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Susana Maria Werner Samuel - One of the best experts on this subject based on the ideXlab platform.
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Ionic liquid as antibacterial agent for an experimental Orthodontic Adhesive.
Dental materials : official publication of the Academy of Dental Materials, 2019Co-Authors: Isadora Martini Garcia, Susana Maria Werner Samuel, Vicente Castelo Branco Leitune, Carolina Jung Ferreira, Virgínia S. Souza, Gabriela De Souza Balbinot, Amanda De Souza Da Motta, Fernanda Visioli, Jackson D. Scholten, Fabrício Mezzomo CollaresAbstract:Abstract Objective The aim of this study was to formulate and evaluate experimental Orthodontic Adhesives with different concentrations of 1-n-butyl-3-methylimidazoilium bis(trifluoromethanesulfonyl)imide (BMIM.NTf2). Methods The experimental Orthodontic Adhesives were formulated with methacrylate monomers, photoinitiators and silica colloidal. The ionic liquid BMIM.NTf2 was synthesized and characterized. BMIM.NTf2 was added at 5 (G5%), 10 (G10%) and 15 (G15%) wt.%. One group contained no BMIM.NTf2 to function as control (GCtrl). The Adhesives were evaluated for polymerization kinetics, degree of conversion (DC), Knoop hardness and softening in solvent, ultimate tensile strength (UTS), shear bond strength (SBS), thermogravimetric analysis (TGA), antibacterial activity and cytotoxicity. Results BMI.NTf2 showed the characteristic chemical peaks. The polymerization kinetics were different among the groups. G10% and G15% showed higher DC (p 0.05). There were no differences for UTS (p > 0.05) and SBS (p > 0.05). TGA showed one different peak for G15%. All groups with BMIM.NTf2 showed antibacterial activity compared to GCtrl (p 0.05). Significance To reduce biofilm formation around brackets and to prevent demineralization at susceptible sites, materials have been developed with antibacterial properties. In this study, a new experimental Orthodontic Adhesive was formulated with an imidazolium ionic liquid (BMIM.NTf2) as antibacterial agent. The incorporation of 5 wt.% of ionic liquid decreased biofilm formation without affecting the physico-chemical properties and cytotoxicity of an experimental Orthodontic resin.
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Evaluation of an antibacterial Orthodontic Adhesive incorporated with niobium-based bioglass: an in situ study
Sociedade Brasileira de Pesquisa Odontológica, 2019Co-Authors: Felipe Weidenbach Degrazia, Aline Segatto Pires Altmann, Susana Maria Werner Samuel, Vicente Castelo Branco Leitune, Rodrigo Alex Arthur, Carolina Jung Ferreira, Fabrício Mezzomo CollaresAbstract:Abstract This in situ study aimed to evaluate the antibacterial and anti-demineralization effects of an experimental Orthodontic Adhesive containing triazine and niobium phosphate bioglass (TAT) around brackets bonded to enamel surfaces. Sixteen volunteers were selected to use intra-oral devices with six metallic brackets bonded to enamel blocks. The experimental Orthodontic Adhesives were composed by 75% BisGMA and 25% TEGDMA containing 0% TAT and 20% TAT. Transbond XT Adhesive (TXT) was used as a control group. Ten volunteers, mean age of 29 years, were included in the study. The six blocks of each volunteer were detached from the appliance after 7 and 14 days to evaluate mineral loss and bacterial growth including total bacteria, total Streptococci, Streptococci mutans, and Lactobacilli. Statistical analysis was performed using GLM model - univariate analysis of variance for microhardness and 2-way ANOVA for bacterial growth (p
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Niobium pentoxide phosphate invert glass as a mineralizing agent in an experimental Orthodontic Adhesive.
The Angle orthodontist, 2017Co-Authors: Alinne Segatto Pires Altmann, Fabrício Mezzomo Collares, Vicente Castelo Branco Leitune, Antonio Shigueaki Takimi, Gabriela De Souza Balbinot, Susana Maria Werner SamuelAbstract:ABSTRACT Objective: The aim of this study was to develop an experimental Orthodontic Adhesive and evaluate how adding phosphate invert glass containing niobium pentoxide (PIG-Nb) affected the Adhesive's properties. Material and Methods: PIG-Nb was added at 1, 2.5, and 5 wt% to experimental Adhesive (75 wt% bisphenol A methacrylate [BisGMA], 25 wt% triethylene glycol dimethacrylate [TEGDMA], 5 wt% colloidal silica and photoinitiator system). The Adhesives were evaluated for mineral deposition, degree of conversion (DC), softening solvent by Knoop microhardness (KNH) variation, pH changes, and shear bond strength (SBS). One-way analysis of variance (ANOVA) (DC and ΔKHN%), two-way ANOVA (SBS), repeated measures ANOVA (pH), and paired test (KNH1 and KNH2) were used at a significance level of P < .05. Results: Adding PIG-Nb to Orthodontic Adhesives induced deposition on its surface associated with a constant neutral pH. The SBS increased after immersion in artificial saliva, and the PIG-Nb5 exhibited less soft...
