The Experts below are selected from a list of 1611 Experts worldwide ranked by ideXlab platform
Read P Montague - One of the best experts on this subject based on the ideXlab platform.
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Asymmetry in Functional Connectivity of the Human Habenula Revealed by High-Resolution Cardiac-Gated Resting State Imaging
2020Co-Authors: S Ebastien, H Etu, Yi Luo, Ignacio Saez, Kimberlee D&apos, Terry Lohrenz, Read P MontagueAbstract:Abstract: The habenula is a hub for cognitive and emotional signals that are relayed to the aminergic centers in the midbrain and, thus, plays an important role in goal-oriented behaviors. Although it is well described in rodents and non-human primates, the habenula functional network remains relatively uncharacterized in humans, partly because of the methodological challenges associated with the functional magnetic resonance imaging of small structures in the brain. Using high-resolution cardiacgated resting state imaging in healthy humans and precisely identifying each participants' habenula, we show that the habenula is functionally coupled with the insula, Parahippocampus, thalamus, periaqueductal grey, pons, striatum and substantia nigra/ventral tegmental area complex. Furthermore, by separately examining and comparing the functional maps from the left and right habenula, we provide the first evidence of an asymmetry in the functional connectivity of the habenula in humans. Hum Brain Mapp 00:000-000, 2016
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asymmetry in functional connectivity of the human habenula revealed by high resolution cardiac gated resting state imaging
Human Brain Mapping, 2016Co-Authors: Sebastien Hetu, Yi Luo, Ignacio Saez, Terry Lohrenz, Read P Montague, Kimberlee DardenneAbstract:The habenula is a hub for cognitive and emotional signals that are relayed to the aminergic centers in the midbrain and, thus, plays an important role in goal-oriented behaviors. Although it is well described in rodents and non-human primates, the habenula functional network remains relatively uncharacterized in humans, partly because of the methodological challenges associated with the functional magnetic resonance imaging of small structures in the brain. Using high-resolution cardiac-gated resting state imaging in healthy humans and precisely identifying each participants' habenula, we show that the habenula is functionally coupled with the insula, Parahippocampus, thalamus, periaqueductal grey, pons, striatum and substantia nigra/ventral tegmental area complex. Furthermore, by separately examining and comparing the functional maps from the left and right habenula, we provide the first evidence of an asymmetry in the functional connectivity of the habenula in humans. Hum Brain Mapp 37:2602-2615, 2016. © 2016 The Authors Human Brain Mapping Published by Wiley Periodicals, Inc.
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distinct contributions of the amygdala and parahippocampal gyrus to suspicion in a repeated bargaining game
Proceedings of the National Academy of Sciences of the United States of America, 2012Co-Authors: Meghana Bhatt, Terry Lohrenz, Colin F Camerer, Read P MontagueAbstract:Humans assess the credibility of information gained from others on a daily basis; this ongoing assessment is especially crucial for avoiding exploitation by others. We used a repeated, two-person bargaining game and a cognitive hierarchy model to test how subjects judge the information sent asymmetrically from one player to the other. The weight that they give to this information is the result of two distinct factors: their baseline suspicion given the situation and the suspicion generated by the other person’s behavior. We hypothesized that human brains maintain an ongoing estimate of the credibility of the other player and sought to uncover neural correlates of this process. In the game, sellers were forced to infer the value of an object based on signals sent from a prospective buyer. We found that amygdala activity correlated with baseline suspicion, whereas activations in bilateral Parahippocampus correlated with trial-by-trial uncertainty induced by the buyer’s sequence of suggestions. In addition, the less credible buyers that appeared, the more sensitive parahippocampal activation was to trial-by-trial uncertainty. Although both of these neural structures have previously been implicated in trustworthiness judgments, these results suggest that they have distinct and separable roles that correspond to their theorized roles in learning and memory.
Terry Lohrenz - One of the best experts on this subject based on the ideXlab platform.
