The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform
Ioannis Vogiatzis - One of the best experts on this subject based on the ideXlab platform.
-
determinants of exercise induced Oxygen Desaturation including pulmonary emphysema in copd results from the eclipse study
Respiratory Medicine, 2016Co-Authors: Vasileios Andrianopoulos, Peter M A Calverley, Victor Pintoplata, Bartolome R Celli, Frits M E Franssen, Ioannis Vogiatzis, Lowie E G W Vanfleteren, Jorgen Vestbo, Alvar Agusti, Per BakkeAbstract:Exercise-induced Oxygen Desaturation (EID) is related to mortality in patients with chronic obstructive pulmonary disease (COPD). We investigated: (1) the prevalence of EID; (2) the relative-weight of several physiological determinants of EID including pulmonary emphysema, and (3) the relationship of EID with certain patients' clinical characteristics. Data from 2050 COPD patients (age: 63.3 ± 7.1years; FEV1: 48.7 ± 15.7%pred.) were analyzed. The occurrence of EID (SpO2post ≤88%) at the six-minute walking test (6MWT) was investigated in association with emphysema quantified by computed-tomography (QCT), and several clinical characteristics. 435 patients (21%) exhibited EID. Subjects with EID had more QCT-emphysema, lower exercise capacity and worse health-status (BODE, ADO indexes) compared to non-EID. Determinant of EID were obesity (BMI≥30 kg/m2), impaired FEV1 (≤44%pred.), moderate or worse emphysema, and low SpO2 at rest (≤93%). Linear regression indicated that each 1-point increase on the ADO-score independently elevates odds ratio (≤1.5fold) for EID. About one in five COPD patients in the ECLIPSE cohort present EID. Advanced emphysema is associated with EID. In addition, obesity, severe airflow limitation, and low resting Oxygen saturation increase the risk for EID. Patients with EID in GOLD stage II have higher odds to have moderate or worse emphysema compared those with EID in GOLD stage III-IV. Emphysematous patients with high ADO-score should be monitored for EID.
-
exercise induced Oxygen Desaturation determinants including pulmonary emphysema in copd eclipse data
European Respiratory Journal, 2016Co-Authors: Vasileios Andrianopoulos, Peter M A Calverley, Victor Pintoplata, Bartolome R Celli, Frits M E Franssen, Ioannis Vogiatzis, Lowie E G W Vanfleteren, Jorgen Vestbo, Alvar Agusti, Per BakkeAbstract:Background: Exercise-induced Oxygen Desaturation (EID) is common in patients with Chronic Obstructive Pulmonary Disease (COPD). We investigated: (1) the prevalence of EID; (2) the relative-weight of several physiological determinants of EID including pulmonary emphysema, and (3) the relationship of EID with certain patients9 clinical characteristics. Methods: 2050 COPD subjects (age: 63.3 ±7.1years; FEV 1 : 48.7 ±15.7%pred.) were recruited. EID (SpO 2 ≤88%) in the six-minute walk test (6MWT), emphysema quantified by computed-tomography (QCT), and clinical characteristics were analysed. Results: 435 subjects (21%) exhibited EID. Subjects with EID had more QCT-emphysema, lower walking distance (6MWD) and worse health-status (BODE, ADO index) compared to non-EID. EID was progressively increased across emphysema-degrees in GOLD II (≤9fold) but this increase was lower in GOLD III-IV. Determinant of EID were obesity (BMI≥30kg/m 2 ), FEV 1 (≤44%pred), moderate or worse emphysema, and low baseline-SpO 2 (≤93%). Each point increase on the ADO-score independently elevated odds ratio (≤1.5fold) for EID. Conclusions: About one in five COPD subjects in the ECLIPSE cohort presents EID. Emphysema severity is more related to EID in GOLD II compared to GOLD III-IV. Moreover, obesity, airflow obstruction, and low baseline Oxygen saturation increase the odds for EID. Emphysematous patients with high ADO-score should be monitored for EID.
