: A. Ranganadha Reddy, R. Bharath Kumar, M. Deepthi, V Ravi Kumar, T. Naga Lohita, M. Sriharsha, K.p. SastryAbstract:Naturally occurring organic biofertilizer vermicompost contains 1.5–2.5% Nitrogen, 0.9–1.7% Phosphorus, 1.5–2.4% Potash, 0.5–1.0% Calcium, 0.2–0.3% Magnesium, 0.4–0.5% Sulphur. Ocimum Tenuiflorum yields aromatic oil containing eugenol (71.3%). The effect of different doses of vermicompost and NPK on essential oil yield of Ocimum Tenuiflorum var. CIM-Ayu was studied. Different doses of vermicompost and NPK was applied and during the course of investigation essential oil from the herbs collected at two different stages (i.e. at 45, 90 days after planting) and noticed that the essential oil content did not follow any particular pattern. Similarly, chemical constituents of the oil were not influenced by the treatments. It was also observed that reduction in plant height and number of tillers/clump that was manifested in reduced herb yield was compensated by a higher oil concentration in the leaves. The highest content of Eugenol was reported in addition to Methyl Eugenol, Beta Elemene and Caryophyllene.
Sukhvinder Singh Purewal - One of the best experts on this subject based on the ideXlab platform.
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Tulsi ( Ocimum Tenuiflorum ) seeds: in vitro DNA damage protection, bioactive compounds and antioxidant potential
Journal of Food Measurement and Characterization, 2018Co-Authors: Pinderpal Kaur, Sanju Bala Dhull, Kawaljit Singh Sandhu, Raj Kumar Salar, Sukhvinder Singh PurewalAbstract:Tulsi (Ocimum Tenuiflorum) seeds (TS) were evaluated for bioactive compounds, antioxidant potential and DNA damage protection activity. TS were extracted with ethanol, methanol, acetone and chloroform at temperature 44.5 °C for 23.8 min in a water bath. Bioactive constituents and antioxidant properties were studied by TPC, CTC, DPPH, ABTS, TAC, RPA, HFRSA and FRAP assays. Two types of bioactive compounds with varying amount (mg/g dwb) were found. TPC in TS ranged from 0.03 to 1.02 (mg GAE/g dwb) whereas CTC was in range from 1.85 to 6.44 (mg CE/g dwb). Comparisons of antioxidant potential of different extracts of TS revealed that methanol extract (TSM) possess significantly (p
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tulsi Ocimum Tenuiflorum seeds in vitro dna damage protection bioactive compounds and antioxidant potential
Journal of Food Measurement and Characterization, 2018Co-Authors: Pinderpal Kaur, Sanju Bala Dhull, Kawaljit Singh Sandhu, Raj Kumar Salar, Sukhvinder Singh PurewalAbstract:Tulsi (Ocimum Tenuiflorum) seeds (TS) were evaluated for bioactive compounds, antioxidant potential and DNA damage protection activity. TS were extracted with ethanol, methanol, acetone and chloroform at temperature 44.5 °C for 23.8 min in a water bath. Bioactive constituents and antioxidant properties were studied by TPC, CTC, DPPH, ABTS, TAC, RPA, HFRSA and FRAP assays. Two types of bioactive compounds with varying amount (mg/g dwb) were found. TPC in TS ranged from 0.03 to 1.02 (mg GAE/g dwb) whereas CTC was in range from 1.85 to 6.44 (mg CE/g dwb). Comparisons of antioxidant potential of different extracts of TS revealed that methanol extract (TSM) possess significantly (p < 0.05) higher value of DPPH (90.9%), ABTS (89.5%), TAC [0.73 mg ascorbic acid equivalent/g dry weight basis (mg AAE/g dwb)] and RPA (9.88 mg Quercetin equivalent/g dwb) as compared to other solvents. HFRSA value of ethanol extract (TSE) was, however, higher than others. Quantitative analysis of antioxidant compounds was performed using HPLC. Four bioactive compounds: gallic acid (0.38 mg), cinnamic acid (0.15 mg), p-coumaric acid (0.17 mg) and catechol (0.08 mg) were found when methanol extract (TSM) was used for their quantification. Correlation analysis also revealed relationships between TPC, CTC and different antioxidant assays. Among solvents used, methanol was found to be best extraction phase for the recovery of bioactive constituents with higher antioxidant potential.