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Asymmetry in Functional Connectivity of the Human Habenula Revealed by High-Resolution Cardiac-Gated Resting State Imaging
2020Co-Authors: S Ebastien, H Etu, Yi Luo, Ignacio Saez, Kimberlee D&apos, Terry Lohrenz, Read P MontagueAbstract:Abstract: The habenula is a hub for cognitive and emotional signals that are relayed to the aminergic centers in the midbrain and, thus, plays an important role in goal-oriented behaviors. Although it is well described in rodents and non-human primates, the habenula functional network remains relatively uncharacterized in humans, partly because of the methodological challenges associated with the functional magnetic resonance imaging of small structures in the brain. Using high-resolution cardiacgated resting state imaging in healthy humans and precisely identifying each participants' habenula, we show that the habenula is functionally coupled with the insula, Parahippocampus, thalamus, periaqueductal grey, pons, striatum and substantia nigra/ventral tegmental area complex. Furthermore, by separately examining and comparing the functional maps from the left and right habenula, we provide the first evidence of an asymmetry in the functional connectivity of the habenula in humans. Hum Brain Mapp 00:000-000, 2016
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asymmetry in functional connectivity of the human habenula revealed by high resolution cardiac gated resting state imaging
Human Brain Mapping, 2016Co-Authors: Sebastien Hetu, Yi Luo, Ignacio Saez, Terry Lohrenz, Read P Montague, Kimberlee DardenneAbstract:The habenula is a hub for cognitive and emotional signals that are relayed to the aminergic centers in the midbrain and, thus, plays an important role in goal-oriented behaviors. Although it is well described in rodents and non-human primates, the habenula functional network remains relatively uncharacterized in humans, partly because of the methodological challenges associated with the functional magnetic resonance imaging of small structures in the brain. Using high-resolution cardiac-gated resting state imaging in healthy humans and precisely identifying each participants' habenula, we show that the habenula is functionally coupled with the insula, Parahippocampus, thalamus, periaqueductal grey, pons, striatum and substantia nigra/ventral tegmental area complex. Furthermore, by separately examining and comparing the functional maps from the left and right habenula, we provide the first evidence of an asymmetry in the functional connectivity of the habenula in humans. Hum Brain Mapp 37:2602-2615, 2016. © 2016 The Authors Human Brain Mapping Published by Wiley Periodicals, Inc.
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distinct contributions of the amygdala and parahippocampal gyrus to suspicion in a repeated bargaining game
Proceedings of the National Academy of Sciences of the United States of America, 2012Co-Authors: Meghana Bhatt, Terry Lohrenz, Colin F Camerer, Read P MontagueAbstract:Humans assess the credibility of information gained from others on a daily basis; this ongoing assessment is especially crucial for avoiding exploitation by others. We used a repeated, two-person bargaining game and a cognitive hierarchy model to test how subjects judge the information sent asymmetrically from one player to the other. The weight that they give to this information is the result of two distinct factors: their baseline suspicion given the situation and the suspicion generated by the other person’s behavior. We hypothesized that human brains maintain an ongoing estimate of the credibility of the other player and sought to uncover neural correlates of this process. In the game, sellers were forced to infer the value of an object based on signals sent from a prospective buyer. We found that amygdala activity correlated with baseline suspicion, whereas activations in bilateral Parahippocampus correlated with trial-by-trial uncertainty induced by the buyer’s sequence of suggestions. In addition, the less credible buyers that appeared, the more sensitive parahippocampal activation was to trial-by-trial uncertainty. Although both of these neural structures have previously been implicated in trustworthiness judgments, these results suggest that they have distinct and separable roles that correspond to their theorized roles in learning and memory.
Jijun Wang - One of the best experts on this subject based on the ideXlab platform.