-
exercise induced Oxygen Desaturation in copd patients without resting hypoxemia
Respiratory Physiology & Neurobiology, 2014Co-Authors: Vasileios Andrianopoulos, Frits M E Franssen, Jos P I Peeters, Tim Ubachs, Halah Bukari, Miriam T J Groenen, Chris Burtin, Ioannis VogiatzisAbstract:Exercise-induced Oxygen Desaturation (EID) is associated with increased risk of mortality in chronic obstructive pulmonary disease (COPD). Several screening tests have been proposed to predict EID, including FEV1, DLCO and baseline-SpO2. We aimed to validate a proposed cut-off of baseline-SpO2 ≤95% as simple screening procedure to predict EID during six-minute walk test (6MWT). In addition, we studied the prevalence and characteristics of patients exhibited EID to SpO2nadir ≤88%. 402 non-hypoxemic COPD patients performed 6MWT. Sensitivity and specificity of baseline SpO2 ≤95% as a cut-off to predict EID and determinants of EID were investigated. 158 patients (39%) exhibited EID. The sensitivity of baseline-SpO2 ≤95% to predict EID was 81.0%, specificity 49.2%, positive and negative predictive values were 50.8% and 80.0%, respectively. In a multivariate model, DLCO <50%, FEV1 <45%, PaO2 <10kPa, baseline-SpO2 <95%, and female sex were the strongest determinants of EID. Baseline Oxygen saturation solely is inaccurate to predict EID. A combination of clinical characteristics (DLCO, FEV1, PaO2, baseline-SpO2, sex) increases the odds for EID in COPD.
David J Plevak - One of the best experts on this subject based on the ideXlab platform.
-
identification of patients at risk for postoperative respiratory complications using a preoperative obstructive sleep apnea screening tool and postanesthesia care assessment
Anesthesiology, 2009Co-Authors: Bhargavi Gali, Francis X Whalen, Darrell R Schroeder, David J PlevakAbstract:Background: Patients with obstructive sleep apnea are at risk for perioperative morbidity. The authors used a screening prediction model for obstructive sleep apnea to generate a sleep apnea clinical score (SACS) that identified patients at high or low risk for obstructive sleep apnea. This was combined with postanesthesia care unit (PACU) monitoring with the aim of identifying patients at high risk of postoperative Oxygen Desaturation and respiratory complications. Methods: In this prospective cohort study, surgical patients with a hospital stay longer than 48 h who consented were enrolled. The SACS (high or low risk) was calculated; all patients were monitored in the PACU for recurrent episodes of bradypnea, apnea, Desaturations, and pain‐sedation mismatch. All patients underwent pulse oximetry postoperatively; complications were documented. Chi-square, two-sample t test, and logistic regression were used for analysis. The Oxygen Desaturation index (number of Desaturations per hour) was calculated. Oxygen Desaturation index and incidence of postoperative cardiorespiratory complications were primary endpoints. Results: Six hundred ninety-three patients were enrolled. From multivariable logistic regression analysis, the likelihood of a postoperative Oxygen Desaturation index greater than 10 was increased with a high SACS (odds ratio 1.9, P < 0.001) and recurrent PACU events (odds ratio 1.5, P 0.036). Postoperative respiratory events were also associated with a high SACS (odds ratio 3.5, P < 0.001) and recurrent PACU events (odds ratio 21.0, P < 0.001). Conclusions: Combination of an obstructive sleep apnea screening tool preoperatively (SACS) and recurrent PACU respiratory events was associated with a higher Oxygen Desaturation index and postoperative respiratory complications. A two-phase process to identify patients at higher risk for perioperative respiratory Desaturations and complications may be useful to stratify and manage surgical patients postoperatively. PATIENTS with obstructive sleep apnea (OSA) are at risk for perioperative morbidity, and many patients who present for surgical procedures may have undiagnosed OSA. 1–5 In 1993, approximately 4% of men and 2% of
-
identification of patients at risk for postoperative respiratory complications using a preoperative obstructive sleep apnea screening tool and postanesthesia care assessment