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In vitro antibacterial and remineralizing effect of Adhesive containing triazine and niobium pentoxide phosphate inverted glass
Clinical Oral Investigations, 2017Co-Authors: Aline Segatto Pires Altmann, Fabrício Mezzomo Collares, Vicente Castelo Branco Leitune, Antonio Shigueaki Takimi, Rodrigo Alex Arthur, Susana Maria Werner SamuelAbstract:ObjectivesWhite spot lesions are still a concern for Orthodontic patients. The objective of this study was to assess the remineralizing and antibacterial effect of a newly developed Orthodontic Adhesive.MethodsThe compounds 1,3,5-tryacryloylhexahydro-1,3,5-triazine (TAT) and phosphate invert glass containing 10 mol% of niobium pentoxide (PIG-Nb) were added at 20 and 5 wt%, respectively, to an experimental Adhesive (75 wt% BisGMA, 25 wt% TEGDMA, 5 wt% fummed silica, and photo-initiator system), called TPN. A group without the addition of these compounds was used as Control and the Orthodontic Adhesive Transbond XT (TXT) was used for comparison. Antibacterial activity was evaluated through surface biofilm formation, mineral deposition, and degree of conversion (DC) through Raman microscopy, Knoop hardness after softening in solvent, and bracket dislodgement (BD).ResultsTPN group presented a reduction in bacterial growth when compared to Control and TXT. Mineral deposits were observed on the surface of TPN Adhesive after 14 and 28 days of immersion in artificial saliva. There was an increase in DC after 28 days, whereas TPN group presented the highest DC. All groups underwent some degree of softening. No significant changes were observed in BD after 28 days of immersion in artificial saliva.ConclusionThe newly developed Orthodontic Adhesive, with addition of 20 wt% TAT and 5w% PIG-Nb, exhibited antibacterial activity and was capable to induce mineral deposition on its surface in vitro.Clinical significanceThe Orthodontic Adhesive developed in this study with antibacterial activity and mineral deposition could be a reliable choice for brackets adhesion.
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In vitro antibacterial and remineralizing effect of Adhesive containing triazine and niobium pentoxide phosphate inverted glass
Clinical Oral Investigations, 2017Co-Authors: Aline Segatto Pires Altmann, Fabrício Mezzomo Collares, Vicente Castelo Branco Leitune, Antonio Shigueaki Takimi, Rodrigo Alex Arthur, Susana Maria Werner SamuelAbstract:ObjectivesWhite spot lesions are still a concern for Orthodontic patients. The objective of this study was to assess the remineralizing and antibacterial effect of a newly developed Orthodontic Adhesive.MethodsThe compounds 1,3,5-tryacryloylhexahydro-1,3,5-triazine (TAT) and phosphate invert glass containing 10 mol% of niobium pentoxide (PIG-Nb) were added at 20 and 5 wt%, respectively, to an experimental Adhesive (75 wt% BisGMA, 25 wt% TEGDMA, 5 wt% fummed silica, and photo-initiator system), called TPN. A group without the addition of these compounds was used as Control and the Orthodontic Adhesive Transbond XT (TXT) was used for comparison. Antibacterial activity was evaluated through surface biofilm formation, mineral deposition, and degree of conversion (DC) through Raman microscopy, Knoop hardness after softening in solvent, and bracket dislodgement (BD).ResultsTPN group presented a reduction in bacterial growth when compared to Control and TXT. Mineral deposits were observed on the surface of TPN Adhesive after 14 and 28 days of immersion in artificial saliva. There was an increase in DC after 28 days, whereas TPN group presented the highest DC. All groups underwent some degree of softening. No significant changes were observed in BD after 28 days of immersion in artificial saliva.ConclusionThe newly developed Orthodontic Adhesive, with addition of 20 wt% TAT and 5w% PIG-Nb, exhibited antibacterial activity and was capable to induce mineral deposition on its surface in vitro.Clinical significanceThe Orthodontic Adhesive developed in this study with antibacterial activity and mineral deposition could be a reliable choice for brackets adhesion.
Fabrício Mezzomo Collares - One of the best experts on this subject based on the ideXlab platform.
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Ionic liquid as antibacterial agent for an experimental Orthodontic Adhesive.
