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J.-f. Cordier - One of the best experts on this subject based on the ideXlab platform.

  • Many Faces of Bronchiolitis and Organizing Pneumonia.
    Seminars in respiratory and critical care medicine, 2016
    Co-Authors: J.-f. Cordier, Romain Lazor, Vincent Cottin, Françoise Thivolet-béjui
    Abstract:

    As the bronchioles have a strategic position between the airways and the alveolar structures, they are at a site where disorders of many origins may develop, including infections, inflammatory and/or fibrosing processes of immune, occupational, environmental, tumoral, and iatrogenic origin, which may result in predominant bronchiolitis and/or Organizing Pneumonia. This etiologic variety results in many distinct entities and syndromes, common or rare, with new or renewed faces such as bronchiolocentric interstitial Pneumonia or Organizing Pneumonia primed by radiation to the breast.

  • cryptogenic Organizing Pneumonia
    Seminars in Respiratory and Critical Care Medicine, 2012
    Co-Authors: Vincent Cottin, J.-f. Cordier
    Abstract:

    Organizing Pneumonia (OP) is a pathological pattern defined by the characteristic presence of buds of granulation tissue within the lumen of distal pulmonary airspaces consisting of fibroblasts and myofibroblasts intermixed with loose connective matrix. This pattern is the hallmark of a clinical pathological entity, namely cryptogenic Organizing Pneumonia (COP) when no cause or etiologic context is found. The process of intraalveolar organization results from a sequence of alveolar injury, alveolar deposition of fibrin, and colonization of fibrin with proliferating fibroblasts. A tremendous challenge for research is represented by the analysis of features that differentiate the reversible process of OP from that of fibroblastic foci driving irreversible fibrosis in usual interstitial Pneumonia because they may determine the different outcomes of COP and idiopathic pulmonary fibrosis (IPF), respectively. Three main imaging patterns of COP have been described: (1) multiple patchy alveolar opacities (typical pattern), (2) solitary focal nodule or mass (focal pattern), and (3) diffuse infiltrative opacities, although several other uncommon patterns have been reported, especially the reversed halo sign (atoll sign). Definitive diagnosis is based on (1) a suggestive clinical radiological presentation, (2) the demonstration of the characteristic pathological pattern at lung histopathology, and (3) exclusion of possible causes. Transbronchial biopsies or a transthoracic biopsy may also contribute to the pathological diagnosis. Rapid clinical and imaging improvement is obtained with corticosteroid therapy. Because of the risk of misdiagnosing alternative conditions that may mimic OP, only typical cases may be managed without histopathological confirmation, and patients should be followed with particular attention paid to any clue of alternate diagnosis, especially in case of incomplete response to treatment. Patients and clinicians must be aware of frequent relapses after stopping corticosteroid treatment.

  • INTERSTITIAL LUNG DISEASE | Cryptogenic Organizing Pneumonia
    Encyclopedia of Respiratory Medicine, 2006
    Co-Authors: J.-f. Cordier
    Abstract:

    Cryptogenic Organizing Pneumonia (formerly called idiopathic bronchiolitis obliterans Organizing Pneumonia) is an infiltrative lung disease of unknown cause defined by a pathologic pattern of Organizing Pneumonia consisting of buds of granulation tissue in the distal airspaces. Symptoms include mild dyspnea, fever, and weight loss. Sparse crackles are heard at auscultation over involved areas. Imaging features typically consist of multiple patchy subpleural alveolar opacities, often containing an air bronchogram, and sometimes migratory. Although many causes of Organizing Pneumonia have been reported (especially infection, and drug-induced reaction) or its occurrence in specific contexts (especially in the connective tissue diseases), it is more often cryptogenic (idiopathic). Improvement is obtained within a few days with corticosteroid treatment, but relapses are common after reducing or stopping treatment.

  • Cryptogenic Organizing Pneumonia
    Clinics in Chest Medicine, 2004
    Co-Authors: J.-f. Cordier
    Abstract:

    Cryptogenic Organizing Pneumonia is a rare, distinct disorder that is sufficiently different from the other diseases in the group of idiopathic interstitial Pneumonias to be designated as a separate entity. In its most typical presentation, it is characterized by dyspnea and cough, with multiple patchy alveolar opacities on pulmonary imaging. Definite diagnosis is obtained by the finding of buds of granulation tissue in the distal airspaces at lung biopsy. No cause (as infection, drug reaction, or associated disease as connective tissue disease) is found. Corticosteroid treatment is rapidly effective, but relapses are common on reducing or stopping treatment.

  • Organizing Pneumonia : Cryptogenic and disease associated
    Seminars in Respiratory and Critical Care Medicine, 2003
    Co-Authors: J.-f. Cordier
    Abstract:

    Organizing Pneumonia is defined by the presence of buds of granulation tissue (fibroblastic cells and connective matrix) within the alveolar lumen, usually associated with proliferative bronchiolitis obliterans. It may result from several causes, but cryptogenic Organizing Pneumonia is a distinct clinicopathologic entity with characteristic clinical and imaging features. Typical COP is thus easily recognized by the clinician, and the diagnosis is made by the finding of Organizing Pneumonia on lung biopsy specimen. The response to corticosteroids is rapid and complete usually without sequelae, but relapses occur frequently and prolonged corticosteroid treatment is often necessary.

