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Ching Hsia Hung - One of the best experts on this subject based on the ideXlab platform.
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serotonin enhances oxybuprocaine and Proxymetacaine induced cutaneous analgesia in rats
European Journal of Pharmacology, 2019Co-Authors: Ankuo Chou, Jhijoung Wang, Yu Wen Chen, Chong Chi Chiu, Ching Hsia HungAbstract:The aim of the study was to investigate the analgesic effects of adding serotonin to oxybuprocaine or Proxymetacaine preparations. We employed a rat model of the cutaneous trunci muscle reflex (CTMR) to conduct the dose-response curves and duration of drugs (oxybuprocaine, Proxymetacaine, or serotonin) as an infiltrative anesthetic. The use of isobolographic methods to analyze the drug-drug interactions. We showed that oxybuprocaine and Proxymetacaine, as well as serotonin produced dose-dependent skin antinociception. On the basis of 50% effective dose (ED50), the rank order of drug potency was serotonin [7.22 (6.45-8.09) μmol/kg] < oxybuprocaine [1.03 (0.93-1.15) μmol/kg] < Proxymetacaine [0.59 (0.53-0.66) μmol/kg] (P < 0.01 for each comparison). The sensory block duration of serotonin was longer (P < 0.01) than that of oxybuprocaine or Proxymetacaine at the equipotent doses (ED25, ED50, and ED75). The mixture of serotonin with oxybuprocaine or Proxymetacaine produced a better analgesic effect than the drug itself. We have concluded that oxybuprocaine, Proxymetacaine, or serotonin displays dose-related cutaneous analgesia. Oxybuprocaine or Proxymetacaine is more potent and has a shorter duration of cutaneous analgesia than serotonin. Serotonin produces a synergistic antinociceptive interaction with oxybuprocaine or Proxymetacaine.
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Serotonin enhances oxybuprocaine- and Proxymetacaine-induced cutaneous analgesia in rats.
European journal of pharmacology, 2019Co-Authors: Ankuo Chou, Jhijoung Wang, Yu Wen Chen, Chong Chi Chiu, Ching Hsia HungAbstract:The aim of the study was to investigate the analgesic effects of adding serotonin to oxybuprocaine or Proxymetacaine preparations. We employed a rat model of the cutaneous trunci muscle reflex (CTMR) to conduct the dose-response curves and duration of drugs (oxybuprocaine, Proxymetacaine, or serotonin) as an infiltrative anesthetic. The use of isobolographic methods to analyze the drug-drug interactions. We showed that oxybuprocaine and Proxymetacaine, as well as serotonin produced dose-dependent skin antinociception. On the basis of 50% effective dose (ED50), the rank order of drug potency was serotonin [7.22 (6.45-8.09) μmol/kg]
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Adding Dopamine to Proxymetacaine or Oxybuprocaine Solutions Potentiates and Prolongs the Cutaneous Antinociception in Rats.
Anesthesia and analgesia, 2018Co-Authors: Yu Wen Chen, Jhijoung Wang, Chong Chi Chiu, Heng Teng Lin, Ching Hsia HungAbstract:BACKGROUND:We evaluated the interaction of dopamine–Proxymetacaine and dopamine– oxybuprocaine antinociception using isobolograms.METHODS:This experiment uses subcutaneous drug (Proxymetacaine, oxybuprocaine, and dopamine) injections under the skin of the rat’s back, thus simulating infiltration blo
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The Addition of Epinephrine to Proxymetacaine or Oxybuprocaine Solution Increases the Depth and Duration of Cutaneous Analgesia in Rats
Regional anesthesia and pain medicine, 2016Co-Authors: Yu Wen Chen, Jhijoung Wang, Chong Chi Chiu, Chung-dann Kan, Ching Hsia HungAbstract:Background The aim of this experiment was to investigate the interaction between epinephrine and 2 local anesthetics (Proxymetacaine or oxybuprocaine) using subcutaneous injections under the hairy skin, thereby simulating infiltration blocks. Methods Using a rat model of cutaneous trunci muscle reflex in response to local skin pinpricks, the anesthetic properties of Proxymetacaine and oxybuprocaine alone and in combination with epinephrine as an infiltrative anesthetic were tested. Isobolographic analysis was used for the analgesic interactions between adjuvant epinephrine and the local anesthetics. Lidocaine was used as a control group. Results Oxybuprocaine, Proxymetacaine, and lidocaine elicited a dose-dependent block to pinpricks. On the 50% effective dose (ED50) basis, their relative potencies were Proxymetacaine [0.126 (0.113–0.141) μmol] greater than oxybuprocaine [0.208 (0.192–0.226) μmol] greater than lidocaine [6.331 (5.662–7.079) μmol] (P Conclusions We concluded that Proxymetacaine and oxybuprocaine were more potent and produced greater duration of nociceptive block than lidocaine. The use of epinephrine augmented the potency and prolonged the duration of Proxymetacaine, oxybuprocaine, and lidocaine as an infiltrative anesthetic.