Dental materials : official publication of the Academy of Dental Materials, 2019Co-Authors: Isadora Martini Garcia, Susana Maria Werner Samuel, Vicente Castelo Branco Leitune, Carolina Jung Ferreira, Virgínia S. Souza, Gabriela De Souza Balbinot, Amanda De Souza Da Motta, Fernanda Visioli, Jackson D. Scholten, Fabrício Mezzomo CollaresAbstract:Abstract Objective The aim of this study was to formulate and evaluate experimental Orthodontic Adhesives with different concentrations of 1-n-butyl-3-methylimidazoilium bis(trifluoromethanesulfonyl)imide (BMIM.NTf2). Methods The experimental Orthodontic Adhesives were formulated with methacrylate monomers, photoinitiators and silica colloidal. The ionic liquid BMIM.NTf2 was synthesized and characterized. BMIM.NTf2 was added at 5 (G5%), 10 (G10%) and 15 (G15%) wt.%. One group contained no BMIM.NTf2 to function as control (GCtrl). The Adhesives were evaluated for polymerization kinetics, degree of conversion (DC), Knoop hardness and softening in solvent, ultimate tensile strength (UTS), shear bond strength (SBS), thermogravimetric analysis (TGA), antibacterial activity and cytotoxicity. Results BMI.NTf2 showed the characteristic chemical peaks. The polymerization kinetics were different among the groups. G10% and G15% showed higher DC (p 0.05). There were no differences for UTS (p > 0.05) and SBS (p > 0.05). TGA showed one different peak for G15%. All groups with BMIM.NTf2 showed antibacterial activity compared to GCtrl (p 0.05). Significance To reduce biofilm formation around brackets and to prevent demineralization at susceptible sites, materials have been developed with antibacterial properties. In this study, a new experimental Orthodontic Adhesive was formulated with an imidazolium ionic liquid (BMIM.NTf2) as antibacterial agent. The incorporation of 5 wt.% of ionic liquid decreased biofilm formation without affecting the physico-chemical properties and cytotoxicity of an experimental Orthodontic resin.
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Antibacterial and Remineralizing Fillers in Experimental Orthodontic Adhesives
Materials (Basel Switzerland), 2019Co-Authors: Carolina Jung Ferreira, Vicente Castelo Branco Leitune, Felipe Weidenbach Degrazia, Gabriela De Souza Balbinot, Marianna Arakelyan, Salvatore Sauro, Fabrício Mezzomo CollaresAbstract:Orthodontic Adhesives with antimicrobial and remineralizing properties may be an alternative to control white spot lesions around brackets. The aim of this study is to develop an experimental Orthodontic Adhesive containing boron nitride nanotubes (BNNT) and alkyl trimethyl ammonium bromide (ATAB). Methacrylate (BisGMA and TEGDMA) monomers were used to formulate the Adhesives. Four experimental groups were produced with the addition of 0.1 wt.% BNNT (GBNNT); 0.1 wt.% ATAB (GATAB); and 0.2 wt.% BNNT with ATAB (GBNNT/ATAB); in the control group, no fillers were added (GCtrl). The degree of conversion, cytotoxicity, softening in solvent, contact angle and free surface energy, antibacterial activity, shear bond strength, and mineral deposition were evaluated. Adhesives achieved degree of conversion higher than 50% and cell viability higher than 90%. GBNNT and GATAB Adhesives exhibited reduced softening in solvent. Mean free surface energy was decreased in the GBNNT Adhesive. Significant reduction in bacterial growth was observed in the GBNNT/ATAB. No statistical difference was found for shear bond strength. Mineral deposition was found in GBNNT, GATAB, and GBNNT/ATAB groups after 14 and 28 days. The addition of 0.2% BNNT/ATAB to an experimental Orthodontic Adhesive inhibited bacterial growth and induced mineral deposition without affecting the properties of the material.
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Evaluation of an antibacterial Orthodontic Adhesive incorporated with niobium-based bioglass: an in situ study
Sociedade Brasileira de Pesquisa Odontológica, 2019Co-Authors: Felipe Weidenbach Degrazia, Aline Segatto Pires Altmann, Susana Maria Werner Samuel, Vicente Castelo Branco Leitune, Rodrigo Alex Arthur, Carolina Jung Ferreira, Fabrício Mezzomo CollaresAbstract:Abstract This in situ study aimed to evaluate the antibacterial and anti-demineralization effects of an experimental Orthodontic Adhesive containing triazine and niobium phosphate bioglass (TAT) around brackets bonded to enamel surfaces. Sixteen volunteers were selected to use intra-oral devices with six metallic brackets bonded to enamel blocks. The experimental Orthodontic Adhesives were composed by 75% BisGMA and 25% TEGDMA containing 0% TAT and 20% TAT. Transbond XT Adhesive (TXT) was used as a control group. Ten volunteers, mean age of 29 years, were included in the study. The six blocks of each volunteer were detached from the appliance after 7 and 14 days to evaluate mineral loss and bacterial growth including total bacteria, total Streptococci, Streptococci mutans, and Lactobacilli. Statistical analysis was performed using GLM model - univariate analysis of variance for microhardness and 2-way ANOVA for bacterial growth (p
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Niobium pentoxide phosphate invert glass as a mineralizing agent in an experimental Orthodontic Adhesive.
