The Experts below are selected from a list of 249 Experts worldwide ranked by ideXlab platform
Giuseppe Rizzotto - One of the best experts on this subject based on the ideXlab platform.
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management of Paratracheal Lymph Nodes in laryngeal cancer with subglottic involvement
Head and Neck-journal for The Sciences and Specialties of The Head and Neck, 2018Co-Authors: Marco Lucioni, Marco Lionello, Andy Bertolin, Elena Nardi, Luca Dascanio, Giuseppe RizzottoAbstract:Background The purpose of this study was to present our findings on the involvement of Paratracheal Lymph Nodes in laryngeal squamous cell carcinoma (SCC) with subglottis extension, which is controversial. Methods We assessed 196 patients with laryngeal SCC involving the subglottis, treated with open laryngeal surgery with or without Paratracheal neck dissection (PTND). The relationship of the Paratracheal Lymph node metastatic pattern with laterocervical nodal status and tumor location within different subglottic subsites was analyzed. The influence of PTND on regional disease control was assessed. Results Paratracheal Lymph Nodes were affected in 12.2% of cases. An increased frequency (P = .064) of Paratracheal metastasis was noticed in case of anterior subglottis extension with respect to other subsites. A correlation (P < .001) between Paratracheal Lymph node and laterocervical node involvement was found among subjects with posterior subglottic extension. Conclusions Prophylactic PTND is indicated in laryngeal SCC with anterior subglottic extension and/or posterior subglottis involvement with clinically apparent laterocervical node metastases.
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Management of Paratracheal Lymph Nodes in laryngeal cancer with subglottic involvement.
Head and Neck-journal for The Sciences and Specialties of The Head and Neck, 2017Co-Authors: Marco Lucioni, Luca D’ascanio, Marco Lionello, Andy Bertolin, Elena Nardi, Giuseppe RizzottoAbstract:Background The purpose of this study was to present our findings on the involvement of Paratracheal Lymph Nodes in laryngeal squamous cell carcinoma (SCC) with subglottis extension, which is controversial. Methods We assessed 196 patients with laryngeal SCC involving the subglottis, treated with open laryngeal surgery with or without Paratracheal neck dissection (PTND). The relationship of the Paratracheal Lymph node metastatic pattern with laterocervical nodal status and tumor location within different subglottic subsites was analyzed. The influence of PTND on regional disease control was assessed. Results Paratracheal Lymph Nodes were affected in 12.2% of cases. An increased frequency (P = .064) of Paratracheal metastasis was noticed in case of anterior subglottis extension with respect to other subsites. A correlation (P
Bo Chen - One of the best experts on this subject based on the ideXlab platform.
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Pretracheal-laryngeal Lymph Nodes in frozen section predicting contralateral Paratracheal Lymph Nodes metastasis.
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 2020Co-Authors: Liguang Zhou, Weili Liang, Chao Gao, Bo ChenAbstract:There has been an ongoing debate concerning the predictors of contralateral Paratracheal Lymph Nodes metastasis (LNM) in unilateral papillary thyroid cancer (PTC). This study aimed to explore the value of pretracheal-laryngeal Lymph Nodes (LNs) in frozen section in predicting contralateral Paratracheal LNM. A total of 242 patients with unilateral PTC were enrolled in this prospective study. Patients who underwent total thyroidectomy and bilateral central Lymph Nodes dissection (LND) were divided into two groups according to positive or negative contralateral Paratracheal LNs. Patients' demographics and clinicopathological features were compared between the two groups. Validity indexes and consistency of pretracheal-laryngeal LNs in frozen sections were calculated. LNM rates in central, ipsilateral Paratracheal, pretracheal-laryngeal, and contralateral Paratracheal regions were 55.37%, 47.03%, 23.55% and 14.05%, respectively. Only pretracheal-laryngeal LNM, regardless of whether detected in frozen or paraffin sections, were independent risk factors for contralateral Paratracheal LNM (OR = 2.707; 95% CI 1.062-6.902; P = 0.037 in frozen section; OR = 3.072; 95% CI 1.248-7.560; P = 0.015 in paraffin section). The sensitivity, specificity, false-negative rate, false-positive rate, accuracy rate, and Kappa value of pretracheal-laryngeal LNM in frozen sections for predicting pretracheal-laryngeal LNM were 87.72%, 100%, 12.28%, 0%, 97.11% and 0.916 respectively, while those for predicting contralateral Paratracheal LNM were 85,29%, 89.90%, 14.71%, 10.10%, 89.22%, and 0.618 respectively. Pretracheal-laryngeal LNs in frozen section accurately predicted contralateral Paratracheal LNM, which could allow the identification of patients who can benefit from an extended central LND. Copyright © 2020 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.
