The Experts below are selected from a list of 10236 Experts worldwide ranked by ideXlab platform

Jie Xu - One of the best experts on this subject based on the ideXlab platform.

  • deformability based circulating tumor cell sepaRation with conical shaped microfilters concept optimization and design criteria
    arXiv: Cell Behavior, 2016
    Co-Authors: Mohammad Aghaamoo, Zhifeng Zhang, Xiaolin Chen, Jie Xu
    Abstract:

    The ability of detecting and separating CTCs can play a key role in early cancer detection and treatment. In recent years, there has been growing interest in using deformability-based CTC sepaRation microfilters due to their simplicity and low cost. Most of previous studies in this area are mainly based on experimental work. Although experimental research provides useful insights in designing CTC sepaRation devices, there is still a lack of design guidelines based on fundamental understandings of the cell sepaRation process in the filers. While experimental efforts face challenges especially microfabrication difficulties, we adopt numerical simulation here to study conical-shaped microfilters using deformability difference between CTCs and blood cells for sepaRation process. We use liquid drop model for modeling a CTC passing through such microfilters. The accuracy of the model in predicting the Pressure signature of the system is validated by comparing with previous experiments. Pressure-deformability analysis of the cell going through the channel is then carried out in detail in order to better understand how a CTC behaves throughout the filtRation process. Different system design criteria such as system throughput and unclogging of the system are discussed. Specifically, Pressure behavior under different system throughput is analyzed. Regarding the unclogging issue, we define Pressure Ratio as a key parameter representing the ability to overcome clogging in such CTC sepaRation devices and investigate the effect of conical angle on the Optimum Pressure Ratio. Finally, the effect of unclogging applied Pressure on the system performance is examined. Our study provides detailed understandings of the cell sepaRation process and its characteristics, which can be used for developing more efficient CTC sepaRation devices.

  • deformability based circulating tumor cell sepaRation with conical shaped microfilters concept optimization and design criteria
    Biomicrofluidics, 2015
    Co-Authors: Mohammad Aghaamoo, Zhifeng Zhang, Xiaolin Chen, Jie Xu
    Abstract:

    Circulating tumor cells (CTCs) sepaRation technology has made positive impacts on cancer science in many aspects. The ability of detecting and separating CTCs can play a key role in early cancer detection and treatment. In recent years, there has been growing interest in using deformability-based CTC sepaRation microfilters due to their simplicity and low cost. Most of the previous studies in this area are mainly based on experimental work. Although experimental research provides useful insights in designing CTC sepaRation devices, there is still a lack of design guidelines based on fundamental understandings of the cell sepaRation process in the filters. While experimental efforts face challenges, especially microfabrication difficulties, we adopt numerical simulation here to study conical-shaped microfilters using deformability difference between CTCs and blood cells for the sepaRation process. We use the liquid drop model for modeling a CTC passing through such microfilters. The accuracy of the model in predicting the Pressure signature of the system is validated by comparing it with previous experiments. Pressure-deformability analysis of the cell going through the channel is then carried out in detail in order to better understand how a CTC behaves throughout the filtRation process. Different system design criteria such as system throughput and unclogging of the system are discussed. Specifically, Pressure behavior under different system throughput is analyzed. Regarding the unclogging issue, we define Pressure Ratio as a key parameter representing the ability to overcome clogging in such CTC sepaRation devices and investigate the effect of conical angle on the Optimum Pressure Ratio. Finally, the effect of unclogging applied Pressure on the system performance is examined. Our study provides detailed understandings of the cell sepaRation process and its characteristics, which can be used for developing more efficient CTC sepaRation devices.

Mohammad Aghaamoo - One of the best experts on this subject based on the ideXlab platform.

