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Jianping Zuo - One of the best experts on this subject based on the ideXlab platform.

  • minor immunosuppressive spiroorthoester group containing pregnane glycosides from the root barks of Periploca sepium
    Bioorganic Chemistry, 2021
    Co-Authors: Xingcheng Shao, Zhenhua Chen, Jianping Zuo, Shuangshuang Liu, Wenhui Wei, Yi Feng, Jiquan Zhang, Weimin Zhao
    Abstract:

    Abstract LC-MS guided chemical investigation of the periploside-rich extract of the root barks of Periploca sepium afforded six new minor pregnane glycosides, named periplosides A1−A6 (1–6). Their structures were characterized on the basis of extensive spectroscopic analysis. Compounds 1–6 were evaluated for their inhibitory activities against the proliferation of T and B lymphocytes in vitro, among them, compound 5 exhibited significant inhibitory activities and the most favorite selective index (SI) values against the proliferation of T lymphocyte (IC50 = 0.30 μM, SI = 176) and B lymphocyte (IC50 = 0.55 μM, SI = 97).

  • anti nociceptive anti inflammatory and anti arthritic activities of pregnane glycosides from the root bark of Periploca sepium bunge
    Journal of Ethnopharmacology, 2021
    Co-Authors: Zemin Lin, Wei Tang, Jianping Zuo, Weimin Zhao, Yuting Liu, Yueteng Huang, Xiaoqian Yang, Fenghua Zhu
    Abstract:

    Abstract Ethnopharmacological relevance Periploca sepium Bunge (P. sepium) is used in traditional Chinese medicine (TCM) for the treatment of autoimmune diseases, particularly rheumatoid arthritis. Periploca sepium periplosides (PePs), isolated from the root bark of P. sepium, characterized as the cardiac glycosides-free pregnane glycosides fraction, is expected to possess therapeutic potential on inflammatory arthritis. Aim of the study The current study is designed to evaluate the anti-nociceptive, anti-inflammatory and anti-arthritic activities effects of the PePs. Materials and methods The anti-nociceptive activity of PePs was examined in the writhing test and hot-plate test in mice. The anti-inflammatory activity of PePs was determined by the 2, 4-dinitro-1-fluorobenzene (DNFB)-induced ear edema model and the carrageenan induced paw edema model in mice. The anti-arthritic activity of PePs was investigated by evaluating the joint inflammation and arthritis pathology in rat adjuvant induced arthritis (AIA) and murine collagen induced arthritis (CIA). Phytohaemagglutinin M (PHA-M) -elicited human peripheral blood mononuclear cells (PBMCs) were further applied to assess the suppressive activity of PePs on IFN-γ and IL-17 production. Results PePs treatment markedly decreased the acetic acid-induced visceral nociceptive response and increased the hot-plate pain threshold. Further, oral administration of PePs exhibited anti-inflammatory activity by decreasing DNFB-induced ear edema in mice and carrageenan-induced paw edema in rats. Moreover, oral treatment of PePs ameliorated joint swelling and attenuated bone erosion in rodent arthritis, and the therapeutic benefits were partially attributed to the suppression of proinflammatory cytokines such IFN-γ and IL-17. Moreover, PePs suppressed the proliferation as well as IFN-γ and IL-17 secretion in PHA-M-elicited human PBMCs in a concentration dependent manner. Conclusions Taken together, our results justified the traditional use of Periploca sepium Bunge for the treatment of diseases associated with inflammation and pain.

  • spiroorthoester group containing pregnane glycosides from the root barks of Periploca chrysantha and their inhibitory activities against the proliferation of b and t lymphocytes
    Bioorganic & Medicinal Chemistry Letters, 2017
    Co-Authors: Junjun Qin, Jianping Zuo, Zemin Lin, Jiwen Ren, Weimin Zhao
    Abstract:

    Abstract Phytochemical investigation of the root barks of Periploca chrysantha D. S. Yao, X. C. Chen et J. W. Ren (Asclepiadaceae) led to the elucidation of four new spiroorthoester group-containing pregnane glycosides ( 1 – 4 ), named periplosides W-Y and 3- O -formyl-periploside F. Their structures were elucidated on the basis of extensive spectroscopic analysis. The four new pregnane glycosides ( 1 – 4 ) were found to exhibit significantly inhibitory activities against the proliferation of B and T lymphocytes and favorable selective index comparable to those of cyclosporin A.