Anesthesiology, 2009Co-Authors: Bhargavi Gali, Francis X Whalen, Darrell R Schroeder, David J PlevakAbstract:Background: Patients with obstructive sleep apnea are at risk for perioperative morbidity. The authors used a screening prediction model for obstructive sleep apnea to generate a sleep apnea clinical score (SACS) that identified patients at high or low risk for obstructive sleep apnea. This was combined with postanesthesia care unit (PACU) monitoring with the aim of identifying patients at high risk of postoperative Oxygen Desaturation and respiratory complications. Methods: In this prospective cohort study, surgical patients with a hospital stay longer than 48 h who consented were enrolled. The SACS (high or low risk) was calculated; all patients were monitored in the PACU for recurrent episodes of bradypnea, apnea, Desaturations, and pain‐sedation mismatch. All patients underwent pulse oximetry postoperatively; complications were documented. Chi-square, two-sample t test, and logistic regression were used for analysis. The Oxygen Desaturation index (number of Desaturations per hour) was calculated. Oxygen Desaturation index and incidence of postoperative cardiorespiratory complications were primary endpoints. Results: Six hundred ninety-three patients were enrolled. From multivariable logistic regression analysis, the likelihood of a postoperative Oxygen Desaturation index greater than 10 was increased with a high SACS (odds ratio 1.9, P < 0.001) and recurrent PACU events (odds ratio 1.5, P 0.036). Postoperative respiratory events were also associated with a high SACS (odds ratio 3.5, P < 0.001) and recurrent PACU events (odds ratio 21.0, P < 0.001). Conclusions: Combination of an obstructive sleep apnea screening tool preoperatively (SACS) and recurrent PACU respiratory events was associated with a higher Oxygen Desaturation index and postoperative respiratory complications. A two-phase process to identify patients at higher risk for perioperative respiratory Desaturations and complications may be useful to stratify and manage surgical patients postoperatively. PATIENTS with obstructive sleep apnea (OSA) are at risk for perioperative morbidity, and many patients who present for surgical procedures may have undiagnosed OSA. 1–5 In 1993, approximately 4% of men and 2% of
Per Bakke - One of the best experts on this subject based on the ideXlab platform.
-
determinants of exercise induced Oxygen Desaturation including pulmonary emphysema in copd results from the eclipse study
Respiratory Medicine, 2016Co-Authors: Vasileios Andrianopoulos, Peter M A Calverley, Victor Pintoplata, Bartolome R Celli, Frits M E Franssen, Ioannis Vogiatzis, Lowie E G W Vanfleteren, Jorgen Vestbo, Alvar Agusti, Per BakkeAbstract:Exercise-induced Oxygen Desaturation (EID) is related to mortality in patients with chronic obstructive pulmonary disease (COPD). We investigated: (1) the prevalence of EID; (2) the relative-weight of several physiological determinants of EID including pulmonary emphysema, and (3) the relationship of EID with certain patients' clinical characteristics. Data from 2050 COPD patients (age: 63.3 ± 7.1years; FEV1: 48.7 ± 15.7%pred.) were analyzed. The occurrence of EID (SpO2post ≤88%) at the six-minute walking test (6MWT) was investigated in association with emphysema quantified by computed-tomography (QCT), and several clinical characteristics. 435 patients (21%) exhibited EID. Subjects with EID had more QCT-emphysema, lower exercise capacity and worse health-status (BODE, ADO indexes) compared to non-EID. Determinant of EID were obesity (BMI≥30 kg/m2), impaired FEV1 (≤44%pred.), moderate or worse emphysema, and low SpO2 at rest (≤93%). Linear regression indicated that each 1-point increase on the ADO-score independently elevates odds ratio (≤1.5fold) for EID. About one in five COPD patients in the ECLIPSE cohort present EID. Advanced emphysema is associated with EID. In addition, obesity, severe airflow limitation, and low resting Oxygen saturation increase the risk for EID. Patients with EID in GOLD stage II have higher odds to have moderate or worse emphysema compared those with EID in GOLD stage III-IV. Emphysematous patients with high ADO-score should be monitored for EID.