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Pretracheal-laryngeal Lymph Nodes in frozen section predicting contralateral Paratracheal Lymph Nodes metastasis.
European Journal of Surgical Oncology, 2020Co-Authors: Liguang Zhou, Weili Liang, Chao Gao, Bo ChenAbstract:Abstract Background There has been an ongoing debate concerning the predictors of contralateral Paratracheal Lymph Nodes metastasis (LNM) in unilateral papillary thyroid cancer (PTC). This study aimed to explore the value of pretracheal–laryngeal Lymph Nodes (LNs) in frozen section in predicting contralateral Paratracheal LNM. Methods A total of 242 patients with unilateral PTC were enrolled in this prospective study. Patients who underwent total thyroidectomy and bilateral central Lymph Nodes dissection (LND) were divided into two groups according to positive or negative contralateral Paratracheal LNs. Patients’ demographics and clinicopathological features were compared between the two groups. Validity indexes and consistency of pretracheal–laryngeal LNs in frozen sections were calculated. Results LNM rates in central, ipsilateral Paratracheal, pretracheal–laryngeal, and contralateral Paratracheal regions were 55.37%, 47.03%, 23.55% and 14.05%, respectively. Only pretracheal–laryngeal LNM, regardless of whether detected in frozen or paraffin sections, were independent risk factors for contralateral Paratracheal LNM (OR = 2.707; 95% CI 1.062–6.902; P = 0.037 in frozen section; OR = 3.072; 95% CI 1.248–7.560; P = 0.015 in paraffin section). The sensitivity, specificity, false-negative rate, false-positive rate, accuracy rate, and Kappa value of pretracheal–laryngeal LNM in frozen sections for predicting pretracheal–laryngeal LNM were 87.72%, 100%, 12.28%, 0%, 97.11% and 0.916 respectively, while those for predicting contralateral Paratracheal LNM were 85,29%, 89.90%, 14.71%, 10.10%, 89.22%, and 0.618 respectively. Conclusion Pretracheal–laryngeal LNs in frozen section accurately predicted contralateral Paratracheal LNM, which could allow the identification of patients who can benefit from an extended central LND.
Jeesun Choi - One of the best experts on this subject based on the ideXlab platform.
