The Experts below are selected from a list of 1284 Experts worldwide ranked by ideXlab platform
Solmaz Abdolrahimzadeh - One of the best experts on this subject based on the ideXlab platform.
-
Deep topical anesthesia with ropivacaine-soaked sponge for phacoemulsification
International Ophthalmology, 2019Co-Authors: Gianluca Scuderi, Luca Scuderi, Silvia Calafiore, Vito Fenicia, Solmaz AbdolrahimzadehAbstract:Purpose To assess safety and efficacy of deep topical anesthesia with ropivacaine-soaked sponge compared with topical anesthesia with Oxybuprocaine in patients undergoing phacoemulsification. Methods This was a retrospective study where records of patients operated for cataract were evaluated. Patients using a visual analogue scale scored pain during surgery, and the surgeon on a questionnaire recorded ease of operation. Medical records were evaluated for patients who received topical anesthesia with multiple administrations of Oxybuprocaine 0.4% or those who received deep topical anesthesia with a polyvinyl acetal sponge impregnated with ropivacaine 0.75% and positioned under the eyelid 30 min before surgery. Results A total of one hundred patient records, equally divided in patients receiving deep topical anesthesia or topical anesthesia, were included. The visual analogue scale scores among the groups were statistically significant for a lower pain score in patients who received deep topical anesthesia with ropivacaine-soaked sponges ( p = 0.0069). The average surgeon score was significantly higher for the deep topical anesthesia group indicating favorable ease of surgery ( p = 0.0341). Six patients had major complications during surgery. No additional anesthesia was necessary to manage the complications in four patients in the deep anesthesia group, whereas propofol was used for the induction and maintenance of anesthesia in two patients in the topical anesthesia group. Conclusions Deep topical anesthesia with ropivacaine-soaked sponges performed as well as topical Oxybuprocaine regarding safety and efficacy. It provided a lower patient pain score, favorable surgeon satisfaction, and long-lasting anesthesia.
-
Deep topical anesthesia with ropivacaine-soaked sponge for phacoemulsification.
International ophthalmology, 2019Co-Authors: Gianluca Scuderi, Luca Scuderi, Silvia Calafiore, Vito Fenicia, Solmaz AbdolrahimzadehAbstract:To assess safety and efficacy of deep topical anesthesia with ropivacaine-soaked sponge compared with topical anesthesia with Oxybuprocaine in patients undergoing phacoemulsification. This was a retrospective study where records of patients operated for cataract were evaluated. Patients using a visual analogue scale scored pain during surgery, and the surgeon on a questionnaire recorded ease of operation. Medical records were evaluated for patients who received topical anesthesia with multiple administrations of Oxybuprocaine 0.4% or those who received deep topical anesthesia with a polyvinyl acetal sponge impregnated with ropivacaine 0.75% and positioned under the eyelid 30 min before surgery. A total of one hundred patient records, equally divided in patients receiving deep topical anesthesia or topical anesthesia, were included. The visual analogue scale scores among the groups were statistically significant for a lower pain score in patients who received deep topical anesthesia with ropivacaine-soaked sponges (p = 0.0069). The average surgeon score was significantly higher for the deep topical anesthesia group indicating favorable ease of surgery (p = 0.0341). Six patients had major complications during surgery. No additional anesthesia was necessary to manage the complications in four patients in the deep anesthesia group, whereas propofol was used for the induction and maintenance of anesthesia in two patients in the topical anesthesia group. Deep topical anesthesia with ropivacaine-soaked sponges performed as well as topical Oxybuprocaine regarding safety and efficacy. It provided a lower patient pain score, favorable surgeon satisfaction, and long-lasting anesthesia.
Ching Hsia Hung - One of the best experts on this subject based on the ideXlab platform.
-
serotonin enhances Oxybuprocaine and proxymetacaine induced cutaneous analgesia in rats
European Journal of Pharmacology, 2019Co-Authors: Ankuo Chou, Jhijoung Wang, Yu Wen Chen, Chong Chi Chiu, Ching Hsia HungAbstract:The aim of the study was to investigate the analgesic effects of adding serotonin to Oxybuprocaine or proxymetacaine preparations. We employed a rat model of the cutaneous trunci muscle reflex (CTMR) to conduct the dose-response curves and duration of drugs (Oxybuprocaine, proxymetacaine, or serotonin) as an infiltrative anesthetic. The use of isobolographic methods to analyze the drug-drug interactions. We showed that Oxybuprocaine and proxymetacaine, as well as serotonin produced dose-dependent skin antinociception. On the basis of 50% effective dose (ED50), the rank order of drug potency was serotonin [7.22 (6.45-8.09) μmol/kg] < Oxybuprocaine [1.03 (0.93-1.15) μmol/kg] < proxymetacaine [0.59 (0.53-0.66) μmol/kg] (P < 0.01 for each comparison). The sensory block duration of serotonin was longer (P < 0.01) than that of Oxybuprocaine or proxymetacaine at the equipotent doses (ED25, ED50, and ED75). The mixture of serotonin with Oxybuprocaine or proxymetacaine produced a better analgesic effect than the drug itself. We have concluded that Oxybuprocaine, proxymetacaine, or serotonin displays dose-related cutaneous analgesia. Oxybuprocaine or proxymetacaine is more potent and has a shorter duration of cutaneous analgesia than serotonin. Serotonin produces a synergistic antinociceptive interaction with Oxybuprocaine or proxymetacaine.