Bernard Padovani - One of the best experts on this subject based on the ideXlab platform.

  • Organizing Pneumonia what is it a conceptual approach and pictorial review
    Diagnostic and interventional imaging, 2014
    Co-Authors: Marie Baquejuston, A Pellegrin, Sylvie Leroy, Charles-hugo Marquette, Bernard Padovani
    Abstract:

    Organizing Pneumonia (formerly named bronchiolitis obliterans with Organizing Pneumonia or BOOP) is a clinical, radiological and histological entity that is classified as an Interstitial Lung Disease. The understanding of this family of diseases has seen great progress over the past twenty years. CT presentation of Organizing Pneumonia is polymorphous but a few patterns have been recently recognized as being more specific to this diagnosis. The aim of this work is to summarize new understandings of the clinical and histological presentation of the disease and to review the most relevant CT features.

  • Organizing Pneumonia: What is it? A conceptual approach and pictorial review
    Diagnostic and interventional imaging, 2014
    Co-Authors: Marie Baque-juston, A Pellegrin, Sylvie Leroy, Charles-hugo Marquette, Bernard Padovani
    Abstract:

    Organizing Pneumonia (formerly named bronchiolitis obliterans with Organizing Pneumonia or BOOP) is a clinical, radiological and histological entity that is classified as an Interstitial Lung Disease. The understanding of this family of diseases has seen great progress over the past twenty years. CT presentation of Organizing Pneumonia is polymorphous but a few patterns have been recently recognized as being more specific to this diagnosis. The aim of this work is to summarize new understandings of the clinical and histological presentation of the disease and to review the most relevant CT features.

Sh Wills - One of the best experts on this subject based on the ideXlab platform.

Debra A. Mangino - One of the best experts on this subject based on the ideXlab platform.

  • A Treatment Alternative for Bronchiolitis Obliterans Organizing Pneumonia
    2017
    Co-Authors: Diane E. Stover, Debra A. Mangino
    Abstract:

    Some macrolides have been found to exert anti-inflammatory effects. Lung diseases such as asthma, panbronchiolitis, cystic fibrosis, and bronchiectasis are thought to respond to the immunomodulatory properties of macrolides. We report three cases of idiopathic bronchiolitis obliterans Organizing Pneumonia, now called cryptogenic Organizing Pneumonia, and three cases of radiation-related bronchiolitis obliterans Organizing Pneumonia that responded to macrolide therapy. An explanation of why macrolides may have anti-inflammatory effects in patients with these syndromes is discussed. These cases help to reinforce accumulating data that macrolides are beneficial as anti-inflammatory agents and Organizing Pneumonia may be another pulmonary disease that can benefit from such therapy. (CHEST 2005; 128:3611–3617)

  • macrolides a treatment alternative for bronchiolitis obliterans Organizing Pneumonia
    Chest, 2005
    Co-Authors: Diane E. Stover, Debra A. Mangino
    Abstract:

    Some macrolides have been found to exert anti-inflammatory effects. Lung diseases such as asthma, panbronchiolitis, cystic fibrosis, and bronchiectasis are thought to respond to the immunomodulatory properties of macrolides. We report three cases of idiopathic bronchiolitis obliterans Organizing Pneumonia, now called cryptogenic Organizing Pneumonia, and three cases of radiation-related bronchiolitis obliterans Organizing Pneumonia that responded to macrolide therapy. An explanation of why macrolides may have anti-inflammatory effects in patients with these syndromes is discussed. These cases help to reinforce accumulating data that macrolides are beneficial as anti-inflammatory agents and Organizing Pneumonia may be another pulmonary disease that can benefit from such therapy.

Gary R. Epler - One of the best experts on this subject based on the ideXlab platform.

  • drug induced bronchiolitis obliterans Organizing Pneumonia
    Clinics in Chest Medicine, 2004
    Co-Authors: Gary R. Epler
    Abstract:

    Several classes of medications cause the bronchiolitis obliterans Organizing Pneumonia (BOOP) reaction, including the antimicrobials, anticancer agents, cardiac agents, and anti-inflammatory agents. The BOOP reaction represents an inflammatory response of the lung, and, therefore, is generally reversible by drug cessation or corticosteroid therapy. Organizing Pneumonia is a general term that includes BOOP. This article includes a review of the clinical findings, radiographic abnormalities, physiologic findings, and management of drug-induced BOOP.

  • Bronchiolitis Obliterans Organizing Pneumonia
    Archives of Internal Medicine, 2001
    Co-Authors: Gary R. Epler
    Abstract:

    Bronchiolar disorders can be divided into 2 general categories: (1) airway disorders (cellular bronchiolitis and obliterative bronchiolitis) and (2) parenchymal disorders (respiratory bronchiolitis-interstitial lung disease, which occurs in smokers and is treatable with smoking cessation or corticosteroid therapy, and bronchiolitis obliterans Organizing Pneumonia, an inflammatory lung disease simultaneously involving the terminal bronchioles and alveoli). This article reviews the clinical findings and therapeutic management of bronchiolitis obliterans Organizing Pneumonia.