-
exercise induced Oxygen Desaturation determinants including pulmonary emphysema in copd eclipse data
European Respiratory Journal, 2016Co-Authors: Vasileios Andrianopoulos, Peter M A Calverley, Victor Pintoplata, Bartolome R Celli, Frits M E Franssen, Ioannis Vogiatzis, Lowie E G W Vanfleteren, Jorgen Vestbo, Alvar Agusti, Per BakkeAbstract:Background: Exercise-induced Oxygen Desaturation (EID) is common in patients with Chronic Obstructive Pulmonary Disease (COPD). We investigated: (1) the prevalence of EID; (2) the relative-weight of several physiological determinants of EID including pulmonary emphysema, and (3) the relationship of EID with certain patients9 clinical characteristics. Methods: 2050 COPD subjects (age: 63.3 ±7.1years; FEV 1 : 48.7 ±15.7%pred.) were recruited. EID (SpO 2 ≤88%) in the six-minute walk test (6MWT), emphysema quantified by computed-tomography (QCT), and clinical characteristics were analysed. Results: 435 subjects (21%) exhibited EID. Subjects with EID had more QCT-emphysema, lower walking distance (6MWD) and worse health-status (BODE, ADO index) compared to non-EID. EID was progressively increased across emphysema-degrees in GOLD II (≤9fold) but this increase was lower in GOLD III-IV. Determinant of EID were obesity (BMI≥30kg/m 2 ), FEV 1 (≤44%pred), moderate or worse emphysema, and low baseline-SpO 2 (≤93%). Each point increase on the ADO-score independently elevated odds ratio (≤1.5fold) for EID. Conclusions: About one in five COPD subjects in the ECLIPSE cohort presents EID. Emphysema severity is more related to EID in GOLD II compared to GOLD III-IV. Moreover, obesity, airflow obstruction, and low baseline Oxygen saturation increase the odds for EID. Emphysematous patients with high ADO-score should be monitored for EID.
-
Oxygen Desaturation in 6 min walk test is a risk factor for adverse outcomes in copd
European Respiratory Journal, 2016Co-Authors: Marie Waatevik, Ane Johannessen, Francisco Gomez Real, Marianne Aanerud, Jon A Hardie, Per Bakke, Tomas Mikal EaganAbstract:The 6-min walk test (6MWT) is an exercise test that measures functional status in chronic obstructive pulmonary disease (COPD) patients and provides information on Oxygen Desaturation. We investigated Oxygen Desaturation during 6MWT as a risk factor for important COPD outcomes: mortality, frequency of exacerbations, decline in lung function and decline in lean body mass. 433 COPD patients were included in the Bergen COPD Cohort Study 2006–2009, and followed-up for 3 years. Patients were characterised using spirometry, bioelectrical impedance measurements, Charlson comorbidity score, exacerbation history, smoking and arterial blood gases. 370 patients completed the 6MWT at the baseline of the study. Information on all-cause mortality was collected in 2011. Patients who experienced Oxygen Desaturation during the 6MWT had an approximately twofold increased risk of death (hazard ratio 2.4, 95% CI 1.2–5.1), a 50% increased risk for experiencing later COPD exacerbations (incidence rate ratio 1.6, 95% CI 1.1–2.2), double the yearly rate of decline in both forced vital capacity and forced expiratory volume in 1 s (3.2% and 1.7% versus 1.7% and 0.9%, respectively) and manifold increased yearly rate of loss of lean body mass (0.18 kg·m −2 versus 0.03 kg·m −2 among those who did not desaturate). Desaturating COPD patients had a significantly worse prognosis than non-desaturating COPD patients, for multiple important disease outcomes.
