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Mojgan Tansaz - One of the best experts on this subject based on the ideXlab platform.
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effect of aslagh capsule a traditional compound herbal product on Oligomenorrhea in patients with polycystic ovary syndrome a three arm open label randomized controlled trial
Galen Medical Journal, 2019Co-Authors: Maryam Bahman, Homa Hajimehdipoor, Soodabeh Bioos, Fataneh Hashemdabaghian, Maryam Afrakhteh, Mojgan TansazAbstract:Background: Oligomenorrhea is a common complaint in patients with polycystic ovary syndrome (PCOS). There are some useful medicinal recommendations such as Aslagh product (include fennel fruits, carrot seeds, chaste tree fruits) in Iranian traditional medicine for the treatment of Oligomenorrhea in PCOS. Hence, the present investigation was designed to compare Aslagh capsule with metformin on the Oligomenorrhea. Materials and Methods: One hundred fifty women aged between 18-43 years with Oligomenorrhea due to PCOS were randomly divided into Aslagh, metformin, and Aslagh + metformin groups. The occurrence of menstrual bleeding was considered as the primary outcome. Menstrual cyclicity, duration, and volume of the bleeding were also evaluated. Results: Occurrence of menstrual bleeding was 87.2% in all patients, with no significant difference between the three groups (P> 0.05). Menstrual cyclicity significantly improved from baseline in Aslagh and Aslagh+ metformin groups (P=0.02). Duration of menstrual bleeding was significantly higher in Aslagh group in the first and the second menstrual bleeding cycle compared to the other two groups (P<0.05). No significant change was observed in the volume of the bleeding after the intervention in any of the three groups. The occurrence of menstrual bleeding in Aslagh group was significantly (P=0.03) higher than the other two groups in the fourth month (drug-free period). Conclusion: Aslagh capsule showed beneficial effects similar to metformin in the treatment of Oligomenorrhea in PCOS women and could be suggested for use as an alternative treatment in these patients.
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celery plus anise versus metformin for treatment of Oligomenorrhea in polycystic ovary syndrome a triple blind randomized clinical trial
Iranian Red Crescent Medical Journal, 2018Co-Authors: Arezoo Moini Jazani, Mojgan Tansaz, Hossein Nazemiyeh, Homayoun Sadeghi Bazargani, Seyed Mohammad Bagher Fazljou, Ramin Nasimi Doost Azgomi, Kobra HamdiAbstract:Background: Polycystic ovary syndrome (PCOS)-induced Oligomenorrhea can leave psychological and non-psychological impacts on women. Among the proposed strategies for its treatment, herbal medications are of importance due to favorable effect profiles. Objectives: We planned a study to compare the effects of Celery and Anise combination (CAC) and metformin (met.) on Oligomenorrhea in PCOS patients. Methods: We conducted a triple-blind, Randomized clinical trial on 72 patients that were randomly allocated into two equal groups to receive six capsules of either CAC (750 mg each) or met. (250 mg each) at three separate doses for 15 days beginning from the follicular phase. If the bleeding occurred, three capsules of either placebo or met. would be administered daily during the menstruation phase, and then the follicular phase step with six capsules would be repeated. If the bleeding did not occur, three capsules of either placebo or met. would be administered each day for 15 days. The regularity of menstrual bleeding as the primary outcome, as well as testosterone, luteinizing hormone/follicular stimulating hormone ratio (LH/FSH), and complications, was assessed before and after the three cycles. Results: The mean age ± standard deviation of patients was 26.5 ± 6.1. The mean Body Mass Index was 26.4 ± 3.5. CAC significantly improved Oligomenorrhea (58.3% vs. 25%, P < 0.01), increased bleeding episodes (P = 0.003), and reduced testosterone (mean difference: 0.16 vs. -0.02, P = 0.005) and LH/FSH (mean difference: 0.75 vs. -0.08, P = 0.002) without any major side effects compared to met. Conclusions: We showed that Celery and Anise combination could regulate menstrual cycles and improve Oligomenorrhea in polycystic ovary syndrome patients superiorly to metformin.
