The Experts below are selected from a list of 291 Experts worldwide ranked by ideXlab platform
Thomas Hummel - One of the best experts on this subject based on the ideXlab platform.
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reduced Olfactory Bulb volume and Olfactory sensitivity in patients with acute major depression
Neuroscience, 2010Co-Authors: Simona Negoias, Johannes Gerber, Ilona Croy, S Puschmann, Katja Petrowski, Peter Joraschky, Thomas HummelAbstract:The purpose of this study was to assess Olfactory function and Olfactory Bulb volume in patients with acute major depression in comparison to a normal population. Twenty-one patients diagnosed with acute major depressive disorder and 21 healthy controls matched by age, sex and smoking behavior participated in this study. Olfactory function was assessed in a lateralized fashion using measures of odor threshold, discrimination and identification. Olfactory Bulb volumes were calculated by manual segmentation of acquired T2-weighted coronal slices according to a standardized protocol. Patients with acute major depressive disorder showed significantly lower Olfactory sensitivity and smaller Olfactory Bulb volumes. Additionally, a significant negative correlation between Olfactory Bulb volume and depression scores was detected. Their results provide the first evidence, to our knowledge, of decreased Olfactory Bulb volume in patients with acute major depression. These results might be related to reduced neurogenesis in major depression that could be reflected also at the level of the Olfactory Bulb.
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increasing Olfactory Bulb volume due to treatment of chronic rhinosinusitis a longitudinal study
Brain, 2009Co-Authors: Volker Gudziol, Philippe Rombaux, Johannes Gerber, D Buschhuter, N Abolmaali, Thomas HummelAbstract:Differentiation of progenitor cells into neurons in the Olfactory Bulb depends on Olfactory stimulation that can lead to an increase in Olfactory Bulb volume. In this study, we investigated whether the human Olfactory Bulb volume increases with increasing Olfactory function due to treatment of chronic rhinosinusitis. Nineteen patients with chronic rhinosinusitis were investigated before and after treatment. For comparison, additional measurements were performed in 18 healthy volunteers. Volumetric measurements of the Olfactory Bulb were based on planimetric manual contouring of magnetic resonance scans. Olfactory function was evaluated separately for each nostril using tests for odour threshold, odour discrimination and odour identification. Measurements were performed on two occasions, 3 months apart. In healthy controls, the Olfactory Bulb volume did not change significantly between the two measurements. In contrast, the Olfactory Bulb volume in patients increased significantly from the initial 64.5 +/- 3.2 to 70.0 +/- 3.5 mm(3) on the left side (P = 0.02) and from 60.9 +/- 3.5 to 72.4 +/- 2.8 mm(3) on the right side (P < 0.001). The increase in Olfactory Bulb volume correlated significantly with an increase in odour thresholds (r = 0.60, P = 0.006, left side; r = 0.49, P = 0.03, right side), but not with changes in odour discrimination or odour identification. Results of this study support the idea that stimulation of Olfactory receptor neurons impacts on the cell death in the Olfactory Bulb, not only in rodents but also in humans. To our knowledge, this is the first longitudinal study that describes an enlargement of the human Olfactory Bulb due to improvement of peripheral Olfactory function.
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Olfactory Bulb volume in the clinical assessment of Olfactory dysfunction.
Rhinology, 2009Co-Authors: Philippe Rombaux, Thierry Duprez, Thomas HummelAbstract:The Olfactory Bulb collects the sensory afferents of the Olfactory receptor cells located in the Olfactory neuroepithelium. The Olfactory Bulb ends with the Olfactory tract and is closely related to the Olfactory sulcus of the frontal lobe. Many studies demonstrated that Olfactory Bulb volume assessed with magnetic resonance imaging is related to the Olfactory function both in normal and pathological conditions. It has been shown that Olfactory Bulb volume changes with the degree of Olfactory dysfunction, that it decreases with the duration of the Olfactory loss and that patients with qualitative disorder such as parosmia have smaller Olfactory Bulbs than patients without parosmia. In this review, we will discuss the actual knowledge regarding Olfactory Bulb function, practical ways to measure Olfactory Bulb volume and Olfactory sulcus depth, and report systematic observations regarding these measurements related to various causes of Olfactory dysfunction, e.g. infection of the upper respiratory tract, head trauma, or neurodegenerative disease. Measurement of Olfactory Bulb volume may provide valuable information for patients with Olfactory dysfunction.