Peter M A Calverley - One of the best experts on this subject based on the ideXlab platform.
-
determinants of exercise induced Oxygen Desaturation including pulmonary emphysema in copd results from the eclipse study
Respiratory Medicine, 2016Co-Authors: Vasileios Andrianopoulos, Peter M A Calverley, Victor Pintoplata, Bartolome R Celli, Frits M E Franssen, Ioannis Vogiatzis, Lowie E G W Vanfleteren, Jorgen Vestbo, Alvar Agusti, Per BakkeAbstract:Exercise-induced Oxygen Desaturation (EID) is related to mortality in patients with chronic obstructive pulmonary disease (COPD). We investigated: (1) the prevalence of EID; (2) the relative-weight of several physiological determinants of EID including pulmonary emphysema, and (3) the relationship of EID with certain patients' clinical characteristics. Data from 2050 COPD patients (age: 63.3 ± 7.1years; FEV1: 48.7 ± 15.7%pred.) were analyzed. The occurrence of EID (SpO2post ≤88%) at the six-minute walking test (6MWT) was investigated in association with emphysema quantified by computed-tomography (QCT), and several clinical characteristics. 435 patients (21%) exhibited EID. Subjects with EID had more QCT-emphysema, lower exercise capacity and worse health-status (BODE, ADO indexes) compared to non-EID. Determinant of EID were obesity (BMI≥30 kg/m2), impaired FEV1 (≤44%pred.), moderate or worse emphysema, and low SpO2 at rest (≤93%). Linear regression indicated that each 1-point increase on the ADO-score independently elevates odds ratio (≤1.5fold) for EID. About one in five COPD patients in the ECLIPSE cohort present EID. Advanced emphysema is associated with EID. In addition, obesity, severe airflow limitation, and low resting Oxygen saturation increase the risk for EID. Patients with EID in GOLD stage II have higher odds to have moderate or worse emphysema compared those with EID in GOLD stage III-IV. Emphysematous patients with high ADO-score should be monitored for EID.
-
exercise induced Oxygen Desaturation determinants including pulmonary emphysema in copd eclipse data
European Respiratory Journal, 2016Co-Authors: Vasileios Andrianopoulos, Peter M A Calverley, Victor Pintoplata, Bartolome R Celli, Frits M E Franssen, Ioannis Vogiatzis, Lowie E G W Vanfleteren, Jorgen Vestbo, Alvar Agusti, Per BakkeAbstract:Background: Exercise-induced Oxygen Desaturation (EID) is common in patients with Chronic Obstructive Pulmonary Disease (COPD). We investigated: (1) the prevalence of EID; (2) the relative-weight of several physiological determinants of EID including pulmonary emphysema, and (3) the relationship of EID with certain patients9 clinical characteristics. Methods: 2050 COPD subjects (age: 63.3 ±7.1years; FEV 1 : 48.7 ±15.7%pred.) were recruited. EID (SpO 2 ≤88%) in the six-minute walk test (6MWT), emphysema quantified by computed-tomography (QCT), and clinical characteristics were analysed. Results: 435 subjects (21%) exhibited EID. Subjects with EID had more QCT-emphysema, lower walking distance (6MWD) and worse health-status (BODE, ADO index) compared to non-EID. EID was progressively increased across emphysema-degrees in GOLD II (≤9fold) but this increase was lower in GOLD III-IV. Determinant of EID were obesity (BMI≥30kg/m 2 ), FEV 1 (≤44%pred), moderate or worse emphysema, and low baseline-SpO 2 (≤93%). Each point increase on the ADO-score independently elevated odds ratio (≤1.5fold) for EID. Conclusions: About one in five COPD subjects in the ECLIPSE cohort presents EID. Emphysema severity is more related to EID in GOLD II compared to GOLD III-IV. Moreover, obesity, airflow obstruction, and low baseline Oxygen saturation increase the odds for EID. Emphysematous patients with high ADO-score should be monitored for EID.
