The Experts below are selected from a list of 33144 Experts worldwide ranked by ideXlab platform
Theodore Garland - One of the best experts on this subject based on the ideXlab platform.
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Are Voluntary Wheel Running and Open-Field Behavior Correlated in Mice? Different Answers from Comparative and Artificial Selection Approaches
Behavior Genetics, 2012Co-Authors: Vincent Careau, Olaf R. P. Bininda-emonds, Genesis Ordonez, Theodore GarlandAbstract:Voluntary wheel running and Open-Field Behavior are probably the two most widely used measures of locomotion in laboratory rodents. We tested whether these two Behaviors are correlated in mice using two approaches: the phylogenetic comparative method using inbred strains of mice and an ongoing artificial selection experiment on voluntary wheel running. After taking into account the measurement error and phylogenetic relationships among inbred strains, we obtained a significant positive correlation between distance run on wheels and distance moved in the Open-Field for both sexes. Thigmotaxis was negatively correlated with distance run on wheels in females but not in males. By contrast, mice from four replicate lines bred for high wheel running did not differ in either distance covered or thigmotaxis in the Open Field as compared with mice from four non-selected control lines. Overall, results obtained in the selection experiment were generally opposite to those observed among inbred strains. Possible reasons for this discrepancy are discussed.
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Open-Field Behavior of house mice selectively bred for high voluntary wheel-running.
Behavior genetics, 2001Co-Authors: Anne M. Bronikowski, Patrick A. Carter, John G. Swallow, Isabelle Girard, Justin S. Rhodes, Theodore GarlandAbstract:Open-Field Behavioral assays are commonly used to test both locomotor activity and emotionality in rodents. We performed Open-Field tests on house mice (Mus domesticus) from four replicate lines genetically selected for high voluntary wheel-running for 22 generations and from four replicate random-bred control lines. Individual mice were recorded by video camera for 3 min in a 1-m2 Open-Field arena on 2 consecutive days. Mice from selected lines showed no statistical differences from control mice with respect to distance traveled, defecation, time spent in the interior, or average distance from the center of the arena during the trial. Thus, we found little evidence that Open-Field Behavior, as traditionally defined, is genetically correlated with wheel-running Behavior. This result is a useful converse test of classical studies that report no increased wheel-running in mice selected for increased Open-Field activity. However, mice from selected lines turned less in their travel paths than did control-line mice, and females from selected lines had slower travel times (longer latencies) to reach the wall. We discuss these results in the context of the historical Open-Field test and newly defined measures of Open-Field activity.
Roberto Frussa-filho - One of the best experts on this subject based on the ideXlab platform.
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Effects of environmental enrichment and paradoxical sleep deprivation on Open-Field Behavior of amphetamine-treated mice
Physiology & behavior, 2007Co-Authors: Daniela F. Fukushiro, Mariana Bendlin Calzavara, T.f. Trombin, G.b. Lopez, Vanessa C. Abílio, Monica L. Andersen, Sergio Tufik, Roberto Frussa-filhoAbstract:Background: Environmental enrichment or paradoxical sleep deprivation (PSD) has been shown to modify some responses elicited by drugs of abuse. The aims of the present study were to examine the effects of environmental enrichment and PSD, conducted separately or in association, on Open-Field Behavior elicited by amphetamine (AMP) in mice. Methods: Male C57BL/6 mice were randomly assigned to live in either an enriched environmental condition (EC) or a standard environmental condition (SC) for 12 months since weaning. Some of the EC and SC mice were sleep deprived for 48 h, while others were maintained in their home-cages. Immediately after PSD or home-cage stay, the animals received an ip injection of saline, 2.5 mg/kg AMP or 5.0 mg/kg AMP. Fifteen minutes later, their Open-Field Behavior was quantified. Results: Whereas PSD enhanced total and peripheral locomotor activity of acutely AMP-treated mice, environmental enrichment presented only a trend toward enhancement. When PSD and environmental enrichment were combined, an increase in the total and peripheral locomotion frequencies of AMP-treated animals, similar to that observed after PSD, was revealed. In addition, PSD, environmental enrichment or their combination did not modify the effects of AMP on the other Open-Field Behavioral parameters that were analyzed. Conclusion: The present findings demonstrate that some (but not all) of the Behavioral effects caused by AMP acute administration can be similarly and specifically enhanced by both environmental enrichment and PSD in C57BL/6 mice.
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Effects of microgram doses of haloperidol on Open-Field Behavior in mice.