The Angle orthodontist, 2017Co-Authors: Alinne Segatto Pires Altmann, Fabrício Mezzomo Collares, Vicente Castelo Branco Leitune, Antonio Shigueaki Takimi, Gabriela De Souza Balbinot, Susana Maria Werner SamuelAbstract:ABSTRACT Objective: The aim of this study was to develop an experimental Orthodontic Adhesive and evaluate how adding phosphate invert glass containing niobium pentoxide (PIG-Nb) affected the Adhesive's properties. Material and Methods: PIG-Nb was added at 1, 2.5, and 5 wt% to experimental Adhesive (75 wt% bisphenol A methacrylate [BisGMA], 25 wt% triethylene glycol dimethacrylate [TEGDMA], 5 wt% colloidal silica and photoinitiator system). The Adhesives were evaluated for mineral deposition, degree of conversion (DC), softening solvent by Knoop microhardness (KNH) variation, pH changes, and shear bond strength (SBS). One-way analysis of variance (ANOVA) (DC and ΔKHN%), two-way ANOVA (SBS), repeated measures ANOVA (pH), and paired test (KNH1 and KNH2) were used at a significance level of P < .05. Results: Adding PIG-Nb to Orthodontic Adhesives induced deposition on its surface associated with a constant neutral pH. The SBS increased after immersion in artificial saliva, and the PIG-Nb5 exhibited less soft...
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In vitro antibacterial and remineralizing effect of Adhesive containing triazine and niobium pentoxide phosphate inverted glass
Clinical Oral Investigations, 2017Co-Authors: Aline Segatto Pires Altmann, Fabrício Mezzomo Collares, Vicente Castelo Branco Leitune, Antonio Shigueaki Takimi, Rodrigo Alex Arthur, Susana Maria Werner SamuelAbstract:ObjectivesWhite spot lesions are still a concern for Orthodontic patients. The objective of this study was to assess the remineralizing and antibacterial effect of a newly developed Orthodontic Adhesive.MethodsThe compounds 1,3,5-tryacryloylhexahydro-1,3,5-triazine (TAT) and phosphate invert glass containing 10 mol% of niobium pentoxide (PIG-Nb) were added at 20 and 5 wt%, respectively, to an experimental Adhesive (75 wt% BisGMA, 25 wt% TEGDMA, 5 wt% fummed silica, and photo-initiator system), called TPN. A group without the addition of these compounds was used as Control and the Orthodontic Adhesive Transbond XT (TXT) was used for comparison. Antibacterial activity was evaluated through surface biofilm formation, mineral deposition, and degree of conversion (DC) through Raman microscopy, Knoop hardness after softening in solvent, and bracket dislodgement (BD).ResultsTPN group presented a reduction in bacterial growth when compared to Control and TXT. Mineral deposits were observed on the surface of TPN Adhesive after 14 and 28 days of immersion in artificial saliva. There was an increase in DC after 28 days, whereas TPN group presented the highest DC. All groups underwent some degree of softening. No significant changes were observed in BD after 28 days of immersion in artificial saliva.ConclusionThe newly developed Orthodontic Adhesive, with addition of 20 wt% TAT and 5w% PIG-Nb, exhibited antibacterial activity and was capable to induce mineral deposition on its surface in vitro.Clinical significanceThe Orthodontic Adhesive developed in this study with antibacterial activity and mineral deposition could be a reliable choice for brackets adhesion.
Theodore Eliades - One of the best experts on this subject based on the ideXlab platform.
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the effect of Orthodontic Adhesive and bracket base design in Adhesive remnant index on enamel
Journal of the world federation of orthodontists, 2015Co-Authors: Argiro Kechagia, Spiros Zinelis, Athanasios E. Athanasiou, Nikolaos Pandis, Theodore EliadesAbstract:Abstract Background The purpose of this study was to identify the effects of bracket-base design and Adhesive on Adhesive remnant index (ARI) and enamel surface area covered by Adhesive. Methods The sample consisted of 32 recently extracted premolars. The teeth were randomly assigned to one of four groups: conventional mesh base and composite resin; laser-etched base and composite resin; conventional mesh base and resin-modified glass ionomer; and laser-etched base and resin-modified glass ionomer. After a week, all brackets were debonded. The debonded bracket-base surface and the buccal surface of each tooth were studied under the microscope, and the remaining Adhesive was scored using the ARI. The extent of coverage of the tooth by Adhesive remnants was also calculated, outlining the different areas of Adhesive. Results A Fisher's exact test indicated significant differences between the groups. The Adhesive resin group showed the highest ARI scores independent of the bracket-base design, whereas between the two bracket-base designs, the laser-etched bracket design showed higher ARI. ARI scores reliably depict the extent of enamel covered by Adhesive compared with the measurement of the actual area covered. Conclusion Varying the bracket base and Adhesive may result in different ARI scores, which can affect the enamel surface during debonding.
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color stability of Orthodontic Adhesive resins
Angle Orthodontist, 2009Co-Authors: Theodore Eliades, George Eliades, Christiana Gioka, Matthew Heim, Margarita MakouAbstract:Abstract Color alteration of Adhesive during treatment and after debonding may be implicated in long- term enamel discoloration. The aim of this study was to assess the color stability of light-cured and chemically cured Adhesives subjected to artificial photoaging. Disk-shaped specimens of Adhesives were colorimetrically evaluated before and after artificial photoaging using an ISO-recommended protocol. The measurement variable was the color change (ΔE) of Adhesives induced by artificial, accelerated photoaging. The ΔE values derived from the two color recordings for the materials at pre- and postaging intervals were statistically analyzed with a one-way analysis of variance (ANOVA), with the Adhesive brand serving as a discriminating variable. Differences among groups were further investigated using the Tukey multiple comparisons test (α = .05). To establish the statistical significance of the difference of the ΔE values of each Adhesive and the ΔE threshold for clinical detection, a paired t-test was u...