-
Oxygen Desaturation and breathlessness during corridor walking in chronic obstructive pulmonary disease: effect of oxitropium bromide.
Thorax, 1993Co-Authors: D. P. S. Spence, J. Carter, J. G. Hay, Michael Pearson, Peter M A CalverleyAbstract:BACKGROUND--Although exercise induced Desaturation can occur in patients with chronic obstructive pulmonary disease (COPD), little is known about its frequency during everyday exercise, or how it relates to dyspnoea or prior drug treatment. METHODS--The effects of 200 micrograms inhaled oxitropium bromide, an anticholinergic bronchodilator drug, on spirometric values, dyspnoea score, and Oxygen saturation during corridor walking and cycle ergometry were studied in a double blind, randomised, placebo controlled study. RESULTS--Oxitropium produced a small increase in forced expired volume in one second (FEV1) from 0.76 (0.28) 1 to 0.93 (0.69) 1 and in six minute walking distance from 311 (93) m to 332 (86) m, but did not change progressive cycle exercise duration. Resting and end exercise breathlessness levels were reduced in both forms of exercise after oxitropium. Resting Oxygen saturation fell significantly after active bronchodilator from 92.9% (3.7%) to 92.0% (4.1%) but the nadir saturation during exercise was unchanged. The patients desaturated more during corridor walking than cycle ergometry [walking 7.8% (4.4%), cycle ergometry 2.1% (2.1%)]. Baseline walking distance was related to FVC, resting breathlessness and resting Oxygen saturation (multiple r2 = 0.46) but only resting saturation correlated with end exercise breathlessness (r2 = -0.25). Improvements in symptoms or exercise performance after oxitropium could not be predicted by changes in spirometric indices or Oxygen saturation. CONCLUSIONS--In patients with COPD arterial Oxygen Desaturation during self-paced walking is common, of greater severity than that during cycle ergometry, but is unaffected by inhaled oxitropium bromide. The factors that predict initial performance are not appropriate markers of functional improvement after an active bronchodilator drug.
Vasileios Andrianopoulos - One of the best experts on this subject based on the ideXlab platform.
-
determinants of exercise induced Oxygen Desaturation including pulmonary emphysema in copd results from the eclipse study
Respiratory Medicine, 2016Co-Authors: Vasileios Andrianopoulos, Peter M A Calverley, Victor Pintoplata, Bartolome R Celli, Frits M E Franssen, Ioannis Vogiatzis, Lowie E G W Vanfleteren, Jorgen Vestbo, Alvar Agusti, Per BakkeAbstract:Exercise-induced Oxygen Desaturation (EID) is related to mortality in patients with chronic obstructive pulmonary disease (COPD). We investigated: (1) the prevalence of EID; (2) the relative-weight of several physiological determinants of EID including pulmonary emphysema, and (3) the relationship of EID with certain patients' clinical characteristics. Data from 2050 COPD patients (age: 63.3 ± 7.1years; FEV1: 48.7 ± 15.7%pred.) were analyzed. The occurrence of EID (SpO2post ≤88%) at the six-minute walking test (6MWT) was investigated in association with emphysema quantified by computed-tomography (QCT), and several clinical characteristics. 435 patients (21%) exhibited EID. Subjects with EID had more QCT-emphysema, lower exercise capacity and worse health-status (BODE, ADO indexes) compared to non-EID. Determinant of EID were obesity (BMI≥30 kg/m2), impaired FEV1 (≤44%pred.), moderate or worse emphysema, and low SpO2 at rest (≤93%). Linear regression indicated that each 1-point increase on the ADO-score independently elevates odds ratio (≤1.5fold) for EID. About one in five COPD patients in the ECLIPSE cohort present EID. Advanced emphysema is associated with EID. In addition, obesity, severe airflow limitation, and low resting Oxygen saturation increase the risk for EID. Patients with EID in GOLD stage II have higher odds to have moderate or worse emphysema compared those with EID in GOLD stage III-IV. Emphysematous patients with high ADO-score should be monitored for EID.