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Herbal Medicine for Oligomenorrhea and Amenorrhea: A Systematic Review of Ancient and Conventional Medicine
Hindawi Limited, 2018Co-Authors: Arezoo Moini Jazani, Mojgan Tansaz, Hossein Nazemiyeh, Homayoun Sadeghi Bazargani, Seyed Mohammad Bagher Fazljou, Kobra Hamdi, Ramin Nasimi Doost AzgomiAbstract:Introduction. Menstrual bleeding cessation is one of the most frequent gynecologic disorders among women in reproductive age. The treatment is based on hormone therapy. Due to the increasing request for alternative medicine remedies in the field of women’s diseases, in present study, it was tried to overview medicinal plants used to treat Oligomenorrhea and amenorrhea according to the pharmaceutical textbooks of traditional Persian medicine (TPM) and review the evidence in the conventional medicine. Methods. This systematic review was designed and performed in 2017 in order to gather information regarding herbal medications of Oligomenorrhea and amenorrhea in TPM and conventional medicine. This study had several steps as searching Iranian traditional medicine literature and extracting the emmenagogue plants, classifying the plants, searching the electronic databases, and finding evidences. To search traditional Persian medicine references, Noor digital library was used, which includes several ancient traditional medical references. The classification of plants was done based on the repetition and potency of the plants in the ancient literatures. The required data was gathered using databases such as PubMed, Scopus, Google Scholar, Cochrane Library, Science Direct, and web of knowledge. Results. In present study of all 198 emmenagogue medicinal plants found in TPM, 87 cases were specified to be more effective in treating Oligomenorrhea and amenorrhea. In second part of present study, where a search of conventional medicine was performed, 12 studies were found, which had 8 plants investigated: Vitex agnus-castus, Trigonella foenum-graecum, Foeniculum vulgare, Cinnamomum verum, Paeonia lactiflora, Sesamum indicum, Mentha longifolia, and Urtica dioica. Conclusion. Traditional Persian medicine has proposed many different medicinal plants for treatment of Oligomenorrhea and amenorrhea. Although just few plants have been proven to be effective for treatment of menstrual irregularities, the results and the classification in present study can be used as an outline for future studies and treatment
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A neuropsychiatric complication of Oligomenorrhea according to iranian traditional medicine
Iranian journal of reproductive medicine, 2014Co-Authors: M Yavari, Mojgan Tansaz, Faezeh Khodabandeh, Safoura RouholaminAbstract:Oligomenorrhea, a prevalent disease with serious complications, has been declared in the Avicenna traditional medicine in detail. Avicenna in his famous book, Cannon of Medicine, presents a syndrome termed ‘uterine strangulation’, as a complication of menstrual bleeding cessation and lack of sexual satisfaction. We have explained this syndrome from both traditional and conventional medicine viewpoints to propose a new hypothesis for diagnosis and treatment of women with Oligomenorrhea and systemic signs/symptoms admitting to clinics for further evaluation. This hypothesis definitely needs to be further assessed and confirmed by strong clinical trials.
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uterus complications of amenorrhea and Oligomenorrhea ehteebas tams in iranian traditional medicine
Medical History Journal, 2012Co-Authors: Maliheh Tabarai Arani, Roshanak Mokaberinejad, Mojgan Tansaz, Soudabe Bioos, Effat Jafari Dehkordi, Elham Akhtari, Seyedeh Sedigheh Yusefi, Somayeh Mahrouzadeh, Nasrin Baeiri, Monirsadat RuhollahiAbstract:Amenorrhea and Oligomenorrhea are the most prevalent menstruation disorder in the world and also in Iran. In Iranian traditional medicine amenorrhea, Oligomenorrhea and also hypomenorrhea have been known just as ”Ehteebas tams”. From the perspective of Iranian traditional medicine, Amenorrhea enables to induce numerous complications on brain, respiratory system, uterus and other organs. Uterus complication of amenorrhea consists of infertility, uterus strangulation (Ekhtenagh rahem), uterus inflammation (varam rahem) and Anatomical changes of the uterus (Mayalan rahem). In this paper, uterine diseases due to amenorrhea and their mechanism is studied. Investigation of these disease complications and its effects on body and uterus in Iranian traditional medicine emphasize on treatment importance and causing of regular and normal menstruation.
Davis Stroop - One of the best experts on this subject based on the ideXlab platform.
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adolescent Oligomenorrhea in a biracial schoolgirl cohort a simple clinical parameter predicting impaired fasting glucose plus type 2 diabetes mellitus insulin glucose insulin resistance and centripetal obesity from age 19 to 25 years
Metabolism-clinical and Experimental, 2011Co-Authors: John A. Morrison, Charles J Glueck, Ping Wang, Stephen R. Daniels, Davis StroopAbstract:We hypothesized that adolescent Oligomenorrhea (ages 14-19) would independently predict impaired fasting glucose (IFG; ≥110 to <126 mg/dL) plus type 2 diabetes mellitus (T2DM; ≥126 mg/dL), insulin and glucose levels, and insulin resistance (IR) in young adulthood (ages 19-25). A prospective 15-year follow-up of 370 schoolgirls starting at age 10 was performed. Age 14 waist circumference was the most important explanatory variable for IFG + T2DM during ages 19 to 24 (P = .002; odds ratio, 1.06; 95% confidence interval, 1.02-1.10), along with Oligomenorrhea category from ages 14 to 19 (0, 1, 2, ≥3 reports over 6 years; P = .032; odds ratio, 1.82; 95% confidence interval, 1.05-3.14). Impaired fasting glucose + T2DM at ages 19 to 24 were more common in girls having 1 (6%), 2 (11%), and ≥3 (38%) Oligomenorrhea reports from ages 14 to 19 than in girls without Oligomenorrhea (3%; P = .0003). Positive explanatory variables (all Ps ≤ .05) for homeostasis model assessment of IR at ages 19 to 24 included age 14 waist (partial R2 = 30.1%), Oligomenorrhea with hyperandrogenism (polycystic ovary syndrome; partial R2 = 4.1%), black race (3.8%), and Oligomenorrhea frequency during ages 14 to 19 (0.8%); sex hormone binding globulin was a negative explanatory variable (0.7%). This is the first prospective study to report an independent association of adolescent Oligomenorrhea with young adult IFG + T2DM, with insulin and glucose levels, and with IR. Age 14 waist circumference, Oligomenorrhea with hyperandrogenism (polycystic ovary syndrome), black race, Oligomenorrhea frequency at ages 14 to 19, and age 14 sex hormone binding globulin were independently associated with IR at ages 19 to 24, potentially facilitating primary prevention of IFG, T2DM, and hyperinsulinemia.
