The Experts below are selected from a list of 291 Experts worldwide ranked by ideXlab platform
Maria Alma Bracho - One of the best experts on this subject based on the ideXlab platform.
-
enterovirus co infections and Onychomadesis after hand foot and mouth disease spain 2008
Emerging Infectious Diseases, 2011Co-Authors: Maria Alma Bracho, Fernando Gonzalezcandelas, Ana Valero, Juan Cordoba, Antonio SalazarAbstract:Hand, foot, and mouth disease (HFMD), a common disease caused by enteroviruses (EVs), usually affects children. Clustered and sporadic HFMD cases, followed by Onychomadesis (nail shedding), occurred during summer and fall 2008 in Valencia, Spain. Fecal samples from Onychomadesis patients, who did or did not have previous HFMD, and from healthy children exposed to Onychomadesis patients tested positive for EV. The complete viral protein 1 capsid gene sequence was obtained for typing and phylogenetic analysis. Two EV serotypes, coxsackievirus A10 and coxsackievirus B1 (CVB1), were mainly detected as a monoinfection or co-infection in a childcare center where an Onychomadesis outbreak occurred. On the basis of our results, and detection of CVB1 in 2 other contemporary Onychomadesis outbreaks in childcare centers in Spain, we propose that mixed infection of an EV serotype that causes HFMD, plus the serotype CVB1, could explain the emergence after HFMD of Onychomadesis, a rare and late complication.
-
Onychomadesis outbreak in valencia spain associated with hand foot and mouth disease caused by enteroviruses
Pediatric Dermatology, 2011Co-Authors: M Javier Lopez D Davia, Maria Alma Bracho, Fernando Gonzalezcandelas, M Pablo Hernandez D Bel, M Violeta Zaragoza D Ninet, M Antonio D Salazar, Miguel Gobernado, M Isabel Febrer D BoschAbstract:This report evaluates the June 2008 Onychomadesis outbreak in Valencia, Spain. The study sample consisted of 221 Onychomadesis cases and 77 nonaffected individuals who lived close to those affected. We collected data on dietary variables, hygiene products, and individual pathological histories. Feces and blood specimens were collected from 44 cases and 24 controls to evaluate exposure to infectious agents. Pathological background data revealed a high frequency (61%) of hand, foot, and mouth disease among the Onychomadesis cases. Coxsackievirus A10 was the most commonly detected enterovirus in both case and control groups (49%). Other enteroviruses such as coxsackieviruses A5, A6, A16, B1, and B3; echoviruses 3, 4, and 9; and enterovirus 71 were present in low frequencies in the case and control groups (3-9%). The 2008 Onychomadesis outbreak in the metropolitan area of Valencia was associated with an outbreak of hand, foot, and mouth disease primarily caused by coxsackievirus A10.
-
Onychomadesis outbreak in valencia spain associated with hand foot and mouth disease caused by enteroviruses
Pediatric Dermatology, 2011Co-Authors: M Javier Lopez D Davia, Maria Alma Bracho, Fernando Gonzalezcandelas, M Violeta Zaragoza D Ninet, M Antonio D Salazar, Miguel Gobernado, M Isabel Febrer D BoschAbstract:This report evaluates the June 2008 Onychomadesis out- break in Valencia, Spain. The study sample consisted of 221 Onychomadesis cases and 77 nonaffected individuals who lived close to those affected. We collected data on dietary variables, hygiene products, and individual path- ological histories. Feces and blood specimens were collected from 44 cases and 24 controls to evaluate exposure to infectious agents. Pathological background data revealed a high frequency (61%) of hand, foot, and mouth disease among the Onychomadesis cases. Coxsackievirus A10 was the most commonly detected enterovirus in both case and control groups (49%). Other enteroviruses such as coxsackieviruses A5, A6, A16, B1, and B3; echoviruses 3, 4, and 9; and enterovirus 71 were present in low frequencies in the case and control groups (3-9%). The 2008 Onychomadesis outbreak in the metropolitan area of Valencia was associated with an outbreak of hand, foot, and mouth disease primarily caused by coxsackievirus A10. Nail matrix arrest has been associated with some systemic illnesses caused by infections and drug expo- sure, although many cases are idiopathic. A wide range of nail dystrophies may result, from transverse ridging of the nail plate (Beau's line) to complete nail shedding from the proximal portion without pain or inflammation (Onychomadesis) (1,2). Hand, foot, and mouth disease (HFMD) has been reported as a possible cause of ony-
Catherine M Stefanato - One of the best experts on this subject based on the ideXlab platform.