  • absolute configuration of periplosides c and f and isolation of minor spiro orthoester group containing pregnane type steroidal glycosides from Periploca sepium and their t lymphocyte proliferation inhibitory activities
    Journal of Natural Products, 2017
    Co-Authors: Luoyi Wang, Zhenhua Chen, Yu Zhou, Wei Tang, Jianping Zuo, Junjun Qin, Weimin Zhao
    Abstract:

    Further phytochemical investigation of the root bark of Periploca sepium afforded nine new spiro-orthoester group-containing pregnane-type glycosides termed periplosides O–V and 3-O-formyl-periploside A. The structures of these glycosides along with the absolute configuration of the unique seven-membered formyl acetal-bridged spiro-orthoester function and the 4,6-dideoxy-3-O-methyl-Δ3-2-hexosulosyl moiety were elucidated on the basis of spectroscopic data interpretation and chemical transformation. The absolute configurations of the major compounds periplosides C and F were established by single-crystal X-ray diffraction analysis. The isolated compounds were evaluated for their inhibitory activities against the proliferation of T-lymphocytes. As a result, periploside C, the most abundant glycoside containing a spiro-orthoester moiety found in the plant, exhibited the most favorite selective index value (SI = 82.5). The length and constitution of the saccharide chain in the periplosides were found to influ...

  • structural revision of periplocosides and periperoxides natural immunosuppressive agents from the genus Periploca
    Phytochemistry, 2011
    Co-Authors: Luoyi Wang, Zhenhua Chen, Yu Zhou, Wei Tang, Jianping Zuo, Weimin Zhao
    Abstract:

    The structures of a series of peroxy function containing pregnane glycosides isolated from Periploca sepium and Periploca forrestii were revised to be orthoester group bearing ones using 2D NMR spectroscopic techniques, as well as chemical transformations and X-ray crystallographic diffraction analysis. The orthoester function appears to be an essential structural feature for immunosuppressive activity.

Carmen Formisano - One of the best experts on this subject based on the ideXlab platform.

  • essential oil composition of the fruits of Periploca laevigata aiton subsp angustifolia labill markgraf apocynaceae periplocoideae
    Natural Product Research, 2011
    Co-Authors: Pietro Zito, Maurizio Sajeva, Maurizio Bruno, Antonella Maggio, Sergio Rosselli, Felice Senatore, Carmen Formisano
    Abstract:

    The essential oil of the fruits of Periploca laevigata Aiton subsp. angustifolia (Labill.) Markgraf (Apocynaceae) from Lampedusa Island was obtained by hydrodistillation and its composition was analysed. The analyses allowed the identification and quantification of 64 volatile compounds belonging to different classes. The most abundant compounds were nonacosane, heptacosane, hentriacontane and δ-cadinene. Among the volatile compounds identified in the fruits of P. laevigata subsp. angustifolia, 31 are present in other taxa of Apocynaceae, 19 have antimicrobial activity and four are pheromones for the butterfly Danaus chrysippus. The possible ecological role of the volatile compounds found is briefly discussed.

Weimin Zhao - One of the best experts on this subject based on the ideXlab platform.

  • minor immunosuppressive spiroorthoester group containing pregnane glycosides from the root barks of Periploca sepium
    Bioorganic Chemistry, 2021
    Co-Authors: Xingcheng Shao, Zhenhua Chen, Jianping Zuo, Shuangshuang Liu, Wenhui Wei, Yi Feng, Jiquan Zhang, Weimin Zhao
    Abstract:

    Abstract LC-MS guided chemical investigation of the periploside-rich extract of the root barks of Periploca sepium afforded six new minor pregnane glycosides, named periplosides A1−A6 (1–6). Their structures were characterized on the basis of extensive spectroscopic analysis. Compounds 1–6 were evaluated for their inhibitory activities against the proliferation of T and B lymphocytes in vitro, among them, compound 5 exhibited significant inhibitory activities and the most favorite selective index (SI) values against the proliferation of T lymphocyte (IC50 = 0.30 μM, SI = 176) and B lymphocyte (IC50 = 0.55 μM, SI = 97).

