The Experts below are selected from a list of 832383 Experts worldwide ranked by ideXlab platform
Defang Ouyang - One of the best experts on this subject based on the ideXlab platform.
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big data analysis of global advances in Pharmaceutics and drug delivery 1980 2014
Drug Discovery Today, 2017Co-Authors: Weixiang Zhang, Junling Deng, Yuanjia Hu, Qianqian Zhao, Yitao Wang, Defang OuyangAbstract:The past three decades have witnessed an upsurge of publications in Pharmaceutics and the drug delivery field. This review provides a landscape of global research advances in Pharmaceutics in the period 1980–2014 from publications, countries and institutions, and their collaborations. The scientific knowledge mapping analysis showed that the research frontier shifted from conventional pharmaceutical techniques (1980–1992) to advanced drug delivery systems (1993–2014). The history of drug delivery for this period is summarized and future prospects of pharmaceutical research are discussed
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Big data analysis of global advances in Pharmaceutics and drug delivery 1980–2014
Drug Discovery Today, 2017Co-Authors: Weixiang Zhang, Junling Deng, Yuanjia Hu, Qianqian Zhao, Yitao Wang, Defang OuyangAbstract:This review provides a comprehensive perspective of the global research advances and frontiers in Pharmaceutics from 1980 to 2014. Furthermore, a historical view and future prospects of drug delivery are discussed.
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Computational Pharmaceutics - Introduction to computational Pharmaceutics
Computational Pharmaceutics, 2015Co-Authors: Defang Ouyang, Sean C. SmithAbstract:Computational Pharmaceutics has the ability to provide multiscale lenses to pharmaceutical scientists, revealing mechanistic details ranging across the chemical reactions of small drug molecules, proteins, nucleic acids, nanoparticles, and powders with the human body. This chapter provides an introduction to the application of computational modeling techniques to problems relating to Pharmaceutics (drug delivery and formulation development) that will be of great relevance for pharmaceutical scientists and computational chemists in both industry and academia. Contributions from leading researchers cover both computational modeling methodologies and various examples where these methods have been applied successfully in this field. Crystal structure prediction (CSP) methods have gained wide attention from pharmaceutical scientists. Polymeric-based micellar vehicles have been widely used in Pharmaceutics for the delivery of both hydrophilic and lipophilic drugs. Physiology-based pharmacokinetics plays an important role in pre-clinical drug development and formulation development.
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computational Pharmaceutics application of molecular modeling in drug delivery
2015Co-Authors: Defang Ouyang, Sean C. SmithAbstract:Molecular modeling techniques have been widely used in drug discovery fields for rational drug design and compound screening. Now these techniques are used to model or mimic the behavior of molecules, and help us study formulation at the molecular level. Computational Pharmaceutics enables us to understand the mechanism of drug delivery, and to develop new drug delivery systems. The book discusses the modeling of different drug delivery systems, including cyclodextrins, solid dispersions, polymorphism prediction, dendrimer-based delivery systems, surfactant-based micelle, polymeric drug delivery systems, liposome, protein/peptide formulations, non-viral gene delivery systems, drug-protein binding, silica nanoparticles, carbon nanotube-based drug delivery systems, diamond nanoparticles and layered double hydroxides (LDHs) drug delivery systems. Although there are a number of existing books about rational drug design with molecular modeling techniques, these techniques still look mysterious and daunting for pharmaceutical scientists. This book fills the gap between Pharmaceutics and molecular modeling, and presents a systematic and overall introduction to computational Pharmaceutics. It covers all introductory, advanced and specialist levels. It provides a totally different perspective to pharmaceutical scientists, and will greatly facilitate the development of Pharmaceutics. It also helps computational chemists to look for the important questions in the drug delivery field.
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introduction to computational Pharmaceutics
Computational Pharmaceutics, 2015Co-Authors: Defang Ouyang, Sean C. SmithAbstract:Computational Pharmaceutics has the ability to provide multiscale lenses to pharmaceutical scientists, revealing mechanistic details ranging across the chemical reactions of small drug molecules, proteins, nucleic acids, nanoparticles, and powders with the human body. This chapter provides an introduction to the application of computational modeling techniques to problems relating to Pharmaceutics (drug delivery and formulation development) that will be of great relevance for pharmaceutical scientists and computational chemists in both industry and academia. Contributions from leading researchers cover both computational modeling methodologies and various examples where these methods have been applied successfully in this field. Crystal structure prediction (CSP) methods have gained wide attention from pharmaceutical scientists. Polymeric-based micellar vehicles have been widely used in Pharmaceutics for the delivery of both hydrophilic and lipophilic drugs. Physiology-based pharmacokinetics plays an important role in pre-clinical drug development and formulation development.