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The Systemic Toxicity of Equipotent Proxymetacaine, Oxybuprocaine, and Bupivacaine During Continuous Intravenous Infusion in Rats
Anesthesia and analgesia, 2009Co-Authors: Ching Hsia Hung, Yu-chung Chen, Kuo Sheng Liu, Dong Zi Shao, Kuang I. Cheng, Yu Wen ChenAbstract:BACKGROUND: Although Proxymetacaine and oxybuprocaine produce topical ocular and spinal anesthesia, they have never been tested as cutaneous anesthetics. We compared cutaneous analgesia of Proxymetacaine and oxybuprocaine with bupivacaine and tested their central nervous system and cardiovascular toxicity. METHODS: After blockade of cutaneous trunci muscle reflex with subcutaneous injections, we evaluated the local anesthetic effect of Proxymetacaine and oxybuprocaine on cutaneous analgesia in rats. After IV infusions of equipotent doses of oxybuprocaine, Proxymetacaine, and bupivacaine, we observed the onset time of seizure, apnea, and impending death and monitored mean arterial blood pressure
Yu Wen Chen - One of the best experts on this subject based on the ideXlab platform.
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serotonin enhances oxybuprocaine and Proxymetacaine induced cutaneous analgesia in rats
European Journal of Pharmacology, 2019Co-Authors: Ankuo Chou, Jhijoung Wang, Yu Wen Chen, Chong Chi Chiu, Ching Hsia HungAbstract:The aim of the study was to investigate the analgesic effects of adding serotonin to oxybuprocaine or Proxymetacaine preparations. We employed a rat model of the cutaneous trunci muscle reflex (CTMR) to conduct the dose-response curves and duration of drugs (oxybuprocaine, Proxymetacaine, or serotonin) as an infiltrative anesthetic. The use of isobolographic methods to analyze the drug-drug interactions. We showed that oxybuprocaine and Proxymetacaine, as well as serotonin produced dose-dependent skin antinociception. On the basis of 50% effective dose (ED50), the rank order of drug potency was serotonin [7.22 (6.45-8.09) μmol/kg] < oxybuprocaine [1.03 (0.93-1.15) μmol/kg] < Proxymetacaine [0.59 (0.53-0.66) μmol/kg] (P < 0.01 for each comparison). The sensory block duration of serotonin was longer (P < 0.01) than that of oxybuprocaine or Proxymetacaine at the equipotent doses (ED25, ED50, and ED75). The mixture of serotonin with oxybuprocaine or Proxymetacaine produced a better analgesic effect than the drug itself. We have concluded that oxybuprocaine, Proxymetacaine, or serotonin displays dose-related cutaneous analgesia. Oxybuprocaine or Proxymetacaine is more potent and has a shorter duration of cutaneous analgesia than serotonin. Serotonin produces a synergistic antinociceptive interaction with oxybuprocaine or Proxymetacaine.
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Serotonin enhances oxybuprocaine- and Proxymetacaine-induced cutaneous analgesia in rats.
European journal of pharmacology, 2019Co-Authors: Ankuo Chou, Jhijoung Wang, Yu Wen Chen, Chong Chi Chiu, Ching Hsia HungAbstract:The aim of the study was to investigate the analgesic effects of adding serotonin to oxybuprocaine or Proxymetacaine preparations. We employed a rat model of the cutaneous trunci muscle reflex (CTMR) to conduct the dose-response curves and duration of drugs (oxybuprocaine, Proxymetacaine, or serotonin) as an infiltrative anesthetic. The use of isobolographic methods to analyze the drug-drug interactions. We showed that oxybuprocaine and Proxymetacaine, as well as serotonin produced dose-dependent skin antinociception. On the basis of 50% effective dose (ED50), the rank order of drug potency was serotonin [7.22 (6.45-8.09) μmol/kg]
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Adding Dopamine to Proxymetacaine or Oxybuprocaine Solutions Potentiates and Prolongs the Cutaneous Antinociception in Rats.