-
alopecia areata incognita in cronkhite canada syndrome
British Journal of Dermatology, 2017Co-Authors: Cristina Rodriguezgarcia, Mike Osborn, Faris Kubba, Julian R.f. Walters, Julien Carton, Sophie Grabczynska, Catherine M StefanatoAbstract:Summary Cronkhite-Canada syndrome is an acquired inflammatory polyposis syndrome in which alopecia, Onychomadesis and hyperpigmentation occur concurrently with gastrointestinal symptoms. The pathophysiology of alopecia in Cronkhite-Canada Syndrome has not been definitively elucidated and we present evidence for alopecia incognita as a possible mechanism of hair loss. This article is protected by copyright. All rights reserved.
Jie Meng - One of the best experts on this subject based on the ideXlab platform.
-
cases report the cronkhite canada syndrome improving the prognosis
Medicine, 2015Co-Authors: Yi Qun Yu, P J Whorwell, Lin Heng Wang, Jun Xiang Li, Qing Chang, Jie MengAbstract:Cronkhite-Canada syndrome (CCS) is a rare nongenetic polyposis syndrome first reported by Cronkhite and Canada in 1955.1 Up to the present time, the literature consists of ∼400 cases of CCS with the majority being reported from Japan2 although 49 cases have been described in China.3 CCS is characterized by diffuse polyposis of the digestive tract in association with ectodermal changes, such as Onychomadesis, alopecia, and cutaneous hyperpigmentation. The principal symptoms of CCS are diarrhea, weight loss, abdominal pain, and other gastrointestinal complications, such as protein-losing enteropathy and malnutrition. It has been traditional to consider that CCS is associated with a poor prognosis. This paper describes a relatively mild case and reviews the literature, which more recently, suggests that it may be a more benign condition that might actually be reversible with treatment. There is some evidence that infection or disturbed immunity may be involved in the pathophysiology and that targeting such abnormalities could have therapeutic potential. A strong case could be made for establishing an international case registry for this disease so that the pathophysiology, treatment, and prognosis could become much better understood.
Miroslav Zavoral - One of the best experts on this subject based on the ideXlab platform.
-
a fulminant course of cronkhite canada syndrome
Endoscopy, 2010Co-Authors: Jan Martinek, T Chvatalova, Filip Zavada, P Vankova, Inna Tuckova, Miroslav ZavoralAbstract:diarrhea, weight loss, and abdominal pain for 4 months. Noticeable signs of nail dystrophy (Onychomadesis of all nails) were present (●" Fig. 1a) along with alopecia and cutaneous foci of hyperpigmentation (●" Fig. 1b). Upper-gastrointestinal endoscopy revealed a large number of strawberry-like polyps of different size in the stomach (●" Fig. 2). Colonoscopy revealed polyposis of the whole colon, including the rectum. The majority of the polyps had a strawberrylike, adenomatous, and hyperplastic appearance (●" Fig. 3). Histologically, the majority of the polyps were juvenile-like with cystic dilatations of the glands and a benign mucinous epithelium. The glands were filled with a large amount of mucin (●" Fig. 4). Some adenomatous polyps with lowgrade dysplasia in the colon were also detected. A subsequent enteroscopy did not find polyps; however, edema and small indentation of the jejunum were present. Immunohistochemistry showed total alactasia and a strong positivity for tumor necrosis factor (TNF) in the macrophages and lymphocytes. Based on both the clinical and endoscopic picture, a diagnosis of Cronkhite-Canada syndrome was established. Despite complex treatment, the clinical course was unfavourable. Since the clinical state of the patient did not improve, anti-TNF-α treatment was considered. TNF-α activity was examined in the small-intestinal mucosa, and the results showed a strong intracellular expression of TNF-α. Unfortunately, an experimental anti-TNF-α treatment could not be introduced, because of the rapid progression of the disease. The patient died 4 months after the diagnosis of Cronkhite-Canada syndrome was established. A fulminant course of Cronkhite-Canada syndrome
Gloria Trallero - One of the best experts on this subject based on the ideXlab platform.
-
Onychomadesis after a hand foot and mouth disease outbreak in spain 2009
Epidemiology and Infection, 2010Co-Authors: Maria Cabrerizo, T De Miguel, A Armada, R Martinezrisco, A Pousa, Gloria TralleroAbstract:Few reports exist regarding the association between Onychomadesis and an enterovirus infection presenting clinically as hand, foot, and mouth disease (HFMD). In February 2009, an outbreak of HFMD occurred in a Spanish nursery school, followed by Onychomadesis 36-69 days later. Twelve of 17 children with HFMD developed nail shedding; enterovirus was detected in stool samples from eight (47%) of the 17. However, in only three of the children could an enterovirus serotype coxsackievirus B1 be identified. The epidemiological results of this study confirm Onychomadesis as a complication in HFMD. In future outbreaks, molecular characterization of enterovirus from appropriate clinical samples should be studied.