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reduced Olfactory Bulb volume in post traumatic and post infectious Olfactory dysfunction
Neuroreport, 2005Co-Authors: A Mueller, Antje Rodewald, Jens Reden, Johannes Gerber, Ruediger Von Kummer, Thomas HummelAbstract:The Olfactory Bulb is a highly plastic structure the volume of which partly reflects the degree of afferent neural activity. In this study, 22 patients with post-infectious Olfactory deficit, nine participants with post-traumatic Olfactory deficit, and 17 healthy controls underwent magnetic resonance volumetry of the Olfactory Bulb. Patients presented with significantly smaller Olfactory Bulb volumes than controls; significant correlations between Olfactory function and Bulb volume were observed. Patients with parosmia exhibited smaller Olfactory Bulb volumes than those without parosmia. Findings indicate that smell deficits leading to a reduced sensory input to the Olfactory Bulb result in structural changes at the level of the Bulb. Reduced Olfactory Bulb volumes may also be considered to be characteristic of parosmia.
Philippe Rombaux - One of the best experts on this subject based on the ideXlab platform.
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Olfactory Bulb Volume for Prognosis in Olfactory Loss
Otolaryngology–Head and Neck Surgery, 2012Co-Authors: Philippe Rombaux, Caroline Huart, Naima Deggouj, Thierry DuprezAbstract:Objective: The Olfactory Bulb (OB) is essential for Olfactory perception, and its volume is correlated to the Olfactory function in normal and pathologic cases. We hypothesized that Olfactory Bulb volume could also be used as a new predictor of Olfactory recovery.Method: A cohort of 60 patients suffering from PI (n = 28) and PT Olfactory loss (n = 32) was studied. Assessment of Olfactory function was performed using orthonasal and retronasal tests, at the time of the diagnosis and 15 months later. All patients were examined on a 3T-MRI. The Olfactory Bulb volume was calculated.Results: Recovery rate was 25% in patients with PT Olfactory loss and 35.7% in patients with PI Olfactory loss. There was a correlation between both the orthonasal and the retronasal score, and between Olfactory testing and the total Olfactory Bulb volume, both at T1 and at T2. In addition, we observed a significant correlation between changes in Olfactory functions and initial measures of the total OB volume, with larger volumes re...
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increasing Olfactory Bulb volume due to treatment of chronic rhinosinusitis a longitudinal study
Brain, 2009Co-Authors: Volker Gudziol, Philippe Rombaux, Johannes Gerber, D Buschhuter, N Abolmaali, Thomas HummelAbstract:Differentiation of progenitor cells into neurons in the Olfactory Bulb depends on Olfactory stimulation that can lead to an increase in Olfactory Bulb volume. In this study, we investigated whether the human Olfactory Bulb volume increases with increasing Olfactory function due to treatment of chronic rhinosinusitis. Nineteen patients with chronic rhinosinusitis were investigated before and after treatment. For comparison, additional measurements were performed in 18 healthy volunteers. Volumetric measurements of the Olfactory Bulb were based on planimetric manual contouring of magnetic resonance scans. Olfactory function was evaluated separately for each nostril using tests for odour threshold, odour discrimination and odour identification. Measurements were performed on two occasions, 3 months apart. In healthy controls, the Olfactory Bulb volume did not change significantly between the two measurements. In contrast, the Olfactory Bulb volume in patients increased significantly from the initial 64.5 +/- 3.2 to 70.0 +/- 3.5 mm(3) on the left side (P = 0.02) and from 60.9 +/- 3.5 to 72.4 +/- 2.8 mm(3) on the right side (P < 0.001). The increase in Olfactory Bulb volume correlated significantly with an increase in odour thresholds (r = 0.60, P = 0.006, left side; r = 0.49, P = 0.03, right side), but not with changes in odour discrimination or odour identification. Results of this study support the idea that stimulation of Olfactory receptor neurons impacts on the cell death in the Olfactory Bulb, not only in rodents but also in humans. To our knowledge, this is the first longitudinal study that describes an enlargement of the human Olfactory Bulb due to improvement of peripheral Olfactory function.
-
Olfactory Bulb volume in the clinical assessment of Olfactory dysfunction.
