The Experts below are selected from a list of 279 Experts worldwide ranked by ideXlab platform
Chia Lang Fang - One of the best experts on this subject based on the ideXlab platform.
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syphilitic Orchitis mimicking a testicular tumor in a clinically occult hiv infected young man a case report with emphasis on a challenging pathological diagnosis
Diagnostic Pathology, 2016Co-Authors: Chia Ying Chu, Wei Yu Chen, Shauh Der Yeh, Huey Min Yeh, Chia Lang FangAbstract:Background Syphilitic Orchitis is a rare manifestation of gumma in tertiary syphilis, microscopically typically characterized by multiple discrete granulomas with central necrosis and peripheral fibrosis. We report a case of syphilitic Orchitis mimicking a testicular tumor with atypical histological features.
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Syphilitic Orchitis mimicking a testicular tumor in a clinically occult HIV-infected young man: a case report with emphasis on a challenging pathological diagnosis
Diagnostic Pathology, 2016Co-Authors: Wei Yu Chen, Chia Lang FangAbstract:Background Syphilitic Orchitis is a rare manifestation of gumma in tertiary syphilis, microscopically typically characterized by multiple discrete granulomas with central necrosis and peripheral fibrosis. We report a case of syphilitic Orchitis mimicking a testicular tumor with atypical histological features. Case presentation A 33-year-old clinically occult HIV-infected man had a testicular tumor. A radical orchiectomy was performed, and a histological examination showed an acute and chronic interstitial inflammatory lesion as well as spindle cell proliferation, without typical gumma formation, necessitating the differential diagnosis having to be made from a panel of etiological factors. Syphilitic Orchitis was confirmed by both an immunohistochemical study and PCR testing for the Treponema pallidum DNA polymerase I gene using paraffin-embedded tissues. However, serology tests, including both the Venereal Disease Research Laboratory (VDRL) test and Treponema pallidum partical agglutination (TTPA), demonstrated false-negative results. Conclusion Syphilitic Orchitis may present atypical and unusual histological features, and should be included in the differential diagnoses of nonspecific interstitial inflammatory lesions of the testes by pathologists, especially in immunocompromised patients.
L. Nakov - One of the best experts on this subject based on the ideXlab platform.
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Serum sperm antibodies are not elevated after mumps Orchitis
Fertility and sterility, 2002Co-Authors: Svetoslav Kalaydjiev, D. Dimitrova, I. Dikov, Marina Nenova, Siika Peneva, L. NakovAbstract:Abstract Objective: To assess the level of serum sperm antibodies after mumps Orchitis. Design: Controlled descriptive study. Setting: Academic research environment. Patient(s): Seventy-four mumps Orchitis patients. Intervention(s):Sampling of serum at different intervals after the onset of Orchitis symptoms: 1 to 7 days, 31 to 60 days, and 61 to 431 days. Main Outcome Measure(s): Level of serum sperm antibodies, using Kibrick's gelatin agglutination test, Friberg's tray agglutination test, Isojima's sperm immobilization test, and ELISA. Result(s):Clinically relevant sperm antibody values were detected by the Friberg method among patients tested from 1 to 7 days (10.5%) and 61 to 431 days (10.5%) after the onset of disease. The Isojima test revealed a statistically insignificant higher incidence among patients at 61 to 431 days (31.6%) as compared with those sampled at 1 to 7 days (10.5%). None of the Orchitis sera tested positive by the Kibrick and ELISA techniques. The established incidences did not differ significantly from the results for negative controls (blood donors) and were lower than the values acquired from positive controls (males with unexplained infertility). Conclusion(s):Mumps Orchitis does not cause enhanced humoral immunity to spermatozoa.
Svetoslav Kalaydjiev - One of the best experts on this subject based on the ideXlab platform.
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Serum sperm antibodies are not elevated after mumps Orchitis
Fertility and sterility, 2002Co-Authors: Svetoslav Kalaydjiev, D. Dimitrova, I. Dikov, Marina Nenova, Siika Peneva, L. NakovAbstract:Abstract Objective: To assess the level of serum sperm antibodies after mumps Orchitis. Design: Controlled descriptive study. Setting: Academic research environment. Patient(s): Seventy-four mumps Orchitis patients. Intervention(s):Sampling of serum at different intervals after the onset of Orchitis symptoms: 1 to 7 days, 31 to 60 days, and 61 to 431 days. Main Outcome Measure(s): Level of serum sperm antibodies, using Kibrick's gelatin agglutination test, Friberg's tray agglutination test, Isojima's sperm immobilization test, and ELISA. Result(s):Clinically relevant sperm antibody values were detected by the Friberg method among patients tested from 1 to 7 days (10.5%) and 61 to 431 days (10.5%) after the onset of disease. The Isojima test revealed a statistically insignificant higher incidence among patients at 61 to 431 days (31.6%) as compared with those sampled at 1 to 7 days (10.5%). None of the Orchitis sera tested positive by the Kibrick and ELISA techniques. The established incidences did not differ significantly from the results for negative controls (blood donors) and were lower than the values acquired from positive controls (males with unexplained infertility). Conclusion(s):Mumps Orchitis does not cause enhanced humoral immunity to spermatozoa.
