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Stewart Lawrence - One of the best experts on this subject based on the ideXlab platform.
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Treatment of asymptomatic conGenital syphilis: benzathine versus procaine Penicillin G therapy.
The Journal of Pediatrics, 1994Co-Authors: Sharon G. Paryani, Arthur J. Vaughn, Maude Crosby, Stewart LawrenceAbstract:We compared the efficacy of two treatment reGimens for asymptomatic conGenital syphilis. Between June 1989 and July 1991, we prospectively and randomly assiGned 169 patients to receive either one dose of benzathine Penicillin G or procaine Penicillin G for 10 days. There were no siGnificant differences between the treatment Groups in reGard to birth weiGht, sex, race, Gestational aGe, ApGar scores, infant or maternal rapid plasma reaGin (RPR) titers, fluorescent treponemal IGM antibody, or maternal treatment. Patients were examined at 2 to 3, 6, and 12 months after treatment; treatment failure was defined as clinical siGns or persistent laboratory evidence of conGenital syphilis. Nine patients were removed from the study durinG the neonatal period, eiGht were lost to follow-up, and 152 patients were examined 2 to 3 months or more after treatment. AmonG these 152 patients, none had clinical evidence of conGenital syphilis at follow-up, and all the patients tested at 2 to 3 months after treatment (68 in the benzathine Penicillin G Group and 61 in the procaine Penicillin G Group) had at least a fourfold decrease in RPR titers. The RPR became nonreactive in all but three of the infants (two in the procaine Penicillin G Group and one in the benzathine Penicillin G Group; all three were 2 to 3 months of aGe when last tested). We conclude that treatment failure did not occur with either reGimen and that there was no siGnificant difference in outcome between the two Groups.
A. Alañón Molina - One of the best experts on this subject based on the ideXlab platform.
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Rapid assay for procaine Penicillin G in pharmaceutical dosaGes by spectrofluorimetry.
Talanta, 1993Co-Authors: J. A. Murillo Pulgarín, A. Alañón MolinaAbstract:Abstract A method for the spectrofluorimetric determination of procaine Penicillin G is proposed (λex = 294 nm, λem = 348 nm) for concentrations between 0.10 and 1.0 ppm. The method was performed in ethanol/water medium (60% V/V), at apparent pH 9.9 provided by addinG ammonium/ammonia buffer solution with pH = 10.0. The effect of other Penicillins on the determination of procaine Penicillin G was examined over a wide ranGe of concentrations, interferences were not observed in the ranGe of studied concentrations. The method was successfully applied to assay all Spanish commercialized injections containinG procaine Penicillin G, Penicillin G and/or benzathine Penicillin G.
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Determination of Procaine Penicillin G and Penicillin G by Second Derivative Spectrophotometry in Pharmaceutical Products
Analytical Letters, 1993Co-Authors: J. A. Murillo Pulgarín, A. Alañón MolinaAbstract:Abstract “Zero-crossinG” derivative spectrophotometry has been used for determininG binary mixtures of Penicillin G and procaine Penicillin G. The procedure is rapid, simple, nondestructive, and does not require resolutions of equations. Calibration Graphs are linear between 2.0 and 50.0 μG mL−1 of the Penicillin G at 226.0 nm, and between 2.0 and 100.0 μG mL−1 of procaine Penicillin G at 319.0 nm, in the presence of each other. A complete and exhausive statistical analysis of the experimental data was realized to demonstrate the validity of method. The method was successfully applied to assay commercial injections of these druGs.
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Simultaneous determination of procaine Penicillin G and benzathine Penicillin G by second derivative spectrophotometry
Analytical Letters, 1992Co-Authors: J. A. Murillo Pulgarín, A. Alañón Molina, J. Rodríguez FloresAbstract:Abstract A new method for determininG the binary mixtures of procaine Penicillin G and benzathine Penicillin G usinG “zero-crossinG” second derivative spectrophotometry is described. Calibration Graphs were linear up to 8.80 10−5 M for procaine Penicillin G and 4.40 10−5 M for benzathine Penicillin G. The method was realized in ethanol/water medium (30 % v/v). A complete and exhaustive statistical analysis of the experimental data was realized to demonstrate the validity of method. The method was applied for determininG procaine Penicillin G and benzathine Penicillin G synthetic mixtures with Good results. The procedure does not require any separation step.
Sharon G. Paryani - One of the best experts on this subject based on the ideXlab platform.
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Treatment of asymptomatic conGenital syphilis: benzathine versus procaine Penicillin G therapy.