Rhinology, 2009Co-Authors: Philippe Rombaux, Thierry Duprez, Thomas HummelAbstract:The Olfactory Bulb collects the sensory afferents of the Olfactory receptor cells located in the Olfactory neuroepithelium. The Olfactory Bulb ends with the Olfactory tract and is closely related to the Olfactory sulcus of the frontal lobe. Many studies demonstrated that Olfactory Bulb volume assessed with magnetic resonance imaging is related to the Olfactory function both in normal and pathological conditions. It has been shown that Olfactory Bulb volume changes with the degree of Olfactory dysfunction, that it decreases with the duration of the Olfactory loss and that patients with qualitative disorder such as parosmia have smaller Olfactory Bulbs than patients without parosmia. In this review, we will discuss the actual knowledge regarding Olfactory Bulb function, practical ways to measure Olfactory Bulb volume and Olfactory sulcus depth, and report systematic observations regarding these measurements related to various causes of Olfactory dysfunction, e.g. infection of the upper respiratory tract, head trauma, or neurodegenerative disease. Measurement of Olfactory Bulb volume may provide valuable information for patients with Olfactory dysfunction.
Johannes Gerber - One of the best experts on this subject based on the ideXlab platform.
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reduced Olfactory Bulb volume and Olfactory sensitivity in patients with acute major depression
Neuroscience, 2010Co-Authors: Simona Negoias, Johannes Gerber, Ilona Croy, S Puschmann, Katja Petrowski, Peter Joraschky, Thomas HummelAbstract:The purpose of this study was to assess Olfactory function and Olfactory Bulb volume in patients with acute major depression in comparison to a normal population. Twenty-one patients diagnosed with acute major depressive disorder and 21 healthy controls matched by age, sex and smoking behavior participated in this study. Olfactory function was assessed in a lateralized fashion using measures of odor threshold, discrimination and identification. Olfactory Bulb volumes were calculated by manual segmentation of acquired T2-weighted coronal slices according to a standardized protocol. Patients with acute major depressive disorder showed significantly lower Olfactory sensitivity and smaller Olfactory Bulb volumes. Additionally, a significant negative correlation between Olfactory Bulb volume and depression scores was detected. Their results provide the first evidence, to our knowledge, of decreased Olfactory Bulb volume in patients with acute major depression. These results might be related to reduced neurogenesis in major depression that could be reflected also at the level of the Olfactory Bulb.
-
increasing Olfactory Bulb volume due to treatment of chronic rhinosinusitis a longitudinal study
Brain, 2009Co-Authors: Volker Gudziol, Philippe Rombaux, Johannes Gerber, D Buschhuter, N Abolmaali, Thomas HummelAbstract:Differentiation of progenitor cells into neurons in the Olfactory Bulb depends on Olfactory stimulation that can lead to an increase in Olfactory Bulb volume. In this study, we investigated whether the human Olfactory Bulb volume increases with increasing Olfactory function due to treatment of chronic rhinosinusitis. Nineteen patients with chronic rhinosinusitis were investigated before and after treatment. For comparison, additional measurements were performed in 18 healthy volunteers. Volumetric measurements of the Olfactory Bulb were based on planimetric manual contouring of magnetic resonance scans. Olfactory function was evaluated separately for each nostril using tests for odour threshold, odour discrimination and odour identification. Measurements were performed on two occasions, 3 months apart. In healthy controls, the Olfactory Bulb volume did not change significantly between the two measurements. In contrast, the Olfactory Bulb volume in patients increased significantly from the initial 64.5 +/- 3.2 to 70.0 +/- 3.5 mm(3) on the left side (P = 0.02) and from 60.9 +/- 3.5 to 72.4 +/- 2.8 mm(3) on the right side (P < 0.001). The increase in Olfactory Bulb volume correlated significantly with an increase in odour thresholds (r = 0.60, P = 0.006, left side; r = 0.49, P = 0.03, right side), but not with changes in odour discrimination or odour identification. Results of this study support the idea that stimulation of Olfactory receptor neurons impacts on the cell death in the Olfactory Bulb, not only in rodents but also in humans. To our knowledge, this is the first longitudinal study that describes an enlargement of the human Olfactory Bulb due to improvement of peripheral Olfactory function.