Pharmacology biochemistry and behavior, 1996Co-Authors: Roberto Frussa-filhoAbstract:This study was designed to evaluate the effects of low doses of haloperidol on the Open-Field Behavior of mice. A three-phase effect of haloperidol on the motor activity of mice was observed (depression, no effect, depression). This three-phase action was clear-cut in three experimental approaches (amphetamine-induced hyperactivity, and apomorphine- and bromocriptine-induced hypoactivity). A differential action of haloperidol on dopamine receptors mediating motor stimulation and motor depression was proposed. The present data indicate that considerably more attention should be paid to the novel Behavioral and biochemical actions of neuroleptic drugs in the microgram dose range.
Vincent Careau - One of the best experts on this subject based on the ideXlab platform.
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Are Voluntary Wheel Running and Open-Field Behavior Correlated in Mice? Different Answers from Comparative and Artificial Selection Approaches
Behavior Genetics, 2012Co-Authors: Vincent Careau, Olaf R. P. Bininda-emonds, Genesis Ordonez, Theodore GarlandAbstract:Voluntary wheel running and Open-Field Behavior are probably the two most widely used measures of locomotion in laboratory rodents. We tested whether these two Behaviors are correlated in mice using two approaches: the phylogenetic comparative method using inbred strains of mice and an ongoing artificial selection experiment on voluntary wheel running. After taking into account the measurement error and phylogenetic relationships among inbred strains, we obtained a significant positive correlation between distance run on wheels and distance moved in the Open-Field for both sexes. Thigmotaxis was negatively correlated with distance run on wheels in females but not in males. By contrast, mice from four replicate lines bred for high wheel running did not differ in either distance covered or thigmotaxis in the Open Field as compared with mice from four non-selected control lines. Overall, results obtained in the selection experiment were generally opposite to those observed among inbred strains. Possible reasons for this discrepancy are discussed.
Anne M. Bronikowski - One of the best experts on this subject based on the ideXlab platform.
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Open-Field Behavior of house mice selectively bred for high voluntary wheel-running.
Behavior genetics, 2001Co-Authors: Anne M. Bronikowski, Patrick A. Carter, John G. Swallow, Isabelle Girard, Justin S. Rhodes, Theodore GarlandAbstract:Open-Field Behavioral assays are commonly used to test both locomotor activity and emotionality in rodents. We performed Open-Field tests on house mice (Mus domesticus) from four replicate lines genetically selected for high voluntary wheel-running for 22 generations and from four replicate random-bred control lines. Individual mice were recorded by video camera for 3 min in a 1-m2 Open-Field arena on 2 consecutive days. Mice from selected lines showed no statistical differences from control mice with respect to distance traveled, defecation, time spent in the interior, or average distance from the center of the arena during the trial. Thus, we found little evidence that Open-Field Behavior, as traditionally defined, is genetically correlated with wheel-running Behavior. This result is a useful converse test of classical studies that report no increased wheel-running in mice selected for increased Open-Field activity. However, mice from selected lines turned less in their travel paths than did control-line mice, and females from selected lines had slower travel times (longer latencies) to reach the wall. We discuss these results in the context of the historical Open-Field test and newly defined measures of Open-Field activity.
Olaf R. P. Bininda-emonds - One of the best experts on this subject based on the ideXlab platform.
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Are Voluntary Wheel Running and Open-Field Behavior Correlated in Mice? Different Answers from Comparative and Artificial Selection Approaches
Behavior Genetics, 2012Co-Authors: Vincent Careau, Olaf R. P. Bininda-emonds, Genesis Ordonez, Theodore GarlandAbstract:Voluntary wheel running and Open-Field Behavior are probably the two most widely used measures of locomotion in laboratory rodents. We tested whether these two Behaviors are correlated in mice using two approaches: the phylogenetic comparative method using inbred strains of mice and an ongoing artificial selection experiment on voluntary wheel running. After taking into account the measurement error and phylogenetic relationships among inbred strains, we obtained a significant positive correlation between distance run on wheels and distance moved in the Open-Field for both sexes. Thigmotaxis was negatively correlated with distance run on wheels in females but not in males. By contrast, mice from four replicate lines bred for high wheel running did not differ in either distance covered or thigmotaxis in the Open Field as compared with mice from four non-selected control lines. Overall, results obtained in the selection experiment were generally opposite to those observed among inbred strains. Possible reasons for this discrepancy are discussed.