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reduced functional connectivity between bilateral precuneus and contralateral Parahippocampus in schizotypal personality disorder
BMC Psychiatry, 2017Co-Authors: Yunxiang Tang, Yongguang He, Chunbo Li, Zheng Lu, Yingying Tang, Hui Li, Tianhong Zhang, Jijun WangAbstract:Abstract Background Schizotypal personality disorder (SPD) is linked to schizophrenia in terms of shared genetics, biological markers and phenomenological characteristics. In the current study, we aimed to determine whether the previously reported altered functional connectivity (FC) with precuneus in patients with schizophrenia could be extended to individuals with SPD. Methods Twenty subjects with SPD and 19 healthy controls were recruited from 4461 freshmen at a university in Shanghai and received a resting-state scan of MRI. All participants were evaluated by the Chinese version of Schizotypal Personality Questionnaire (SPQ) and the Chinese version of Symptom Checklist (SCL-90). The imaging data were analysed using the seed-based functional connectivity method. Results Compared with the controls, SPD subjects exhibited reduced FC between bilateral precuneus and contralateral Parahippocampus. In SPD group, SPQ total score was negatively correlated with FC between right precuneus and left Parahippocampus ( r = −0.603, p = 0.006); there was a negative trend between SPQ subscale score of suspiciousness and FC between left precuneus and right Parahippocampus ( r = −0.553, p = 0.014); and a positive trend was found between SPQ subscale score of odd or eccentric behaviour and FC between left precuneus and right superior temporal gyrus ( r = 0.543, p = 0.016). As for the SCL-90 score, a similar negative trend was found between SCL-90 subscale score of suspiciousness and FC between right precuneus and left Parahippocampus ( r = −0.535, p = 0.018) in SPD group. Conclusions Our findings suggest that the decreased functional connectivity between precuneus and contralateral Parahippocampus might play a key role in the pathophysiology of schizophrenia spectrum disorder.
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reduced functional connectivity between bilateral precuneus and contralateral Parahippocampus in schizotypal personality disorder
BMC Psychiatry, 2017Co-Authors: Yunxiang Tang, Yingying Tang, Tianhong Zhang, Yikang Zhu, Xingguang Luo, Jijun WangAbstract:Schizotypal personality disorder (SPD) is linked to schizophrenia in terms of shared genetics, biological markers and phenomenological characteristics. In the current study, we aimed to determine whether the previously reported altered functional connectivity (FC) with precuneus in patients with schizophrenia could be extended to individuals with SPD. Twenty subjects with SPD and 19 healthy controls were recruited from 4461 freshmen at a university in Shanghai and received a resting-state scan of MRI. All participants were evaluated by the Chinese version of Schizotypal Personality Questionnaire (SPQ) and the Chinese version of Symptom Checklist (SCL-90). The imaging data were analysed using the seed-based functional connectivity method. Compared with the controls, SPD subjects exhibited reduced FC between bilateral precuneus and contralateral Parahippocampus. In SPD group, SPQ total score was negatively correlated with FC between right precuneus and left Parahippocampus (r = −0.603, p = 0.006); there was a negative trend between SPQ subscale score of suspiciousness and FC between left precuneus and right Parahippocampus (r = −0.553, p = 0.014); and a positive trend was found between SPQ subscale score of odd or eccentric behaviour and FC between left precuneus and right superior temporal gyrus (r = 0.543, p = 0.016). As for the SCL-90 score, a similar negative trend was found between SCL-90 subscale score of suspiciousness and FC between right precuneus and left Parahippocampus (r = −0.535, p = 0.018) in SPD group. Our findings suggest that the decreased functional connectivity between precuneus and contralateral Parahippocampus might play a key role in the pathophysiology of schizophrenia spectrum disorder.
Sebastien Hetu - One of the best experts on this subject based on the ideXlab platform.
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asymmetry in functional connectivity of the human habenula revealed by high resolution cardiac gated resting state imaging
Human Brain Mapping, 2016Co-Authors: Sebastien Hetu, Yi Luo, Ignacio Saez, Terry Lohrenz, Read P Montague, Kimberlee DardenneAbstract:The habenula is a hub for cognitive and emotional signals that are relayed to the aminergic centers in the midbrain and, thus, plays an important role in goal-oriented behaviors. Although it is well described in rodents and non-human primates, the habenula functional network remains relatively uncharacterized in humans, partly because of the methodological challenges associated with the functional magnetic resonance imaging of small structures in the brain. Using high-resolution cardiac-gated resting state imaging in healthy humans and precisely identifying each participants' habenula, we show that the habenula is functionally coupled with the insula, Parahippocampus, thalamus, periaqueductal grey, pons, striatum and substantia nigra/ventral tegmental area complex. Furthermore, by separately examining and comparing the functional maps from the left and right habenula, we provide the first evidence of an asymmetry in the functional connectivity of the habenula in humans. Hum Brain Mapp 37:2602-2615, 2016. © 2016 The Authors Human Brain Mapping Published by Wiley Periodicals, Inc.