Anesthesia and analgesia, 2018Co-Authors: Yu Wen Chen, Jhijoung Wang, Chong Chi Chiu, Heng Teng Lin, Ching Hsia HungAbstract:BACKGROUND:We evaluated the interaction of dopamine–Proxymetacaine and dopamine– oxybuprocaine antinociception using isobolograms.METHODS:This experiment uses subcutaneous drug (Proxymetacaine, oxybuprocaine, and dopamine) injections under the skin of the rat’s back, thus simulating infiltration blo
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The Addition of Epinephrine to Proxymetacaine or Oxybuprocaine Solution Increases the Depth and Duration of Cutaneous Analgesia in Rats
Regional anesthesia and pain medicine, 2016Co-Authors: Yu Wen Chen, Jhijoung Wang, Chong Chi Chiu, Chung-dann Kan, Ching Hsia HungAbstract:Background The aim of this experiment was to investigate the interaction between epinephrine and 2 local anesthetics (Proxymetacaine or oxybuprocaine) using subcutaneous injections under the hairy skin, thereby simulating infiltration blocks. Methods Using a rat model of cutaneous trunci muscle reflex in response to local skin pinpricks, the anesthetic properties of Proxymetacaine and oxybuprocaine alone and in combination with epinephrine as an infiltrative anesthetic were tested. Isobolographic analysis was used for the analgesic interactions between adjuvant epinephrine and the local anesthetics. Lidocaine was used as a control group. Results Oxybuprocaine, Proxymetacaine, and lidocaine elicited a dose-dependent block to pinpricks. On the 50% effective dose (ED50) basis, their relative potencies were Proxymetacaine [0.126 (0.113–0.141) μmol] greater than oxybuprocaine [0.208 (0.192–0.226) μmol] greater than lidocaine [6.331 (5.662–7.079) μmol] (P Conclusions We concluded that Proxymetacaine and oxybuprocaine were more potent and produced greater duration of nociceptive block than lidocaine. The use of epinephrine augmented the potency and prolonged the duration of Proxymetacaine, oxybuprocaine, and lidocaine as an infiltrative anesthetic.
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The Systemic Toxicity of Equipotent Proxymetacaine, Oxybuprocaine, and Bupivacaine During Continuous Intravenous Infusion in Rats
Anesthesia and analgesia, 2009Co-Authors: Ching Hsia Hung, Yu-chung Chen, Kuo Sheng Liu, Dong Zi Shao, Kuang I. Cheng, Yu Wen ChenAbstract:BACKGROUND: Although Proxymetacaine and oxybuprocaine produce topical ocular and spinal anesthesia, they have never been tested as cutaneous anesthetics. We compared cutaneous analgesia of Proxymetacaine and oxybuprocaine with bupivacaine and tested their central nervous system and cardiovascular toxicity. METHODS: After blockade of cutaneous trunci muscle reflex with subcutaneous injections, we evaluated the local anesthetic effect of Proxymetacaine and oxybuprocaine on cutaneous analgesia in rats. After IV infusions of equipotent doses of oxybuprocaine, Proxymetacaine, and bupivacaine, we observed the onset time of seizure, apnea, and impending death and monitored mean arterial blood pressure
C Carr - One of the best experts on this subject based on the ideXlab platform.
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Randomised controlled trial of sub-Tenon’s block versus topical anaesthesia for cataract surgery: a comparison of patient satisfaction
The British journal of ophthalmology, 2005Co-Authors: Heinrich Rüschen, D Celaschi, Catey Bunce, C CarrAbstract:Background/aim: Sub-Tenon’s block (STB) or topical anaesthesia alone (TOP) are popular techniques employed during cataract surgery. TOP is often preferred by healthcare providers because of financial or staffing reasons, despite existing evidence that pain during surgery is better controlled with STB. Pain is not the only consideration that determines patient preference for the anaesthesia technique. The authors decided to investigate the issue of patient satisfaction using the recently developed Iowa Satisfaction with Anesthesia Scale (ISAS). Method: In a randomised controlled pilot trial, 28 patients were enrolled to receive either STB with 3 ml of 2% lidocaine and hyaluronidase, or TOP with Proxymetacaine 0.5% and amethocaine 1% (Tetracaine) eye drops. Postoperatively patients rated their satisfaction with anaesthesia care by filling in the self administered written questionnaire, the ISAS. Results: One patient in the TOP group dropped out of the study because of intolerable pain. Analysis of the questionnaire results with a two sample Wilcoxon rank sum test showed a significant difference in patient satisfaction (p Conclusion: In the setting of day case cataract surgery, patients report significantly higher satisfaction scores with STB than with TOP alone.