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sex hormone binding globulin Oligomenorrhea polycystic ovary syndrome and childhood insulin at age 14 years predict metabolic syndrome and class iii obesity at age 24 years
The Journal of Pediatrics, 2011Co-Authors: Charles J Glueck, John A. Morrison, Ping Wang, Stephen R. Daniels, Davis StroopAbstract:Objective We hypothesized that Oligomenorrhea (menstrual cyclicity ≥42 days), hyperandrogenism, low levels of sex hormone-binding globulin (SHBG), childhood insulin, and metabolic syndrome (MetS) at age 14 years would predict MetS and class III obesity (body mass index ≥40 kg/m 2 ) at age 24 years. Study design In this prospective study of schoolgirls, at age 14 years, the girls were categorized as regularly cycling (n = 375), oligomenorrheic (n = 18), or Oligomenorrhea plus biochemical hyperandrogenism (polycystic ovary syndrome [PCOS]; n=12), together designated PCOS. Results Significant explanatory variables for MetS at age 24 years included childhood insulin, MetS, and PCOS category (all positive) and SHBG (negative) at age 14 years. Using categorical data, top decile of childhood insulin, MetS at age 14, bottom decile of SHBG, and PCOS category were significant positive predictors for MetS at age 24. SHBG (negative), black race (positive), and Oligomenorrhea (positive) were significant explanatory variables for class III obesity at age 24. Using categorical data, black race, MetS at age 14, bottom decile of SHBG, PCOS category, and top decile of childhood insulin were positive explanatory variables for class III obesity at age 24 years. Conclusions Oligomenorrhea, PCOS (a subcohort of Oligomenorrhea), hyperandrogenism, low SHBG, MetS, and childhood insulin at age 14 years may represent a critical, reversible pathway for the development of MetS and class III obesity in young adulthood.
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Adolescent Oligomenorrhea in a biracial schoolgirl cohort: a simple clinical parameter predicting impaired fasting glucose plus type 2 diabetes mellitus, insulin, glucose, insulin resistance, and centripetal obesity from age 19 to 25 years.
Metabolism, 2011Co-Authors: John A. Morrison, Charles J Glueck, Ping Wang, Stephen R. Daniels, Davis StroopAbstract:We hypothesized that adolescent Oligomenorrhea (ages 14-19) would independently predict impaired fasting glucose (IFG; ≥110 to
Saara Taponen - One of the best experts on this subject based on the ideXlab platform.
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metabolic cardiovascular disease risk factors in women with self reported symptoms of Oligomenorrhea and or hirsutism northern finland birth cohort 1966 study
The Journal of Clinical Endocrinology and Metabolism, 2004Co-Authors: Saara Taponen, Hannu Martikainen, Marjo-riitta Järvelin, Ulla Sovio, Jaana Laitinen, Anneli Pouta, Anna-liisa Hartikainen, Mark I. MccarthyAbstract:The metabolic cardiovascular disease (CVD) risk factors of women with self-reported Oligomenorrhea and/or hirsutism, which are symptoms of polycystic ovary syndrome (PCOS), were investigated in a general population-based Northern Finland Birth Cohort 1966 Study to determine whether women with PCOS symptoms at 31 yr would be distinguishable from asymptomatic controls in terms of CVD risk factors. A total of 518 cases with Oligomenorrhea and/or hirsutism and 1036 randomly selected controls were analyzed. C-Reactive protein (CRP; median, 0.70 vs. 0.60 mg/liter; P = 0.026), triglycerides (mean, 0.97 vs. 0.91 mmol/liter; P = 0.039), body mass index (BMI; mean, 25.1 vs. 24.2 kg/m(2); P or=30 kg/m(2)) groups, the waist/hip ratio was significantly higher among the overweight cases (mean, 0.84 vs. 0.83; P = 0.04). Among the obese women, high-density lipoprotein cholesterol was significantly lower (mean, 1.32 vs. 1.48 mmol/liter; P = 0.002) among the cases, and triglycerides tended to be higher (mean, 1.43 vs. 1.27 mmol/liter; P = 0.068) than in controls. In conclusion, these results indicate that self-reported symptoms of Oligomenorrhea and/or hirsutism, particularly in the presence of both symptoms, may be helpful to identify women with metabolic cardiovascular risk factor accumulation associated with PCOS.