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characterization and in vitro estrogenicity of Orthodontic Adhesive particulates produced by simulated debonding
Dental Materials, 2009Co-Authors: C Gioka, Theodore Eliades, Athanasios E. Athanasiou, George Eliades, Spiros Zinelis, Harris Pratsinis, D KletsasAbstract:Abstract Objective To investigate the structure and composition of ground Orthodontic Adhesive particulates produced under simulated clinical conditions and assess their estrogenic action in vitro . Materials and methods A chemically cured and a light-cured Adhesive were included in the study. Specimens were prepared by simulating bonding procedures, covering the bracket base surface with cellulose films to detach the full set material. The Adhesives prepared under this method were grounded in glass chambers with an 8-fluted tungsten carbide on a high-speed handpiece; a new bur and different chamber was used for each Adhesive sample and grindings were performed on different days to avoid contamination of the room. The Adhesive particulates produced were subjected to FT-IR spectroscopy for the molecular characterization of particles; scanning electron microscopy for the morphologic condition and structure; and X-ray microanalysis for the elemental composition of the particles. Amounts of the ground Adhesives were immersed in saline for 1 month at 37 °C. Eluents from solution of the two Adhesives were added to media of an estrogen-responsive cell line derived from human breast adenocarcinoma (MCF-7), to assess the estrogenicity. Positive (estradiol and bisphenol-A) and negative (saline) controls were used; all assays were repeated four times and the results were averaged. Estrogenicity data were analyzed with one-way ANOVA and the Tukey test at the .05 level of significance. Results The study of the composition of particles revealed compounds related to monomers with no major differences noted. Significant structural alterations were observed between the materials studied, with the chemically cured Adhesive having larger particles. The ground samples contained Si, Na and Al apparently deriving from fillers, whereas large Ba fillers were identified only in the chemically cured group, whereas no distinct molecular variation was noted between the set material and its corresponding particulate form. Both chemically cured and light-cured Adhesives exhibited an estrogenic action through induction of the proliferation rate of MCF-7 cells (160% and 128%, respectively, compared to control). Significance Apart from the potentially hazardous action of Adhesive particulate aerosol produced by grinding, composite resin particulates may act as endocrinological disruptors.
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Effect of in vivo aging on the shear bond strength of an Orthodontic Adhesive.
Australian orthodontic journal, 2009Co-Authors: Evangelia Chatzistavrou, Theodore Eliades, Athanasios E. Athanasiou, Spiros Zinelis, George EliadesAbstract:Aims: To assess the effect of intra-oral aging on the shear bond strength of a composite resin Orthodontic Adhesive (Transbond XT, 3M Unitek, Monrovia, CA, USA) after 6 months in the oral cavity and to compare it with control specimens not subjected to intra-oral aging. Methods: The sample consisted of patients aged 13‐36 years, in need of premolar extractions for Orthodontic purposes. Ten premolars were bonded with Transbond XT. After 6 months in vivo, the teeth were carefully extracted, sectioned at the amelo-cemental junction, mounted in cold cure acrylic resin cylinders and subjected to shear bond strength testing using a universal testing machine. The debonded bracket base surfaces were then studied under light microscope, photographed digitally and analysed with SigmaScan Image Measurement Software (Jandel GmbH, Erkrath, Germany) for the percentage of coverage of the debonded brackets with the Orthodontic Adhesive. The same procedure was followed for 14 premolars from the same patients bonded in vitro with the same Adhesive. Results: No statistically significant differences were found in the shear bond strength between the two groups of composite resin Adhesive systems (with and without clinical aging) or in the Adhesive remnant coverage following debonding. No significant correlation was detected between the shear bond strength and the Adhesive remnant coverage in the test specimens with and without aging. Conclusions: Laboratory studies of shear bond strength appear to be clinically relevant. (Aust Orthod J 2009; 25: XXXX)
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Oestrogenicity of Orthodontic Adhesive resins
European journal of orthodontics, 2007Co-Authors: Theodore Eliades, V Gioni, Dimitris Kletsas, Athanasios E. Athanasiou, George EliadesAbstract:The purpose of this study was to assess the oestrogenic action of a chemically cured, no-mix (Rely-a-Bond) and a light-cured (Reliance) Orthodontic Adhesive resin. The Adhesives were bonded to 40 stainless steel maxillary incisor brackets (Diamond) divided into two equal groups, employing a method which simulated the clinical handling of materials. In total, three series of specimens were prepared for each Adhesive–bracket group. All specimens were immersed in normal saline. Samples of eluent were removed from each group at 1 day and 1 week following incubation and tested for oestrogenicity by measuring their effect on the proliferation of the oestrogen-responsive MCF-7 breast cancer cells, while an oestrogen-insensitive cell line (MB-231 human breast adenocarcinoma) was used as a control. Three-way analysis of variance with Adhesive, concentration of eluent, and immersion period were used as discriminating variables. No evidence was found of stimulation of proliferation of these cells, indicating the absence of any oestrogenicity of Orthodontic Adhesive eluents.