Xiaodong Zhang - One of the best experts on this subject based on the ideXlab platform.
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decreased coupling between functional connectivity density and amplitude of low frequency fluctuation in non neuropsychiatric systemic lupus erythematosus a resting stage functional mri study
Molecular Neurobiology, 2017Co-Authors: Rongfeng Qi, Xiao Lu Jiang, Zhen Cheng, Qiang Xu, Yan Zhou, Xiaodong Zhang, Hui Juan ChenAbstract:In this study, we seek to explore alterations of coupling between functional connectivity density (FCD) and amplitude of low frequency fluctuation (ALFF) in systemic lupus erythematosus patients without overt neuropsychiatric symptoms (non-NPSLE) by using resting-state functional MR imaging. This study was approved by the institutional ethical review board, and all participants signed written informed consent prior to the study. Twenty six non-NPSLE patients and 35 matched healthy controls underwent resting-state functional MR imaging. The correlation analysis between FCD and ALFF was conducted to assess the imaging coupling. Pearson correlation analysis was performed to correlate imaging variables to clinical and neuropsychological data in non-NPSLE patients. According to the consistent alteration of FCD and ALFF, region of interests were identified including the right inferior temporal gyrus, bilateral hippocampus-Parahippocampus (H-PH), left posterior cingulate cortex, superior parietal gyrus, postcentral gyrus, and bilateral precuneus. Across-voxel correlation analysis showed decreased coupling strengths in some brain regions. Correlations between FCD, ALFF, and coupling strength in H-PH and C3/C4/MoCA were found. The imaging coupling between FCD and ALFF was decreased in non-NPSLE patients, indicating brain function alteration in non-NPSLE patients, especially the abnormal coupling between FCD and ALFF of the hippocampus-Parahippocampus might be an imaging biomarker of brain dysfunction in non-NPSLE patients.
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altered default mode network configuration in posttraumatic stress disorder after earthquake a resting stage functional magnetic resonance imaging study
Medicine, 2017Co-Authors: Xiaodong Zhang, Yan Yin, Lian DuanAbstract:The neural substrates of posttraumatic stress disorder (PTSD) are still not fully elucidated. Hence, this study is to explore topological alterations of the default mode network (DMN) in victims with PTSD after a magnitude of 8.0 earthquake using resting-state functional magnetic resonance imaging (rs-fMRI).This study was approved by the local ethical review board, and all participants signed written informed consent. Sixty-two PTSD victims from the 2008 Sichuan earthquake and 62 matched exposed controls underwent rs-fMRI. PTSD was diagnosed by Clinician-Administered PTSD Scale, and underwent PTSD Checklist-Civilian Version for symptom scoring. The DMN was analyzed by using graph theoretical approaches. Further, Pearson correlation analysis was performed to correlate neuroimaging metrics to neuropsychological scores in victims with PTSD.Victims with PTSD showed decreased DMN functional connectivity strength between the right superior frontal gyrus and left inferior parietal lobule (IPL), and showed increased functional connectivity between the right IPL and precuneus or left posterior cingulate cortex. It was also found that victims with PTSD exhibited decreased nodal efficiency in right superior frontal gyrus and precuneus, and increased nodal efficiency in right hippocampus/Parahippocampus. Apart from that, PTSD showed higher nodal degree in bilateral hippocampus/Parahippocampus. In addition, the functional connectivity strength between the right IPL and precuneus correlated negatively to the avoid scores (r = -0.26, P = .04).This study implicates alteration of topological features on the DMN in PTSD victims after major earthquake, and provides new insights into DMN malfunction in PTSD based on graph theory.