Ibrahim T Ozbolat - One of the best experts on this subject based on the ideXlab platform.
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9 – Applications of 3D Bioprinting
3D Bioprinting, 2017Co-Authors: Ibrahim T OzbolatAbstract:Three-dimensional bioprinting has been a powerful tool in patterning and precisely placing biologics including living cells, nucleic acids, drug particles, proteins, and growth factors to recapitulate tissue biology. Since the first time of cytoscribing cells demonstrated by Klebe in 1986, bioprinting has made a substantial leap forward, particularly in the last 10years, and been widely used in fabrication of living tissues for various application areas. The technology has been recently commercialized by a number of emerging businesses, and bioprinters and bioprinted tissues have gained significant interest in medicine and Pharmaceutics. This chapter presents the application areas of bioprinting technology including tissue engineering and regenerative medicine, transplantation and clinics, drug testing and high-throughput screening, and cancer research.
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3D bioprinting for drug discovery and development in Pharmaceutics
Acta Biomaterialia, 2017Co-Authors: Weijie Peng, Veli Ozbolat, Bugra Ayan, Donna Sosnoski, Pallab Datta, Ibrahim T OzbolatAbstract:Successful launch of a commercial drug requires significant investment of time and financial resources wherein late-stage failures become a reason for catastrophic failures in drug discovery. This calls for infusing constant innovations in technologies, which can give reliable prediction of efficacy, and more importantly, toxicology of the compound early in the drug discovery process before clinical trials. Though computational advances have resulted in more rationale in silico designing, in vitro experimental studies still require gaining industry confidence and improving in vitro-in vivo correlations. In this quest, due to their ability to mimic the spatial and chemical attributes of native tissues, three-dimensional (3D) tissue models have now proven to provide better results for drug screening compared to traditional two-dimensional (2D) models. However, in vitro fabrication of living tissues has remained a bottleneck in realizing the full potential of 3D models. Recent advances in bioprinting provide a valuable tool to fabricate biomimetic constructs, which can be applied in different stages of drug discovery research. This paper presents the first comprehensive review of bioprinting techniques applied for fabrication of 3D tissue models for pharmaceutical studies. A comparative evaluation of different bioprinting modalities is performed to assess the performance and ability of fabricating 3D tissue models for pharmaceutical use as the critical selection of bioprinting modalities indeed plays a crucial role in efficacy and toxicology testing of drugs and accelerates the drug development cycle. In addition, limitations with current tissue models are discussed thoroughly and future prospects of the role of bioprinting in Pharmaceutics are provided to the reader. Statement of Significance Present advances in tissue biofabrication have crucial role to play in aiding the pharmaceutical development process achieve its objectives. Advent of three-dimensional (3D) models, in particular, is viewed with immense interest by the community due to their ability to mimic in vivo hierarchical tissue architecture and heterogeneous composition. Successful realization of 3D models will not only provide greater in vitro-in vivo correlation compared to the two-dimensional (2D) models, but also eventually replace pre-clinical animal testing, which has their own shortcomings. Amongst all fabrication techniques, bioprinting- comprising all the different modalities (extrusion-, droplet- and laser-based bioprinting), is emerging as the most viable fabrication technique to create the biomimetic tissue constructs. Notwithstanding the interest in bioprinting by the pharmaceutical development researchers, it can be seen that there is a limited availability of comparative literature which can guide the proper selection of bioprinting processes and associated considerations, such as the bioink selection for a particular pharmaceutical study. Thus, this work emphasizes these aspects of bioprinting and presents them in perspective of differential requirements of different pharmaceutical studies like in vitro predictive toxicology, high-throughput screening, drug delivery and tissue-specific efficacies. Moreover, since bioprinting techniques are mostly applied in regenerative medicine and tissue engineering, a comparative analysis of similarities and differences are also expounded to help researchers make informed decisions based on contemporary literature.