Carr C - One of the best experts on this subject based on the ideXlab platform.
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Randomised controlled trial of sub-Tenon’s block versus topical anaesthesia for cataract surgery: a comparison of patient satisfaction
Copyright 2005 British Journal of Ophthalmology, 2005Co-Authors: Rüschen H, Celaschi D, Bunce C, Carr CAbstract:Background/aim: Sub-Tenon’s block (STB) or topical anaesthesia alone (TOP) are popular techniques employed during cataract surgery. TOP is often preferred by healthcare providers because of financial or staffing reasons, despite existing evidence that pain during surgery is better controlled with STB. Pain is not the only consideration that determines patient preference for the anaesthesia technique. The authors decided to investigate the issue of patient satisfaction using the recently developed Iowa Satisfaction with Anesthesia Scale (ISAS). Method: In a randomised controlled pilot trial, 28 patients were enrolled to receive either STB with 3 ml of 2% lidocaine and hyaluronidase, or TOP with Proxymetacaine 0.5% and amethocaine 1% (Tetracaine) eye drops. Postoperatively patients rated their satisfaction with anaesthesia care by filling in the self administered written questionnaire, the ISAS. Results: One patient in the TOP group dropped out of the study because of intolerable pain. Analysis of the questionnaire results with a two sample Wilcoxon rank sum test showed a significant difference in patient satisfaction (p
Jhijoung Wang - One of the best experts on this subject based on the ideXlab platform.
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serotonin enhances oxybuprocaine and Proxymetacaine induced cutaneous analgesia in rats
European Journal of Pharmacology, 2019Co-Authors: Ankuo Chou, Jhijoung Wang, Yu Wen Chen, Chong Chi Chiu, Ching Hsia HungAbstract:The aim of the study was to investigate the analgesic effects of adding serotonin to oxybuprocaine or Proxymetacaine preparations. We employed a rat model of the cutaneous trunci muscle reflex (CTMR) to conduct the dose-response curves and duration of drugs (oxybuprocaine, Proxymetacaine, or serotonin) as an infiltrative anesthetic. The use of isobolographic methods to analyze the drug-drug interactions. We showed that oxybuprocaine and Proxymetacaine, as well as serotonin produced dose-dependent skin antinociception. On the basis of 50% effective dose (ED50), the rank order of drug potency was serotonin [7.22 (6.45-8.09) μmol/kg] < oxybuprocaine [1.03 (0.93-1.15) μmol/kg] < Proxymetacaine [0.59 (0.53-0.66) μmol/kg] (P < 0.01 for each comparison). The sensory block duration of serotonin was longer (P < 0.01) than that of oxybuprocaine or Proxymetacaine at the equipotent doses (ED25, ED50, and ED75). The mixture of serotonin with oxybuprocaine or Proxymetacaine produced a better analgesic effect than the drug itself. We have concluded that oxybuprocaine, Proxymetacaine, or serotonin displays dose-related cutaneous analgesia. Oxybuprocaine or Proxymetacaine is more potent and has a shorter duration of cutaneous analgesia than serotonin. Serotonin produces a synergistic antinociceptive interaction with oxybuprocaine or Proxymetacaine.
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Serotonin enhances oxybuprocaine- and Proxymetacaine-induced cutaneous analgesia in rats.
European journal of pharmacology, 2019Co-Authors: Ankuo Chou, Jhijoung Wang, Yu Wen Chen, Chong Chi Chiu, Ching Hsia HungAbstract:The aim of the study was to investigate the analgesic effects of adding serotonin to oxybuprocaine or Proxymetacaine preparations. We employed a rat model of the cutaneous trunci muscle reflex (CTMR) to conduct the dose-response curves and duration of drugs (oxybuprocaine, Proxymetacaine, or serotonin) as an infiltrative anesthetic. The use of isobolographic methods to analyze the drug-drug interactions. We showed that oxybuprocaine and Proxymetacaine, as well as serotonin produced dose-dependent skin antinociception. On the basis of 50% effective dose (ED50), the rank order of drug potency was serotonin [7.22 (6.45-8.09) μmol/kg]
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Adding Dopamine to Proxymetacaine or Oxybuprocaine Solutions Potentiates and Prolongs the Cutaneous Antinociception in Rats.