-
Serotonin enhances Oxybuprocaine- and proxymetacaine-induced cutaneous analgesia in rats.
European journal of pharmacology, 2019Co-Authors: Ankuo Chou, Jhijoung Wang, Yu Wen Chen, Chong Chi Chiu, Ching Hsia HungAbstract:The aim of the study was to investigate the analgesic effects of adding serotonin to Oxybuprocaine or proxymetacaine preparations. We employed a rat model of the cutaneous trunci muscle reflex (CTMR) to conduct the dose-response curves and duration of drugs (Oxybuprocaine, proxymetacaine, or serotonin) as an infiltrative anesthetic. The use of isobolographic methods to analyze the drug-drug interactions. We showed that Oxybuprocaine and proxymetacaine, as well as serotonin produced dose-dependent skin antinociception. On the basis of 50% effective dose (ED50), the rank order of drug potency was serotonin [7.22 (6.45-8.09) μmol/kg]
-
Adding Dopamine to Proxymetacaine or Oxybuprocaine Solutions Potentiates and Prolongs the Cutaneous Antinociception in Rats.
Anesthesia and analgesia, 2018Co-Authors: Yu Wen Chen, Jhijoung Wang, Chong Chi Chiu, Heng Teng Lin, Ching Hsia HungAbstract:BACKGROUND:We evaluated the interaction of dopamine–proxymetacaine and dopamine– Oxybuprocaine antinociception using isobolograms.METHODS:This experiment uses subcutaneous drug (proxymetacaine, Oxybuprocaine, and dopamine) injections under the skin of the rat’s back, thus simulating infiltration blo
-
The Addition of Epinephrine to Proxymetacaine or Oxybuprocaine Solution Increases the Depth and Duration of Cutaneous Analgesia in Rats
Regional anesthesia and pain medicine, 2016Co-Authors: Yu Wen Chen, Jhijoung Wang, Chong Chi Chiu, Chung-dann Kan, Ching Hsia HungAbstract:Background The aim of this experiment was to investigate the interaction between epinephrine and 2 local anesthetics (proxymetacaine or Oxybuprocaine) using subcutaneous injections under the hairy skin, thereby simulating infiltration blocks. Methods Using a rat model of cutaneous trunci muscle reflex in response to local skin pinpricks, the anesthetic properties of proxymetacaine and Oxybuprocaine alone and in combination with epinephrine as an infiltrative anesthetic were tested. Isobolographic analysis was used for the analgesic interactions between adjuvant epinephrine and the local anesthetics. Lidocaine was used as a control group. Results Oxybuprocaine, proxymetacaine, and lidocaine elicited a dose-dependent block to pinpricks. On the 50% effective dose (ED50) basis, their relative potencies were proxymetacaine [0.126 (0.113–0.141) μmol] greater than Oxybuprocaine [0.208 (0.192–0.226) μmol] greater than lidocaine [6.331 (5.662–7.079) μmol] (P Conclusions We concluded that proxymetacaine and Oxybuprocaine were more potent and produced greater duration of nociceptive block than lidocaine. The use of epinephrine augmented the potency and prolonged the duration of proxymetacaine, Oxybuprocaine, and lidocaine as an infiltrative anesthetic.