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Extent of Prophylactic Lymph Node Dissection in the Central Neck Area of the Patients with Papillary Thyroid Carcinoma: Comparison of Limited Versus Comprehensive Lymph Node Dissection in a 2-Year Safety Study
2014Co-Authors: Jeon Yeob Jang, Jeesun ChoiAbstract:cheal, prelaryngeal Lymph Nodes) (CCND) with ‘‘limited’ ’ (saving contralateral Paratracheal Lymph Nodes) central node dissection (LCND) for postoperative complications and disease recurrence rate in sonographically node-negative papillary thyroid carcinomas. Materials and Methods: From 2003 to 2005, 114 consecutive patients, diagnosed as sonographically node-negative thyroid papillary carcinomas, were included retrospectively. Among them, the LCND was performed in 56 patients and CCND in 58 patients, in com-bination with total thyroidectomy, based on the operator-dependent decision. We compared the complication rates and the recurrence rates between these two groups with a mean follow-up duration of 2 years. Results: Transient hypocalcemia was more frequent in the CCND group than in the LCND group (48.3 % vs 26.8%, P =.02, odds ratio [OR] = 2.55). However, the other complication rates were similar in the two groups. In addition, the immediate postoperative reduction of parathyroid hormone (PTH) was more evident in the CCND group. The postoperative PTH levels increased up to a similar level (12.4 vs 11.8 pg/mL) over 6 months. The incidence of permanent hypocalcemia did not differ significantly between the two groups. Four (7.1%) an
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extent of prophylactic Lymph node dissection in the central neck area of the patients with papillary thyroid carcinoma comparison of limited versus comprehensive Lymph node dissection in a 2 year safety study
Annals of Surgical Oncology, 2008Co-Authors: Hansin Jeong, Chunghwan Baek, Man Ki Chung, Jaehoon Chung, Yoon Kyung So, Jeon Yeob Jang, Jeesun ChoiAbstract:Background To compare the “comprehensive” (including bilateral Paratracheal, pretracheal, prelaryngeal Lymph Nodes) (CCND) with “limited” (saving contralateral Paratracheal Lymph Nodes) central node dissection (LCND) for postoperative complications and disease recurrence rate in sonographically node-negative papillary thyroid carcinomas.
Marco Lucioni - One of the best experts on this subject based on the ideXlab platform.
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management of Paratracheal Lymph Nodes in laryngeal cancer with subglottic involvement
Head and Neck-journal for The Sciences and Specialties of The Head and Neck, 2018Co-Authors: Marco Lucioni, Marco Lionello, Andy Bertolin, Elena Nardi, Luca Dascanio, Giuseppe RizzottoAbstract:Background The purpose of this study was to present our findings on the involvement of Paratracheal Lymph Nodes in laryngeal squamous cell carcinoma (SCC) with subglottis extension, which is controversial. Methods We assessed 196 patients with laryngeal SCC involving the subglottis, treated with open laryngeal surgery with or without Paratracheal neck dissection (PTND). The relationship of the Paratracheal Lymph node metastatic pattern with laterocervical nodal status and tumor location within different subglottic subsites was analyzed. The influence of PTND on regional disease control was assessed. Results Paratracheal Lymph Nodes were affected in 12.2% of cases. An increased frequency (P = .064) of Paratracheal metastasis was noticed in case of anterior subglottis extension with respect to other subsites. A correlation (P < .001) between Paratracheal Lymph node and laterocervical node involvement was found among subjects with posterior subglottic extension. Conclusions Prophylactic PTND is indicated in laryngeal SCC with anterior subglottic extension and/or posterior subglottis involvement with clinically apparent laterocervical node metastases.
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Management of Paratracheal Lymph Nodes in laryngeal cancer with subglottic involvement.
Head and Neck-journal for The Sciences and Specialties of The Head and Neck, 2017Co-Authors: Marco Lucioni, Luca D’ascanio, Marco Lionello, Andy Bertolin, Elena Nardi, Giuseppe RizzottoAbstract:Background The purpose of this study was to present our findings on the involvement of Paratracheal Lymph Nodes in laryngeal squamous cell carcinoma (SCC) with subglottis extension, which is controversial. Methods We assessed 196 patients with laryngeal SCC involving the subglottis, treated with open laryngeal surgery with or without Paratracheal neck dissection (PTND). The relationship of the Paratracheal Lymph node metastatic pattern with laterocervical nodal status and tumor location within different subglottic subsites was analyzed. The influence of PTND on regional disease control was assessed. Results Paratracheal Lymph Nodes were affected in 12.2% of cases. An increased frequency (P = .064) of Paratracheal metastasis was noticed in case of anterior subglottis extension with respect to other subsites. A correlation (P
Liguang Zhou - One of the best experts on this subject based on the ideXlab platform.
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Pretracheal-laryngeal Lymph Nodes in frozen section predicting contralateral Paratracheal Lymph Nodes metastasis.