  • deformability based circulating tumor cell sepaRation with conical shaped microfilters concept optimization and design criteria
    arXiv: Cell Behavior, 2016
    Co-Authors: Mohammad Aghaamoo, Zhifeng Zhang, Xiaolin Chen, Jie Xu
    Abstract:

    The ability of detecting and separating CTCs can play a key role in early cancer detection and treatment. In recent years, there has been growing interest in using deformability-based CTC sepaRation microfilters due to their simplicity and low cost. Most of previous studies in this area are mainly based on experimental work. Although experimental research provides useful insights in designing CTC sepaRation devices, there is still a lack of design guidelines based on fundamental understandings of the cell sepaRation process in the filers. While experimental efforts face challenges especially microfabrication difficulties, we adopt numerical simulation here to study conical-shaped microfilters using deformability difference between CTCs and blood cells for sepaRation process. We use liquid drop model for modeling a CTC passing through such microfilters. The accuracy of the model in predicting the Pressure signature of the system is validated by comparing with previous experiments. Pressure-deformability analysis of the cell going through the channel is then carried out in detail in order to better understand how a CTC behaves throughout the filtRation process. Different system design criteria such as system throughput and unclogging of the system are discussed. Specifically, Pressure behavior under different system throughput is analyzed. Regarding the unclogging issue, we define Pressure Ratio as a key parameter representing the ability to overcome clogging in such CTC sepaRation devices and investigate the effect of conical angle on the Optimum Pressure Ratio. Finally, the effect of unclogging applied Pressure on the system performance is examined. Our study provides detailed understandings of the cell sepaRation process and its characteristics, which can be used for developing more efficient CTC sepaRation devices.

  • deformability based circulating tumor cell sepaRation with conical shaped microfilters concept optimization and design criteria
    Biomicrofluidics, 2015
    Co-Authors: Mohammad Aghaamoo, Zhifeng Zhang, Xiaolin Chen, Jie Xu
    Abstract:

    Circulating tumor cells (CTCs) sepaRation technology has made positive impacts on cancer science in many aspects. The ability of detecting and separating CTCs can play a key role in early cancer detection and treatment. In recent years, there has been growing interest in using deformability-based CTC sepaRation microfilters due to their simplicity and low cost. Most of the previous studies in this area are mainly based on experimental work. Although experimental research provides useful insights in designing CTC sepaRation devices, there is still a lack of design guidelines based on fundamental understandings of the cell sepaRation process in the filters. While experimental efforts face challenges, especially microfabrication difficulties, we adopt numerical simulation here to study conical-shaped microfilters using deformability difference between CTCs and blood cells for the sepaRation process. We use the liquid drop model for modeling a CTC passing through such microfilters. The accuracy of the model in predicting the Pressure signature of the system is validated by comparing it with previous experiments. Pressure-deformability analysis of the cell going through the channel is then carried out in detail in order to better understand how a CTC behaves throughout the filtRation process. Different system design criteria such as system throughput and unclogging of the system are discussed. Specifically, Pressure behavior under different system throughput is analyzed. Regarding the unclogging issue, we define Pressure Ratio as a key parameter representing the ability to overcome clogging in such CTC sepaRation devices and investigate the effect of conical angle on the Optimum Pressure Ratio. Finally, the effect of unclogging applied Pressure on the system performance is examined. Our study provides detailed understandings of the cell sepaRation process and its characteristics, which can be used for developing more efficient CTC sepaRation devices.

Zhifeng Zhang - One of the best experts on this subject based on the ideXlab platform.

  • deformability based circulating tumor cell sepaRation with conical shaped microfilters concept optimization and design criteria
    arXiv: Cell Behavior, 2016
    Co-Authors: Mohammad Aghaamoo, Zhifeng Zhang, Xiaolin Chen, Jie Xu
    Abstract:

    The ability of detecting and separating CTCs can play a key role in early cancer detection and treatment. In recent years, there has been growing interest in using deformability-based CTC sepaRation microfilters due to their simplicity and low cost. Most of previous studies in this area are mainly based on experimental work. Although experimental research provides useful insights in designing CTC sepaRation devices, there is still a lack of design guidelines based on fundamental understandings of the cell sepaRation process in the filers. While experimental efforts face challenges especially microfabrication difficulties, we adopt numerical simulation here to study conical-shaped microfilters using deformability difference between CTCs and blood cells for sepaRation process. We use liquid drop model for modeling a CTC passing through such microfilters. The accuracy of the model in predicting the Pressure signature of the system is validated by comparing with previous experiments. Pressure-deformability analysis of the cell going through the channel is then carried out in detail in order to better understand how a CTC behaves throughout the filtRation process. Different system design criteria such as system throughput and unclogging of the system are discussed. Specifically, Pressure behavior under different system throughput is analyzed. Regarding the unclogging issue, we define Pressure Ratio as a key parameter representing the ability to overcome clogging in such CTC sepaRation devices and investigate the effect of conical angle on the Optimum Pressure Ratio. Finally, the effect of unclogging applied Pressure on the system performance is examined. Our study provides detailed understandings of the cell sepaRation process and its characteristics, which can be used for developing more efficient CTC sepaRation devices.