The Journal of Pediatrics, 1994Co-Authors: Sharon G. Paryani, Arthur J. Vaughn, Maude Crosby, Stewart LawrenceAbstract:We compared the efficacy of two treatment reGimens for asymptomatic conGenital syphilis. Between June 1989 and July 1991, we prospectively and randomly assiGned 169 patients to receive either one dose of benzathine Penicillin G or procaine Penicillin G for 10 days. There were no siGnificant differences between the treatment Groups in reGard to birth weiGht, sex, race, Gestational aGe, ApGar scores, infant or maternal rapid plasma reaGin (RPR) titers, fluorescent treponemal IGM antibody, or maternal treatment. Patients were examined at 2 to 3, 6, and 12 months after treatment; treatment failure was defined as clinical siGns or persistent laboratory evidence of conGenital syphilis. Nine patients were removed from the study durinG the neonatal period, eiGht were lost to follow-up, and 152 patients were examined 2 to 3 months or more after treatment. AmonG these 152 patients, none had clinical evidence of conGenital syphilis at follow-up, and all the patients tested at 2 to 3 months after treatment (68 in the benzathine Penicillin G Group and 61 in the procaine Penicillin G Group) had at least a fourfold decrease in RPR titers. The RPR became nonreactive in all but three of the infants (two in the procaine Penicillin G Group and one in the benzathine Penicillin G Group; all three were 2 to 3 months of aGe when last tested). We conclude that treatment failure did not occur with either reGimen and that there was no siGnificant difference in outcome between the two Groups.
Basilio Morelli - One of the best experts on this subject based on the ideXlab platform.
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determination of a ternary mixture of Penicillin G sodium salt Penicillin G procain salt and dihydrostreptomycin sulphate by third derivative spectrophotometry
Talanta, 1994Co-Authors: Basilio MorelliAbstract:Abstract Ternary mixtures of antibiotics, i.e. Penicillin-G sodium salt, Penicillin-G procain salt and dihydrostreptomycin sulphate salt, are assayed by ‘zero-crossinG’ third-derivative spectrophotometry. Calibration plots follows Beer's law up to 40 μG/ml of Penicillin-G sodium at 222.5 nm ( r = 0.9997), 46 μG/ml of Penicillin-G procain at 217 nm ( r = 0.9999) and 36 μG/ml of dihydrostreptomycin sulphate at 211.5 nm ( r = 0.9999), in the presence of one another. Detection limits at p = 0.05 level of siGnificance were calculated to be, respectively, 0.66, 0.41 and 0.25 μG/ml. The procedure is rapid, simple, nondestructive and does not require solution of equations. The method was successfully applied for determininG laboratory mixtures and commercial injections.
Jettanong Klaewsongkram - One of the best experts on this subject based on the ideXlab platform.
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Alkali-treated Penicillin G solution is a better option than Penicillin G as an alternative source of minor determinants for Penicillin skin test.
Allergy and asthma proceedings, 2012Co-Authors: Pongsak Wangrattanasopon, Kiat Ruxrungtham, Hiroshi Chantaphakul, Supranee Buranapraditkun, Jettanong KlaewsongkramAbstract:Both benzylpenicilloyl-polylysine (PPL) and minor determinant mixture (MDM) are the recommended standard reaGents for Penicillin skin testinG. However, Penicillin G is commonly suGGested as an alternative source of minor determinants. This study evaluated the accuracy of Penicillin G and alkali-treated Penicillin G compared with the standardized MDM for skin testinG. Sixty-eiGht patients with histories of allerGies to Penicillin or semisynthetic Penicillins were skin tested with commercial Kit Penicillin allerGenic determinants (DAP) (PPL and DAP-MDM; Diater Laboratorios, Madrid, Spain). The in-house MDM (IH-MDM), prepared by alkali-treated aGed Penicillin, and fresh Penicillin G sodium (PGs) were tested alonGside DAP-MDM. Positive Penicillin skin test results were identified in 22 patients (32.4%) usinG commercial reaGents (PPL+ DAP-MDM) and 19 of them reacted to DAP-MDM alone or toGether with PPL. The accuracy of IH-MDM and PGs compared with DAP-MDM was 89.7 and 76.5%, respectively. Our study shows that alkali-treated Penicillin G is a better option than Penicillin G as an alternative source of MDM for skin testinG in case the commercialized MDM is not available. Minor determinants play a siGnificant role for Penicillin allerGy in Thailand and should be included in the Penicillin skin test panel to verify suspected cases of Penicillin allerGy. (ClinicalTrials.Gov number: NCT00789217).