George Eliades - One of the best experts on this subject based on the ideXlab platform.
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color stability of Orthodontic Adhesive resins
Angle Orthodontist, 2009Co-Authors: Theodore Eliades, George Eliades, Christiana Gioka, Matthew Heim, Margarita MakouAbstract:Abstract Color alteration of Adhesive during treatment and after debonding may be implicated in long- term enamel discoloration. The aim of this study was to assess the color stability of light-cured and chemically cured Adhesives subjected to artificial photoaging. Disk-shaped specimens of Adhesives were colorimetrically evaluated before and after artificial photoaging using an ISO-recommended protocol. The measurement variable was the color change (ΔE) of Adhesives induced by artificial, accelerated photoaging. The ΔE values derived from the two color recordings for the materials at pre- and postaging intervals were statistically analyzed with a one-way analysis of variance (ANOVA), with the Adhesive brand serving as a discriminating variable. Differences among groups were further investigated using the Tukey multiple comparisons test (α = .05). To establish the statistical significance of the difference of the ΔE values of each Adhesive and the ΔE threshold for clinical detection, a paired t-test was u...
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characterization and in vitro estrogenicity of Orthodontic Adhesive particulates produced by simulated debonding
Dental Materials, 2009Co-Authors: C Gioka, Theodore Eliades, Athanasios E. Athanasiou, George Eliades, Spiros Zinelis, Harris Pratsinis, D KletsasAbstract:Abstract Objective To investigate the structure and composition of ground Orthodontic Adhesive particulates produced under simulated clinical conditions and assess their estrogenic action in vitro . Materials and methods A chemically cured and a light-cured Adhesive were included in the study. Specimens were prepared by simulating bonding procedures, covering the bracket base surface with cellulose films to detach the full set material. The Adhesives prepared under this method were grounded in glass chambers with an 8-fluted tungsten carbide on a high-speed handpiece; a new bur and different chamber was used for each Adhesive sample and grindings were performed on different days to avoid contamination of the room. The Adhesive particulates produced were subjected to FT-IR spectroscopy for the molecular characterization of particles; scanning electron microscopy for the morphologic condition and structure; and X-ray microanalysis for the elemental composition of the particles. Amounts of the ground Adhesives were immersed in saline for 1 month at 37 °C. Eluents from solution of the two Adhesives were added to media of an estrogen-responsive cell line derived from human breast adenocarcinoma (MCF-7), to assess the estrogenicity. Positive (estradiol and bisphenol-A) and negative (saline) controls were used; all assays were repeated four times and the results were averaged. Estrogenicity data were analyzed with one-way ANOVA and the Tukey test at the .05 level of significance. Results The study of the composition of particles revealed compounds related to monomers with no major differences noted. Significant structural alterations were observed between the materials studied, with the chemically cured Adhesive having larger particles. The ground samples contained Si, Na and Al apparently deriving from fillers, whereas large Ba fillers were identified only in the chemically cured group, whereas no distinct molecular variation was noted between the set material and its corresponding particulate form. Both chemically cured and light-cured Adhesives exhibited an estrogenic action through induction of the proliferation rate of MCF-7 cells (160% and 128%, respectively, compared to control). Significance Apart from the potentially hazardous action of Adhesive particulate aerosol produced by grinding, composite resin particulates may act as endocrinological disruptors.
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Effect of in vivo aging on the shear bond strength of an Orthodontic Adhesive.
Australian orthodontic journal, 2009Co-Authors: Evangelia Chatzistavrou, Theodore Eliades, Athanasios E. Athanasiou, Spiros Zinelis, George EliadesAbstract:Aims: To assess the effect of intra-oral aging on the shear bond strength of a composite resin Orthodontic Adhesive (Transbond XT, 3M Unitek, Monrovia, CA, USA) after 6 months in the oral cavity and to compare it with control specimens not subjected to intra-oral aging. Methods: The sample consisted of patients aged 13‐36 years, in need of premolar extractions for Orthodontic purposes. Ten premolars were bonded with Transbond XT. After 6 months in vivo, the teeth were carefully extracted, sectioned at the amelo-cemental junction, mounted in cold cure acrylic resin cylinders and subjected to shear bond strength testing using a universal testing machine. The debonded bracket base surfaces were then studied under light microscope, photographed digitally and analysed with SigmaScan Image Measurement Software (Jandel GmbH, Erkrath, Germany) for the percentage of coverage of the debonded brackets with the Orthodontic Adhesive. The same procedure was followed for 14 premolars from the same patients bonded in vitro with the same Adhesive. Results: No statistically significant differences were found in the shear bond strength between the two groups of composite resin Adhesive systems (with and without clinical aging) or in the Adhesive remnant coverage following debonding. No significant correlation was detected between the shear bond strength and the Adhesive remnant coverage in the test specimens with and without aging. Conclusions: Laboratory studies of shear bond strength appear to be clinically relevant. (Aust Orthod J 2009; 25: XXXX)
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Oestrogenicity of Orthodontic Adhesive resins
European journal of orthodontics, 2007Co-Authors: Theodore Eliades, V Gioni, Dimitris Kletsas, Athanasios E. Athanasiou, George EliadesAbstract:The purpose of this study was to assess the oestrogenic action of a chemically cured, no-mix (Rely-a-Bond) and a light-cured (Reliance) Orthodontic Adhesive resin. The Adhesives were bonded to 40 stainless steel maxillary incisor brackets (Diamond) divided into two equal groups, employing a method which simulated the clinical handling of materials. In total, three series of specimens were prepared for each Adhesive–bracket group. All specimens were immersed in normal saline. Samples of eluent were removed from each group at 1 day and 1 week following incubation and tested for oestrogenicity by measuring their effect on the proliferation of the oestrogen-responsive MCF-7 breast cancer cells, while an oestrogen-insensitive cell line (MB-231 human breast adenocarcinoma) was used as a control. Three-way analysis of variance with Adhesive, concentration of eluent, and immersion period were used as discriminating variables. No evidence was found of stimulation of proliferation of these cells, indicating the absence of any oestrogenicity of Orthodontic Adhesive eluents.