  • deformability based circulating tumor cell sepaRation with conical shaped microfilters concept optimization and design criteria
    Biomicrofluidics, 2015
    Co-Authors: Mohammad Aghaamoo, Zhifeng Zhang, Xiaolin Chen, Jie Xu
    Abstract:

    Circulating tumor cells (CTCs) sepaRation technology has made positive impacts on cancer science in many aspects. The ability of detecting and separating CTCs can play a key role in early cancer detection and treatment. In recent years, there has been growing interest in using deformability-based CTC sepaRation microfilters due to their simplicity and low cost. Most of the previous studies in this area are mainly based on experimental work. Although experimental research provides useful insights in designing CTC sepaRation devices, there is still a lack of design guidelines based on fundamental understandings of the cell sepaRation process in the filters. While experimental efforts face challenges, especially microfabrication difficulties, we adopt numerical simulation here to study conical-shaped microfilters using deformability difference between CTCs and blood cells for the sepaRation process. We use the liquid drop model for modeling a CTC passing through such microfilters. The accuracy of the model in predicting the Pressure signature of the system is validated by comparing it with previous experiments. Pressure-deformability analysis of the cell going through the channel is then carried out in detail in order to better understand how a CTC behaves throughout the filtRation process. Different system design criteria such as system throughput and unclogging of the system are discussed. Specifically, Pressure behavior under different system throughput is analyzed. Regarding the unclogging issue, we define Pressure Ratio as a key parameter representing the ability to overcome clogging in such CTC sepaRation devices and investigate the effect of conical angle on the Optimum Pressure Ratio. Finally, the effect of unclogging applied Pressure on the system performance is examined. Our study provides detailed understandings of the cell sepaRation process and its characteristics, which can be used for developing more efficient CTC sepaRation devices.

Xiaolin Chen - One of the best experts on this subject based on the ideXlab platform.

  • deformability based circulating tumor cell sepaRation with conical shaped microfilters concept optimization and design criteria
    arXiv: Cell Behavior, 2016
    Co-Authors: Mohammad Aghaamoo, Zhifeng Zhang, Xiaolin Chen, Jie Xu
    Abstract:

    The ability of detecting and separating CTCs can play a key role in early cancer detection and treatment. In recent years, there has been growing interest in using deformability-based CTC sepaRation microfilters due to their simplicity and low cost. Most of previous studies in this area are mainly based on experimental work. Although experimental research provides useful insights in designing CTC sepaRation devices, there is still a lack of design guidelines based on fundamental understandings of the cell sepaRation process in the filers. While experimental efforts face challenges especially microfabrication difficulties, we adopt numerical simulation here to study conical-shaped microfilters using deformability difference between CTCs and blood cells for sepaRation process. We use liquid drop model for modeling a CTC passing through such microfilters. The accuracy of the model in predicting the Pressure signature of the system is validated by comparing with previous experiments. Pressure-deformability analysis of the cell going through the channel is then carried out in detail in order to better understand how a CTC behaves throughout the filtRation process. Different system design criteria such as system throughput and unclogging of the system are discussed. Specifically, Pressure behavior under different system throughput is analyzed. Regarding the unclogging issue, we define Pressure Ratio as a key parameter representing the ability to overcome clogging in such CTC sepaRation devices and investigate the effect of conical angle on the Optimum Pressure Ratio. Finally, the effect of unclogging applied Pressure on the system performance is examined. Our study provides detailed understandings of the cell sepaRation process and its characteristics, which can be used for developing more efficient CTC sepaRation devices.

