The Experts below are selected from a list of 2115 Experts worldwide ranked by ideXlab platform
T Mukaiyama - One of the best experts on this subject based on the ideXlab platform.
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from a synthetic Organic Chemist
Pure and Applied Chemistry, 1997Co-Authors: T MukaiyamaAbstract:The great advance in physical Organic Chemistry during the past sixty years has made an invaluable contribution to wide areas of Organic Chemistry, such as in natural products and in synthetic Chemistry. Physical methods were adapted to the structural Chemistry of Organic compounds as powerful tools for elucidating the structures of even complex molecules in a period when many important and interesting synthetic targets appeared one after the other. The elucidation of reaction mechanisms enabled us to understand pathways necessarily employed in a synthetic approach and led us to find the most suitable methods and proper reaction conditions. Assisted by this understanding, we now have a strong background in the development of synthetic Organic Chemistry, using the above as the weft in an utterly routine way.
Satoshi Maeda - One of the best experts on this subject based on the ideXlab platform.
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Discovery of a synthesis method for a difluoroglycine derivative based on a path generated by quantum chemical calculations
Chemical Science, 2020Co-Authors: Tsuyoshi Mita, Yu Harabuchi, Satoshi MaedaAbstract:The systematic exploration of synthetic pathways to afford a desired product through quantum chemical calculations remains a considerable challenge. In 2013, Maeda et al. introduced ‘quantum Chemistry aided retrosynthetic analysis’ (QCaRA), which uses quantum chemical calculations to search systematically for the decomposition paths of a target product and proposes a synthesis method. However, until now, no new reactions suggested by QCaRA have been reported to lead to experimental discoveries. Using a difluoroglycine derivative as a target, this study investigated the ability of QCaRA to suggest various synthetic paths to the target without relying on previous data or the knowledge and experience of Chemists. Furthermore, experimental verification of the most promising path chosen by an Organic Chemist among the predicted paths led to the discovery of a synthesis method for a difluoroglycine derivative. We emphasize that the purpose of this study is not to propose a fully automated workflow. Therefore, the extent of the hands-on expertise of Chemists required during the verification process was also evaluated. These insights are expected to advance the applicability of QCaRA to the discovery of viable experimental synthetic routes.
Nicholas J Turro - One of the best experts on this subject based on the ideXlab platform.
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fun with photons reactive intermediates and friends skating on the edge of the paradigms of physical Organic Chemistry Organic supramolecular photoChemistry and spin Chemistry
Journal of Organic Chemistry, 2011Co-Authors: Nicholas J TurroAbstract:This Perspective presents a review and survey of the science and philosophy of my research career over the past five decades at Columbia as a physical Organic Chemist and photoChemist. I explore the role of paradigms, structure, and geometric thinking in my own cognitive and intellectual development. The Perspective describes my investigations of high energy content molecules in electronically excited states and the development of electronic spin and supramolecular photoChemistry Chemistry. Current research dealing with the nuclear spin Chemistry of H2 incarcerated in buckyballs is illustrated. In the second part of this Perspective, I recount a personal role of the philosophy and history of science and the scientific communities’ use of paradigms in their every day research and intellectual activities. Examples are given of the crucial role of geometry and structure in the rapid development of Organic Chemistry and physical Organic Chemistry over the past century.
M. Lahav - One of the best experts on this subject based on the ideXlab platform.
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The physical Organic Chemist as a materials scientist in the 21st century
Pure and Applied Chemistry, 1997Co-Authors: M. LahavAbstract:Biography: Meir Lahav studied at the Hebrew University of Jerusalem, and received the M.Sc. in 1963 in the field of Organic polymers, and the Ph.D. in 1967 for studies of Organic solid state reactions. After postdoctoral work with P.D. Bartlett at Harvard he joined the Weizmann Institute of Science in 1971, where he is currently Head of the Department of Materials and Interfaces, and Director of The Minerva G.M.J. Schmidt Interdisciplinary Center of Supramolecular Architectures. He is incumbent of the M. Thatcher chair of Chemistry. He has been the recipient of the Kolthoff Prize of Chemistry from the Technion in Haifa and the Prelog Medal for StereoChemistry (with L. Leiserowitz) from the E.T.H. in Zurich, and was Centenary Lecturer of the Royal Society of Chemistry. He has research interests in the origin of chirality, stereoChemistry, mechanistic study of solid state reactions, crystal engineering, thin Organic films, and related fields.
Charles L Perrin - One of the best experts on this subject based on the ideXlab platform.
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the logic behind a physical Organic Chemist s research topics
Journal of Organic Chemistry, 2017Co-Authors: Charles L PerrinAbstract:Although my research has no common theme or defining area, a coherence connects the diverse topics insofar as one project leads logically to another. Thus, studies on mechanisms of hydrogen exchange in amides and amidines led to the influence of hydrogen bonding and to NMR methods for chemical kinetics, including 2D-EXSY spectroscopy. Another connection was the OH–-catalyzed NH exchange in amines that had supported the hypothesis of stereoelectronic control. We therefore analyzed that hypothesis critically, tested it, found counterexamples, and proposed an alternative hypothesis. We next addressed one-bond NMR coupling constants in ethers and the reverse anomeric effect. The latter studies required a highly accurate NMR titration method that we developed to measure the additional steric bulk resulting from protonation of a substituent. This method is also applicable to measuring secondary isotope effects on acidity, and we could demonstrate that they arise from n-σ* delocalization, not from an inductive e...