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Metabolic Cardiovascular Disease Risk Factors in Women with Self-Reported Symptoms of Oligomenorrhea and/or Hirsutism: Northern Finland Birth Cohort 1966 Study
The Journal of Clinical Endocrinology & Metabolism, 2004Co-Authors: Saara Taponen, Hannu Martikainen, Marjo-riitta Järvelin, Ulla Sovio, Jaana Laitinen, Anneli Pouta, Anna-liisa Hartikainen, Mark I. Mccarthy, Stephen Franks, Mika PaldaniusAbstract:The metabolic cardiovascular disease (CVD) risk factors of women with self-reported Oligomenorrhea and/or hirsutism, which are symptoms of polycystic ovary syndrome (PCOS), were investigated in a general population-based Northern Finland Birth Cohort 1966 Study to determine whether women with PCOS symptoms at 31 yr would be distinguishable from asymptomatic controls in terms of CVD risk factors. A total of 518 cases with Oligomenorrhea and/or hirsutism and 1036 randomly selected controls were analyzed. C-Reactive protein (CRP; median, 0.70 vs. 0.60 mg/liter; P = 0.026), triglycerides (mean, 0.97 vs. 0.91 mmol/liter; P = 0.039), body mass index (BMI; mean, 25.1 vs. 24.2 kg/m(2); P or=30 kg/m(2)) groups, the waist/hip ratio was significantly higher among the overweight cases (mean, 0.84 vs. 0.83; P = 0.04). Among the obese women, high-density lipoprotein cholesterol was significantly lower (mean, 1.32 vs. 1.48 mmol/liter; P = 0.002) among the cases, and triglycerides tended to be higher (mean, 1.43 vs. 1.27 mmol/liter; P = 0.068) than in controls. In conclusion, these results indicate that self-reported symptoms of Oligomenorrhea and/or hirsutism, particularly in the presence of both symptoms, may be helpful to identify women with metabolic cardiovascular risk factor accumulation associated with PCOS.
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Hormonal profile of women with self-reported symptoms of Oligomenorrhea and/or hirsutism: Northern Finland birth cohort 1966 study.
The Journal of Clinical Endocrinology & Metabolism, 2003Co-Authors: Saara Taponen, Hannu Martikainen, Marjo-riitta Järvelin, Ulla Sovio, Jaana Laitinen, Anneli Pouta, Anna-liisa Hartikainen, Mark I. Mccarthy, Stephen Franks, Aimo RuokonenAbstract:The hormonal profiles of nested female patients (n = 500) with self-reported symptoms typical of polycystic ovary syndrome (PCOS), Oligomenorrhea, and/or hirsutism and their randomly selected controls (n = 1026) at the age of 31 yr were analyzed in a general population-based Northern Finland birth cohort 1966 to find out whether the symptomatic women also have the endocrine characteristics of PCOS and could be detected in a general population using simple questions. Higher medians of serum testosterone (T) (2.10 vs. 1.90 nmol/liter, P < 0.001), LH (5.40 vs. 4.85 U/liter, P = 0.005), insulin (53.8 vs. 51.66 pmol/liter, P = 0.040), and free androgen index (FAI) (4.01 vs. 3.03, P < 0.001) and lower glucose/insulin ratio (91.1 x 10(8) vs. 94.9 x 10(8), P = 0.048) and SHBG (52.4 vs. 60.7 nmol/liter, P < 0.001) were observed among the cases, but no difference was observed in cortisol and glucose levels between the cases and controls. Of all the women in the cohort, 10.2% reported only Oligomenorrhea and had biochemical findings similar to the whole case group. Those who reported only hirsutism (10.4%) were in between the case and control groups according to biochemical findings. The subjects who reported both Oligomenorrhea and hirsutism (3.4%) had the highest T, LH, FAI, insulin, and glucose and the lowest SHBG and glucose/insulin ratio, compared with the case group and the groups with either symptom only indicating a dose-response manner in typical endocrine profile of PCOS by adding up symptoms. The levels of T and FAI were higher and SHBG lower in groups with overweight or obesity both at 14 and 31 yr, compared with groups with normal weight at 14 yr and overweight or obesity at 31 yr. In the group with normal weight at 14 and 31 yr and the group with overweight or obesity at 14 yr but normal weight at 31 yr, the levels of T and FAI were lowest and SHBG highest. T and FAI were higher and SHBG lower among the cases than the controls in groups stratified by weight development from adolescence to adulthood. In conclusion, this longitudinal study of a large, stable population indicates that women with self-reported symptoms of hirsutism and/or Oligomenorrhea show endocrine characteristics of PCOS and can be detected in a general population using simple questions. These symptoms are markers of the underlying metabolic alterations possibly associated with increased health risks in later life.