-
clonidine as adjuvant for Oxybuprocaine bupivacaine or dextrorphan has a significant peripheral action in intensifying and prolonging analgesia in response to local dorsal cutaneous noxious pinprick in rats
Neuroscience Letters, 2011Co-Authors: Yu Wen Chen, Meng I Hsueh, Ching Hsia Hung, Yu-chung Chen, Jhijoung WangAbstract:The aim of the study was to evaluate co-administration of clonidine with Oxybuprocaine (ester type), bupivacaine (amide type) or dextrorphan (non-ester or non-amide type) and to see whether it could have a peripheral action in enhancing local anesthesia on infiltrative cutaneous analgesia in rats. Cutaneous analgesia was evaluated by a block of the cutaneous trunci muscle reflex (CTMR) in response to local dorsal cutaneous noxious pinprick in rats. The analgesic effect of the addition of clonidine with Oxybuprocaine, bupivacaine or dextrorphan by subcutaneous injection was evaluated. On an ED50 basis, the rank of drug potency was Oxybuprocaine > bupivacaine > dextrorphan (P < 0.01). Mixtures of clonidine (0.12 μmol) with Oxybuprocaine, bupivacaine or dextrorphan (ED50 or ED95) extended the duration of action and increased the potency on infiltrative cutaneous analgesia. Among these drugs, the addition of clonidine to bupivacaine (amide type) elicits the most effective cutaneous analgesia. Clonidine at the dose of 0.12 and 0.24 μmol did not produce cutaneous analgesia. Oxybuprocaine showed more potent cutaneous analgesia than bupivacaine or dextrorphan in rats. Co-administration of Oxybuprocaine, bupivacaine or dextrorphan with clonidine increased the potency and duration on infiltrative cutaneous analgesia. The addition of clonidine to bupivacaine (amide type) elicits more effective cutaneous analgesia than Oxybuprocaine (ester type) or dextrorphan (non-ester or non-amide type).
J A A Govan - One of the best experts on this subject based on the ideXlab platform.
-
Topical anaesthesia with Oxybuprocaine versus sub-Tenon's infiltration with 2% lignocaine for small incision cataract surgery
The British journal of ophthalmology, 1997Co-Authors: H B Chittenden, W R Meacock, J A A GovanAbstract:AIMS To determine whether topical anaesthesia in small incision self-sealing phacoemulsification cataract surgery provides comparable anaesthesia to sub-Tenon’s infiltration. METHODS Thirty five patients undergoing small incision self-sealing phacoemulsification cataract surgery were allocated randomly to receive topical anaesthesia with 0.4% Oxybuprocaine or sub-Tenon’s infiltration with 2% lignocaine. Pain experienced during the operation was assessed by asking the patient to score on a visual analogue graphic pain score chart. RESULTS The median pain score for the topical group (3) was significantly higher than that of the sub-Tenon’s group (0) (p = 0.004). CONCLUSION Sub-Tenon’s infiltration is superior to topical anaesthesia in ensuring patient comfort during small incision scleral tunnel self-sealing phacoemulsification cataract surgery.
Gianluca Scuderi - One of the best experts on this subject based on the ideXlab platform.
-
Deep topical anesthesia with ropivacaine-soaked sponge for phacoemulsification
International Ophthalmology, 2019Co-Authors: Gianluca Scuderi, Luca Scuderi, Silvia Calafiore, Vito Fenicia, Solmaz AbdolrahimzadehAbstract:Purpose To assess safety and efficacy of deep topical anesthesia with ropivacaine-soaked sponge compared with topical anesthesia with Oxybuprocaine in patients undergoing phacoemulsification. Methods This was a retrospective study where records of patients operated for cataract were evaluated. Patients using a visual analogue scale scored pain during surgery, and the surgeon on a questionnaire recorded ease of operation. Medical records were evaluated for patients who received topical anesthesia with multiple administrations of Oxybuprocaine 0.4% or those who received deep topical anesthesia with a polyvinyl acetal sponge impregnated with ropivacaine 0.75% and positioned under the eyelid 30 min before surgery. Results A total of one hundred patient records, equally divided in patients receiving deep topical anesthesia or topical anesthesia, were included. The visual analogue scale scores among the groups were statistically significant for a lower pain score in patients who received deep topical anesthesia with ropivacaine-soaked sponges ( p = 0.0069). The average surgeon score was significantly higher for the deep topical anesthesia group indicating favorable ease of surgery ( p = 0.0341). Six patients had major complications during surgery. No additional anesthesia was necessary to manage the complications in four patients in the deep anesthesia group, whereas propofol was used for the induction and maintenance of anesthesia in two patients in the topical anesthesia group. Conclusions Deep topical anesthesia with ropivacaine-soaked sponges performed as well as topical Oxybuprocaine regarding safety and efficacy. It provided a lower patient pain score, favorable surgeon satisfaction, and long-lasting anesthesia.
-
Deep topical anesthesia with ropivacaine-soaked sponge for phacoemulsification.