-
exercise induced Oxygen Desaturation determinants including pulmonary emphysema in copd eclipse data
European Respiratory Journal, 2016Co-Authors: Vasileios Andrianopoulos, Peter M A Calverley, Victor Pintoplata, Bartolome R Celli, Frits M E Franssen, Ioannis Vogiatzis, Lowie E G W Vanfleteren, Jorgen Vestbo, Alvar Agusti, Per BakkeAbstract:Background: Exercise-induced Oxygen Desaturation (EID) is common in patients with Chronic Obstructive Pulmonary Disease (COPD). We investigated: (1) the prevalence of EID; (2) the relative-weight of several physiological determinants of EID including pulmonary emphysema, and (3) the relationship of EID with certain patients9 clinical characteristics. Methods: 2050 COPD subjects (age: 63.3 ±7.1years; FEV 1 : 48.7 ±15.7%pred.) were recruited. EID (SpO 2 ≤88%) in the six-minute walk test (6MWT), emphysema quantified by computed-tomography (QCT), and clinical characteristics were analysed. Results: 435 subjects (21%) exhibited EID. Subjects with EID had more QCT-emphysema, lower walking distance (6MWD) and worse health-status (BODE, ADO index) compared to non-EID. EID was progressively increased across emphysema-degrees in GOLD II (≤9fold) but this increase was lower in GOLD III-IV. Determinant of EID were obesity (BMI≥30kg/m 2 ), FEV 1 (≤44%pred), moderate or worse emphysema, and low baseline-SpO 2 (≤93%). Each point increase on the ADO-score independently elevated odds ratio (≤1.5fold) for EID. Conclusions: About one in five COPD subjects in the ECLIPSE cohort presents EID. Emphysema severity is more related to EID in GOLD II compared to GOLD III-IV. Moreover, obesity, airflow obstruction, and low baseline Oxygen saturation increase the odds for EID. Emphysematous patients with high ADO-score should be monitored for EID.
-
exercise induced Oxygen Desaturation in copd patients without resting hypoxemia
Respiratory Physiology & Neurobiology, 2014Co-Authors: Vasileios Andrianopoulos, Frits M E Franssen, Jos P I Peeters, Tim Ubachs, Halah Bukari, Miriam T J Groenen, Chris Burtin, Ioannis VogiatzisAbstract:Exercise-induced Oxygen Desaturation (EID) is associated with increased risk of mortality in chronic obstructive pulmonary disease (COPD). Several screening tests have been proposed to predict EID, including FEV1, DLCO and baseline-SpO2. We aimed to validate a proposed cut-off of baseline-SpO2 ≤95% as simple screening procedure to predict EID during six-minute walk test (6MWT). In addition, we studied the prevalence and characteristics of patients exhibited EID to SpO2nadir ≤88%. 402 non-hypoxemic COPD patients performed 6MWT. Sensitivity and specificity of baseline SpO2 ≤95% as a cut-off to predict EID and determinants of EID were investigated. 158 patients (39%) exhibited EID. The sensitivity of baseline-SpO2 ≤95% to predict EID was 81.0%, specificity 49.2%, positive and negative predictive values were 50.8% and 80.0%, respectively. In a multivariate model, DLCO <50%, FEV1 <45%, PaO2 <10kPa, baseline-SpO2 <95%, and female sex were the strongest determinants of EID. Baseline Oxygen saturation solely is inaccurate to predict EID. A combination of clinical characteristics (DLCO, FEV1, PaO2, baseline-SpO2, sex) increases the odds for EID in COPD.