  • anti nociceptive anti inflammatory and anti arthritic activities of pregnane glycosides from the root bark of Periploca sepium bunge
    Journal of Ethnopharmacology, 2021
    Co-Authors: Zemin Lin, Wei Tang, Jianping Zuo, Weimin Zhao, Yuting Liu, Yueteng Huang, Xiaoqian Yang, Fenghua Zhu
    Abstract:

    Abstract Ethnopharmacological relevance Periploca sepium Bunge (P. sepium) is used in traditional Chinese medicine (TCM) for the treatment of autoimmune diseases, particularly rheumatoid arthritis. Periploca sepium periplosides (PePs), isolated from the root bark of P. sepium, characterized as the cardiac glycosides-free pregnane glycosides fraction, is expected to possess therapeutic potential on inflammatory arthritis. Aim of the study The current study is designed to evaluate the anti-nociceptive, anti-inflammatory and anti-arthritic activities effects of the PePs. Materials and methods The anti-nociceptive activity of PePs was examined in the writhing test and hot-plate test in mice. The anti-inflammatory activity of PePs was determined by the 2, 4-dinitro-1-fluorobenzene (DNFB)-induced ear edema model and the carrageenan induced paw edema model in mice. The anti-arthritic activity of PePs was investigated by evaluating the joint inflammation and arthritis pathology in rat adjuvant induced arthritis (AIA) and murine collagen induced arthritis (CIA). Phytohaemagglutinin M (PHA-M) -elicited human peripheral blood mononuclear cells (PBMCs) were further applied to assess the suppressive activity of PePs on IFN-γ and IL-17 production. Results PePs treatment markedly decreased the acetic acid-induced visceral nociceptive response and increased the hot-plate pain threshold. Further, oral administration of PePs exhibited anti-inflammatory activity by decreasing DNFB-induced ear edema in mice and carrageenan-induced paw edema in rats. Moreover, oral treatment of PePs ameliorated joint swelling and attenuated bone erosion in rodent arthritis, and the therapeutic benefits were partially attributed to the suppression of proinflammatory cytokines such IFN-γ and IL-17. Moreover, PePs suppressed the proliferation as well as IFN-γ and IL-17 secretion in PHA-M-elicited human PBMCs in a concentration dependent manner. Conclusions Taken together, our results justified the traditional use of Periploca sepium Bunge for the treatment of diseases associated with inflammation and pain.

  • spiroorthoester group containing pregnane glycosides from the root barks of Periploca chrysantha and their inhibitory activities against the proliferation of b and t lymphocytes
    Bioorganic & Medicinal Chemistry Letters, 2017
    Co-Authors: Junjun Qin, Jianping Zuo, Zemin Lin, Jiwen Ren, Weimin Zhao
    Abstract:

    Abstract Phytochemical investigation of the root barks of Periploca chrysantha D. S. Yao, X. C. Chen et J. W. Ren (Asclepiadaceae) led to the elucidation of four new spiroorthoester group-containing pregnane glycosides ( 1 – 4 ), named periplosides W-Y and 3- O -formyl-periploside F. Their structures were elucidated on the basis of extensive spectroscopic analysis. The four new pregnane glycosides ( 1 – 4 ) were found to exhibit significantly inhibitory activities against the proliferation of B and T lymphocytes and favorable selective index comparable to those of cyclosporin A.

  • absolute configuration of periplosides c and f and isolation of minor spiro orthoester group containing pregnane type steroidal glycosides from Periploca sepium and their t lymphocyte proliferation inhibitory activities
    Journal of Natural Products, 2017
    Co-Authors: Luoyi Wang, Zhenhua Chen, Yu Zhou, Wei Tang, Jianping Zuo, Junjun Qin, Weimin Zhao
    Abstract:

    Further phytochemical investigation of the root bark of Periploca sepium afforded nine new spiro-orthoester group-containing pregnane-type glycosides termed periplosides O–V and 3-O-formyl-periploside A. The structures of these glycosides along with the absolute configuration of the unique seven-membered formyl acetal-bridged spiro-orthoester function and the 4,6-dideoxy-3-O-methyl-Δ3-2-hexosulosyl moiety were elucidated on the basis of spectroscopic data interpretation and chemical transformation. The absolute configurations of the major compounds periplosides C and F were established by single-crystal X-ray diffraction analysis. The isolated compounds were evaluated for their inhibitory activities against the proliferation of T-lymphocytes. As a result, periploside C, the most abundant glycoside containing a spiro-orthoester moiety found in the plant, exhibited the most favorite selective index value (SI = 82.5). The length and constitution of the saccharide chain in the periplosides were found to influ...

