The Experts below are selected from a list of 159 Experts worldwide ranked by ideXlab platform
Suidong Wang - One of the best experts on this subject based on the ideXlab platform.
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saturated deep blue emitter based on a spiro benzoanthracene fluorene linked Phenanthrene Derivative for non doped organic light emitting diodes
New Journal of Chemistry, 2014Co-Authors: Houjie Liang, Xinxin Wang, Xingye Zhang, Zhiyang Liu, Xinhua Ouyang, Suidong WangAbstract:A spiro[benzoanthracene–fluorene] Derivative containing a Phenanthrene moiety, 2′,3-di(phenanthren-9-yl)spiro[benzo[de]anthracene-7,9′-fluorene] (DPSBAF), was prepared by a Suzuki coupling reaction. The photophysical and photochemical properties were investigated systematically. A non-doped organic light-emitting diode using DPSBAF as the emitter achieved a luminance efficiency of 2.18 cd A−1 with Commission Internationale de l'Eclairage 1931 chromaticity coordinates of (0.15, 0.09). The synthesized spiro[benzoanthracene–fluorene] Derivative with a high thermal stability, a glass transition temperature of 210 °C and a decomposition temperature of 410 °C, shows potential for application in non-doped saturated deep-blue organic light-emitting diodes.
Sevser Sahpaz - One of the best experts on this subject based on the ideXlab platform.
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Biocontrol activity of effusol from the extremophile plant, Juncus maritimus, against the wheat pathogen Zymoseptoria tritici
Environmental Science and Pollution Research, 2018Co-Authors: Ramla Sahli, Céline Rivière, Ali Siah, Abderrazak Smaoui, Jennifer Samaillie, Thierry Hennebelle, Vincent Roumy, Riadh Ksouri, Patrice Halama, Sevser SahpazAbstract:Zymoseptoria tritici , responsible for Septoria tritici blotch, is the most important pathogen of wheat. The control of this parasite relies mainly on synthetic fungicides, but their use is increasingly controversial and searching for alternative management strategies is encouraged. In this context, the biocontrol potential of crude methanolic extracts of eight extremophile plant species from Tunisia, including three xerophytes and five halophytes, against Z. tritici was assessed. Only the extract of Juncus maritimus rhizomes showed significant in vitro antifungal activity . In extremophile plants, the production of secondary metabolites is often influenced by abiotic conditions. Thus, we collected several samples of J. maritimus rhizomes at different vegetative stages, at different periods, and from different substrates to compare their antifungal activities. Our results suggest that the plant environment, especially the substrate of the soil, should be taken into account to identify great sources of natural antifungal products. From the most active sample, a 9,10-dehydroPhenanthrene Derivative, effusol, absent from other J. maritimus rhizomes extracts, was purified. This product showed a strong antifungal activity against the pathogen, with a minimal inhibitory concentration of 19 μg mL^−1 and an half-maximal inhibitory concentration of 9.98 μg mL^−1. This Phenanthrene Derivative could be a promising biocontrol molecule against Z . tritici .
Ralf Zimmermann - One of the best experts on this subject based on the ideXlab platform.
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First field application of a thermal desorption resonance-enhanced multiphoton-ionisation single particle time-of-flight mass spectrometer for the on-line detection of particle-bound polycyclic aromatic hydrocarbons
Analytical and Bioanalytical Chemistry, 2011Co-Authors: Markus Oster, Michael Elsasser, Jürgen Schnelle-kreis, Ralf ZimmermannAbstract:The on-line analysis of single aerosol particles with mass spectrometrical methods is an important tool for the investigation of aerosols. Often, a single laser pulse is used for one-step laser desorption/ionisation of aerosol particles. Resulting ions are detected with time-of-flight mass spectrometry. With this method, the detection of inorganic compounds is possible. The detection of more fragile organic compounds and carbon clusters can be accomplished by separating the desorption and the ionisation in two steps, e.g. by using two laser pulses. A further method is, using a heated metal surface for thermal desorption of aerosol particles. If an ultraviolet laser is used for ionisation, a selective ionisation of polycyclic aromatic hydrocarbons (PAH) and alkylated PAH is possible via a resonance-enhanced multiphoton-ionisation process. Laser velocimetry allows individual laser triggering for single particles and additionally delivers information on aerodynamic particle diameters. It was shown that particles deriving from different combustion sources can be differentiated according to their PAH patterns. For example, retene, a C_4-alkylated Phenanthrene Derivative, is a marker for the combustion of coniferous wood. In this paper, the first field application of a thermal desorption resonance-enhanced multiphoton-ionisation single particle time-of-flight mass spectrometer during a measurement campaign in Augsburg, Germany in winter 2010 is presented. Larger PAH-containing particles (i.e. with aerodynamic diameters larger than 1 μm), which are suspected to be originated by re-suspension processes of agglomerated material, were in the focus of the investigation. Due to the low concentration of these particles, an on-line virtual impactor enrichment system was used. The detection of particle-bound PAH in ambient particles in this larger size region was possible and in addition, retene could be detected on several particles, which allows to identify wood combustion as generic source of these particles. The observed diurnal distribution of these larger particles, however, support the origin by traffic induced re-suspension of sedimented/agglomerated material. Figure TD-REMPI mass spectrum of a single particle from ambient air exhibiting an aerodynamic diameter of 1.3 μm, showing typical PAH masses. The intense peak at m/z = 234 (retene) allows to identify wood combustion as a generic source of this particle
Carine Ali - One of the best experts on this subject based on the ideXlab platform.