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hormonal profile of women with self reported symptoms of Oligomenorrhea and or hirsutism northern finland birth cohort 1966 study
The Journal of Clinical Endocrinology and Metabolism, 2003Co-Authors: Saara Taponen, Hannu Martikainen, Marjo-riitta Järvelin, Ulla Sovio, Jaana Laitinen, Anneli Pouta, Anna-liisa HartikainenAbstract:The hormonal profiles of nested female patients (n = 500) with self-reported symptoms typical of polycystic ovary syndrome (PCOS), Oligomenorrhea, and/or hirsutism and their randomly selected controls (n = 1026) at the age of 31 yr were analyzed in a general population-based Northern Finland birth cohort 1966 to find out whether the symptomatic women also have the endocrine characteristics of PCOS and could be detected in a general population using simple questions. Higher medians of serum testosterone (T) (2.10 vs. 1.90 nmol/liter, P < 0.001), LH (5.40 vs. 4.85 U/liter, P = 0.005), insulin (53.8 vs. 51.66 pmol/liter, P = 0.040), and free androgen index (FAI) (4.01 vs. 3.03, P < 0.001) and lower glucose/insulin ratio (91.1 x 10(8) vs. 94.9 x 10(8), P = 0.048) and SHBG (52.4 vs. 60.7 nmol/liter, P < 0.001) were observed among the cases, but no difference was observed in cortisol and glucose levels between the cases and controls. Of all the women in the cohort, 10.2% reported only Oligomenorrhea and had biochemical findings similar to the whole case group. Those who reported only hirsutism (10.4%) were in between the case and control groups according to biochemical findings. The subjects who reported both Oligomenorrhea and hirsutism (3.4%) had the highest T, LH, FAI, insulin, and glucose and the lowest SHBG and glucose/insulin ratio, compared with the case group and the groups with either symptom only indicating a dose-response manner in typical endocrine profile of PCOS by adding up symptoms. The levels of T and FAI were higher and SHBG lower in groups with overweight or obesity both at 14 and 31 yr, compared with groups with normal weight at 14 yr and overweight or obesity at 31 yr. In the group with normal weight at 14 and 31 yr and the group with overweight or obesity at 14 yr but normal weight at 31 yr, the levels of T and FAI were lowest and SHBG highest. T and FAI were higher and SHBG lower among the cases than the controls in groups stratified by weight development from adolescence to adulthood. In conclusion, this longitudinal study of a large, stable population indicates that women with self-reported symptoms of hirsutism and/or Oligomenorrhea show endocrine characteristics of PCOS and can be detected in a general population using simple questions. These symptoms are markers of the underlying metabolic alterations possibly associated with increased health risks in later life.
Ulla Sovio - One of the best experts on this subject based on the ideXlab platform.
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metabolic cardiovascular disease risk factors in women with self reported symptoms of Oligomenorrhea and or hirsutism northern finland birth cohort 1966 study
The Journal of Clinical Endocrinology and Metabolism, 2004Co-Authors: Saara Taponen, Hannu Martikainen, Marjo-riitta Järvelin, Ulla Sovio, Jaana Laitinen, Anneli Pouta, Anna-liisa Hartikainen, Mark I. MccarthyAbstract:The metabolic cardiovascular disease (CVD) risk factors of women with self-reported Oligomenorrhea and/or hirsutism, which are symptoms of polycystic ovary syndrome (PCOS), were investigated in a general population-based Northern Finland Birth Cohort 1966 Study to determine whether women with PCOS symptoms at 31 yr would be distinguishable from asymptomatic controls in terms of CVD risk factors. A total of 518 cases with Oligomenorrhea and/or hirsutism and 1036 randomly selected controls were analyzed. C-Reactive protein (CRP; median, 0.70 vs. 0.60 mg/liter; P = 0.026), triglycerides (mean, 0.97 vs. 0.91 mmol/liter; P = 0.039), body mass index (BMI; mean, 25.1 vs. 24.2 kg/m(2); P or=30 kg/m(2)) groups, the waist/hip ratio was significantly higher among the overweight cases (mean, 0.84 vs. 0.83; P = 0.04). Among the obese women, high-density lipoprotein cholesterol was significantly lower (mean, 1.32 vs. 1.48 mmol/liter; P = 0.002) among the cases, and triglycerides tended to be higher (mean, 1.43 vs. 1.27 mmol/liter; P = 0.068) than in controls. In conclusion, these results indicate that self-reported symptoms of Oligomenorrhea and/or hirsutism, particularly in the presence of both symptoms, may be helpful to identify women with metabolic cardiovascular risk factor accumulation associated with PCOS.