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Serum sperm antibodies unrelated to mumps Orchitis.
Andrologia, 2001Co-Authors: Svetoslav Kalaydjiev, D. Dimitrova, P. Tsvetkova, D. TsvetkovAbstract:In order to determine whether there is an association between mumps Orchitis and serum sperm antibodies, we tested patients at the time Orchitis was diagnosed (n=7) and individuals who had had Orchitis at least 1 month previously (n=14). Data were compared with the results for a control group of blood donors (n=20). Sperm antibodies were detected by the gelatin agglutination test of Kibrick, the tray agglutination test of Friberg and the ELISA. Clinically significant sperm antibody levels were not found in patients in the early stages of the disease. Four subjects tested post-disease were positive in the Friberg test and one was positive in the ELISA. One control serum was also positive in the latter test. Significant differences were not found between levels in patients in the early stages of the disease and levels in individuals post-disease, although the results of the Friberg test differed significantly between controls and former mumps Orchitis cases. These data do not support the assumption of an involvement of humoral immunity against spermatozoa in mumps Orchitis patients.
Wei Yu Chen - One of the best experts on this subject based on the ideXlab platform.
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syphilitic Orchitis mimicking a testicular tumor in a clinically occult hiv infected young man a case report with emphasis on a challenging pathological diagnosis
Diagnostic Pathology, 2016Co-Authors: Chia Ying Chu, Wei Yu Chen, Shauh Der Yeh, Huey Min Yeh, Chia Lang FangAbstract:Background Syphilitic Orchitis is a rare manifestation of gumma in tertiary syphilis, microscopically typically characterized by multiple discrete granulomas with central necrosis and peripheral fibrosis. We report a case of syphilitic Orchitis mimicking a testicular tumor with atypical histological features.
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Syphilitic Orchitis mimicking a testicular tumor in a clinically occult HIV-infected young man: a case report with emphasis on a challenging pathological diagnosis
Diagnostic Pathology, 2016Co-Authors: Wei Yu Chen, Chia Lang FangAbstract:Background Syphilitic Orchitis is a rare manifestation of gumma in tertiary syphilis, microscopically typically characterized by multiple discrete granulomas with central necrosis and peripheral fibrosis. We report a case of syphilitic Orchitis mimicking a testicular tumor with atypical histological features. Case presentation A 33-year-old clinically occult HIV-infected man had a testicular tumor. A radical orchiectomy was performed, and a histological examination showed an acute and chronic interstitial inflammatory lesion as well as spindle cell proliferation, without typical gumma formation, necessitating the differential diagnosis having to be made from a panel of etiological factors. Syphilitic Orchitis was confirmed by both an immunohistochemical study and PCR testing for the Treponema pallidum DNA polymerase I gene using paraffin-embedded tissues. However, serology tests, including both the Venereal Disease Research Laboratory (VDRL) test and Treponema pallidum partical agglutination (TTPA), demonstrated false-negative results. Conclusion Syphilitic Orchitis may present atypical and unusual histological features, and should be included in the differential diagnoses of nonspecific interstitial inflammatory lesions of the testes by pathologists, especially in immunocompromised patients.
Audrey Wang - One of the best experts on this subject based on the ideXlab platform.
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Testicular infarction and rupture: an uncommon complication of epididymo-Orchitis
Journal of surgical case reports, 2016Co-Authors: Daniel Chia, Peter Penkoff, Matthew Stanowski, Kieran Beattie, Audrey WangAbstract:Epididymo-Orchitis is a common diagnosis in men presenting with unilateral testicular pain. It can be of an infectious or non-infectious aetiology. Clinical examination and laboratory investigations do not reliably differentiate testicular infarction secondary to epididymo-Orchitis from uncomplicated epididymo-Orchitis. Definitive diagnosis is usually made by ultrasound. Misdiagnosis and under-treatment can lead to poor outcome, such as infarction and loss of the affected testis. We present an uncommon case of epididymo-Orchitis resulting in testicular infarction and rupture despite normal initial investigations.