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Selective inhibition of GluN2D-containing N-methyl-D-aspartate receptors prevents tissue plasminogen activator-promoted neurotoxicity both in vitro and in vivo
Molecular Neurodegeneration, 2011Co-Authors: Amandine Jullienne, Axel Montagne, Cyrille Orset, Flavie Lesept, Eric Maubert, Denis Vivien, David E Jane, Daniel T Monaghan, Carine AliAbstract:Background Tissue plasminogen activator (tPA) exerts multiple functions in the central nervous system, depending on the partner with which it interacts. In particular, tPA acts as a positive neuromodulator of N-methyl-D-aspartate glutamatergic receptors (NMDAR). At the molecular level, it has been proposed that the pro-neurotoxicity mediated by tPA might occur through extrasynaptic NMDAR containing the GluN2D subunit. Thus, selective antagonists targeting tPA/GluN2D-containing NMDAR signaling would be of interest to prevent noxious effects of tPA. Results Here, we compared three putative antagonists of GluN2D-containing NMDAR and we showed that the new compound UBP145 ((2R*,3S*)-1-(9-bromophenan-threne-3-carbonyl)piperazine-2,3-dicarboxylic acid) is far more selective for GluN2D subunits than memantine and PPDA (Phenanthrene Derivative (2S*, 3R*)-1-(Phenanthrene-2-carbonyl)piperazine-2,3-dicarboxylic acid). Indeed, in vitro, in contrast to the two other compounds, UBP145 prevented NMDA toxicity only in neurons expressing GluN2D (ie, in cortical but not hippocampal neurons). Furthermore, in cultured cortical neurons, UBP145 fully prevented the pro-excitotoxic effect of tPA. In vivo, we showed that UBP145 potently prevented the noxious action of exogenous tPA on excitotoxic damages. Moreover, in a thrombotic stroke model in mice, administration of UBP145 prevented the deleterious effect of late thrombolysis by tPA. Conclusions In conclusion, tPA exerts noxious effects on neurons by acting on GluN2D-containing NMDAR and pharmacological antagonists of GluN2D-containing NMDAR could be used to prevent the ability of tPA to promote neurotoxicity.
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Selective inhibition of GluN2D-containing N-methyl-D-aspartate receptors prevents tissue plasminogen activator-promoted neurotoxicity both in vitro and in vivo.
Molecular Neurodegeneration, 2011Co-Authors: Amandine Jullienne, Axel Montagne, Cyrille Orset, Flavie Lesept, David Jane, Daniel Monaghan, Eric Maubert, Denis Vivien, Carine AliAbstract:UNLABELLED: ABSTRACT: BACKGROUND: Tissue plasminogen activator (tPA) exerts multiple functions in the central nervous system, depending on the partner with which it interacts. In particular, tPA acts as a positive neuromodulator of N-methyl-D-aspartate glutamatergic receptors (NMDAR). At the molecular level, it has been proposed that the pro-neurotoxicity mediated by tPA might occur through extrasynaptic NMDAR containing the GluN2D subunit. Thus, selective antagonists targeting tPA/GluN2D-containing NMDAR signaling would be of interest to prevent noxious effects of tPA. RESULTS: Here, we compared three putative antagonists of GluN2D-containing NMDAR and we showed that the new compound UBP145 ((2R*,3S*)-1-(9-bromophenan-threne-3-carbonyl)piperazine-2,3-dicarboxylic acid) is far more selective for GluN2D subunits than memantine and PPDA (Phenanthrene Derivative (2S*, 3R*)-1-(Phenanthrene-2-carbonyl)piperazine-2,3-dicarboxylic acid). Indeed, in vitro, in contrast to the two other compounds, UBP145 prevented NMDA toxicity only in neurons expressing GluN2D (ie, in cortical but not hippocampal neurons). Furthermore, in cultured cortical neurons, UBP145 fully prevented the pro-excitotoxic effect of tPA. In vivo, we showed that UBP145 potently prevented the noxious action of exogenous tPA on excitotoxic damages. Moreover, in a thrombotic stroke model in mice, administration of UBP145 prevented the deleterious effect of late thrombolysis by tPA. CONCLUSIONS: In conclusion, tPA exerts noxious effects on neurons by acting on GluN2D-containing NMDAR and pharmacological antagonists of GluN2D-containing NMDAR could be used to prevent the ability of tPA to promote neurotoxicity.
Houjie Liang - One of the best experts on this subject based on the ideXlab platform.
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saturated deep blue emitter based on a spiro benzoanthracene fluorene linked Phenanthrene Derivative for non doped organic light emitting diodes
New Journal of Chemistry, 2014Co-Authors: Houjie Liang, Xinxin Wang, Xingye Zhang, Zhiyang Liu, Xinhua Ouyang, Suidong WangAbstract:A spiro[benzoanthracene–fluorene] Derivative containing a Phenanthrene moiety, 2′,3-di(phenanthren-9-yl)spiro[benzo[de]anthracene-7,9′-fluorene] (DPSBAF), was prepared by a Suzuki coupling reaction. The photophysical and photochemical properties were investigated systematically. A non-doped organic light-emitting diode using DPSBAF as the emitter achieved a luminance efficiency of 2.18 cd A−1 with Commission Internationale de l'Eclairage 1931 chromaticity coordinates of (0.15, 0.09). The synthesized spiro[benzoanthracene–fluorene] Derivative with a high thermal stability, a glass transition temperature of 210 °C and a decomposition temperature of 410 °C, shows potential for application in non-doped saturated deep-blue organic light-emitting diodes.