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Metabolic Cardiovascular Disease Risk Factors in Women with Self-Reported Symptoms of Oligomenorrhea and/or Hirsutism: Northern Finland Birth Cohort 1966 Study
The Journal of Clinical Endocrinology & Metabolism, 2004Co-Authors: Saara Taponen, Hannu Martikainen, Marjo-riitta Järvelin, Ulla Sovio, Jaana Laitinen, Anneli Pouta, Anna-liisa Hartikainen, Mark I. Mccarthy, Stephen Franks, Mika PaldaniusAbstract:The metabolic cardiovascular disease (CVD) risk factors of women with self-reported Oligomenorrhea and/or hirsutism, which are symptoms of polycystic ovary syndrome (PCOS), were investigated in a general population-based Northern Finland Birth Cohort 1966 Study to determine whether women with PCOS symptoms at 31 yr would be distinguishable from asymptomatic controls in terms of CVD risk factors. A total of 518 cases with Oligomenorrhea and/or hirsutism and 1036 randomly selected controls were analyzed. C-Reactive protein (CRP; median, 0.70 vs. 0.60 mg/liter; P = 0.026), triglycerides (mean, 0.97 vs. 0.91 mmol/liter; P = 0.039), body mass index (BMI; mean, 25.1 vs. 24.2 kg/m(2); P or=30 kg/m(2)) groups, the waist/hip ratio was significantly higher among the overweight cases (mean, 0.84 vs. 0.83; P = 0.04). Among the obese women, high-density lipoprotein cholesterol was significantly lower (mean, 1.32 vs. 1.48 mmol/liter; P = 0.002) among the cases, and triglycerides tended to be higher (mean, 1.43 vs. 1.27 mmol/liter; P = 0.068) than in controls. In conclusion, these results indicate that self-reported symptoms of Oligomenorrhea and/or hirsutism, particularly in the presence of both symptoms, may be helpful to identify women with metabolic cardiovascular risk factor accumulation associated with PCOS.
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Hormonal profile of women with self-reported symptoms of Oligomenorrhea and/or hirsutism: Northern Finland birth cohort 1966 study.
The Journal of Clinical Endocrinology & Metabolism, 2003Co-Authors: Saara Taponen, Hannu Martikainen, Marjo-riitta Järvelin, Ulla Sovio, Jaana Laitinen, Anneli Pouta, Anna-liisa Hartikainen, Mark I. Mccarthy, Stephen Franks, Aimo RuokonenAbstract:The hormonal profiles of nested female patients (n = 500) with self-reported symptoms typical of polycystic ovary syndrome (PCOS), Oligomenorrhea, and/or hirsutism and their randomly selected controls (n = 1026) at the age of 31 yr were analyzed in a general population-based Northern Finland birth cohort 1966 to find out whether the symptomatic women also have the endocrine characteristics of PCOS and could be detected in a general population using simple questions. Higher medians of serum testosterone (T) (2.10 vs. 1.90 nmol/liter, P < 0.001), LH (5.40 vs. 4.85 U/liter, P = 0.005), insulin (53.8 vs. 51.66 pmol/liter, P = 0.040), and free androgen index (FAI) (4.01 vs. 3.03, P < 0.001) and lower glucose/insulin ratio (91.1 x 10(8) vs. 94.9 x 10(8), P = 0.048) and SHBG (52.4 vs. 60.7 nmol/liter, P < 0.001) were observed among the cases, but no difference was observed in cortisol and glucose levels between the cases and controls. Of all the women in the cohort, 10.2% reported only Oligomenorrhea and had biochemical findings similar to the whole case group. Those who reported only hirsutism (10.4%) were in between the case and control groups according to biochemical findings. The subjects who reported both Oligomenorrhea and hirsutism (3.4%) had the highest T, LH, FAI, insulin, and glucose and the lowest SHBG and glucose/insulin ratio, compared with the case group and the groups with either symptom only indicating a dose-response manner in typical endocrine profile of PCOS by adding up symptoms. The levels of T and FAI were higher and SHBG lower in groups with overweight or obesity both at 14 and 31 yr, compared with groups with normal weight at 14 yr and overweight or obesity at 31 yr. In the group with normal weight at 14 and 31 yr and the group with overweight or obesity at 14 yr but normal weight at 31 yr, the levels of T and FAI were lowest and SHBG highest. T and FAI were higher and SHBG lower among the cases than the controls in groups stratified by weight development from adolescence to adulthood. In conclusion, this longitudinal study of a large, stable population indicates that women with self-reported symptoms of hirsutism and/or Oligomenorrhea show endocrine characteristics of PCOS and can be detected in a general population using simple questions. These symptoms are markers of the underlying metabolic alterations possibly associated with increased health risks in later life.