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 2020Co-Authors: Liguang Zhou, Weili Liang, Chao Gao, Bo ChenAbstract:There has been an ongoing debate concerning the predictors of contralateral Paratracheal Lymph Nodes metastasis (LNM) in unilateral papillary thyroid cancer (PTC). This study aimed to explore the value of pretracheal-laryngeal Lymph Nodes (LNs) in frozen section in predicting contralateral Paratracheal LNM. A total of 242 patients with unilateral PTC were enrolled in this prospective study. Patients who underwent total thyroidectomy and bilateral central Lymph Nodes dissection (LND) were divided into two groups according to positive or negative contralateral Paratracheal LNs. Patients' demographics and clinicopathological features were compared between the two groups. Validity indexes and consistency of pretracheal-laryngeal LNs in frozen sections were calculated. LNM rates in central, ipsilateral Paratracheal, pretracheal-laryngeal, and contralateral Paratracheal regions were 55.37%, 47.03%, 23.55% and 14.05%, respectively. Only pretracheal-laryngeal LNM, regardless of whether detected in frozen or paraffin sections, were independent risk factors for contralateral Paratracheal LNM (OR = 2.707; 95% CI 1.062-6.902; P = 0.037 in frozen section; OR = 3.072; 95% CI 1.248-7.560; P = 0.015 in paraffin section). The sensitivity, specificity, false-negative rate, false-positive rate, accuracy rate, and Kappa value of pretracheal-laryngeal LNM in frozen sections for predicting pretracheal-laryngeal LNM were 87.72%, 100%, 12.28%, 0%, 97.11% and 0.916 respectively, while those for predicting contralateral Paratracheal LNM were 85,29%, 89.90%, 14.71%, 10.10%, 89.22%, and 0.618 respectively. Pretracheal-laryngeal LNs in frozen section accurately predicted contralateral Paratracheal LNM, which could allow the identification of patients who can benefit from an extended central LND. Copyright © 2020 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.
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Pretracheal-laryngeal Lymph Nodes in frozen section predicting contralateral Paratracheal Lymph Nodes metastasis.
European Journal of Surgical Oncology, 2020Co-Authors: Liguang Zhou, Weili Liang, Chao Gao, Bo ChenAbstract:Abstract Background There has been an ongoing debate concerning the predictors of contralateral Paratracheal Lymph Nodes metastasis (LNM) in unilateral papillary thyroid cancer (PTC). This study aimed to explore the value of pretracheal–laryngeal Lymph Nodes (LNs) in frozen section in predicting contralateral Paratracheal LNM. Methods A total of 242 patients with unilateral PTC were enrolled in this prospective study. Patients who underwent total thyroidectomy and bilateral central Lymph Nodes dissection (LND) were divided into two groups according to positive or negative contralateral Paratracheal LNs. Patients’ demographics and clinicopathological features were compared between the two groups. Validity indexes and consistency of pretracheal–laryngeal LNs in frozen sections were calculated. Results LNM rates in central, ipsilateral Paratracheal, pretracheal–laryngeal, and contralateral Paratracheal regions were 55.37%, 47.03%, 23.55% and 14.05%, respectively. Only pretracheal–laryngeal LNM, regardless of whether detected in frozen or paraffin sections, were independent risk factors for contralateral Paratracheal LNM (OR = 2.707; 95% CI 1.062–6.902; P = 0.037 in frozen section; OR = 3.072; 95% CI 1.248–7.560; P = 0.015 in paraffin section). The sensitivity, specificity, false-negative rate, false-positive rate, accuracy rate, and Kappa value of pretracheal–laryngeal LNM in frozen sections for predicting pretracheal–laryngeal LNM were 87.72%, 100%, 12.28%, 0%, 97.11% and 0.916 respectively, while those for predicting contralateral Paratracheal LNM were 85,29%, 89.90%, 14.71%, 10.10%, 89.22%, and 0.618 respectively. Conclusion Pretracheal–laryngeal LNs in frozen section accurately predicted contralateral Paratracheal LNM, which could allow the identification of patients who can benefit from an extended central LND.