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Orthodontic bonding to wet enamel with water insensitive and water activated Orthodontic Adhesive resins
In: Dental Hard Tissues and Bonding. Heidelberg Germany: Springer-Verlag; 2005. p. 71-85., 2005Co-Authors: Theodore Eliades, George Eliades, Nick Silikas, D C WattsAbstract:The interference of moisture in enamel bonding procedures is of interest mainly for Orthodontic applications and to a lesser extent for bonded restorations. The mechanism and interfacial phenomena of enamel bonding from a restorative dentistry perspective are analyzed in Chap. 1.
Aline Segatto Pires Altmann - One of the best experts on this subject based on the ideXlab platform.
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Evaluation of an antibacterial Orthodontic Adhesive incorporated with niobium-based bioglass: an in situ study
Sociedade Brasileira de Pesquisa Odontológica, 2019Co-Authors: Felipe Weidenbach Degrazia, Aline Segatto Pires Altmann, Susana Maria Werner Samuel, Vicente Castelo Branco Leitune, Rodrigo Alex Arthur, Carolina Jung Ferreira, Fabrício Mezzomo CollaresAbstract:Abstract This in situ study aimed to evaluate the antibacterial and anti-demineralization effects of an experimental Orthodontic Adhesive containing triazine and niobium phosphate bioglass (TAT) around brackets bonded to enamel surfaces. Sixteen volunteers were selected to use intra-oral devices with six metallic brackets bonded to enamel blocks. The experimental Orthodontic Adhesives were composed by 75% BisGMA and 25% TEGDMA containing 0% TAT and 20% TAT. Transbond XT Adhesive (TXT) was used as a control group. Ten volunteers, mean age of 29 years, were included in the study. The six blocks of each volunteer were detached from the appliance after 7 and 14 days to evaluate mineral loss and bacterial growth including total bacteria, total Streptococci, Streptococci mutans, and Lactobacilli. Statistical analysis was performed using GLM model - univariate analysis of variance for microhardness and 2-way ANOVA for bacterial growth (p
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In vitro antibacterial and remineralizing effect of Adhesive containing triazine and niobium pentoxide phosphate inverted glass
Clinical Oral Investigations, 2017Co-Authors: Aline Segatto Pires Altmann, Fabrício Mezzomo Collares, Vicente Castelo Branco Leitune, Antonio Shigueaki Takimi, Rodrigo Alex Arthur, Susana Maria Werner SamuelAbstract:ObjectivesWhite spot lesions are still a concern for Orthodontic patients. The objective of this study was to assess the remineralizing and antibacterial effect of a newly developed Orthodontic Adhesive.MethodsThe compounds 1,3,5-tryacryloylhexahydro-1,3,5-triazine (TAT) and phosphate invert glass containing 10 mol% of niobium pentoxide (PIG-Nb) were added at 20 and 5 wt%, respectively, to an experimental Adhesive (75 wt% BisGMA, 25 wt% TEGDMA, 5 wt% fummed silica, and photo-initiator system), called TPN. A group without the addition of these compounds was used as Control and the Orthodontic Adhesive Transbond XT (TXT) was used for comparison. Antibacterial activity was evaluated through surface biofilm formation, mineral deposition, and degree of conversion (DC) through Raman microscopy, Knoop hardness after softening in solvent, and bracket dislodgement (BD).ResultsTPN group presented a reduction in bacterial growth when compared to Control and TXT. Mineral deposits were observed on the surface of TPN Adhesive after 14 and 28 days of immersion in artificial saliva. There was an increase in DC after 28 days, whereas TPN group presented the highest DC. All groups underwent some degree of softening. No significant changes were observed in BD after 28 days of immersion in artificial saliva.ConclusionThe newly developed Orthodontic Adhesive, with addition of 20 wt% TAT and 5w% PIG-Nb, exhibited antibacterial activity and was capable to induce mineral deposition on its surface in vitro.Clinical significanceThe Orthodontic Adhesive developed in this study with antibacterial activity and mineral deposition could be a reliable choice for brackets adhesion.