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hormonal profile of women with self reported symptoms of Oligomenorrhea and or hirsutism northern finland birth cohort 1966 study
The Journal of Clinical Endocrinology and Metabolism, 2003Co-Authors: Saara Taponen, Hannu Martikainen, Marjo-riitta Järvelin, Ulla Sovio, Jaana Laitinen, Anneli Pouta, Anna-liisa HartikainenAbstract:The hormonal profiles of nested female patients (n = 500) with self-reported symptoms typical of polycystic ovary syndrome (PCOS), Oligomenorrhea, and/or hirsutism and their randomly selected controls (n = 1026) at the age of 31 yr were analyzed in a general population-based Northern Finland birth cohort 1966 to find out whether the symptomatic women also have the endocrine characteristics of PCOS and could be detected in a general population using simple questions. Higher medians of serum testosterone (T) (2.10 vs. 1.90 nmol/liter, P < 0.001), LH (5.40 vs. 4.85 U/liter, P = 0.005), insulin (53.8 vs. 51.66 pmol/liter, P = 0.040), and free androgen index (FAI) (4.01 vs. 3.03, P < 0.001) and lower glucose/insulin ratio (91.1 x 10(8) vs. 94.9 x 10(8), P = 0.048) and SHBG (52.4 vs. 60.7 nmol/liter, P < 0.001) were observed among the cases, but no difference was observed in cortisol and glucose levels between the cases and controls. Of all the women in the cohort, 10.2% reported only Oligomenorrhea and had biochemical findings similar to the whole case group. Those who reported only hirsutism (10.4%) were in between the case and control groups according to biochemical findings. The subjects who reported both Oligomenorrhea and hirsutism (3.4%) had the highest T, LH, FAI, insulin, and glucose and the lowest SHBG and glucose/insulin ratio, compared with the case group and the groups with either symptom only indicating a dose-response manner in typical endocrine profile of PCOS by adding up symptoms. The levels of T and FAI were higher and SHBG lower in groups with overweight or obesity both at 14 and 31 yr, compared with groups with normal weight at 14 yr and overweight or obesity at 31 yr. In the group with normal weight at 14 and 31 yr and the group with overweight or obesity at 14 yr but normal weight at 31 yr, the levels of T and FAI were lowest and SHBG highest. T and FAI were higher and SHBG lower among the cases than the controls in groups stratified by weight development from adolescence to adulthood. In conclusion, this longitudinal study of a large, stable population indicates that women with self-reported symptoms of hirsutism and/or Oligomenorrhea show endocrine characteristics of PCOS and can be detected in a general population using simple questions. These symptoms are markers of the underlying metabolic alterations possibly associated with increased health risks in later life.
John A. Morrison - One of the best experts on this subject based on the ideXlab platform.
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Adolescent Oligomenorrhea (age 14-19) tracks into the third decade of life (age 20-28) and predicts increased cardiovascular risk factors and metabolic syndrome.
Metabolism, 2015Co-Authors: Charles J Glueck, John A. Morrison, Stephen R. Daniels, Jessica G. Woo, Philip R. Khoury, Ping WangAbstract:Abstract Objective Assess whether adolescent Oligomenorrhea (age 14–19) tracks into young adulthood (age 20–28) and predicts increased cardiometabolic risk factors, metabolic syndrome (MetS), and impaired fasting glucose-type II diabetes mellitus (IFG + T2DM). Materials and methods Prospective study of menstrual cyclicity and its metabolic effects in 865 black and white schoolgirls from age 9 to 19, and 605 of these 865 girls from age 20 to 28. Main findings Patterns of menstrual delays (Oligomenorrhea) during ages 14–19 and ages 20–28 were closely related (p Principal conclusions Menstrual patterns track from adolescence to young adulthood, and Oligomenorrhea predicts MetS and IFG + T2DM. Patterns of menses delays in adolescence should be considered as a significant risk factor for future development of young adult IFG + T2DM, MetS, Oligomenorrhea, and polycystic ovary syndrome.
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Early and late menarche are associated with Oligomenorrhea and predict metabolic syndrome 26 years later
Metabolism, 2013Co-Authors: Charles J Glueck, John A. Morrison, Ping Wang, Jessica G. WooAbstract:Abstract Objective We determined whether simple, clinical information on late and early menarche could help identify adult women with metabolic syndrome (MetS) and Oligomenorrhea. Materials/Methods We carried out a 26-year prospective follow-up of 272 suburban schoolgirls from ages 5–22 to 30–46. Results Early menarche (≤10years, 5.2% of girls) and late menarche (≥16years, 6.7% of girls) were both associated with Oligomenorrhea (≥42days) in adulthood, 29% and 11%, vs. 5% for normal menarche (11–15years), p=.004. Early menarche was characterized by high childhood BMI (LS mean±SE: 21.2 ±1.0kg/m 2 ) and by high childhood and adult MetS (15%, 36%). Girls with late menarche had the lowest childhood BMI (18.1±1.0), no childhood MetS, and the highest adult MetS (47%). Increasing age at menarche was associated with uniformly decreasing childhood BMI and MetS, but with a U-shaped pattern of BMI (p = .05), MetS (p=.008), and Oligomenorrhea (p=.02) in adulthood. Change to MetS from median ages 13 to 38 was associated with early–late menarche (OR=3.11, 95% CI 1.37–7.07, p=.007). MetS in adulthood was associated with childhood MetS (OR=8.03, 95% CI 2.57–25.08, p=.0003) and with early–late menarche (OR =3.43, 95% CI 1.44–8.15, p=.005). Conclusions Menarche age had a curvilinear (‘U' shaped) relationship with MetS and Oligomenorrhea in adulthood. Late menarche and early menarche are risk factors for adult Oligomenorrhea, MetS, and cardiometabolic abnormalities. Girls with early (≤ age 10) and with late menarche (≥ 16) represent a group at high risk for adult cardiometabolic abnormalities and Oligomenorrhea that is easily identifiable by physicians.