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Two Photon Polymerisation
3D Bioprinting: Fundamentals Principles and Applications, 2016Co-Authors: Ibrahim T OzbolatAbstract:3D Bioprinting: Fundamentals, Principles and Applications provides the latest information on the fundamentals, principles, physics, and applications of 3D bioprinting. It contains descriptions of the various bioprinting processes and technologies used in additive biomanufacturing of tissue constructs, tissues, and organs using living cells. The increasing availability and decreasing costs of 3D printing technologies are driving its use to meet medical needs, and this book provides an overview of these technologies and their integration. Each chapter discusses current limitations on the relevant technology, giving future perspectives. Professor Ozbolat has pulled together expertise from the fields of bioprinting, tissue engineering, tissue fabrication, and 3D printing in his inclusive table of contents. Topics covered include raw materials, processes, machine technology, products, applications, and limitations. The information in this book will help bioengineers, tissue and manufacturing engineers, and medical doctors understand the features of each bioprinting process, as well as bioink and bioprinter types. In addition, the book presents tactics that can be used to select the appropriate process for a given application, such as tissue engineering and regenerative medicine, transplantation, clinics, or Pharmaceutics. Describes all aspects of the bioprinting process, from bioink processing through design for bioprinting, bioprinting techniques, bioprinter technologies, organ printing, applications, and future trends Provides a detailed description of each bioprinting technique with an in-depth understanding of its process modeling, underlying physics and characteristics, suitable bioink and cell types printed, and major accomplishments achieved thus far Explains organ printing technology in detail with a step-by-step roadmap for the 3D bioprinting of organs from isolating stem cells to the post-transplantation of organs Presents tactics that can be used to select the appropriate process for a given application, such as tissue engineering and regenerative medicine, transplantation, clinics, or Pharmaceutics
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3D Bioprinting: Fundamentals, Principles and Applications
3D Bioprinting: Fundamentals Principles and Applications, 2016Co-Authors: Ibrahim T OzbolatAbstract:© 2017 Elsevier Inc. All rights reserved. 3D Bioprinting: Fundamentals, Principles and Applications provides the latest information on the fundamentals, principles, physics, and applications of 3D bioprinting. It contains descriptions of the various bioprinting processes and technologies used in additive biomanufacturing of tissue constructs, tissues, and organs using living cells. The increasing availability and decreasing costs of 3D printing technologies are driving its use to meet medical needs, and this book provides an overview of these technologies and their integration. Each chapter discusses current limitations on the relevant technology, giving future perspectives. Professor Ozbolat has pulled together expertise from the fields of bioprinting, tissue engineering, tissue fabrication, and 3D printing in his inclusive table of contents. Topics covered include raw materials, processes, machine technology, products, applications, and limitations. The information in this book will help bioengineers, tissue and manufacturing engineers, and medical doctors understand the features of each bioprinting process, as well as bioink and bioprinter types. In addition, the book presents tactics that can be used to select the appropriate process for a given application, such as tissue engineering and regenerative medicine, transplantation, clinics, or Pharmaceutics. Describes all aspects of the bioprinting process, from bioink processing through design for bioprinting, bioprinting techniques, bioprinter technologies, organ printing, applications, and future trends Provides a detailed description of each bioprinting technique with an in-depth understanding of its process modeling, underlying physics and characteristics, suitable bioink and cell types printed, and major accomplishments achieved thus far Explains organ printing technology in detail with a step-by-step roadmap for the 3D bioprinting of organs from isolating stem cells to the post-transplantation of organs Presents tactics that can be used to select the appropriate process for a given application, such as tissue engineering and regenerative medicine, transplantation, clinics, or Pharmaceutics.
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Application areas of 3D bioprinting
Drug Discovery Today, 2016Co-Authors: Ibrahim T Ozbolat, Weijie Peng, Veli OzbolatAbstract:Three dimensional (3D) bioprinting has been a powerful tool in patterning and precisely placing biologics, including living cells, nucleic acids, drug particles, proteins and growth factors, to recapitulate tissue anatomy, biology and physiology. Since the first time of cytoscribing cells demonstrated in 1986, bioprinting has made a substantial leap forward, particularly in the past 10 years, and it has been widely used in fabrication of living tissues for various application areas. The technology has been recently commercialized by several emerging businesses, and bioprinters and bioprinted tissues have gained significant interest in medicine and Pharmaceutics. This Keynote review presents the bioprinting technology and covers a first-time comprehensive overview of its application areas from tissue engineering and regenerative medicine to Pharmaceutics and cancer research.