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In vitro antibacterial and remineralizing effect of Adhesive containing triazine and niobium pentoxide phosphate inverted glass
Clinical Oral Investigations, 2017Co-Authors: Aline Segatto Pires Altmann, Fabrício Mezzomo Collares, Vicente Castelo Branco Leitune, Antonio Shigueaki Takimi, Rodrigo Alex Arthur, Susana Maria Werner SamuelAbstract:ObjectivesWhite spot lesions are still a concern for Orthodontic patients. The objective of this study was to assess the remineralizing and antibacterial effect of a newly developed Orthodontic Adhesive.MethodsThe compounds 1,3,5-tryacryloylhexahydro-1,3,5-triazine (TAT) and phosphate invert glass containing 10 mol% of niobium pentoxide (PIG-Nb) were added at 20 and 5 wt%, respectively, to an experimental Adhesive (75 wt% BisGMA, 25 wt% TEGDMA, 5 wt% fummed silica, and photo-initiator system), called TPN. A group without the addition of these compounds was used as Control and the Orthodontic Adhesive Transbond XT (TXT) was used for comparison. Antibacterial activity was evaluated through surface biofilm formation, mineral deposition, and degree of conversion (DC) through Raman microscopy, Knoop hardness after softening in solvent, and bracket dislodgement (BD).ResultsTPN group presented a reduction in bacterial growth when compared to Control and TXT. Mineral deposits were observed on the surface of TPN Adhesive after 14 and 28 days of immersion in artificial saliva. There was an increase in DC after 28 days, whereas TPN group presented the highest DC. All groups underwent some degree of softening. No significant changes were observed in BD after 28 days of immersion in artificial saliva.ConclusionThe newly developed Orthodontic Adhesive, with addition of 20 wt% TAT and 5w% PIG-Nb, exhibited antibacterial activity and was capable to induce mineral deposition on its surface in vitro.Clinical significanceThe Orthodontic Adhesive developed in this study with antibacterial activity and mineral deposition could be a reliable choice for brackets adhesion.
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Orthodontic bracket bonding without previous Adhesive priming a meta regression analysis
Angle Orthodontist, 2016Co-Authors: Aline Segatto Pires Altmann, Susana Maria Werner Samuel, Vicente Castelo Branco Leitune, Felipe Weidenbach Degrazia, Roger Keller Celeste, Fabrício Mezzomo CollaresAbstract:ABSTRACT Objective: To determine the consensus among studies that Adhesive resin application improves the bond strength of Orthodontic brackets and the association of methodological variables on the influence of bond strength outcome. Materials and Methods: In vitro studies were selected to answer whether Adhesive resin application increases the immediate shear bond strength of metal Orthodontic brackets bonded with a photo-cured Orthodontic Adhesive. Studies included were those comparing a group having Adhesive resin to a group without Adhesive resin with the primary outcome measurement shear bond strength in MPa. A systematic electronic search was performed in PubMed and Scopus databases. Results: Nine studies were included in the analysis. Based on the pooled data and due to a high heterogeneity among studies (I2 = 93.3), a meta-regression analysis was conducted. The analysis demonstrated that five experimental conditions explained 86.1% of heterogeneity and four of them had significantly affected...
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Effect of methacrylated-based antibacterial monomer on Orthodontic Adhesive system properties
American Journal of Orthodontics and Dentofacial Orthopedics, 2015Co-Authors: Aline Segatto Pires Altmann, Fabrício Mezzomo Collares, Fabrício Aulo Ogliari, Susana Maria Werner SamuelAbstract:Introduction Antibacterial Adhesives were developed to reduce the incidence of white spot lesions in Orthodontic patients. Compounds that contain triazine are known as effective antibacterial agents. The aims of this study were to develop an experimental Orthodontic Adhesive containing 1,3,5-triacryloylhexahydro-1,3,5-triazine (TAT) and to characterize it. Methods TAT was added in 3 concentrations (10%, 15%, and 20%) to the experimental Orthodontic Adhesive. Antibacterial activity was assayed by brain-heart infusion broth dilution against Streptococcus mutans. The degree of conversion was measured using Fourier transform infrared spectroscopy, and solvent degradation was evaluated by Knoop microhardness before and after immersion in ethanol for 2 hours. The shear bond strength of metal brackets bonded to bovine enamel surface was assessed. Results All experimental Adhesives reduced bacterial growth. The addition of 15% and 20% TAT increased the degree of conversion compared with the control group (0%) and the 10% group. All groups showed a decrease in hardness after ethanol immersion, and there was also a decrease in the percentage of variation of Knoop hardness in the experimental Adhesives containing TAT, whereas the shear bond strength increased. Conclusions Orthodontic Adhesives containing TAT are promising antibacterial materials, especially those with 15% and 20% TAT.