-
reduced Olfactory Bulb volume in post traumatic and post infectious Olfactory dysfunction
Neuroreport, 2005Co-Authors: A Mueller, Antje Rodewald, Jens Reden, Johannes Gerber, Ruediger Von Kummer, Thomas HummelAbstract:The Olfactory Bulb is a highly plastic structure the volume of which partly reflects the degree of afferent neural activity. In this study, 22 patients with post-infectious Olfactory deficit, nine participants with post-traumatic Olfactory deficit, and 17 healthy controls underwent magnetic resonance volumetry of the Olfactory Bulb. Patients presented with significantly smaller Olfactory Bulb volumes than controls; significant correlations between Olfactory function and Bulb volume were observed. Patients with parosmia exhibited smaller Olfactory Bulb volumes than those without parosmia. Findings indicate that smell deficits leading to a reduced sensory input to the Olfactory Bulb result in structural changes at the level of the Bulb. Reduced Olfactory Bulb volumes may also be considered to be characteristic of parosmia.
Thierry Duprez - One of the best experts on this subject based on the ideXlab platform.
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Olfactory Bulb Volume for Prognosis in Olfactory Loss
Otolaryngology–Head and Neck Surgery, 2012Co-Authors: Philippe Rombaux, Caroline Huart, Naima Deggouj, Thierry DuprezAbstract:Objective: The Olfactory Bulb (OB) is essential for Olfactory perception, and its volume is correlated to the Olfactory function in normal and pathologic cases. We hypothesized that Olfactory Bulb volume could also be used as a new predictor of Olfactory recovery.Method: A cohort of 60 patients suffering from PI (n = 28) and PT Olfactory loss (n = 32) was studied. Assessment of Olfactory function was performed using orthonasal and retronasal tests, at the time of the diagnosis and 15 months later. All patients were examined on a 3T-MRI. The Olfactory Bulb volume was calculated.Results: Recovery rate was 25% in patients with PT Olfactory loss and 35.7% in patients with PI Olfactory loss. There was a correlation between both the orthonasal and the retronasal score, and between Olfactory testing and the total Olfactory Bulb volume, both at T1 and at T2. In addition, we observed a significant correlation between changes in Olfactory functions and initial measures of the total OB volume, with larger volumes re...
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Olfactory Bulb volume in the clinical assessment of Olfactory dysfunction.
Rhinology, 2009Co-Authors: Philippe Rombaux, Thierry Duprez, Thomas HummelAbstract:The Olfactory Bulb collects the sensory afferents of the Olfactory receptor cells located in the Olfactory neuroepithelium. The Olfactory Bulb ends with the Olfactory tract and is closely related to the Olfactory sulcus of the frontal lobe. Many studies demonstrated that Olfactory Bulb volume assessed with magnetic resonance imaging is related to the Olfactory function both in normal and pathological conditions. It has been shown that Olfactory Bulb volume changes with the degree of Olfactory dysfunction, that it decreases with the duration of the Olfactory loss and that patients with qualitative disorder such as parosmia have smaller Olfactory Bulbs than patients without parosmia. In this review, we will discuss the actual knowledge regarding Olfactory Bulb function, practical ways to measure Olfactory Bulb volume and Olfactory sulcus depth, and report systematic observations regarding these measurements related to various causes of Olfactory dysfunction, e.g. infection of the upper respiratory tract, head trauma, or neurodegenerative disease. Measurement of Olfactory Bulb volume may provide valuable information for patients with Olfactory dysfunction.
Samireh Farshchi - One of the best experts on this subject based on the ideXlab platform.
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Olfactory Bulb Volume in Nasal Polyposis
Otolaryngology–Head and Neck Surgery, 2013Co-Authors: Amin Amali, Mohammad Sadeghi, Amir A. Sazgar, Maziar Motiee Langroudi, Samireh FarshchiAbstract:Objectives:There is still a debate about the relation of Olfactory Bulb volume (OBV) to Olfactory function. Many studies suggest that Olfactory deprivation decreases Olfactory Bulb volume. The aim of this study was to compare the Olfactory threshold and Olfactory Bulb volume of patients with nasal polyps and healthy individuals.Methods:This was a case control study that was carried out in Valiasr hospital of Tehran University of Medical Sciences in 2010-2011. 22 patients with nasal polyps were compared with 37 healthy individuals. Olfactory threshold test and magnetic resonance imaging (MRI) were performed in all participants. Age, gender, left OBV, right OBV, total OBV, and Olfactory threshold were recorded.Results:There was no significant difference between the age, gender, and Olfactory Bulb volume of patients of the two groups (P > 0.05). However, the difference between Olfactory threshold of the two groups was significant (P < 0.0001). Also, Olfactory function and threshold showed no significant rela...