  • deformability based circulating tumor cell sepaRation with conical shaped microfilters concept optimization and design criteria
    Biomicrofluidics, 2015
    Co-Authors: Mohammad Aghaamoo, Zhifeng Zhang, Xiaolin Chen, Jie Xu
    Abstract:

    Circulating tumor cells (CTCs) sepaRation technology has made positive impacts on cancer science in many aspects. The ability of detecting and separating CTCs can play a key role in early cancer detection and treatment. In recent years, there has been growing interest in using deformability-based CTC sepaRation microfilters due to their simplicity and low cost. Most of the previous studies in this area are mainly based on experimental work. Although experimental research provides useful insights in designing CTC sepaRation devices, there is still a lack of design guidelines based on fundamental understandings of the cell sepaRation process in the filters. While experimental efforts face challenges, especially microfabrication difficulties, we adopt numerical simulation here to study conical-shaped microfilters using deformability difference between CTCs and blood cells for the sepaRation process. We use the liquid drop model for modeling a CTC passing through such microfilters. The accuracy of the model in predicting the Pressure signature of the system is validated by comparing it with previous experiments. Pressure-deformability analysis of the cell going through the channel is then carried out in detail in order to better understand how a CTC behaves throughout the filtRation process. Different system design criteria such as system throughput and unclogging of the system are discussed. Specifically, Pressure behavior under different system throughput is analyzed. Regarding the unclogging issue, we define Pressure Ratio as a key parameter representing the ability to overcome clogging in such CTC sepaRation devices and investigate the effect of conical angle on the Optimum Pressure Ratio. Finally, the effect of unclogging applied Pressure on the system performance is examined. Our study provides detailed understandings of the cell sepaRation process and its characteristics, which can be used for developing more efficient CTC sepaRation devices.

Fengrui Sun - One of the best experts on this subject based on the ideXlab platform.

  • Optimum distribution of heat exchanger inventory for power density optimization of an endoreversible closed Brayton cycle
    Journal of Physics D: Applied Physics, 2001
    Co-Authors: Lingen Chen, Junlin Zheng, Fengrui Sun
    Abstract:

    In this paper, the power density (defined as the Ratio of the power output to the maximum specific volume in the cycle) is taken as the objective for performance optimizations of an endoreversible closed Brayton cycle coupled to constant-temperature heat reservoirs in the viewpoint of finite-time thermodynamics (FTT) or entropy geneRation minimization (EGM). The Optimum heat conductance distribution corresponding to the Optimum power density of the hot- and cold-side heat exchangers for the fixed heat exchanger inventory is analysed using numerical examples. The influence of some design parameters on the Optimum heat conductance distribution and the maximum power density and the Optimum Pressure Ratio corresponding to the maximum power density are provided. The power plant design with optimization leads to higher efficiency and smaller size.} \fnm{3}{Author to whom correspondence should be addressed.

  • Power Density Optimization for an Irreversible Closed Brayton Cycle
    Open Systems & Information Dynamics, 2001
    Co-Authors: Lingen Chen, Junlin Zheng, Fengrui Sun
    Abstract:

    In this paper, the power density, defined as the Ratio of power output to the maximum specific volume in the cycle, is taken as objective for performance optimization of an irreversible closed Brayton cycle coupled to constant-temperature heat reservoirs in the viewpoint of finite time thermodynamics (FTT) or entropy geneRation minimization (EGM). The analytical formulas about the relations between power density and Pressure Ratio are derived with the heat resistance losses in the hot- and cold-side heat exchangers and the irreversible compression and expansion losses in the compressor and turbine. The maximum power density optimization is performed by searching the Optimum heat conductance distribution corresponding to the Optimum power density of the hot- and cold- side heat exchangers for the fixed heat exchanger inventory. The influence of some design parameters on the Optimum heat conductance distribution, the maximum power density, and the Optimum Pressure Ratio corresponding to the maximum power density are provided. The power plant design with optimization leads to a higher efficiency and smaller size including the compressor, turbine, and the hot- and cold-side heat exchangers.