Weixiang Zhang - One of the best experts on this subject based on the ideXlab platform.
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big data analysis of global advances in Pharmaceutics and drug delivery 1980 2014
Drug Discovery Today, 2017Co-Authors: Weixiang Zhang, Junling Deng, Yuanjia Hu, Qianqian Zhao, Yitao Wang, Defang OuyangAbstract:The past three decades have witnessed an upsurge of publications in Pharmaceutics and the drug delivery field. This review provides a landscape of global research advances in Pharmaceutics in the period 1980–2014 from publications, countries and institutions, and their collaborations. The scientific knowledge mapping analysis showed that the research frontier shifted from conventional pharmaceutical techniques (1980–1992) to advanced drug delivery systems (1993–2014). The history of drug delivery for this period is summarized and future prospects of pharmaceutical research are discussed
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Big data analysis of global advances in Pharmaceutics and drug delivery 1980–2014
Drug Discovery Today, 2017Co-Authors: Weixiang Zhang, Junling Deng, Yuanjia Hu, Qianqian Zhao, Yitao Wang, Defang OuyangAbstract:This review provides a comprehensive perspective of the global research advances and frontiers in Pharmaceutics from 1980 to 2014. Furthermore, a historical view and future prospects of drug delivery are discussed.
Qianqian Zhao - One of the best experts on this subject based on the ideXlab platform.
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big data analysis of global advances in Pharmaceutics and drug delivery 1980 2014
Drug Discovery Today, 2017Co-Authors: Weixiang Zhang, Junling Deng, Yuanjia Hu, Qianqian Zhao, Yitao Wang, Defang OuyangAbstract:The past three decades have witnessed an upsurge of publications in Pharmaceutics and the drug delivery field. This review provides a landscape of global research advances in Pharmaceutics in the period 1980–2014 from publications, countries and institutions, and their collaborations. The scientific knowledge mapping analysis showed that the research frontier shifted from conventional pharmaceutical techniques (1980–1992) to advanced drug delivery systems (1993–2014). The history of drug delivery for this period is summarized and future prospects of pharmaceutical research are discussed
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Big data analysis of global advances in Pharmaceutics and drug delivery 1980–2014
Drug Discovery Today, 2017Co-Authors: Weixiang Zhang, Junling Deng, Yuanjia Hu, Qianqian Zhao, Yitao Wang, Defang OuyangAbstract:This review provides a comprehensive perspective of the global research advances and frontiers in Pharmaceutics from 1980 to 2014. Furthermore, a historical view and future prospects of drug delivery are discussed.
Yuanjia Hu - One of the best experts on this subject based on the ideXlab platform.
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big data analysis of global advances in Pharmaceutics and drug delivery 1980 2014
Drug Discovery Today, 2017Co-Authors: Weixiang Zhang, Junling Deng, Yuanjia Hu, Qianqian Zhao, Yitao Wang, Defang OuyangAbstract:The past three decades have witnessed an upsurge of publications in Pharmaceutics and the drug delivery field. This review provides a landscape of global research advances in Pharmaceutics in the period 1980–2014 from publications, countries and institutions, and their collaborations. The scientific knowledge mapping analysis showed that the research frontier shifted from conventional pharmaceutical techniques (1980–1992) to advanced drug delivery systems (1993–2014). The history of drug delivery for this period is summarized and future prospects of pharmaceutical research are discussed
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Big data analysis of global advances in Pharmaceutics and drug delivery 1980–2014
Drug Discovery Today, 2017Co-Authors: Weixiang Zhang, Junling Deng, Yuanjia Hu, Qianqian Zhao, Yitao Wang, Defang OuyangAbstract:This review provides a comprehensive perspective of the global research advances and frontiers in Pharmaceutics from 1980 to 2014. Furthermore, a historical view and future prospects of drug delivery are discussed.