International ophthalmology, 2019Co-Authors: Gianluca Scuderi, Luca Scuderi, Silvia Calafiore, Vito Fenicia, Solmaz AbdolrahimzadehAbstract:To assess safety and efficacy of deep topical anesthesia with ropivacaine-soaked sponge compared with topical anesthesia with Oxybuprocaine in patients undergoing phacoemulsification. This was a retrospective study where records of patients operated for cataract were evaluated. Patients using a visual analogue scale scored pain during surgery, and the surgeon on a questionnaire recorded ease of operation. Medical records were evaluated for patients who received topical anesthesia with multiple administrations of Oxybuprocaine 0.4% or those who received deep topical anesthesia with a polyvinyl acetal sponge impregnated with ropivacaine 0.75% and positioned under the eyelid 30 min before surgery. A total of one hundred patient records, equally divided in patients receiving deep topical anesthesia or topical anesthesia, were included. The visual analogue scale scores among the groups were statistically significant for a lower pain score in patients who received deep topical anesthesia with ropivacaine-soaked sponges (p = 0.0069). The average surgeon score was significantly higher for the deep topical anesthesia group indicating favorable ease of surgery (p = 0.0341). Six patients had major complications during surgery. No additional anesthesia was necessary to manage the complications in four patients in the deep anesthesia group, whereas propofol was used for the induction and maintenance of anesthesia in two patients in the topical anesthesia group. Deep topical anesthesia with ropivacaine-soaked sponges performed as well as topical Oxybuprocaine regarding safety and efficacy. It provided a lower patient pain score, favorable surgeon satisfaction, and long-lasting anesthesia.
Juan A Sanchisgimeno - One of the best experts on this subject based on the ideXlab platform.
-
the effect of a combination of 0 1 tetracaine hcl and 0 4 Oxybuprocaine hcl on human central corneal thickness measurements
European journal of anatomy, 2004Co-Authors: I Asensio, L. Alonso, M.s. Rahhal, Jose M Palancasanfrancisco, M Granellgil, Francisco Martinezsoriano, Juan A SanchisgimenoAbstract:SUMMARY A combination of 0.1% tetracaine HCl and 0.4% Oxybuprocaine HCl is used when carrying out morphometrical corneal studies in vivo by means of ultrasound pachymetry. The aim of this was to determine the effect of a combination of 0.1% tetracaine HCl and 0.4% Oxybuprocaine HCl anesthetic eye drops on central corneal thickness values. We carried out a prospective study involving 30 eyes of 30 healthy subjects. The mean age of the subjects was 26.13±2.62 years (age ranged from 20 to 30 years old). Central pachymetry was carried out prior to and three minutes after the instillation of two saline solution eye drops, and three minutes after the administration of a combination of 0.1% tetracaine HCl and 0.4% Oxybuprocaine HCl anesthetic eye drops. The mean of three consecutive measurements of the central corneal thickness obtained with the Orbscan Topography System II (Orbscan, Inc., Salt Lake City, UT. USA) was used as the corneal thickness value. No significant differences were found (p=0.714) in the mean central corneal thickness values before and three minutes after saline solution eye drops had been instilled. Nevertheless, after anesthesia there was a significant increase in mean central corneal thickness (p<0.001). Increases ranged from 22 to 131 micrometers, with a mean of approximately 47 micrometers. Following the instillation of a combination of 0.1% tetracaine HCl and 0.4% Oxybuprocaine HCl eye drops corneal thickness increase. Researchers must be aware of this effect of topical anesthetic eye drops on corneal morphometry in order to analyze corneal thickness results correctly.
-
corneal thickness values before and after Oxybuprocaine 0 4 eye drops
Cornea, 2003Co-Authors: I Asensio, L. Alonso, Jose M Palancasanfrancisco, Saleh M Rahhal, Juan A SanchisgimenoAbstract:PURPOSE: To determine changes in corneal thickness after topical anesthesia. METHODS: Corneal thickness was measured before and 3 minutes after administration of two drops of Oxybuprocaine 0.4% to 26 patients (26 eyes). We analyzed the corneal thickness of a control group, which was made up of 26 patients (26 eyes) before and 3 minutes after administration of two drops of saline solution. Corneal thickness was measured with the Orbscan Topography System II (Bausch Lomb Surg., Barcelona). RESULTS: Variations higher than +/- 10 microm were found following the instillation of 2 Oxybuprocaine eye drops in eight eyes (30.76%) at the inferonasal cornea, in six eyes (23.08%) at the superotemporal, temporal and inferotemporal cornea, in five eyes (19.23%) at the nasal cornea, in three eyes (11.53%) at the central cornea, and in two eyes (7.69%) at the superonasal cornea. Nevertheless, no significant differences in the mean corneal thickness at each corneal location between the first and the second corneal thickness measurements were found in anesthetized eyes. CONCLUSIONS: Some individuals can present important increases and decreases in corneal thickness values after anesthetic eye drops. This effect of anesthetic eye drops must be considered by refractive surgeons when carrying out preoperative laser in situ keratomileusis corneal thickness measurements.