  • Periplocoside E, an effective compound from Periploca sepium Bge, inhibited T cell activation
    2016
    Co-Authors: Yi-na Zhu, Yu Zhou, Weimin Zhao, Qunfang Liu, Yi-fu Yang, Jia Tian, Xiang-gen Zhong, Wei Tang
    Abstract:

    Periploca sepium Bge, a traditional Chinese herb medicine, is used for treating rheumatoid arthritis in China. Followed the bioactivity-guided isolation, the most potent immunosuppres-sive compound, periplocoside E (PSE), a pregnane glycoside, had been identified from P. sepium Bge. We investigated the immunosuppressive effects of PSE in vitro and in vivo. The results showed that PSE in a dose-dependent manner signifi-cantly inhibited the proliferation of splenocytes induced by concanavalin A and mixed lymphocyte culture reaction at no cytotoxic concentrations (5 M). Administration of PSE sup-pressed a delayed-type hypersensitivity reaction, and ovalbu-min (OVA) induced antigen-specific immune responses in mice. In vivo treatment with PSE dose dependently suppressed OVA-induced proliferation and cytokine [interleukin (IL)-2 and inter

Maurizio Sajeva - One of the best experts on this subject based on the ideXlab platform.

  • Periploca microsatellite data matrix
    2016
    Co-Authors: Carlos García-verdugo, Maurizio Sajeva, Tommaso La Mantia, Cherif Harrouni, Fouad Msanda, Juli Caujapé-castells
    Abstract:

    Genotyping of 661 Periploca individuals using 13 microsatellite nuclear loci (Genetix format). Population codes correspond with those provided in the "Periploca populations" text fil

  • do island plant populations really have lower genetic variation than mainland populations effects of selection and distribution range on genetic diversity estimates
    Molecular Ecology, 2015
    Co-Authors: Carlos Garciaverdugo, Maurizio Sajeva, T La Mantia, C Harrouni, F Msanda, Juli Caujapecastells
    Abstract:

    Ecological and evolutionary studies largely assume that island populations display low levels of neutral genetic variation. However, this notion has only been formally tested in a few cases involving plant taxa, and the confounding effect of selection on genetic diversity (GD) estimates based on putatively neutral markers has typically been overlooked. Here, we generated nuclear microsatellite and plastid DNA sequence data in Periploca laevigata, a plant taxon with an island–mainland distribution area, to (i) investigate whether selection affects GD estimates of populations across contrasting habitats; and (ii) test the long-standing idea that island populations have lower GD than their mainland counterparts. Plastid data showed that colonization of the Canary Islands promoted strong lineage divergence within P. laevigata, which was accompanied by selective sweeps at several nuclear microsatellite loci. Inclusion of loci affected by strong divergent selection produced a significant downward bias in the GD estimates of the mainland lineage, but such underestimates were substantial (>14%) only when more than one loci under selection were included in the computations. When loci affected by selection were removed, we did not find evidence that insular Periploca populations have less GD than their mainland counterparts. The analysis of data obtained from a comprehensive literature survey reinforced this result, as overall comparisons of GD estimates between island and mainland populations were not significant across plant taxa (N = 66), with the only exception of island endemics with narrow distributions. This study suggests that identification and removal of markers potentially affected by selection should be routinely implemented in estimates of GD, particularly if different lineages are compared. Furthermore, it provides compelling evidence that the expectation of low GD cannot be generalized to island plant popula

  • essential oil composition of the fruits of Periploca laevigata aiton subsp angustifolia labill markgraf apocynaceae periplocoideae
    Natural Product Research, 2011
    Co-Authors: Pietro Zito, Maurizio Sajeva, Maurizio Bruno, Antonella Maggio, Sergio Rosselli, Felice Senatore, Carmen Formisano
    Abstract:

    The essential oil of the fruits of Periploca laevigata Aiton subsp. angustifolia (Labill.) Markgraf (Apocynaceae) from Lampedusa Island was obtained by hydrodistillation and its composition was analysed. The analyses allowed the identification and quantification of 64 volatile compounds belonging to different classes. The most abundant compounds were nonacosane, heptacosane, hentriacontane and δ-cadinene. Among the volatile compounds identified in the fruits of P. laevigata subsp. angustifolia, 31 are present in other taxa of Apocynaceae, 19 have antimicrobial activity and four are pheromones for the butterfly Danaus chrysippus. The possible ecological role of the volatile compounds found is briefly discussed.

Tatyana Livshultz - One of the best experts on this subject based on the ideXlab platform.