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adolescent Oligomenorrhea in a biracial schoolgirl cohort a simple clinical parameter predicting impaired fasting glucose plus type 2 diabetes mellitus insulin glucose insulin resistance and centripetal obesity from age 19 to 25 years
Metabolism-clinical and Experimental, 2011Co-Authors: John A. Morrison, Charles J Glueck, Ping Wang, Stephen R. Daniels, Davis StroopAbstract:We hypothesized that adolescent Oligomenorrhea (ages 14-19) would independently predict impaired fasting glucose (IFG; ≥110 to <126 mg/dL) plus type 2 diabetes mellitus (T2DM; ≥126 mg/dL), insulin and glucose levels, and insulin resistance (IR) in young adulthood (ages 19-25). A prospective 15-year follow-up of 370 schoolgirls starting at age 10 was performed. Age 14 waist circumference was the most important explanatory variable for IFG + T2DM during ages 19 to 24 (P = .002; odds ratio, 1.06; 95% confidence interval, 1.02-1.10), along with Oligomenorrhea category from ages 14 to 19 (0, 1, 2, ≥3 reports over 6 years; P = .032; odds ratio, 1.82; 95% confidence interval, 1.05-3.14). Impaired fasting glucose + T2DM at ages 19 to 24 were more common in girls having 1 (6%), 2 (11%), and ≥3 (38%) Oligomenorrhea reports from ages 14 to 19 than in girls without Oligomenorrhea (3%; P = .0003). Positive explanatory variables (all Ps ≤ .05) for homeostasis model assessment of IR at ages 19 to 24 included age 14 waist (partial R2 = 30.1%), Oligomenorrhea with hyperandrogenism (polycystic ovary syndrome; partial R2 = 4.1%), black race (3.8%), and Oligomenorrhea frequency during ages 14 to 19 (0.8%); sex hormone binding globulin was a negative explanatory variable (0.7%). This is the first prospective study to report an independent association of adolescent Oligomenorrhea with young adult IFG + T2DM, with insulin and glucose levels, and with IR. Age 14 waist circumference, Oligomenorrhea with hyperandrogenism (polycystic ovary syndrome), black race, Oligomenorrhea frequency at ages 14 to 19, and age 14 sex hormone binding globulin were independently associated with IR at ages 19 to 24, potentially facilitating primary prevention of IFG, T2DM, and hyperinsulinemia.
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sex hormone binding globulin Oligomenorrhea polycystic ovary syndrome and childhood insulin at age 14 years predict metabolic syndrome and class iii obesity at age 24 years
The Journal of Pediatrics, 2011Co-Authors: Charles J Glueck, John A. Morrison, Ping Wang, Stephen R. Daniels, Davis StroopAbstract:Objective We hypothesized that Oligomenorrhea (menstrual cyclicity ≥42 days), hyperandrogenism, low levels of sex hormone-binding globulin (SHBG), childhood insulin, and metabolic syndrome (MetS) at age 14 years would predict MetS and class III obesity (body mass index ≥40 kg/m 2 ) at age 24 years. Study design In this prospective study of schoolgirls, at age 14 years, the girls were categorized as regularly cycling (n = 375), oligomenorrheic (n = 18), or Oligomenorrhea plus biochemical hyperandrogenism (polycystic ovary syndrome [PCOS]; n=12), together designated PCOS. Results Significant explanatory variables for MetS at age 24 years included childhood insulin, MetS, and PCOS category (all positive) and SHBG (negative) at age 14 years. Using categorical data, top decile of childhood insulin, MetS at age 14, bottom decile of SHBG, and PCOS category were significant positive predictors for MetS at age 24. SHBG (negative), black race (positive), and Oligomenorrhea (positive) were significant explanatory variables for class III obesity at age 24. Using categorical data, black race, MetS at age 14, bottom decile of SHBG, PCOS category, and top decile of childhood insulin were positive explanatory variables for class III obesity at age 24 years. Conclusions Oligomenorrhea, PCOS (a subcohort of Oligomenorrhea), hyperandrogenism, low SHBG, MetS, and childhood insulin at age 14 years may represent a critical, reversible pathway for the development of MetS and class III obesity in young adulthood.
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Adolescent Oligomenorrhea in a biracial schoolgirl cohort: a simple clinical parameter predicting impaired fasting glucose plus type 2 diabetes mellitus, insulin, glucose, insulin resistance, and centripetal obesity from age 19 to 25 years.
Metabolism, 2011Co-Authors: John A. Morrison, Charles J Glueck, Ping Wang, Stephen R. Daniels, Davis StroopAbstract:We hypothesized that adolescent Oligomenorrhea (ages 14-19) would independently predict impaired fasting glucose (IFG; ≥110 to