Anesthesia and analgesia, 2018Co-Authors: Yu Wen Chen, Jhijoung Wang, Chong Chi Chiu, Heng Teng Lin, Ching Hsia HungAbstract:BACKGROUND:We evaluated the interaction of dopamine–Proxymetacaine and dopamine– oxybuprocaine antinociception using isobolograms.METHODS:This experiment uses subcutaneous drug (Proxymetacaine, oxybuprocaine, and dopamine) injections under the skin of the rat’s back, thus simulating infiltration blo
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The Addition of Epinephrine to Proxymetacaine or Oxybuprocaine Solution Increases the Depth and Duration of Cutaneous Analgesia in Rats
Regional anesthesia and pain medicine, 2016Co-Authors: Yu Wen Chen, Jhijoung Wang, Chong Chi Chiu, Chung-dann Kan, Ching Hsia HungAbstract:Background The aim of this experiment was to investigate the interaction between epinephrine and 2 local anesthetics (Proxymetacaine or oxybuprocaine) using subcutaneous injections under the hairy skin, thereby simulating infiltration blocks. Methods Using a rat model of cutaneous trunci muscle reflex in response to local skin pinpricks, the anesthetic properties of Proxymetacaine and oxybuprocaine alone and in combination with epinephrine as an infiltrative anesthetic were tested. Isobolographic analysis was used for the analgesic interactions between adjuvant epinephrine and the local anesthetics. Lidocaine was used as a control group. Results Oxybuprocaine, Proxymetacaine, and lidocaine elicited a dose-dependent block to pinpricks. On the 50% effective dose (ED50) basis, their relative potencies were Proxymetacaine [0.126 (0.113–0.141) μmol] greater than oxybuprocaine [0.208 (0.192–0.226) μmol] greater than lidocaine [6.331 (5.662–7.079) μmol] (P Conclusions We concluded that Proxymetacaine and oxybuprocaine were more potent and produced greater duration of nociceptive block than lidocaine. The use of epinephrine augmented the potency and prolonged the duration of Proxymetacaine, oxybuprocaine, and lidocaine as an infiltrative anesthetic.
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Intrathecal oxybuprocaine and Proxymetacaine produced potent and long-lasting spinal anesthesia in rats.
Neuroscience letters, 2009Co-Authors: Ching Hsia Hung, Jhijoung Wang, Yu-chung Chen, Chin-chen Chu, Yu Wen ChenAbstract:Proxymetacaine and oxybuprocaine were clinically used for topical ocular anesthesia but never for spinal anesthesia, and therefore spinal anesthetic effects of Proxymetacaine and oxybuprocaine were performed and compared with bupivacaine and lidocaine. After rats were injected intrathecally with Proxymetacaine, oxybuprocaine, bupivacaine, and lidocane, dose-response curves were constructed. We evaluated the potencies (ED50) and durations (time to full recovery) of Proxymetacaine and oxybup- rocaine on spinal blockades of motor function, proprioception, and nociception and compared with bupivacaine and lidocaine in rats. We found that Proxymetacaine and oxybuprocaine acted like bupi- vacaine or lidocaine and produced dose-related spinal blockades of motor function, proprioception and nociception. On the ED50 basis, the ranks of potencies in motor, proprioception, and nociception were Proxymetacaine > oxybuprocaine > bupivacaine > lidocaine (P < 0.01 for the differences). On an equipo- tent basis (ED20 ,E D 50 ,E D 80), oxybuprocaine and bupivacaine produced similarly longer spinal blockades than did Proxymetacaine or lidocaine (P < 0.05 for the differences). Intrathecal Proxymetacaine, oxy- buprocaine, and bupivacaine also produced longer sensory blockade than motor blockade. These data demonstrated that oxybuprocaine and Proxymetacaine produced more potent spinal blockades, when compared with bupivacaine or lidocaine. Oxybuprocaine and bupivacaine with a more sensory-selective action over motor blockade produced longer spinal blockade than did Proxymetacaine or lidocaine. © 2009 Elsevier Ireland Ltd. All rights reserved.
